This book provides an in-depth investigation of recent advances in biodegradable hydrogels. Based on extensive research and experience, the book is the first to deal exclusively with this important area in drug delivery. A valuable guide for all, the book begins with a detailed introduction to current biodegradable hydrogel technology. Following chapters present advanced R&D, delivery systems, and more. It covers the mechanisms of biodegradation, types of biodegradable hydrogels, chemical and physical gels, chemical and enzymatic degradation, and examples of biodegradable drug delivery systems.
This new edition discusses areas of apoptosis, cytokines, growth factors, oncogenes, cell cycling, transcription factors, signaling pathways, and genomics.
This authoritative reference is written by many distinguished professionals in the field, and offers clear, concise descriptions of the key concepts in toxicology. It is extensive and complete, covering a broad range of topics in sufficient detail. Both as a reference and as an educational tool, this book exceeds its goal of serving as a reference for toxicologists, other scientists, and students of the discipline.
Long established as the gold standard in the field, Casarett & Doull′s Toxicology equips you with an unsurpassed understanding of modern toxicology, including the principles, concepts, mechanisms, and modes of thought that are the foundation of the discipline. The new seventh edition features is updated throughout and includes many new contributors.
A collection of updated and core techniques for the neurological study of drugs of abuse. These detailed protocols cover a variety of coherent methods for gathering information on quantitative changes in protein and mRNA at both tissue and cellular levels. There are various methods for detecting single and multiple alterations in single and multiple gene expression, for analyzing the functional roles of genes and proteins, for studying release kinetics of striatal dopamine, and for quantitative measurement of such neurotransmitters as acetylcholine. Review articles address current topics on the effect of drugs of abuse on the brain.
Stop wasting time hunting for the right HPLC assay techniques. With this book, you will quickly identify and replicate the ideal procedures without having to refer to original source publications. It arms you with established HPLC assay techniques for hundreds of newly approved drugs, as well as drugs for which assay methods were only recently developed. This handbook includes: HPLC methods for 390 commonly prescribed pharmaceutical compounds; Methods for drugs in biological fluids and for bulk and formulated drugs; Chemical structures, molecular weights and formulas, and CAS Registry Numbers; Cross-references to The Merck Index; Retention times of other drugs that can be assayed using the same methods.
Xenobiotic metabolism encompasses physiology, pathophysiology, pharmacology, toxicology, environmental issues, biochemistry, genetics, medical chemistry, computational (bio)chemistry, analytical chemistry, etc., and reactions of hydrolysis play a central role in metabolic pathways. Testa conceptualizes reactions of drug metabolism, and presents a review of all metabolic reactions and enzymes involved in the hydrolysis of drugs and prodrugs. Nothing of this sort has been written before, as hydrolysis together with some other reactions of drug metabolism have been in the shadow of the drug-metabolism community’s preoccupation with the ‘P450 hype’ and the superfamily of CYP genes coding for oxidative enzymes of drug metabolism.
This book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmaceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops.
Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. Written by leading experts, this book provides a comprehensive overview of the rapidly evolving field and developing formulation methods and covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage.
It includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more. The text discusses the mechanisms of adjuvant actions, and covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants.