Bode Group – Professor Product Portal

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Professor Jeffrey W. Bode

The Bode Group aims to develop new reactions and reagents for the synthesis of complex molecules.

The Bode Group has developed N-mesityl-substituted NHCs as organocatalysts for the catalytic generation of reactive species including activated carboxylates, homoenolates, and enolates. These novel catalysts and reactions have made possible a new generation of highly enantioselective annulations from simple starting materials under mild reaction conditions, usually at room temperature and without added reagents.

Furthering the goal of designing new reagents to enable the assembly of complex molecules, the Bode group has developed SnAP reagents for the facile, one-pot conversion of aldehydes into N-unprotected, saturated N-heterocycles, including bicyclic and spirocyclic structures. These easy to handle reagents provide a simple and robust alternative to the challenging and restrictive cross-coupling methods for the functionalization of saturated N-heterocycles.

Bode Group website
Link to Contemporary Carbene Chemistry abstract (2013)
Link to Aldrichimica Acta review (2015)

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Products available at Aldrich from the Bode Laboratory

     
Michael U Luescher, Cam-Van T Vo, Jeffrey W Bode
Organic Letters 2014-02-21
Substituted piperazines and morpholines are valuable structural motifs in biologically active compounds, but are not easily prepared by contemporary cross-coupling approaches. In this report, we introduce SnAP reagents for the transformation of aldehydes into N-unprotected piperazines and morpholines. This approach offers simple...Read More
Cam-Van T Vo, Michael U Luescher, Jeffrey W Bode
Nature Chemistry 2014-04-01
Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is increasing. Reliable and predictable synthetic methods for the preparation of these compounds, especially medium-sized rings, are limited. We describe the development of SnAP (Sn amino protocol) reagents for the transformation of aldehy...Read More