 | P2481 | 2-D Proteome Analysis Protocols | Leading investigators in the field show how to make protein extracts, reproducibly run them on 2-D gels, detect them, analyze the data, and precisely identify each protein. The book covers the latest methods of using carrier ampholytes in the 1st dimension, casting and running immobilized pH gradient 2-D gels, MALDI-TOF-based peptide mapping, automated tandem mass spectrometry, and nanoelectrospray ionization technology. For the 2nd dimension, there are methods for running flatbed or vertical gels and for protein detection using autoradiography, and Coomassie, silver, and reversible metal-chelate stains.
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 | Z730300 | PCR 2nd ed. | A thoroughly updated version of the successful first edition with a new chapter on Real-Time PCR, more prokaryotic applications, and more detail in the complex mutagenesis sections. Information on PCR applications in genomics and proteomics have been expanded and integrated throughout the text. There is also advice on available products and specific pointers to the most appropriate methods. As with the first edition, this will be an ideal practical introduction and invaluable guide to PCR and its applications.
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 | P4609 | PCR Applications: Protocols for Functional Genomics | From ready mutation of DNA/RNA to speedy analysis of tens of thousands of nucleotide sequences, PCR Applications examines the latest developments in this field. It includes statistical refinement of primer design parameters, techniques used in microscopic tissue samples, such as single cell PCR, whole cell PCR, laser capture microdissection, and in situ PCR. The manual discusses techniques that focus on gene discovery, genomics, and DNA array technology.
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 | P8117 | PCR Cloning Protocols, 2nd ed. | This edition update and expands Bruce White′s best-selling “PCR Protocols” (1997) with the newest procedures for DNA cloning and mutagenesis. Here the researcher will find readily reproducible methods for all the major aspects of PCR use, including PCR optimization, computer programs for PCR primer design and analysis, and novel variations for cloning genes of special characteristics or origin, with emphasis on long PCR and GC-rich template amplification. Powerful applications of PCR in library construction and sublibrary generation and screening are presented.
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 | P8867 | PCR Mutation Detection Protocols | This book provides biological and clinical investigators with a comprehensive collection of new, recent, and updated PCR-based screening methods suitable for detecting the presence of both known and novel mutations. The methods cover point mutations (e.g., ASO-PCR, SSCP, DGGE, chemical cleavage), deletions (multiplex PCR, FISH, blotting), non-sense mutations (PTT), and more. The new techniques of DNA array analysis, along with such recently developed experimental methods as conformation-sensitive gel electrophoresis, are also included.
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 | Z701270 | PCR Primer: A Laboratory Manual, 2nd ed. | This second edition of a much praised and widely used manual has been entirely revised and updated. Each technique is presented with extensive background information, advice, and troubleshooting. All current applications of PCR are covered in protocols that have the hallmark reliability of the previous edition.
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 | Z369918 | PCR Protocols for Emerging Infectious Diseases | The spectres of completely new infectious diseases and multiple drug-resistant pathogens are frightening reminders of our frailty. Modern PCR techniques provide the best methods for identifying the causes. This book presents 12 detailed protocols that can serve as models for development of new protocols when they are needed.
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 | Z701351 | PCR Protocols, 2nd ed. | This edition has updated and expanded the number of protocols to take advantage of the newest technologies. These methods include real time PCR, SNP analysis, nested PCR, direct PCR, and long range PCR. Among the highlights are chapters on genome profiling by SAGE, differential display and chip technologies, the amplification of whole genome DNA by random degenerate oligonucleotide PCR, and the refinement of PCR methods for the analysis of fragmented DNA from fixed tissues. Each protocol is described in step-by-step detail and includes a background introduction outlining the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and a discussion of the interpretation and use of results.
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| | P8177 | PCR Protocols: A Guide to Methods and Applications | The polymerase chain reaction (PCR) is a powerful new molecular biological method with widespread applications in genetics and disease diagnosis. This manual details current PCR methods.
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 | Z373818 | PCR Sequencing Protocols | This book offers a comprehensive collection of the most reliable protocols for PCR Sequencing. Informative explanations of why certain steps are necessary and extensive tips that help make the difference between success and failure are also included. This book will offer time-saving techniques for even highly skilled researchers.
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| | Z364452 | PCR Strategies | A compilation of short articles written by PCR experts specifically for this volume. Practical information and advice includes background on key PCR concepts, analysis of PCR products, special applications, and alternatives to PCR for gene amplification.
