This useful handbook provides the theoretical and practical information necessary to explore new applications for Grignard reagents on a day-to-day basis. Presents a comprehensive overview of current research activities in Grignard chemistry. Surveys specific reactions and applications of Grignard reagents, organized by type of substrate and the general category of reaction.
The book opens with a general overview of the constitution and reactivity of organomagnesium compounds, followed by information on handling them and on their detection and estimation. Throughout, practical aspects as well as principles are emphasized. The chapters on the synthesis of organomagnesium compounds cover the preparation of special forms of metallic magnesium and the reaction of magnesium with substrates such as dienes, as well as the traditional preparation of Grignard reagents. Preparations by metallation and metal-halogen exchanges are also included, as are newer methods such as hydromagnesiation of alkenes and alkynes. Systematic coverage is provided on synthetically useful reactions of organomagnesium compounds.
Palladium is one of the most popular compounds used in the synthesis of pharmaceuticals, foods, cosmetics, and materials worldwide. Now in paperback, this book provides a comprehensive overview of palladium chemistry, highlighting recent discoveries and applications, and detailing new synthetic methods.
This updated second edition is a guide to the selection of reducing reagents in organic synthesis. It is an indispensable working resource for organic synthetic chemists and the only reference focusing exclusively on aluminohydrides and borohydrides and their derivatives.