 | Z701386 | Absorption and Drug Development: Solubility, Permeability, and Charge State | Many times drugs work fine when tested outside the body, but in the body they fail. One of the major reasons is that the drug cannot be absorbed. This book shows readers how to examine a compound′s pharmaceutical properties, emphasizing oral absorption. It explains the different physicochemical methods used to analyze drug candidates and how to interpret these methods. This book also helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars. Also included are physicochemical data for over 200 commercial drugs.
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 | Z702226 | Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics | This reference presents recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds—offering strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate developments in controlled drug delivery and targeting. This book contains current applications and procedures to identify binding constants between drugs, biological structures, proteins, nucleic acids, and plasmids; increase drug bioavailability; enhance the permeability, solubility, strength, and function of drug formulations; examine protein-protein exchanges and reactions; calculate pKa values.
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 | Z700541 | BioNMR in Drug Research | This book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use benefits the rational development of drugs. This interaction can now be investigated and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by case studies from pharmaceutical research. This guide contains basic information, application strategies and real-life examples.
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| | Z269662 | Biodegradable Hydrogels for Drug Delivery | This book provides an in-depth investigation of recent advances in biodegradable hydrogels. Based on extensive research and experience, the book is the first to deal exclusively with this important area in drug delivery. A valuable guide for all, the book begins with a detailed introduction to current biodegradable hydrogel technology. Following chapters present advanced R&D, delivery systems, and more. It covers the mechanisms of biodegradation, types of biodegradable hydrogels, chemical and physical gels, chemical and enzymatic degradation, and examples of biodegradable drug delivery systems.
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 | B8308 | Bioinformatics: From Genomes to Drugs, 2 Volume Set | Bioinformatics promises to revolutionize the process of drug discovery and development. This book provides an application-oriented overview of this technology. In addition, the state-of-the-art in bioinformatics is evaluated from a global view by introducing real application scenarios such as genome projects that require the use of a whole set of bioinformatics tools. The knowledge on bioinformatics presented enables readers to go beyond a mere push-button approach to using bioinformatics software and interpreting the data generated, but also to assess the potential and limitations of today′s bioinformatics software and future challenges.
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 | Z705012 | Biomaterials for Delivery and Targeting of Protein and Nucleic Acids | This book introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids.
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 | Z701017 | Burger’s Medicinal Chemistry and Drug Discovery® 6th ed.,Volume 1: Drug Discovery | This edition of Dr. Burger’s classic helps researchers with both traditional and state-of-the-art principles and practices governing new medicinal drug research and development. Completely revised to reflect the many changes that have occurred in the field, it brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery. This volume contains new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery.
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| | Z566748 | Casarett and Doull’s Toxicology: The Basic Science of Poisons, 7th edition | The new edition discusses areas of apoptosis, cytokines, growth factors, oncogenes, cell cycling, transcription factors, signaling pathways, and genomics.
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 | Z702145 | Cellular Drug Delivery: Principles and Practice | An authoritative survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.
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| | Z513598 | Chiral Drugs & Chiral Intermediates, 2-Volume Set | Save over 15% when you order both Chiral Drugs (Z51,357-1) and Chiral Intermediates (Z51,356-3) together!
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| | Z513563 | Chiral Intermediates | Chiral Intermediates is an invaluable resource for information on available chiral molecules. Presents 4,700 commercially available chiral compounds with structures, physical properties, applications, manufacturers and suppliers for each listing. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended.
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 | Z702234 | Computational Medicinal Chemistry for Drug Discovery | Observing computational chemistry′s proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized for ligand deisgn. This book examines molecular mechanics, semi-empirical methods, wave function-based quantum chemistry, density functional theory, 3-D structure generation, conformational analysis and hybrid methods. It views pharmacophore discovery and the use of 3D pharmacophore models in 3D database searching and studies vibrational circular dichroism spectroscopy for the stereochemical characterization of chiral molecules.
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 | Z705845 | Computer Applications in Pharmaceutical Research and Development | While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth.