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| | P5855 | PCR Technique: Quantitative PCR | This volume in the “BioTechniques Update Series” collects a number of important papers focused on various aspects of quantitative PCR that first appeared in BioTechniques from 1991 to 1996. This period of time witnessed the introduction, rapid development and numerous improvements of this laboratory method. These papers, most of which were reviewed and updated by the original authors, present novel methods to quantitate PCR products, improvements and modifications of previously published methods, and applications of quantitative PCR to several clinical situationa.
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 | Z704318 | PCR Technology: Current Innovations, 2nd ed. | This book is a fundamental reference for scientists new to PCR technology and a source of up-to-date applications for those familiar with the method. It provides theoretical considerations, discussions, and a selection of state-of-the-art techniques for mutation studies, clinical diagnosis, and the detection of food-borne pathogens. The book begins with discussions of the preparation of PCR experiments, followed by examples of analytical PCR divided into qualitative and quantitative applications. The final section explores preparative methods addressing DNA generation for further analysis and in vitro evolution. Featuring detailed protocols, this volume contains critical information for practitioners in a wide variety of fields, including forensics, molecular biology research, clinical DNA diagnostics, botany, and paleontology.
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 | Z705489 | PCR Troubleshooting: the Essential Guide | A unique PCR troubleshooting guide that is an essential companion for anyone who uses the polymerase chain reaction technique. Aimed at a reader with some experience in PCR the book discusses the many and varied problems encountered with PCR together with tips, advice and procedures to obviate rather than overcome the PCR problems. Written in the language of the laboratory with a little humour and a down-to-earth approach, the book is easy to read and understand. If you fail at PCR, consult this book! The advice in these pages is invaluable and is the sort of advice that is not usually found elsewhere.
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 | Z379603 | PCR in Bioanalysis: Methods in Molecular Biology, Vol. 92 | Marking the transformation of PCR from a purely research technique to an analytical tool, this volume details 22 cutting-edge protocols for molecular diagnosis of specific diseases. Coverage extends to infectious diseases, genetic syndromes, and cancer in humans, animals and plants. Diagnose such diseases as hepatitis C, tuberculosis, chlamydia and trichomonad infections. Animal tests include those for a bovine HIV-like virus, rodent parvoviruses, and Ross River virus. There are also general protocols for selective UV radiation fractionation (SURF) and for detecting circulating cancer cells. Overall, a concise but thorough introduction to practical diagnostic PCR.
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 | Z702374 | PCR/RT-PCR in situ Light and Electron Microscopy | Although the polymerase chain reaction has revolutionized genetic analysis by amplifying rare nucleic acid sequences, the in situ application is the only method that allows the localization of amplified signal within tissue structure. This book covers methods of in situ PCR and reverse transcription PCR (RT-PCR), two approaches in visualizing very low amounts of DNA and RNA in tissues and cell cultures at the light and electron microscopy levels. It provides theoretical consideration, as well as practical approaches to in situ PCR. Authors provide detailed protocols including the preparation of tissue samples, the rationale for the design of primers and revelation. They emphasize the need for appropriate controls to meet the requirements of in situ PCR and RT-PCR specificity.
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| | P7186 | PCR: A Practical Approach | This book covers gene analysis at the level of restriction fragment polymorphism, point mutation, and sequence analysis. Methods are given for using different source materials: cloned DNA, genomic DNA, RNA, nucleic acid from archive material, and PCR products themselves.
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 | Z378399 | PCR 3: PCR In Situ Hybridization | An extension of a popular series, this volume is subtitled “PCR In Situ Hybridization.” Coverage emphasizes the power of the combined techniques to detect and amplify rare nucleic acid sequences in biological samples. Step-by-step details of key procedures, advice, and troubleshooting tips improve reliability and help prove the enormous potential for research and diagnosis.
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| | Z731498 | PET Chemistry: The Driving Force in Molecular Imaging | The incessant progress in the comprehension of molecular processes of disease formation and progression is accompanied by an increasing importance of biomedical molecular imaging methods. PET, a nuclear medical imaging modality, is ideally suited to produce such kinds of images by use of positron-emitting chemical entities. The purpose of this workshop was to discuss and overview applications and technologies in the area of PET chemistry. The book provides the reader with state-of-the-art information on the different applications of PET isotopes, such as F-18, C-11, Ga-68, Cu-64, Y-86, Br-76, Br-77 and I-124, and their impact on molecular imaging. New technical features such as microwaves, microreactors and modules for the synthesis of new PET tracers are discussed.
