 | Z705853 | Analogue-Based Drug Discovery | The easiest way to create a new drug is to modify an existing one. These so-called drug analogs account for about half of all "new" drugs. In addition, drug analogs can be modeled on naturally occurring bioactive substances that do not make good drugs on their own. This first authoritative overview discusses analog-based drug discovery for, among others, beta-blockers, ACE inhibitors, steroids, opiates, coxibs, stigmines, proton pump inhibitors, platinum compounds and quinolones. In addition, case studies on selected commercially successful drug analogs provide prime advice for new drug development projects based on modification. The book has an exclusive table of the 1,000 most successful drug analogs according to IMS ranking, classified in terms of chemical structure, mode of action and patentability. It is officially endorsed by the IUPAC's Drug Development Committee.
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 | Z379794 | Antisense Technology: A Practical Approach | Use of antisense oligonucleotides is a powerful technique for silencing specific genes, but it requires careful optimization and species-specific methods for success. Each chapter is written by an acknowledged expert with a record of success at the bench; each includes authoritative guidance, tips for success, and trouble-shooting advice.
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 | Z370010 | Antisense Therapeutics | An authoritative survey of this fascinating strategy for drug discovery: using complementary oligonucleotides to block expression of disease-associated genes. Contributors discuss selection of gene targets, synthesis of oligonucleotides, routes of administration, and issues of pharmacokinetics. Current research on anti-viral drugs, cancer treatment, and therapies for genetic disorders is summarized.
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 | Z704008 | Applying Genomic and Proteomic Microarray Technology in Drug Discovery | The book covers the issues surrounding gene expression and protein microarrays for pharmacogenomic and pharmacoproteomic applications. The author critically assesses those studies that have helped define applications in genomics and proteomics, explains gene expression microarray applications, and examines the utility of the protein microarray. He covers alternative substrates and the preparation of various surface chemistries together with their suitability for immobilization of nucleic acids and proteins. He delineates the mechanics of microarraying including environmental conditions, printer and pin performance. The book supplies protocols for printing nucleic acids and proteins and a discussion of other important parameters such as print buffers (inks) and factors influencing print quality.
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 | Z700843 | Beginner’s Guide to Microarrays | The manufacture, experimental design, and analysis of microarrays are not always straightforward, and researchers run into roadblocks that hinder progress. This book is directed to the core facility manager who produces, hybridizes, and scans arrays, and the research scientist who will be performing the analysis and interpreting the results. It provides a user friendly coverage and protocols for the technical steps and procedures involved in many facets of microarray technology, including: Coating glass slides; Designing oligonucleotide probes; Troubleshooting spotting problems; Normalizing background signal and controlling for systematic variance; Analyzing data with statistical procedures.
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 | B5056 | Bioinformatics Basics: Applications in Biological Science and Medicine | Scientists use an extensive databank to access structural information on proteins and nucleic acids and a specialized form of software to analyze the hybridization pattern of DNA chips. The success of biotechnology and pharmaceutical industries has been a result of technical advancements in genomics, proteomics, and bioinformatics. This book describes the organization of public domain databases with a tutorial for the services described. It concentrates on three major database clusters and relevant software tools that are maintained in the US, Europe, and Japan.
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 | Z704415 | Bioinformatics and Drug Discovery | A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.
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 | B2931 | Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, 2nd ed. | The second edition covers the broad spectrum of topics in bioinformatics, ranging from Internet concepts to predictive algorithms used on sequence, structure, and expression data. It includes: (a) all new end-of-chapter Web resources, bibliographies, and problem sets, (b) accompanying Website containing the answers to the problems, as well as links to relevant Web resources, (c) new coverage of comparative genomics, large-scale genome analysis, sequence assembly, and expressed sequence tags, (d) a glossary of commonly used terms in bioinformatics and genomics.
