EDC-mediated couplings of Polyester-16-hydroxyl-1-carboxyl bis-MPA dendron

Product Description




Theoretical MW: 1,759.7 g/mol
Average Molecular Formula: C75H125O46
Number of hydroxyl groups: 16
Number of carboxylic acid groups: 1


This monodisperse compound has multiple surface hydroxyl groups and a single carboxylic acid focal point function. The carboxylic acid function is well suited for EDC-mediated coupling to amine-containing reagents. The hydroxyl groups are selectively reactive with anhydrides or acyl halides (see Figure 1). It is transparent to light in the UV/Vis wavelength region.


Figure 1. Reaction Scheme (686662)


The product is a freeze-dried, white powder, which may contain traces of methanol or ether.

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Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses. Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.

Preparation Instructions

The product is soluble in polar organic solvents (THF, DMSO, DMF, and methanol) and water.

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Storage/Stability

Polyester dendrons are susceptible to hydrolysis, which is accelerated when material is dissolve d in water, at acidic/basic pH, or at elevated temperatures. For extended storage, store the dry powder at 2–8 °C.

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Related Products

Polyester-8-hydroxyl-1-carboxyl bis-MPA dendron, generation 3 (Catalog Number 686670)
Polyester-32-hydroxyl-1-carboxyl bis-MPA dendron, generation 5 (Catalog Number 686654)
EDC, N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (Catalog Number E1769)

Manufactured by Polymer Factory Sweden AB.

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Materials

     

References

EDC-mediated couplings:

  1. Desai, M.C., and Stramiello, L.M.S., Polymer Bound EDC (P-EDC): A Convenient Reagent for Formation of an Amide Bond. Tetrahedron Letters, 34, 7685-7866 (1993).
  2. Xu, Y., and Miller, M.J., Total Syntheses of Myobactin Analogues as Potent Antimycobacterial Agents Using a Minimal Protecting Group Strategy. J. Org. Chem., 63, 4314-4322 (1998).
  3. Futami, J. et al., Preparation of Potent Cytotoxic Ribonuecleases by Cationization. Enhanced Cellular Uptake and Decreased Interaction with Ribonuclease Inhibitor by Chemcial Modification of Carboxyl Group. Biochemistry, 40, 7518-7524 (2001).

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