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 | Z704857 | PG200 (Progenesis) software | Progenesis PG200 provides simple laboratory image analysis for single stain 2D gels using a routine, three step approach – Set-up, Process and Review. With this approach an analysis is set-up in minutes, processed automatically and reviewed using a comprehensive suite of display options to show spots of interest. Analysis workflows can be tailored to the specific requirements of your lab using an intuitive user interface and step by step approach. Key features of PG200 include
• Analysis Wizard to set-up entire an experiment for analysis
• Automated Matching with option for manual seed placement
• Background subtraction that is flexible and fully informative
• Normalisation methods to perform accurate intensity calibration and MW/pl determination on your 2D gels
• Editing tools to optimize analysis results
• SameSpots spot outline method, which offers a brand new approach for analysing aligned images
• Image views and measurements tables that highlight areas of interest and present results
• Workspaces that can be recalled to display custom window layouts for easy data review
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 | Z705608 | PRINS and In Situ PCR Protocols, 2nd ed. | This completely revised and updated edition takes advantage of the many new developments and applications that have occurred in PRINS and in situ PCR technology, including a new fast multicolor PRINS method for identifying human chromosomes, PRINS protocols for in situ detection of unique sequences and point mutation analysis, a new dideoxy PRINS procedure, and in situ PCR and PRINS protocols for plants. The authors describe in detail various applications of PRINS in human (detection of gene deletions in cancer detection of fetal cells in maternal blood, and assessment of aneuploidy in brain tissues and embryos) as well as plant cells. Readily reproducible in situ PCR techniques are also presented for the detection of cytomegalovirus, and for use in combination with microdissection.
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| | Z373931 | PRINS and In Situ PCR Protocols: Methods in Molecular Biology, Vol. 71 | This new, cutting edge publication demonstrates clearly how oligonucleotide primers may be successfully used to detect and amplify, or extend, complementary sequences ::FIin situ. It provides methods for rapid identification and characterization of chromosomal cDNA sequences, viral genomes, and rare messenger RNAs in cells.
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| | Z276642 | Palladium Reagents and Catalysts: Innovations in Organic Synthesis | Palladium is one of the most popular compounds used in the synthesis of pharmaceuticals, foods, cosmetics, and materials worldwide. Now in paperback, this book provides a comprehensive overview of palladium chemistry, highlighting recent discoveries and applications, and detailing new synthetic methods.
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 | Z706027 | Palladium Reagents and Catalysts: New Perspectives for the 21st Century | Jiro Tsuji, one of the pioneers in this field of organic synthesis, provides synthetic organic chemists with a remarkable overview of the many applications of organopalladium chemistry. Tsuji discusses the recent developments in the field as well as the explosive growth over the last five years. Highlighting the most recent discoveries in this rapidly expanding field, the book focuses on new aspects of organopalladium chemistry, putting emphasis on synthetic applications and investigates the new perspectives on the synthetic uses of contemporary organopalladium chemistry This is an essential reference source and companion for students, and both industrial and academic research chemists working in organic synthesis, particularly on synthesis of natural products and medicinal compounds.
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 | Z730203 | Palladium in Heterocyclic Chemistry: A Guide for the Synthetic Chemist, 2nd ed. | Heterocycles are of paramount importance in the pharmaceutical industry and palladium chemistry is one of the most novel and efficient ways of making heterocycles. Today, palladium-catalyzed coupling is the method of choice for the synthesis of a wide range of biaryls and heterobiaryls. The number of applications of palladium chemistry to the syntheses of heterocycles has grown exponentially. These developments highlight the need for a monograph dedicated solely to the palladium chemistry in heterocycles and this book provides a comprehensive explanation of the subject. The principal aim of the book is to highlight important palladium-mediated reactions of heterocycles with emphasis on the unique characteristics of individual heterocycles. This book comprises a compilation of important preparations of heteroaryl halides, boranes and stannanes for each heterocycle.
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 | P9234 | Passion for DNA: Genes, Genomes, and Society | A principal architect and visionary of the new biology, a Nobel Prize-winner at 34 and best-selling author at 40 (The Double Helix), James D. Watson had the authority and courage to take a prominent role as commentator on the march of DNA science and its implications for society. In essays for publications and in lectures, he delivered what were, in effect, dispatches from the front lines of the revolution. This book is a collection of outspoken and sparkling ideas and opinions.