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 | B8308 | Bioinformatics: From Genomes to Drugs, 2 Volume Set | Bioinformatics promises to revolutionize the process of drug discovery and development. This book provides an application-oriented overview of this technology. In addition, the state-of-the-art in bioinformatics is evaluated from a global view by introducing real application scenarios such as genome projects that require the use of a whole set of bioinformatics tools. The knowledge on bioinformatics presented enables readers to go beyond a mere push-button approach to using bioinformatics software and interpreting the data generated, but also to assess the potential and limitations of today's bioinformatics software and future challenges.
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 | B4306 | Bioinformatics: Sequence and Genome Analysis | Application of computational methods to DNA and protein science is an exciting development. This book features sequence alignment, structure prediction, phylogenetic and gene prediction, database searching, and genome analysis that are clearly explained and illustrated along with underlying algorithms and assumptions. Theoretical underpinnings are linked to biological problems and solutions. Extensive tables provide descriptions and Web sources for a range of available software. An associated Website, accessible free of charge by book purchasers, provides links to Internet sources referred to in the text (http://www.BioinformaticsOnline.org ).
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 | B8161 | Bioinformatics: Sequence, Structure and Databanks, A Practical Approach | Covers practical important topics in the analysis of protein sequences and structures. It compares amino acid sequences to structures comparing structures to each other, and presents searching information on entire protein families as well as searching with single sequences. It shows how to set up and use the SRS molecular biology database management system. There are chapters on multiple sequence alignment and protein secondary structure prediction.
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 | B7183 | Biologist’s Guide to Analysis of DNA Microarray Data | This is the first authoritative text to focus on microarray analysis (as opposed to technology) in diverse biological and medical applications. Written for biologists without special training in data analysis and statistics, the Guide takes over where the image analysis software that accompanies DNA array equipment typically leaves off-with a file of signal intensities and fold changes compared to a control. The broad spectrum of established analysis approaches is covered, including cluster analysis, function prediction, and principal component analysis. A thorough, critical review of software programs is presented.
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 | Z701017 | Burger’s Medicinal Chemistry and Drug Discovery® 6th ed.,Volume 1: Drug Discovery | This edition of Dr. Burger’s classic helps researchers with both traditional and state-of-the-art principles and practices governing new medicinal drug research and development. Completely revised to reflect the many changes that have occurred in the field, it brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery. This volume contains new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery.
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 | Z702609 | Chemical Genomics | The most comprehensive reference on this new and rapidly accelerating area of biotechnological innovation.This highly interdisciplinary reference/text identifies and elucidates the most influential developments in chemical genomics for improved research and advancement in a diverse array of fields ranging from proteomics, bioinformatics, and microfluidics to drug discovery and toxicology.
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 | Z704393 | Chemical Genomics: Reviews and Protocols | An up-to-date introduction for the uninitiated into the various “flavors” of chemical genomics with a series of readily reproducible techniques for applications in organic chemistry, protein chemistry, and computer science, emphasizing the high-throughput approaches that are the essence of chemical genomics. The techniques range from the classic design of small molecules as affinity ligands for specific protein families, to in silico docking for computational approaches to protein–small molecule interactions, to producing highly diverse collections of proteins, carbohydrates, and small molecules for use in arrays containing large numbers of these molecules. There are also methods for the production of proteins and carbohydrates using different expression systems, for analyzing proteins using mass spectrometry, and for arraying proteins and carbohydrates on solid supports.
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 | Z703478 | Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective | Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and from leading pharmaceutical companies, this book is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
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 | Z702676 | Chemoinformatics: Concepts, Methods and Tools for Drug Discovery | The authors explain the theory behind the crucial concepts of molecular similarity and diversity, describe the challenging efforts to use chemoinformatics approaches to virtual and high-throughput screening, and illuminate the latest developments in multidimensional QSAR analysis. Other topics of interest include the use of partitioning algorithms and classification methods for analyzing large compound databases, screening sets, and virtual screening for active molecules; different approaches to target class-specific library design; and the generation of a novel class of molecular surface properties descriptors that can be readily calculated from 2D representations of molecular structures.
