changing-gc-inlet-liner

GC Performance Tip, Reporter Vol. 19.9

No sample is perfectly clean and over time nonvolatile sample residues contaminate liners. As these contaminants accumulate they adversely affect chromatography by creating sites that lead to the absorption or decomposition of critical analytes. The principle mechanism is one of acid or base interaction between accumulated residues and the analyte functionality. The result is reduced analyte response, irreproducible quantitation, tailing or even missing peaks.

After running an extremely dirty sample the user should visually inspect the inlet liner. If there is notable contaminant build up on the liner, replace it before compromising your data.

A bad inlet liner may impact data quality before you notice the symptoms. For the best overall system performance the analyst must change the liner before noticing a problem. The only way to do this is to have a routine maintenance procedure in place that includes liner replacement and liner inspection.

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