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 | Z700657 | Patch-Clamp Analysis: Advanced Techniques | This book describes in reproducible detail all applications that involve patch pipet. Beginning with updated basic patch-clamp techniques, it presents the newest developments, ranging from fast external solution switching and the switching of the pipet solution during recording, to the loose patch, the perforated patch, and the patch cram detection technique. The advanced techniques covered combine molecular biology and imaging to produce the patch pipet with RT-PCR and fluorometric techniques.
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 | Z528684 | Patent Strategy for Researchers and Research Managers, 2nd ed. | This edition introduces researchers to patent applications and patent portfolios. With minimum use of ''legal jargon", it provides the technical professional with the help and advice they require to understand the legal complexities that they may encounter before and during a patent application. It also discusses the responsibilities of the researcher after patent applications have been filed and the role the researcher can play in the maintenance of a global patent estate. Over the last five years intellectual property has taken center stage around the world as countries realize the value of having a consistent and enforceable patent business. The increase in patent activity has resulted in a number of new laws being created. To reflect these changes this edition has been reorganised and completely updated.
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 | Z702811 | Patents, Copyrights & Trademarks for Dummies | This book explains, in layman's terms, the basic nature, function, and application of intellectual property (IP) rights, including how you can acquire those rights, wield them effectively against your competitors, or exploit them lucratively through licensing agreements and other rewarding adventures. This book covers all of these critical concepts, such as Working with IP professionals, Presenting a patent explanation, Determining what is copyrighted and what isn't, Protecting your commercial identity, Inspecting the basic elements of a license, Determining infringement, Avoiding the ten worst naming blunders.
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| | Z213675 | Patterson’s German-English Dictionary for Chemists, 4th Ed. | First published by Wiley in 1917, it set the standard for the entire field. Maintaining the same convenient layout and Patterson format with the same high standards of quality, here is the first revision of this invaluable work since 1950. With expanded coverage and new terms, it captures the wealth of scientific discoveries made in the last four decades, including the DNA double helix, practical computers and microelectronic devices, plate tectonics and man in space. Once again German and English-speaking scientists and engineers have an up-to-date and authoritative resource for understanding each other's language.
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 | P1994 | Peptide Antibiotics: Discovery, Modes of Action and Applications | This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct antibacterial action and as part of the adaptive immune response. It discusses these compounds and their applications including: the distribution and classification of diverse, antimicrobial peptides throughout nature, the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins, and the genetic basis determining the production of bacterial peptide antibiotics.
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 | Z700215 | Peptide Arrays on Membrane Supports: Synthesis and Applications | Proteins interacting with diverse ligands - proteins, peptides or DNA - are the basic principles underlying many biological processes, such as antigen-antibody binding, signal transduction or receptor binding. The technique of oligopeptide synthesis on a cellulose membrane and the subsequent binding assays allow the investigation of protein interactions. A particular advantage of these peptide arrays (SPOT - technology) is the high number of oligopeptide probes that can be tested in parallel. Detailed protocols for peptide synthesis, and the analysis of protein-protein, protein-DNA interactions as well as epitope mapping are presented.
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 | Z703826 | Peptide Synthesis and Applications | Experts describe in detail the methodologies of contemporary peptide synthesis and illustrate their numerous applications. Techniques presented include protocols for chemical ligation, the synthesis of cyclic and phosphotyrosine-containing peptides, lipoamino acid- and sugar-conjugated peptides, and peptide purification and analyses. Additional chapters detail methodologies and instrumentation for high-throughput peptide synthesis, many different applications of peptides as novel research tools and biological probes, and the design and application of fluorescent substrate-based peptides that can be used to determine the selectivity and activity of peptidases. A practical guide to the identification of proteins using mass spectrometric analyses of peptide mixtures is also included.
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 | Z553751 | Peptides: Biology and Chemistry | Peptides play a decisive role in many physiological processes, whether as neurotransmitters, hormones or antibiotics. The rapid developments in peptide research over the past few decades make it almost impossible for newcomers to gain an overview. This unique work covers all the important aspects of this wide-ranging field in one handy volume. On the basis of the fundamental chemical and structural properties of peptides, this reference runs the gamut from analysis, the occurrence and biological importance of peptides, via chemical, biochemical and genetic methods of peptide synthesis, right up to peptide libraries, peptide design and their role in drug research. Yet this book offers much more than a mere overview of the latest level of research. An encyclopedic appendix with valuable data on more than 500 biological relevant peptides and proteins, a comprehensive register and details of further literature references make this the ideal reference for all questions regarding peptide research.