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 | Z703532 | Contemporary Drug Synthesis | Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. This book examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. This timely volume focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others. It provides an in-depth introduction to each drug, followed by a detailed account of its synthesis, and organizes the drugs into fourteen therapeutic areas for clarity and ease of use.
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 | Z701157 | Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability | Efficacy of drug uptake depends on the chemical characteristics of the active substance, its solubility and membrane permeability. Also it is determined by the organism′s ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for efficacy is its so-called bioavailability. This book covers all aspects of oral bioavailability and focuses on methods for determining relevant parameters. These range from physico-chemical techniques via biological studies in vitro and in vivo along with computer-aided predictions.
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 | Z700916 | Drugs of Abuse: Neurological Reviews and Protocols | A collection of updated and core techniques for the neurological study of drugs of abuse. These detailed protocols cover a variety of coherent methods for gathering information on quantitative changes in protein and mRNA at both tissue and cellular levels. There are various methods for detecting single and multiple alterations in single and multiple gene expression, for analyzing the functional roles of genes and proteins, for studying release kinetics of striatal dopamine, and for quantitative measurement of such neurotransmitters as acetylcholine. Review articles address current topics on the effect of drugs of abuse on the brain.
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| | Z540382 | Drugs: Synonyms & Properties, 2nd Edition | The second edition of this popular reference has now been updated with additional drug compounds, synonyms, and information on biological activity. The book provides comprehensive coverage of over 10,000 drugs currently in use worldwide. Includes an index of 60,000 drug synonyms and trade names with a cross reference to their main entry. For each main entry, the following information is provided: chemical name and a list of trade names and synonyms, CAS registry number, EINECS number, Merck Index number, physical properties, and the known biological activity and indicated applications.
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 | Z700754 | Foye’s Principles of Medicinal Chemistry, 5th ed. | This fifth edition has been revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist as therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.
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| | Z552275 | Fundamentals of Medicinal Chemistry | Contains a review of the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms, and covers the discovery and design of drugs, pharmacokinetics and drug metabolism. The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing of the final product.
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 | G6417 | Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 10th ed. | Thoroughly updated by authors who are experts, this edition continues the tradition of being the best available text and reference source for information on the actions and uses of drugs. Well organized, extensively indexed, and reference to the most up-to-date literature in the field. It remains the premier reference for physicians, pharmacists, and medical pharmacy students. New edition covers the latest developments in molecular pharmacology and clinical developments on the newest agents.
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 | Z704296 | HPLC Methods for Recently Approved Pharmaceuticals | Stop wasting time hunting for the right HPLC assay techniques. With this book, you will quickly identify and replicate the ideal procedures without having to refer to original source publications. It arms you with established HPLC assay techniques for hundreds of newly approved drugs, as well as drugs for which assay methods were only recently developed. This handbook includes: HPLC methods for 390 commonly prescribed pharmaceutical compounds; Methods for drugs in biological fluids and for bulk and formulated drugs; Chemical structures, molecular weights and formulas, and CAS Registry Numbers; Cross-references to The Merck Index; Retention times of other drugs that can be assayed using the same methods.
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 | Z731307 | Handbook of Nutraceuticals and Functional Foods | The Second Edition compiles the latest data and provides hard evidence on the prophylactic and medicinal properties of many natural foods. This handbook reviews more than 200 nutraceutical compounds. Each chapter includes the chemical properties, biochemical activity, dietary sources, and evidentiary findings for each compound. New topics include the use of exopolysaccharides from lactic acid bacteria, protein as a functional ingredient for weight loss, and nutraceuticals to be used in the adjunctive treatment of depression. Two new chapters discuss recent evidence on oxidative stress and the antioxidant requirements of athletes as well as the use of nutraceuticals for inflammation. The scientific investigation of nutrition and lifestyle changes on the pain and debilitation of osteoarthritis is the subject of another new article.
