Handbook of Derivatization Reactions for HPLC, Book and CD-ROM
This print and electronic database represents a tremendous time-saver for analytical chemists working in the popular area of HPLC. By abstracting and evaluating the most important derivatization procedures, chemists can avoid lengthy information searches to consult the primary literature. Both the print and fully-searchable CD-ROM databases offer everything an analytical chemist needs to conduct derivatizations.
This book is a reference on state-of-the-art sample preparation techniques for bioanalysis. It focuses on high throughput techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A review of the literature is included within each of these chapters: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. Objectives that can be accomplished when the presented strategies are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods and return on investment in automation for sample preparation.
Sample Preparation Techniques in Analytical Chemistry
The importance of accurate sample preparation techniques cannot be overstated. It is the midway point where the analytes from the sample matrix are transformed so they are suitable for analysis. Even the best analytical techniques cannot rectify problems generated by sloppy sample pretreatment. This book addresses diverse aspects of these necessary pretreatment steps. These include: State-of-the-art extraction techniques for organic and inorganic analytes; Sample preparation in biological measurements; Sample pretreatment in microscopy; Surface enhancement as a sample preparation tool in Raman and IR spectroscopy; Sample concentration and clean-up methods; Quality control steps.
Sample Preparation for Hyphenated Analytical Techniques
Hyphenation - linking together of "standard" analytical techniques - generally leads to enhanced analytical performance. Hyphenated techniques are widely used in analytical chemistry, and particularly in areas where samples are presented in complex matrices, e.g. environmental, pharmaceutical and biochemical or biomedical analysis. Sample preparation is often the most time consuming step in these analyses, exerting a huge influence on the speed, accuracy and precision of the analytical results. This book demonstrates the sample preparation chemistry that has enabled the present sensitivity, specificity and high throughput available and illustrates the successful utilization of existing sample preparation methodologies in various analytical applications.
Solid phase microextraction (SPME) is a recently proposed solvent-free sampling and sample preparation technique. SPME represents a quick, sensitive, and economical approach that can be adopted for field work and can be easily integrated with present analytical instrumentation into an automation process. Written by the inventor of the technique, this book describes the theoretical and practical aspects of this new technology. This book offers the reader the following: • An overview of SPME technique, theory, method development, and applications • Experiments for beginners • A summary of the practical applications of SPME in environmental, food, and pharmaceutical, and forensic settings • Material suitable for SPME courses or self-guided study
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