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| | Z410217 | Perfume Handbook, 2nd ed. | The first edition of this book established itself as an unparalleled source of information on perfume. This edition is now aimed squarely at perfumery marketing specialists and others in the industry and covers in particular the needs of publicity/advertising teams, who like to have a wide range of information at their fingertips. Changes include: an expansion of the number of profiles of the perfume houses, and of the 50 or so new perfumes worthy of record which have been launched since the previous edition. There is also increased coverage of the essences and the plants and other material from which they are derived. Coverage of perfume containers is substantially expanded and linked to other parts of the book
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 | Z704121 | Perspectives in Flavor and Fragrance Research | Research is more than ever central to the F&F industry with its constant demand for innovation and its frequently changing trends. Especially, in the classic and well-explored domains of musks and amber odorants fascinating new discoveries were made only very recently, which proves the endless possibilities in the search for new aroma chemicals. Fragrance and fragrance materials by definition elicit a biological response, serve as versatile signals, trigger the sense of smell and taste in various ways - and every odorant design is nothing more than 'chemistry probing nature'. But Fragrance Chemistry can also document and even preserve the biodiversity of scents.
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| | Z701939 | Pesticide Manual, 13th ed. | This edition of this world compendium is an essential reference book for anyone with a professional interest in pesticides. Extensively revised and updated, it contains 858 detailed main entries as well as abbreviated details covering 611 superseded products. Entries cover herbicides, fungicides, insecticides, acaricides, nematicides, plant growth regulators, herbicide safeners, repellents, synergists, pheromones, beneficial microbial and invertebrate agents, rodenticides and animal ectoparasiticides. 50 new entries added, including more than 30 new synthetic molecules, 13 further minor substances not previously listed and several more pheromones
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 | P5861 | Phage Display: A Laboratory Manual | Phage display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage display technology is challenging and the aim of this manual is to provide comprehensive instruction in its theory and application.
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| | Z730815 | Phage and the Origins of Molecular Biology, the Centennial Edition | This hugely influential book, published in 1966 as a 60th birthday tribute to Max Delbrück, is now republished as The Centennial Edition. On first publication, the book was hailed as “[introducing] into the literature of science, for the first time, a self–conscious historical element in which the participants in scientific discovery engage in writing their own chronicle. As such, it is an important document in the history of biology...” (Journal of History of Biology). And in another review it was described as “required reading for every student of experimental biology...[who] will sense the smell and rattle of the laboratory” (Bioscience). The book was a formative influence on many of today’s leading scientists.
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 | Z701637 | Pharmaceutical Analysis | This single-volume text explores the analytical aspects of drug development and manufacture. This reference provides pharmacists and scientists - specifically, analytical and organic chemists and biochemists -- with a source of information to a broad range of techniques and their applications. This allows readers to choose the most appropriate analytical technique for a particular purpose. The text discusses a variety of concepts, including: quality control and regulatory requirements, chiral and solid state analyses, vibrational spectroscopy, particle properties, microscopy and imaging, and nuclear magnetic resonance
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 | Z700746 | Pharmaceutical Chemistry: Therapeutic Aspects of Biomacromolecules | In this introductory book, key strategies involved in the development and production of a range of clinically useful compounds are presented along with a broad overview of the way in which peptides, proteins, nucleic acids and carbohydrates are used therapeutically. Illustrated with numerous examples, the book covers essential compounds and explains how they exert their influence through an understanding of biological processes. Pharmaceutical chemistry has become progressively more important in terms of both research and teaching, and this book includes latest developments with examples selected in order to emphasise the molecular basis of specific disease processes
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 | Z703206 | Pharmaceutical Excipients: Characterization by IR, Raman and NMR Spectroscopy | Recognizing the need for a hands-on guide elucidating the role of molecular spectroscopy in the physical characterization of pharmaceutical solids, two experts gather theoretical discussions of infrared, Raman, and NMR spectroscopy, and helpful recommendations on spectral data acquisition techniques, as well as 600 spectra for 300 of the most commonly used excipients in pharmaceutical dosage formulation. Furnishes accurate spectral data on each compound for interpretation, such as peak listings for identifying observed spectral features, excipient grades, Chemical Abstracts Service (CAS) registry numbers, molecular formulae, molecular weights, other common excipient names, and excipient usage.
