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Professor Pierangelo Metrangolo

Our group has developed in collaboration with the Politecnico di Milano spin-off company FluorIT Srl a novel contrast agent possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are excellent for in vivo 19F-MRI applications1. The overall concept underpinning our technology is illustrated by the unique properties of a novel fluorinated molecule recently reported by our group2. This molecule called PERFECTA (suPERFluorinatEd ContrasT Agent) bears 36 equivalent 19F atoms and therefore shows a single, intense NMR peak. PERFECTA is neither perfluorinated nor contains long perfluoroalkyl chains like current competing molecules, thus being more environmental compliant and avoiding bioaccumulation issues. Furthermore, it possesses a hydrocarbon polar core with ether bonds, thus offering the possibility for biodegradation in vivo. PERFECTA can be easily formulated in water in large quantities with trivial methods and surfactants and its excellent 19F-MRI performance was demonstrated both in in vitro imaging of labeled cells and in vivo, on rats. Finally, PERFECTA’s molecular structure can be easily modified yielding several asymmetrically substituted derivatives, thus opening up a plethora of new possible applications in the field of multimodal imaging platforms and theranostics3. For example, functionalization with a thiol group allowed to bind to gold nanoparticles (Au-NPs), while the introduction of a fluorescent chromophore allows to combine MRI and optical imaging.

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Ilaria Tirotta, Valentina Dichiarante, Claudia Pigliacelli, Gabriella Cavallo, Giancarlo Terraneo, Francesca Baldelli Bombelli, Pierangelo Metrangolo, Giuseppe Resnati
Chemical Reviews 2015-01-28
Ilaria Tirotta, Alfonso Mastropietro, Chiara Cordiglieri, Lara Gazzera, Fulvio Baggi, Giuseppe Baselli, Maria Grazia Bruzzone, Ileana Zucca, Gabriella Cavallo, Giancarlo Terraneo, Francesca Baldelli Bombelli, Pierangelo Metrangolo, Giuseppe Resnati
Journal of the American Chemical Society 2014-06-18
(19)F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo (19)F-MRI app...Read More
Daniele Maiolo, Pablo Del Pino, Pierangelo Metrangolo, Wolfgang J Parak, Francesca Baldelli Bombelli
Nanomedicine 2015-01-01
Nanomedicine aims to find novel solutions for urgent biomedical needs. Despite this, one of the most challenging hurdles that nanomedicine faces is to successfully target therapeutic nanoparticles to cells of interest in vivo. As for any biomaterials, once in vivo, nanoparticles can interact with plasma biomolecules, forming new...Read More
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