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 | Z704849 | Handbook of Pharmaceutical Additives, 2nd ed. | The second edition has been extensively updated. It describes more than 4200 trade name products and 3300 generic chemicals and materials, available from worldwide manufacturers, that function as pharmaceutical additives. Pharmaceutical additives are defined in this reference as secondary ingredients present in both prescription and over-the-counter drug formulations. Thus, the definition of pharmaceutical additives for the purpose of this work encompasses excipients, synergists, or chemicals that substantively contribute to the effectiveness of the active ingredient. Entries for both trade names and chemicals contain extensive information gathered from worldwide manufacturers, distributors, trade journals, government documents, and other reference sources.
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| | Z553697 | Handbook of Radiopharmaceuticals | Covers radiochemistry and clinical applications including the production of various radionuclides, positron emission tomography (PET) and drug development. Discussions on the uses of radiopharmaceuticals in the diagnosis and therapy of cancer and other diseases are also included.
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 | Z705179 | Human Drug Metabolism: an Introduction | This book provides an accessible introduction to human drug metabolism for those who already have some understanding of the life sciences. It focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolising systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs
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 | Z701335 | Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry and Enzymology | Xenobiotic metabolism encompasses physiology, pathophysiology, pharmacology, toxicology, environmental issues, biochemistry, genetics, medical chemistry, computational (bio)chemistry, analytical chemistry, etc., and reactions of hydrolysis play a central role in metabolic pathways. Testa conceptualizes reactions of drug metabolism, and presents a review of all metabolic reactions and enzymes involved in the hydrolysis of drugs and prodrugs. Nothing of this sort has been written before, as hydrolysis together with some other reactions of drug metabolism have been in the shadow of the drug-metabolism community’s preoccupation with the ‘P450 hype’ and the superfamily of CYP genes coding for oxidative enzymes of drug metabolism.
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| | Z287628 | Impact of Stereochemistry on Drug Development and Use | This book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmaceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops.
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 | I6532 | Integrated Drug Discovery Technologies | This first of its kind reference provides a global overview of emerging drug discovery technologies by presenting and integrating new techniques. Combining integration of contemporary mechanization with strategies in drug discovery, this volume features the most current advances that will afford better, faster, and more cost-effective means of design and screening. This book presents the most promising science with the potential to revolutionize the drug discovery process, explains the rationale and developmental background behind evolving practices, highlights the impact of Information Technology on drug discovery, and details information management, including strategies and infrastructure
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 | Z730408 | Introduction to Medicinal Chemistry, 3rd ed. | Many of us think nothing of taking a painkiller to ease a headache, or to relieve the symptoms of ′flu. But how do drugs have their effect in the human body? How are new drugs discovered and designed to be as effective as possible? An Introduction to Medicinal Chemistry offers an engaging insight into the one field of chemistry that arguably has the greatest impact on our quality of life than any other.
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| | Z420662 | Introduction to Medicinal Chemistry: How Drugs Act and Why | This book is a comprehensive and well illustrated presentation of the major areas of pharmaceutical drug research. It integrates the chemical and pharmacological aspects of drugs, and links the sciences of organic chemistry, biochemistry, and biology with the clinical areas required for a thorough understanding of modern medicinal drugs. Three introductory chapters cover the essentials of drug activity, mechanisms, and metabolism. Subsequent chapters are organized according to therapeutic topic.
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 | Z703117 | Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis | This revised and expanded second edition is the definitive text on stable and radioactive isotope tracers. In multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This edition includes: all-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis; major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques; latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics; Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies.
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 | Z558494 | Lipases and Phospholipases in Drug Development | Lipases and phospholipases are key control elements in mammalian intermediary metabolism. They share many common features that set them apart from other metabolic enzyme classes, most importantly their association with "two-dimensional" substrates. Their potential as drug targets for the treatment of metabolic diseases is increasingly recognized, and the first lipase inhibitor drugs have been successfully introduced.