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| | Z515078 | Pharmaceutical Master Validation Plan: The Ultimate Guide to FDA, GMP, and GLP Compliance | Pharmaceutical Master Validation Plan: The Ultimate Guide to FDA, GMP, and GLP Compliance will allow you to more easily achieve satisfactory inspections, new medical product approval, minimize non-conformance, reduce rework and rejected lots, and avoid recall lots by developing and managing a Master Validation Plan. The accompanying CD allows users to input the template plan into their computers and tailor it to incorporate additional regulatory requirements specific to individual companies worldwide and print the required documents. Together, the book and CD contain everything required to develop and execute a successful Master Validation Plan based on FDA guidelines for the pharmaceutical industry, and allows the templates to be extended to diagnostic products, medical device, medical equipment, and biotech industry products. It supplies valuable text establishing a master plan in compliance with FDA, GMP, and GLP requirements and provides a missing link between the Validation Master Plan to the Validation Standard Operating Procedures and Protocols developed and executed
The Master Validation Plan provides a roadmap to management for on-time start-up of facility operations, and validation of existing facilities, in compliance with GMP requirements. The lack of a comprehensive Master Validation Plan and well-documented validation procedures is the main reason that new drug, medical device, medical equipment, and related product applications are rejected by the FDA. This thorough guide provides the needed solutions and guidance for both foreign and U.S. companies to achieve FDA compliance and authorization to market their products in the United States.
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 | Z702250 | Pharmaceutical Process Validation, 3rd ed. | This edition details strategies to establish appropriate validation protocols and conduct process validation assignments; monitor and test specific manufacturing processes for compliance with design limits, specifications, and requirements; identify critical process or test parameters and their respective control limits; enhance the quality and consistency of product outcomes; streamline validation operations; validate computerized systems; and revalidate quality assurance systems after equipment, formulation or packaging modifications. It contains new chapters covering troubleshooting procedures, validation in contract manufacturing and current harmonization trends.
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| | Z511862 | Pharmaceuticals: Classes, Therapeutic Agents, Areas of Application, 4-Volume Set | Important pharmaceuticals and disease symptoms are discussed along with an authoritative introduction to the industry. The pharmaceuticals are grouped into six categories: cardiovascular drugs, neuropharmaceuticals, gastrointestinal drugs, respiratory tract, antiinfectives, and endocrine and metabolic drugs. Includes a keyword, author, and CAS-registry-number index as well as extensive references to the literature.
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 | Z704385 | Pharmacogenomics: Methods and Protocols | Experts provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
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| | Z272302 | Pharmacokinetics for the Pharmaceutical Scientist | Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
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 | Z730513 | Pharmacology 6th ed. | A straightforward way to master a complex subject. This bestselling textbook presents all the knowledge you need to get through your pharmacology course and beyond—using a clear and accessible approach that makes the material easy and interesting to learn. Progressing logically from a molecular understanding of receptors and drug actions to the clinical uses of the most important groups of drugs, it delivers the latest information on cannabinoids and rimonabant, Cox 2 inhibitors, pharmacogenetics, biopharmaceuticals, and drug abuse—as well as "lifestyle drugs" such as performance-enhancing substances, botulinum toxin, and Viagra®. And now, online access via Student Consult makes it an even more effective learning resource.
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 | Z706035 | Pharmacology Primer; Theory, Application and Methods, 2nd ed. | The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments.
• Over 30 new figures and tables
• New section on new biological concepts relevant to pharmacological research (i.e., systems biology)
• New study sections organized with ASPET and other international pharmacology organizations
• New coverage of pharmacokinetics and drug disposition
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| | Z507253 | Pharmacology for Chemists | This practical book provides an ideal guide, covering the aspects of pharmacology most important and useful to chemists engaged in drug discovery. The book is based upon a popular three-day Americal Chemical Society short course, "Pharmacology for Chemists," which the author has taught for twenty years, and the book retains the lively and accessible presentation of the course while including more detailed discussions, references, and definitions. Any chemist who is considering research on drugs will find this volume an invaluable tool.
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 | P2988 | Pharmacology of Cytokines | Modulation of production and action of cytokines has been the object of intense research. This book overviews the field of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. The book in the framework of the immunobiology of cytokines, examines interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products. It analyzes specific contexts for the pathophysiology of these mediators as well as pharmacological approaches for their control.
