The sixth edition has a broader coverage than its name implies, since it includes definitions of strictly genetic words along with a variety of non-genetic terms often encountered in the literature of genetics. There are about 7,000 definitions, and tables or drawings that illustrate 395 of these. In addition to the main body of the dictionary, this work features new Appendices covering the genomic sizes and gene numbers of about 30 organisms ranging from the smallest known virus to humans, an up-to-date listing of internet addresses for easy access to genetic databanks, and a list of developments, inventions and advances in genetics, cytology, and evolutionary science from the past 400 years.
This book has been the world′s most trusted genetics text for more than 30 years. With balanced, integrated reporting on both the basic science and clinical implications of genetics, the content has been thoroughly updated for this edition to keep abreast of this fast-changing subject. There is new coverage of hot topics such as gene therapy, the human genome project and ethical issues in medical genetics, while a brand new illustration program has been specially designed to further help students to understand concepts and retain information.
Highly skilled investigators in gene targeting and mouse genetics describe their best techniques for the design of targeting constructs and for the analysis of the mouse phenotype. These include embryo transplantation, in vitro embryonic stem cell differentiation, creation of aggregation chimeras, mouse pathology, embryo cryopreservation, and transplantation. State-of-the-art and highly practical, it constitutes an invaluable source of readily reproducible techniques for genetic researchers today.
This provides an overview of the approaches encompassed by the emerging discipline of molecular epidemiology. Concepts and methods at the forefront of infectious disease studies are discussed along with recent advances in studying host genetics, methods for the detection of mutations and polymorphisms, the relationship between pathologies and immune system genetics, and the use of DNA sequence information to garner insights into the evolution of infectious pathogens. The evolution and function of the immune system and a synopsis of general epidemiological design and analysis are included.
This update presents techniques for generation and analysis of transgenic animals, with emphasis on manipulation of the mammalian genome. It concentrates on creation and maintenance of genetically modified murine strains, providing access to the germline by conventional pronuclear injection, and by retroviral and adenoviral infection. Emphasis is given to the generation, maintenance, and manipulation of embryonic stem cell lineages, with protocols for constitutive and conditional gene targeting. Chapters include techniques for cryopreservation of male and female germlines and for generation of transgenic sheep by nuclear transfer.