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| | M7185 | Martindale: The Complete Drug Reference, 32nd ed. | For everyone in the health profession, The Martindale is a book they need to have. This drug reference provides pharmacists, physicians and researchers with information on drugs and medicines used worldwide. All monographs have been revised, with over 300 deleted and more than 250 new ones added. Includes a new chapter on bronchodilators. Part one: 4,336 monographs. Part two: 825 monographs. Previous editions were entitled �Martindale: The Extra Pharmacopoeia.�
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 | Z730211 | Mass Spectrometry Data Analysis in Proteomics | This book is a guide to analyzing raw mass spectrometry (MS) data in proteomics. As MS is a high throughput technique, proteomic researchers must attend carefully to the associated field of data analysis, and this volume outlines available bioinformatics programs, algorithms, and databases available for MS data analysis. Guidelines for data analysis using search engines such as Mascot, Xtandem, and VEMS are provided. Several different types of MS data are discussed, followed by a description of optimal methods for conversion of raw data into peak lists for input to search engines. Methods for assembling expressed sequence tags (ESTs) into assembled nonredundant databases are provided, along with protocols for further processing the sequences into a format suitable for MS data.
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 | Z704709 | Medicinal Chemistry of Bioactive Natural Products | This book contains articles dealing with discovery, structure elucidation, and elegant synthetic strategies developed for natural products, with an emphasis on the structure activity relationship of bioactive natural products. The topics are selected carefully since bioactive natural products are clinically useful pharmaceuticals or the primary compounds under extensive medicinal chemistry exploration. The book provides examples with updated research results while also bringing a historical perspective to the chemistry and biology, a technique which could inform researchers about the process of developing pharmaceuticals, from discovery to application as drugs.
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 | Z547948 | Medicinal Chemistry: Principles and Practices, 2nd edition | This book covers the key topics for drug discovery from the perspective of the practising industrial scientist and manager. Presenting all aspects of the subject from initial lead through to final development, this new edition builds on the highly successful foundations laid by the first edition by introducing new topics such as combinatorial chemistry, genomics and cheminformatics, alongside revised and updated original chapters.
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 | Z700878 | Medicinal Plants of the World, Volume 1: Chemical Constituents, Traditional and Modern Medicinal Uses, 2nd ed. | Ross takes advantage of the growth in the amount of new data available to update and expand his first edition. This edition compiles new clinical research and references 26 widely used medicinal plants, including Allium sativum, Mangifera indica, Punica granatum;, Momoridica charantia, Mucuna pruriens; Arbus precatorius; Moringa pterysgosperma, Phyllanthus niruri, and Jatrpha curcas. Each chapter on a particular plant species contains: Common Names, Botanical Description, Origin and Distribution, Traditional Medicinal Uses, Chemical Constituents, and Pharmacological Activities and Clinical Trials.
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 | Z704237 | Method Validation in Pharmaceutical Analysis: A Guide to Best Practice | Authors provide a detailed interpretation of the existing regulations (GMP, ICH), while also discussing the appropriate calculations, parameters and tests. The book allows readers to validate the analysis of pharmaceutical compounds while complying with both the regulations as well as the industry demands for robustness and cost effectiveness. Following an introduction to the basic parameters and tests in pharmaceutical validation, including specificity, linearity, range, precision, accuracy, detection and quantitation limits, the text focuses on a life-cycle approach to validation and the integration of validation into the analytical quality assurance system.
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 | Z702072 | Microbiological Assay for Pharmaceutical Analysis | This book provides an explanation of the sources of error in microbiological assay and helps analysts choose efficient assay designs to minimize those errors. Beginning with the quantitative aspects, the author discusses microbiological assay as a branch of pharmaceutical analysis and distinguishes it from biological assay in general. He draws attention to the microbiological aspects that may not be so obvious to the chemical analyst and to the analytical aspects not so obvious to the microbiologist. It contains detailed evaluations of assays that illustrate typical experimental designs and addresses how to present a realistic assessment of the best potency estimate from a series of assays. This book expands on the guidance given in pharmacopoeias.
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 | Z704679 | Microwaves in Organic and Medicinal Chemistry | The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the ACS and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists.