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 | Z702048 | Pharmacology, Fifth Edition | Pharmacology's successful approach emphasizes the mechanisms by which drugs act and relates these to the overall pharmacological effects and clinical uses. In doing so it sets out a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs. This edition has been fully updated, incorporating significant new information published in the last few years. New agents are fully discussed as well as extensions of basic knowledge. One new chapter in the final section on drug discovery looks at the rapidly changing processes involved which are driven by advances in molecular biology, and contains a brief account of the regulatory controls involved.
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| | Z557552 | Phosgenations: A Handbook | In this manual, the authors compare the range of applications for phosgene with that of the alternative compounds, dealing in detail with the possible uses of diphosgene, triphosgene, carbon dioxide, organic carbonates, oxalychloride and many other alternative materials used in synthesis. However, they clearly point out those cases where phosgene continues to have the advantage. The results is a mine of information for synthetic chemists working in industry and academia faced with the question of where the toxic phosgene can be replaced by an unproblematic compound, including the safety phosgenation.
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 | Z704423 | Phosphodiesterase Methods and Protocols | Research leaders describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. These methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs. Additional chapters discuss the generation of PDE4 knockout mice to demonstrate not only the potential role of targeted PDEs, but also their use in further studies of the central role of PDE regulation in intracellular signaling control. Alterations of intracellular signaling related to PDE deregulation in such pathologies as inflammation, neurodegeneration, and cancer may explain the difficulties observed in their prevention and treatment.
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 | P1603 | Phospholipid Signaling Protocols | This collection of state-of-the-art techniques for the assay of phospholipid and phospholid-derived second messengers allows the identification and quantitation of signal pathway activation. Techniques cover all the major phospholipases (C, D, A2), as well as sphingomyelinase and associated metabolites. Additional protocols are provided for the assay of phosphoinositide 3-, 4-, and 5-kinase activities and for the separation and identification of phospholipids, diacylglycerol and sphingolipids, as well as their phosphoinositol, choline and fatty acid metabolites.
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| | Z555703 | Photoinitiated Polymerization | Photoinitiated Polymerization is divided into five sections. Free radical photopolymerizations command most of the interest and activity within the field and thus is discussed first. The second section discusses kinetic studies of the mechanism of free radical polymerizations. The third section covers cationic photopolymerizations, which along with free radical polymerizations, are being used in many industrial applications. The fourth section is devoted to recent developments in novel photopolymeriztion chemistry. This section describes new photobase generators, developments in monomers, oligomers and templated polymerizations of liquid crystal polymers. Finally, the fifth section portrays new and emerging applications for photopolymerizations.
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| | Z258792 | Physical Organic Chemistry, 2nd ed. | Covers the underlying principles of reaction pathways, physical forces, and techniques for mechanistic investigations.
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 | Z730181 | Pilot Plant Real Book 2nd ed. | This book is a unique and highly practical handbook for R&D chemists, chemical engineers, technicians and students. Bridging the gap between chemistry and engineering, it is designed for process R&D, kilo-lab and pilot plant personnel, and is packed with information for the safe and effective scale-up of new processes. The revised and expanded second edition is richly illustrated with over 200 distinctive charts, graphs, figures and data tables, and contains countless tips and techniques, an exhaustive index, bibliography and recommended reading list.
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 | Z705497 | Pitfalls and Errors of HPLC in Pictures, 2nd ed. | Every user of HPLC is confronted with a multitude of pitfalls and sources of error. Adding 12 new topics to this new, second edition, Veronika Meyer now offers almost 100 exemplary solutions for such problems. All examples are presented with a concise, instructive text and an informative figure. These examples also include essential fundamentals as well as helpful strategies such as equipment tests or quality assurance strategies. A practice-oriented guide for obtaining correct and reliable analytical results.
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 | P0366 | Plant Cell Biology: A Practical Approach 2nd ed. | With the post genomics era, comes a demand for techniques of cell biology, critical to interpreting function and location of the cell's many proteins and macromolecules. This edition balances established techniques, including classical histochemistry and electron microscopy, with new developments. It covers a range of methods for working on living cells, including the application of fluorescent probes, cytometry, expression systems, the use of green fluorescent protein, micromanipulation and electrophysiological techniques. It concludes with a range of biochemical techniques for the isolation of cytoplasmic organelles.
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 | Z703001 | Plant Cell Culture | Plant cell culture is an essential methodology in plant sciences, with numerous variant techniques depending on the cell type and organism. Plant Cell Culture: the basics provides the reader with a concise overview of these techniques, including basic plant biology for cell culture, basic sterile technique and media preparation, specific techniques for various plant cell and tissue types including applications, tissue culture in agriculture, horticulture and forestry and culture for genetic engineering and biotechnology.