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 | Z702455 | Chirality in Drug Design and Development | Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals -- supporting researchers as they critically evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds.
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 | Z411604 | Combinatorial Chemistry and Molecular Diversity in Drug Discovery | This book highlights the critical concepts and issues involved in implementing combinatorial chemistry to create chemical libraries. It not only covers both the techniques and tools used in this field, but also the organizational and strategic questions faced by pharmaceutical managers. The authors apply combinatorial technologies to drug discovery and development and place co-evolving technologies and practices in a global framework. Included among the many topics are Library strategy and design; Solid-phase synthesis; Small molecular libraries; Automation, analytical, and computational methodology; Biological diversity; Strategies for screening combinatorial libraries; Combinatorial drug screening and development.
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 | C8476 | Combinatorial Chemistry: A Practical Approach | Being a powerful modern technology, combinatorial chemistry has had implications in many areas of chemistry and biology, and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation, and explains the use of automation and robotics.
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| | Z539937 | Combinatorial Chemistry: A Practical Approach | This book shows that modern combinatorial synthesis is possible not only in the solid phase, but also in solution. Moreover, it discusses computer-assisted methods as well as the apparatus and instrumentation required for the combinatorial method. Successful and experienced researchers offer their well-founded insight and perspective into this diverse field.
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 | Z424277 | Combinatorial Chemistry: Synthesis, Analysis, Screening | Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book. The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry.
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 | Z422509 | Combinatorial Index | This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled "Points of Interest," which highlights the strengths and weaknesses of the various studies. The index covers the use of solution-based synthesis for the generation of molecular diversity and includes a structural appendix showing functional group transformations.
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| | Z513733 | Combinatorial Library Design and Evaluation: Principles, Software Tools, and Applications in Drug Discovery | This book traces the latest advances in rational drug discovery and combinatorial library design, covering basic principles, design strategies, methodologies, software tools and algorithms, and applications. Specific topics include fast continuum electrostatics methods for structure-based ligand design, knowledge- based approaches for the design of small-molecule libraries for drug discovery, relative and absolute diversity analysis of combinatorial libraries, and design of combinatorial libraries that mimic biological motifs.
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 | Z700665 | Combinatorial Library: Methods and Protocols | A panel of expert researchers have collected a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of such combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR.
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| | Z514764 | Combinatorial Strategies in Biology and Chemistry | Combinatorial chemistry has taken the pharmaceutical industry by storm over the past ten to fifteen years. There has been a massive investment in automation by pharmaceutical companies and a demand for graduates/PhDs with experience and knowledge of combinatorial chemistry. These days the academic education of chemists and biologists is gradually converging, so those entering the pharmaceutical industry need to be not only chemistry graduates but also biologists applying their biological knowledge to chemistry. Many chemists, however, still require experience in biological methods and similarly biologists have not yet realized the power of chemical methods. This book will therefore help ease the transition from biology into chemistry and vice versa, for those working in the combinatorial chemistry field. Because combinatorial chemistry evolved from the requirements of the biology field, the authors have written this book with both biologists and chemists in mind. Combinatorial chemistry is a new and highly influential area of modern synthetic chemistry based on efficient, parallel synthesis of molecules, as opposed to the use of several synthetic steps, to produce many sets of compounds for biological evaluation. The techniques used in this area are key to the discovery of new drug compounds in the pharmaceutical and agrochemical industries. Combinatorial Methods in Chemistry and Biology describes the origins, basics and techniques used both in combinatorial chemistry and molecular biology.
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 | Z702234 | Computational Medicinal Chemistry for Drug Discovery | Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized for ligand deisgn. This book examines molecular mechanics, semi-empirical methods, wave function-based quantum chemistry, density functional theory, 3-D structure generation, conformational analysis and hybrid methods. It views pharmacophore discovery and the use of 3D pharmacophore models in 3D database searching and studies vibrational circular dichroism spectroscopy for the stereochemical characterization of chiral molecules.