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| | Z424331 | New Trends in Synthetic Medicinal Chemistry | Even though computational methods are becoming increasingly important, synthetic chemistry is an indispensable area of research for both medicinal chemistry and drug development. This book discusses state-of-the-art developments in several important classes of compounds, such as carbohydrates and nucleotides. Synthetic methods such as combinatorial chemistry, solid-phase synthesis, bioassisted organic synthesis and asymmetric reactions are also discussed.
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| | Z513555 | Nomenclature of Organic Compounds: Principles and Practice, 2nd ed. | The book is divided into two parts. The first is a general overview of organic nomenclature, the second uses concepts from the first part to answer the question "How do I name this compound?". Individual chapters are concerned with almost every class of organic derivative, stressing the relationship between structure and names.
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 | N6410 | Novel Therapeutic Proteins: Selected Case Studies | This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins.
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| | Z411620 | Organic Chemistry of Drug Synthesis 6 Volume Set | This series is a guide to virtually all syntheses used in the preparation of compounds given generic names.
Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
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| | Z253367 | Organic Chemistry of Drug Synthesis Volume 5 | This series is a guide to virtually all syntheses used in the preparation of compounds given generic names.
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| | Z411612 | Organic Chemistry of Drug Synthesis Volume 6 | This series is a guide to virtually all syntheses used in the preparation of compounds given generic names.
Volume 6 covers the literature on the synthesis of medicinal agents from 1994 to 1998. This well-received series meets the needs of practitioners in the field who seek a quick overview of the synthetic routes that have been used to access specific classes of therapeutic agents. While most books on medicinal chemistry are organized on the basis of therapeutic or biochemical classes, materials in this series are arranged and discussed in terms of chemical structure. Thus, the preparation and detailed organic chemistry of the classes are presented in a unified way. Only drugs that have been granted a U.S. Adopted Name are included in this series.
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| | Z514225 | Organic-Chemical Drugs and Their Synonyms, 8th ed. | For all scientists concerned with the development of new drugs, this standard work is well-known as "the Negwer". The 8th edition of the Negwer once again shows an impressive enlargement: Including more than 4.000 newly developed drugs, it now compiles more than 16.000 chemically unique drugs with more than 125.000 synonyms. The main part of the book (volumes 1-4) consists of the list of organo-chemical drugs arranged by increasing molecular formulas. The following items are given for each of the drugs included: molecular formula, CAS number, structure, references, synonyms, characterization and therapeutic use. The indices to facilitate working with the list are assembled in volumes 5 and 6: a group index (for finding drugs related to each other chemically or pharmacologically), the CAS number index, and the index of synonyms.
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 | Z701637 | Pharmaceutical Analysis | This single-volume text explores the analytical aspects of drug development and manufacture. This reference provides pharmacists and scientists - specifically, analytical and organic chemists and biochemists -- with a source of information to a broad range of techniques and their applications. This allows readers to choose the most appropriate analytical technique for a particular purpose. The text discusses a variety of concepts, including: quality control and regulatory requirements, chiral and solid state analyses, vibrational spectroscopy, particle properties, microscopy and imaging, and nuclear magnetic resonance
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 | Z700746 | Pharmaceutical Chemistry: Therapeutic Aspects of Biomacromolecules | In this introductory book, key strategies involved in the development and production of a range of clinically useful compounds are presented along with a broad overview of the way in which peptides, proteins, nucleic acids and carbohydrates are used therapeutically. Illustrated with numerous examples, the book covers essential compounds and explains how they exert their influence through an understanding of biological processes. Pharmaceutical chemistry has become progressively more important in terms of both research and teaching, and this book includes latest developments with examples selected in order to emphasise the molecular basis of specific disease processes
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 | Z703206 | Pharmaceutical Excipients: Characterization by IR, Raman and NMR Spectroscopy | Recognizing the need for a hands-on guide elucidating the role of molecular spectroscopy in the physical characterization of pharmaceutical solids, two experts gather theoretical discussions of infrared, Raman, and NMR spectroscopy, and helpful recommendations on spectral data acquisition techniques, as well as 600 spectra for 300 of the most commonly used excipients in pharmaceutical dosage formulation. Furnishes accurate spectral data on each compound for interpretation, such as peak listings for identifying observed spectral features, excipient grades, Chemical Abstracts Service (CAS) registry numbers, molecular formulae, molecular weights, other common excipient names, and excipient usage.
