Water-Soluble Fullerene Materials

By: Joe Porwoll, Material Matters 2009, 4.1, 1.

Material Matters 2009, 4.1, 1.

Joe Porwoll, President
Aldrich Chemical Co., Inc.

Dr. Michael Diener of TDA Research Inc., kindly suggested that we offer the pyrrolidine-derivatized C60 molecule with a tris acid functionality (Aldrich Prod. No. 709085). This water-soluble material serves as a superoxide quencher,1 on account of the redox properties of the C60 moiety. It shows almost 100% improvement in the O2 - quenching activity, which is measured by the decreased levels in reduction of cytochrome c by O2 -, (IC50 = 103.4 μM) over analogous water-soluble C60 molecules (IC50 ~ 200 μM).2 Fullerene-based compounds therefore have the potential to be patent antioxidants to protect against oxidative stress.3 These materials are expected to play a major part in the fight against Alzheimer’s, Parkinson’s, AIDS and many other diseases in which oxidation mechanisms play major roles.

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References

  1. Okuda, K.; Hirota, T.; Hirobe, M.; Nagano, T.; Mochizuki, M.; Mashino, T. Fullerene. Sci. Technol. 2000, 8, 89-104.
  2. Sun, T.; Xu, Z. Bioorg. Med. Chem. Lett. 2006, 16, 3731-3734.
  3. Lin, A. M. Y.; Chyi, B. Y.; Wang, S. D.; Yu, H.-H.; Kanakamma, P. P.; Lu, T.-Y.; Chou, C. K.; Ho, L. T. J. Neurochem. 1999, 72,1634-40.

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