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 | Z700320 | DNA Array Image Analysis: Nuts & Bolts | DNA Microarrays are an indispensable tool in molecular biology, which allows researchers to gain insight into the intricate mechanisms of gene expression. Common to all array-based technologies is the necessity to analyze digital images of the scanned DNA array. This book emphasizes aspects of both theory and application. It offers the basics of machine vision and image analysis for biologists, "how-to" approach to microarray image analysis, and practical tips for both the novice in the field and the advanced user.
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 | D6064 | DNA Arrays: Methods and Protocols | Microarray technology is used in research of gene expression, mutation analysis, proteomics and gene sequencing. Protocols provide instruction in designing and constructing DNA arrays as well as hybridizing them with biological samples for analysis. Details include how to attach or print arrays on various matrices, biological sample preparation (DNA and RNA), hybridization conditions, signal detection, probe optimization, different printing technologies and data collection and analysis. Other topics are genotyping, sequencing by hybridization, antisense reagents, gene expression analysis, and business aspects of biochip technology.
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 | D5565 | DNA Arrays: Technologies and Experimental Strategies | A giant leap in technology took place with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of thousands of genes. This book offers a view of different aspects of this rapidly developing technology, including oligonucleotides and electrochemical arrays. Up-to-date insights into methodological fundamentals of construction of DNA arrays, optimization of hybridization conditions, the use of expression data in bioinformatics, different software tools, and the application of microarray technology for drug discovery process are provided.
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 | D5440 | DNA Microarrays: A Molecular Cloning Manual | DNA microarray, or DNA chip technology is a new and powerful means of discovering, characterizing and analyzing genes and their expression patterns. This manual assembles and synthesizes the expertise of over 30 innovators in this emerging field to provide authoritative, detailed instruction on the design, construction, and applications of microarrays, as well as comprehensive descriptions of the software tools and strategies required for extensive image and data analysis. It complements the best selling manual "Molecular Cloning".
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 | D6187 | DNA Microarrays: A Practical Approach | Written and edited by experts in the field, this book provides valuable insight into the remarkable advancement of DNA microarrays. It is essential for researchers investigating patterns of gene expression and useful for all those interested in the use of biochips.
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 | Z700185 | DNA Microarrays: Gene Expression Applications | This complete and practical manual on expression measurement using DNA arrays covers the existing methods (from nylon macroarrays to oligonucleotide chips) and includes detailed protocols. It has been written by scientists who have experienced the difficulties involved in actually using microarrays, and provides helpful advice and hints on setting up these powerful but tricky methods. Software, data mining procedures and probable future developments, which should be useful to anyone interested in expression measurement, are also covered. It provides detailed protocols as well as many helpful hints to achieve experimental success and to avoid pitfalls.
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 | Z704504 | Drug Discovery Handbook | This book gives professionals a tool to facilitate drug discovery by bringing together for the first time, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology; Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more; Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques.
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 | Z701025 | Drug Discovery and Evaluation: Pharmacological Assays, 6th ed. | This edition contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic respiratory, renal and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed CD-ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments will help one plan experiments more effectively.
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 | Z703370 | Drug Discovery for Nervous System Diseases | The neurosciences have been a difficult field for drug discovery, but enormous progress in molecular biology has yielded breakthrough discoveries of the causes of nervous system diseases leading to better-targeted therapies. This book presents the latest techniques and approaches for drug discovery, organizing them according to diseases rather than classes of drugs or drug targets, as past books have done. The coverage includes: * Fundamentals of drug discovery-receptors, target selection, and drug development * Schizophrenia * Depression * Alzheimer's disease * Parkinson's disease * Ischemic stroke, brain, and spinal cord injury. Each chapter contains a description of existing drugs leading to recent molecular biological and genetic findings, translational research and the interface to clinical trials, and an outlook on future drug targets.