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| | Z515078 | Pharmaceutical Master Validation Plan: The Ultimate Guide to FDA, GMP, and GLP Compliance | Pharmaceutical Master Validation Plan: The Ultimate Guide to FDA, GMP, and GLP Compliance will allow you to more easily achieve satisfactory inspections, new medical product approval, minimize non-conformance, reduce rework and rejected lots, and avoid recall lots by developing and managing a Master Validation Plan. The accompanying CD allows users to input the template plan into their computers and tailor it to incorporate additional regulatory requirements specific to individual companies worldwide and print the required documents. Together, the book and CD contain everything required to develop and execute a successful Master Validation Plan based on FDA guidelines for the pharmaceutical industry, and allows the templates to be extended to diagnostic products, medical device, medical equipment, and biotech industry products. It supplies valuable text establishing a master plan in compliance with FDA, GMP, and GLP requirements and provides a missing link between the Validation Master Plan to the Validation Standard Operating Procedures and Protocols developed and executed
The Master Validation Plan provides a roadmap to management for on-time start-up of facility operations, and validation of existing facilities, in compliance with GMP requirements. The lack of a comprehensive Master Validation Plan and well-documented validation procedures is the main reason that new drug, medical device, medical equipment, and related product applications are rejected by the FDA. This thorough guide provides the needed solutions and guidance for both foreign and U.S. companies to achieve FDA compliance and authorization to market their products in the United States.
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 | Z702250 | Pharmaceutical Process Validation, 3rd ed. | This edition details strategies to establish appropriate validation protocols and conduct process validation assignments; monitor and test specific manufacturing processes for compliance with design limits, specifications, and requirements; identify critical process or test parameters and their respective control limits; enhance the quality and consistency of product outcomes; streamline validation operations; validate computerized systems; and revalidate quality assurance systems after equipment, formulation or packaging modifications. It contains new chapters covering troubleshooting procedures, validation in contract manufacturing and current harmonization trends.
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| | Z511862 | Pharmaceuticals: Classes, Therapeutic Agents, Areas of Application, 4-Volume Set | Important pharmaceuticals and disease symptoms are discussed along with an authoritative introduction to the industry. The pharmaceuticals are grouped into six categories: cardiovascular drugs, neuropharmaceuticals, gastrointestinal drugs, respiratory tract, antiinfectives, and endocrine and metabolic drugs. Includes a keyword, author, and CAS-registry-number index as well as extensive references to the literature.
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 | Z704385 | Pharmacogenomics: Methods and Protocols | Experts provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
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| | Z272302 | Pharmacokinetics for the Pharmaceutical Scientist | Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
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 | Z730513 | Pharmacology 6th ed. | A straightforward way to master a complex subject. This bestselling textbook presents all the knowledge you need to get through your pharmacology course and beyond—using a clear and accessible approach that makes the material easy and interesting to learn. Progressing logically from a molecular understanding of receptors and drug actions to the clinical uses of the most important groups of drugs, it delivers the latest information on cannabinoids and rimonabant, Cox 2 inhibitors, pharmacogenetics, biopharmaceuticals, and drug abuse—as well as "lifestyle drugs" such as performance-enhancing substances, botulinum toxin, and Viagra®. And now, online access via Student Consult makes it an even more effective learning resource.
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 | Z703214 | Pharmacology Primer: Theory, Application and Methods | Pharmaceutical companies continue to face a growing need for scientists trained in the basics of pharmacology. At GlaxoSmithKline, Terry Kenakin regularly teaches this course and has drawn on his valuable experience to write this book. This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. Important chapters cover: Drug Receptor Theory; Drug Antagonism; The Drug Discovery Process; Pharmacological Assay Formats; Statistics & Experimental Design; and many more. This book is stocked with helpful resources, such as derivations of all formulae in every chapter, a glossary and appendices, scores of full-color illustrations.
