Carreira Group – Professor Product Portal

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Professor Erick M. Carreira

The Carreira Research Group is focused on expanding and creating access to uncharted landscape in chemical space. In joint efforts with SpiroChem, Carreira develops innovative spirocyclic building blocks, seeking to make them available to the community at large. Molecules constructed from these building blocks take on unique three-dimensional profiles due to the underlying spirocyclic scaffold, enriched by the presence of diverse combinations of exit vectors as sites for functionalization. Importantly, the spirocyclic building blocks possess physicochemical properties useful in the drug discovery process. Thus, drug leads can be tuned through appending these subunits to the periphery of a given scaffold. Moreover, these compact modules represent a useful collection of unprecedented inputs for fragment-based libraries. In all applications, the inherent novelty of the structure affords researchers new opportunities to run wild in their designs and avenues to chemical space – with their imagination as the sole limitations. Sigma-Aldrich is proud to partner in the efforts to make these building blocks widely available.

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For recent articles from the Carreira Laboratory:


Products available from Aldrich in collaboration with Professor Dr. Carreira and SpiroChem

     
Dong Bo Li, Mark Rogers-Evans, Erick M Carreira
Organic Letters 2013-09-20
New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to the spirocycles are reported.Read More
Johannes A Burkhard, Carine Guérot, Henner Knust, Erick M Carreira
Organic Letters 2012-01-06
The preparation of versatile azaspiro[3.3]heptanes carrying multiple exit vectors is disclosed. Expedient synthetic routes enable the straightforward access to these novel modules that are expected to have significance in drug discovery and design. © 2011 American Chemical SocietyRead More
Jean-François Paquin, Christian Defieber, Corey R J Stephenson, Erick M Carreira
Journal of the American Chemical Society 2005-08-10
A general route to enantioenriched 3,3-diarylpropanals is presented. These useful building blocks are prepared via an asymmetric rhodium-catalyzed conjugate addition of arylboronic acids to cinnamaldehyde derivatives in the presence of chiral dienes. The addition of both electron-poor as well as electron-rich boronic acids proce...Read More
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