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 | Z704172 | Enzymes and Their Inhibition: Drug Development | Once an enzyme target is selected or discovered for a particular disease or infection, detailed information must be compiled for the rational design of an inhibitor. This book examines enzyme inhibition in detail, and describes the design and development of such inhibitors. It provides an overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss various types of enzyme inhibitors and the principles involved in developing them into effective drugs. This book describes the problems that can be encountered in translating results from the bench to the market place, and suggests approaches that circumvent these difficulties
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 | Z703923 | Evaluation of Enzyme Inhibitors in Drug Discovery | While providing an understanding of enzyme-inhibitor evaluation. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, it delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted.
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| | Z540722 | Experimental Design for Combinatorial and High Throughput Materials Development | In the past decade, combinatorial and high throughput experimental methods have revolutionized the pharmaceutical industry, allowing researchers to conduct more experiments in a week than was previously possible in a year. Now high throughput experimentation is rapidly spreading from its origins in the pharmaceutical world to larger industrial research establishments such as GE and DuPont, and even to smaller companies and universities. Consequently, researchers need to know the kinds of problems, desired outcomes, and appropriate patterns for these new strategies. Editor James Cawse's far-reaching study identifies and applies, with specific examples, these important new principles and techniques. This book progresses from methods that are now standard, such as gradient arrays, to mathematical developments that are breaking new ground. The former will be particularly useful to researchers entering the field, while the latter should inspire and challenge advanced practitioners. The book's contents are contributed by leading researchers in their respective fields. The text also contains over 200 useful charts and drawings.
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| | Z424269 | Fmoc Solid Phase Peptide Synthesis: A Practical Approach | In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is not the standard approach for the routine production of peptides. The focus of this new volume is much broader; it covers not only the essential procedures for the production of linear peptides but also more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification.
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 | Z705365 | Handbook of Assay Development in Drug Discovery | The need to screen targets faster and more efficiently, coupled with advances in parallel and multiplex chemical synthesis, has contributed to the increasing use of multiwell assays for drug discovery. This book is a reference that describes the complete armament of tools available for performing various assay techniques. It presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. The handbook describes biochemical assay classes as well as non-class specific assay development for cell-based assays. It covers a wide range of target classes-including kinases, proteases, nuclear receptors, and GPCRs-and describes currently employed methods and assay types, such as radioligand binding assays, image analysis assays, enzyme fragment complementation, and bioluminescent and fluorescent-based assays.
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| | Z514837 | Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials, 2 Volume Set | At long last, the mechanism-based and application-oriented handbook of combinatorial chemistry. Since its very beginning, research in this field has continued to develop at a rapid rate. Increasingly elegant methods are being invented and an even wider range of possible applications is still being discovered, such that combinatorial chemistry is now an integral part of industrial and academic research. The high-class editorial team - K. C. Nicolaou of The Scripps Institute and UCSD, and R. Hanko and W. Hartwig from Bayer - ensure comprehensive coverage and top quality contributions. This two-volume work deals with synthetic chemistry in all its forms, applications from life sciences, chemistry and material sciences, all there is to know about compound library design and synthesis, and, of course, the general basics - making it an indispensable reference for synthetic, organic and medicinal chemists, chemical biologists as well as material scientists.
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 | Z703958 | High Throughput Analysis for Early Drug Discovery | This book offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all investigating combinatorial techniques to increase overall efficiency and productivity.
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 | H8161 | High Throughput Screening: Methods and Protocols | Leading scientists explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing the guidebook they wish had been available when they started in HTS, they illuminate the HTS process with detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Discussions provide those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points.
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 | H6285 | High Throughput Screening: The Discovery of Bioactive Substances | Furnishing information on the most important investigational system for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a foundation for the implementation and development of HTS in bio-based industries and associated academic environments. Topics include how to attain natural products for HTS programs.