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 | Z706035 | Pharmacology Primer; Theory, Application and Methods, 2nd ed. | The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments.
• Over 30 new figures and tables
• New section on new biological concepts relevant to pharmacological research (i.e., systems biology)
• New study sections organized with ASPET and other international pharmacology organizations
• New coverage of pharmacokinetics and drug disposition
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| | Z507253 | Pharmacology for Chemists | This practical book provides an ideal guide, covering the aspects of pharmacology most important and useful to chemists engaged in drug discovery. The book is based upon a popular three-day Americal Chemical Society short course, "Pharmacology for Chemists," which the author has taught for twenty years, and the book retains the lively and accessible presentation of the course while including more detailed discussions, references, and definitions. Any chemist who is considering research on drugs will find this volume an invaluable tool.
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 | Z702048 | Pharmacology, Fifth Edition | Pharmacology′s successful approach emphasizes the mechanisms by which drugs act and relates these to the overall pharmacological effects and clinical uses. In doing so it sets out a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs. This edition has been fully updated, incorporating significant new information published in the last few years. New agents are fully discussed as well as extensions of basic knowledge. One new chapter in the final section on drug discovery looks at the rapidly changing processes involved which are driven by advances in molecular biology, and contains a brief account of the regulatory controls involved.
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 | Z701963 | Practical Pharmaceutical Laboratory Automation | Although many laboratory scientists understand the methods and principles involved in laboratory automation, most lack the necessary engineering and programming skills needed to successfully automate or interface equipment in the lab. This how-to reference guide explores the processes needed to automate the majority of tasks required in research. Author discusses topics ranging from automated mathematical analysis to robotic automation of chemical processes, to combinations of these and other processes. He presents a detailed discussion of high throughput screening and assay development and takes an in-depth look at Visual Basic as the primary programming language used in laboratories. The text has a dedicated web site (http://www.pharmalabauto.com ) which contains all the sample code and examples in the text as well as other information related to laboratory automation.
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 | Z700819 | Practice of Medicinal Chemistry, 2nd ed | This is an essential handbook for the medicinal chemist - a complete guide to the drug discovery process. It reviews practical aspects of Medicinal Chemistry, emphasizing the daily problems when dealing with lead discovery/identification methodologies, with structure-activity relationship studies aimed to scale up potency and target selectivity, and when optimizing pharmacokinetic and pharmaceutical properties by means of ultimate chemical modifications. This edition is revised, with around 30% new material, and refocussed to reflect the developments in genomics, proteomics, high throughput screening of compounds and drug solubilization.
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| | Z423017 | Principles of Process Research and Chemical Development in the Pharmaceutical Industry | The purpose of process research and development is to transform a research synthetic procedure into a large-scale plant process. In essence, it involves taking a few milligrams of a drug, pesticide or chemical and redesigning the steps to accommodate large scale production of the substance. This book covers the key aspects of synthesis that must be considered when scaling up a process. It discusses such topics as minimizing by-product impurities, synthesizing enantipure compounds, criteria for an ideal cost effective synthesis and licensing.
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 | Z701971 | Textbook of Receptor Pharmacology, 2nd ed. | In the bestselling first edition the innovative format united four major approaches to the study of receptors: molecular biology, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction systems. The second edition builds on this foundation. It streamlines the material and focuses on cell membrane receptors along with their immediate signal transducers. The section on the molecular structure of receptors reflects the advances in this area. This edition also includes two restructured new chapters, one on G-proteins and one on tyrosine kinases, as signal transductors.
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 | Z731358 | Vaccine Adjuvants and Delivery Systems | This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. Written by leading experts, this book provides a comprehensive overview of the rapidly evolving field and developing formulation methods and covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage. It includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more. The text discusses the mechanisms of adjuvant actions, and covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants
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