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Drug Discovery Books

Best Books for the Best Minds

Our Drug Discovery books offer the drug discovery and bioassay research community resource information on assay development and screening for new drugs.

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Z759856 Applications of Transition Metal Catalysis in Drug Discovery and Development: An Industrial Perspective M.L. Crawley and B.M. Trost, John Wiley & Sons, New York, NY, 2012, 376 pp., hard cover This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development - it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
B4306 Bioinformatics: Sequence and Genome Analysis Application of computational methods to DNA and protein science is an exciting development. This book features sequence alignment, structure prediction, phylogenetic and gene prediction, database searching, and genome analysis that are clearly explained and illustrated along with underlying algorithms and assumptions. Theoretical underpinnings are linked to biological problems and solutions. Extensive tables provide descriptions and Web sources for a range of available software. An associated Website, accessible free of charge by book purchasers, provides links to Internet sources referred to in the text (http://www.BioinformaticsOnline.org).
Z287598 Combinatorial Chemistry: Synthesis and Application Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world′s leading chemists, many of whom played a key role in its development. Includes examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available.
  Z288160 Combinatorial Peptide and Nonpeptide Libraries: A Handbook The use of binatorial chemistry and peptide libraries in drug screening and development is a new and rapidly expanding technology. This first handbook on the topic contains background information and step-by-step experimental procedures. It will be indispensable for anyone working in the field.
D5440 DNA Microarrays: A Molecular Cloning Manual DNA microarray, or DNA chip technology is a new and powerful means of discovering, characterizing and analyzing genes and their expression patterns. This manual assembles and synthesizes the expertise of over 30 innovators in this emerging field to provide authoritative, detailed instruction on the design, construction, and applications of microarrays, as well as comprehensive descriptions of the software tools and strategies required for extensive image and data analysis. It complements the best selling manual "Molecular Cloning".
H1037 Handbook of Drug Screening This reference provides coverage of current screening techniques, modern technologies, and high-capacity instrumentation for development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It describes the construction and compilation of chemical compound databases and clinical trials. It contains applications and examples of strategies in cell-based and cell-free screens, as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies It covers identification of transcriptional factors for drug targeting; affinity-based approaches to screening; the role of proteomics and bioinformatics in target identification; laboratory automation and assay miniaturization in ultrahigh-throughput screening.
  Z288152 Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery Reports progress on chemical, enzymatic, phage, and cell-derived libraries. Discusses synergy between structure-based design and combinatorial libraries. Presents applications of combinatorial libraries to drug discovery and new synthetic catalysis. Reports library screening approaches, including the use of NMR. Presents recent advances in solid-phase organic synthesis, liquid-phase organic synthesis, and high-throughput combinatorial organic synthesis. Discusses automation of organic synthesis as well as new methodologies for monitoring solid-phase organic synthesis.