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 | H6410 | High Throughput Synthesis: Principles and Practices | This reference presents an extensive compilation of "how-to" methods, novel materials, and catalyst developments for creating a multitude of new compounds. It couples introductory sections with case studies that clarify theory through practice, emphasizing potential for reproducing experiments in detail. This text explores research areas such as microfluidics and sensor development. It describes hands-on mechanics toward high-throughput synthesis of new materials and catalysts, along with automated, robotic, and nonautomated synthesizers for production of compound libraries.
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 | Z704997 | Industrialization of Drug Discovery: From Target Selection Through Lead Optimization | The book delineates the basic tenets underlying modern drug discovery, how they have evolved, and their use in various approaches and strategies. It examines the regulations, requirements, guidelines, and draft documents that guide so many FDA actions. The editor devotes the remainder of the discussion to industrialization, compound and knowledge management functions, the drug screening process, collaboration, and ethical issues. Drawing on real-life examples, the book elucidates a new approach to drug discovery and development. It includes three steps: understand the science, unravel the story, and then intelligently apply the technology, using all techniques, not just automation. Using these steps, you can meet the goals of more specific targets, more selective compounds, and decreased cycle times.
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 | I6532 | Integrated Drug Discovery Technologies | This first of its kind reference provides a global overview of emerging drug discovery technologies by presenting and integrating new techniques. Combining integration of contemporary mechanization with strategies in drug discovery, this volume features the most current advances that will afford better, faster, and more cost-effective means of design and screening. This book presents the most promising science with the potential to revolutionize the drug discovery process, explains the rationale and developmental background behind evolving practices, highlights the impact of Information Technology on drug discovery, and details information management, including strategies and infrastructure
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 | Z704245 | Integrated Strategies for Drug Discovery Using Mass Spectrometry | Today, new analytical strategies and techniques are necessary to meet sample throughput requirements and manpower constraints. Among them, mass spectrometry has grown to be a front-line tool throughout drug discovery. This book provides a thorough review of current analytical approaches, industry practices, and strategies in drug discovery. The topics represent current industry benchmarks in specific drug discovery activities that deal with proteomics, biomarker discovery, metabonomic approaches for toxicity screening, lead identification, compound libraries, quantitative bioanalytical support, biotransformation, reactive metabolite characterization, lead optimization, pharmaceutical property profiling, sample preparation strategies, and automation
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 | Z558494 | Lipases and Phospholipases in Drug Development | Lipases and phospholipases are key control elements in mammalian intermediary metabolism. They share many common features that set them apart from other metabolic enzyme classes, most importantly their association with "two-dimensional" substrates. Their potential as drug targets for the treatment of metabolic diseases is increasingly recognized, and the first lipase inhibitor drugs have been successfully introduced.
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 | M1066 | Mass Spectrometry in Drug Discovery | This reference summarizes the theory, instrumentation, and application of mass spectrometry and atmospheric pressure ionization to screen, evaluate, and improve the performance and quality of drug candidates. It covers: recent advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing; cassette dosing; the utilization of liquid chromatography/mass spectrometry (LC/MS) in chemical library characterization, combinatorial chemistry, drug transport, and in vivo microdialysis; reliable methods of sample preparation and handling; novel strategies to determine and characterize metabolite structures; the impact of absorption, distribution, metabolism, and elimination properties on drug discovery.
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 | Z700290 | Microarray Analysis | Microarrays enable one to analyze genes, proteins and other biological molecules on a genomic scale. This comprehensive and multidisciplinary text contains separate chapters devoted to surface chemistry, target and probe preparation, microarray manufacture and detection, and data analysis and modeling. Methodology, clean room technology, gene expression profiling, genetic screening and diagnostics, and novel technologies are also covered. It rapidly teaches the fundamentals of microarrays; describes protein microarrays and other rapidly advancing forefronts; builds a conceptual foundation for the entire field; presents commercial opportunities in microarray science; emphasizes the exciting clinical applications of microarrays.
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 | Z700312 | Microarrays for an Integrative Genomics | The growing use of DNA microarrays allows researchers to assess the expression of tens of thousands of genes at a time. This book provides an introduction to the use of DNA microarrays as an investigative tool for functional genomics. The presentation is appropriate for readers from biology or bioinformatics. After presenting a framework for the design of microarray-driven functional genomics experiments, the book discusses the foundations for analyzing microarray data sets, genomic data-mining, the creation of standardized nomenclature and data models, clinical applications of functional genomics research, and the future of functional genomics.
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 | Z701173 | Modern Methods of Drug Discovery | This volume offers an interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. It covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds-, and NMR-based-screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each of the thirteen chapters reviews the theory, background and application of a key technology in drug discovery and is complemented by an extensive list of references to the original literature. The book is written from the viewpoint of the drug researcher working in the pharmaceutical industry and provides an overview of the drug discovery process.
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 | Z703656 | Optimization in Drug Discovery: In Vitro Methods | Researchers and experts from leading universities and major pharmaceutical companies systematically describe cutting-edge experimental protocols for the early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. By uncovering early in the discovery stage the defects that can eliminate candidate drugs from preclinical and clinical development, these techniques can save millions of dollars in time and effort
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| | Z513601 | Optimization of Solid-Phase Combinatorial Synthesis | This book addresses the key topic in combinatorial synthesis—how to optimize the quality of a combinatorial library—by determining the usefulness of synthesized compounds, the reliability of biological assay results, and analyzing academic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies. It introduces a four-step approach to full-blown optimization. Presenting guidelines for the translation of solution chemistry to solid-phase chemistry, this book outlines resin selection criteria, supports, and characterization methods; reviews quantitation of standards for calibration, kinetic measurements of compound cleavage from resin, and bead encoding; documents the use of single bead infrared spectroscopy as a versatile reaction monitoring tool for synthesis optimization; covers methods used for conducting feasibility, validation, and rehearsal of library synthesis; quantifies bulk-released compounds and estimates average concentration and synthesis yield; considers application of the Hammett relationship to predict solid-state reactivity; assesses the state of the art in multispectral imaging of resin-supported libraries.
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 | Z702390 | Organic Chemistry of Drug Design and Drug Action, 2nd ed. | Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate to many related classes of drug molecules. The second edition reflects the significant changes in the drug industry over the past decade, and now includes color illustrations, chapter problems, and other elements that make concepts easier to understand.
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| | Z408425 | Practical Guide to Combinatorial Chemistry | This book is a practical guide for those engaged in small-molecule combinatorial chemistry as well as those wishing to learn the field. Aimed at nonspecialists, the chapters are written in a tutorial style by internationally recognized experts. The text reviews the use of computational tools to analyze molecular diversity and presents a detailed survey of solid-phase peptide synthesis and the tools used for small-molecule synthesis. Up-to-date automated approaches and equipment for synthesizing solid- and solution-phase libraries are reviewed, including synthesis, analytical, and deconvolution tools.
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 | Z702013 | Protein Crystallography in Drug Discovery | Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. In this book, researchers from academia and from leading pharmaceutical companies present valuable first-hand information on how to obtain the desired protein structures and how to exploit crystallographic data for the drug discovery process. Topics include: Crystallography of important target classes such as kinases and proteases; Structure-based design of protease inhibitors; Structure-based design of kinase inhibitors; Ribosome and the proteasome as drug targets; Recent methodological advances in high-throughput crystallography and microcrystallization.
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| | Z557749 | Pseudo-Peptides in Drug Discovery | Peptides are among the most versatile bioactive molecules, yet they do not make good drugs, because they are quickly degraded or modified in the body. Thus, drug discovery has turned to the field of peptidomimetics, i.e. to design non-peptide compounds mimicking the pharmacophore and thus the activity of the original peptide. These compounds open up new perspectives in drug design by providing a range of highly specific pharmaceuticals that have a high bioavailability. The following classes of pseudo-peptides are examined with regard to their chemical properties, pharmacological activity, as well as practical aspects of synthesis: Oligo-glycines; Beta-peptides; Gamma-peptides; Pyrrole-imidazole polyamides; DNA-like peptide nucleic acids; Alpha-helical peptide nucleic acids; DNA-cleaving pseudo-peptides.
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 | Z424307 | Quantitative Molecular Pharmacology and Informatics in Drug Discovery | Recent years have seen the emergence of the new field of bioinformatics which, together with new techniques in molecular biology, has revolutionized drug discovery. The fusion of information technologies with biochemistry, including combinatorial chemistry, high-throughput screening, and robotic assay systems, have introduced new paradigms for pharmaceutical research. This book explains the field for scientists working in the pharmaceutical industry who need to understand the new methods and the different types of information obtained in the drug discovery processes in laboratories today.
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 | Z730459 | Short Protocols in Pharmacology and Drug Discovery | Short Protocols in Pharmacology and Drug Discovery provides condensed descriptions of more than 350 methods compiled from the successful title Current Protocols in Pharmacology. The book is specifically designed to provide quick access to step-by-step instructions for the essential methods used in every major area of pharmaceutical research, and especially stresses drug discovery techniques.
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| | Z513776 | Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries | This book addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.
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| | Z540056 | Solid-Phase Organic Syntheses, Volume 1 | This series is dedicated to providing researchers in the field with validated and tested methodologies for the solid-phase synthesis of interesting and biologically relevant molecules. Solid-phase methods will virtually always be invented for application in combinatorial organic synthesis. To meet these specific needs, Solid-Phase Organic Syntheses, Volume 1 focuses on a single type of synthetic transformation accomplished on solid support, and indicates how procedures are optimized to work with a structurally-wide variety of reagents. Written by recognized leaders in the field who review and test all chemical protocols before publication, organic transformations are organized by type of compound synthesized and reaction type.
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 | Z421731 | Solid-Phase Organic Synthesis | Combinatorial chemistry is a rapidly-growing field in organic and pharmaceutical synthesis. Articles on organic synthesis of solid support have grown exponentially over the last three years. This new work brings together the latest research in the field, highlighting and reviewing some of the hottest topics relevant to combinatorial chemistry, including solid-phase synthesis of natural product derivations, synthesis of guanidine, palladium catalyzed C-C bond forming reactions, resin supported capture agents and other reagents, synthesis on pins, and monitoring of supporting reactions using IR.
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 | Z536857 | Solid-Phase Synthesis and Combinatorial Technologies | Provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines. Features a detailed bibliography of more than 1,700 relevant sources.
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 | Z408565 | Strategies for Organic Drug Synthesis and Design | Organic synthesis is the use of organic transformations in preparing new compounds with more or less complex structures. It has had a profound effect on modern organic chemistry. This book offers a selection of syntheses chosen to illustrate the strategies and organic transformations which have been used to prepare the various structural classes of drugs.
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 | Z730645 | Target Validation in Drug Discovery | This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book
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 | Z700886 | Textbook of Drug Design and Discovery, 3rd ed. | This edition has been thoroughly revised and updated to provide a complete source of information on all facets of drug design. The book follows drug design from the initial structure-activity relationship to the final processes of clinical evaluation and registration. Chapters investigate the design of drugs for particular cellular targets such as ion channels and receptors whilst others examine specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques and combinatorial approaches are also included.
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 | V1763 | Virtual Screening for Bioactive Molecules | Screening techniques are very common in biochemistry and biology to find out if new molecules are potential drugs. The huge amounts of new potential drugs are tested in most of the cases in a screening in view of only one special disease or one special function. There is not enough human power or financial resources to test these substances with common screening methods in order to know if they are active or helpful. Virtual screening can help industry to increase their efficiency drastically by estimating the activity of compounds not in an experiment, but with the computer.
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