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 | Z705039 | Plant Cell Culture Protocols, 2nd ed. | A collection of the most frequently used techniques for plant cell and tissue culture. The readily reproducible methods range from general methodologies, such as culture induction, growth and viability evaluation, and contamination control, to such highly specialized techniques as chloroplast transformation involving the laborious process of protoplast isolation and culture. Most of the protocols are currently used in the research programs of the authors or represent important parts of business projects aimed at the generation of improved plant materials. Two new appendices explain the principles for formulating culture media and the composition of the eight most commonly used media formulations, and list more than 100 very useful internet sites.
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| | Z358975 | Plant Cell Culture: A Practical Approach, 2nd ed. | The second edition of this book incorporates a number of significant changes which reflect the impact of molecular biology on the plant sciences. The inclusion of new sections on cell selection for cold, salinity and toxin resistance will aid in understanding plant stress physiology at the molecular level. Methods for the establishment and manipulation of well-characterized cell culture systems, as well as general advice for protocol development, is presented.
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 | Z701874 | Plant Functional Genomics | Leading plant scientists describe the most commonly used methods for investigating plant gene function in a wide variety of plants, during plant pathogen interactions, and even in algae. These readily reproducible protocols include computational, molecular, and genetic methodologies designed for both general and specific problems. The reader will learn about powerful computational and statistical tools to help predict gene function either on the basis of comparative genomics, or from the analysis of complex genome sequences. Numerous loss-of-function and gain-of-function techniques for discovering gene function are presented in step-by-step detail
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 | P2744 | Plant Growth and Development: Hormones and Environment | This book provides information on synthesis of plant hormones, how their concentrations are regulated, and how they modulate various plant processes. It details how plants sense and tolerate such factors as drought, salinity, and cold temperature, factors that limit plant productivity on earth. It also explains how plants sense two other environmental signals, light and gravity, and modify their developmental patterns in response to those signals. This book proceeds from basic concepts to current thinking. Features include a review of hormonal and environmental regulation of plant growth and development and more than 600 illustrations.
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 | P4734 | Plant Hormone Protocols | Established investigators describe in step-by-step detail their best techniques for the study of plant hormones and their regulatory activities. These methods include contemporary approaches to identifying the biosynthetic pathways of plant hormones, monitoring their levels, characterizing the receptors with which they interact, and analyzing the signaling systems by which they exert their effects.
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 | Z700851 | Plant Pathologist’s Pocketbook, 3rd ed. | This essential handbook has been reorganized and updated. This edition includes: rearrangement of topics to facilitate use; 49 short succinct chapters, each providing valuable practical information; new topics such as landmarks in plant pathology, survey of sampling procedures, disease evaluation, effects of climate change, biochemical and molecular techniques, epidemic modelling, breeding for resistance, laboratory safety and electronic databases; seven overall sections covering disease recognition and evaluation, causation, diagnosis, investigation, control, general techniques, and presentation of results.
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 | Z365599 | Plant Propagation by Tissue Culture, Part 1: The Technology | Topics addressed include: methods available for in vitro propagation, variation in cultures and plants, the control of contaminants and diseases, genetic, environmental and tissue dependent factors affecting growth and morphogenesis in cultures, the nature and uses of plant growth regulators, and the components, preparation and uses of culture media.
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 | Z701815 | Plant Protease Inhibitors Significance in Nutrition, Plant Protection, Cancer Prevention and Genetic Engineering | Plant protease inhibitors are diverse in number and in specificity towards various proteolytic enzymes. This book focuses on the isolation, structure, characterization, physiochemical and physiological properties, synthesis, functions and mechanisms of action of plant protease inhibitors. It deals with their inhibitory effects on insects and pathogens and with their induction and introduction into plants by genetic engineering for plant protection. The induced resistance of insects to the inhibitors and the hazards to friendly insects are also discussed. Findings are presented on the cancer chemopreventive properties of the inhibitors at the cellular, tissue and organ levels and in the organism
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 | Z701831 | Plant Tissue Culture: Techniques and Experiments, 2nd ed. | This second edition provides laboratory exercises in plant tissue culture that demonstrate major educational concepts. The experiments can be conducted with a variety of plant materials that are available year round from easily accessible sources. Students as well as new and experienced plant scientists in agriculture, university, and industry settings will find this concise manual to be of great value. The strength of this book lies in its descriptions of essential concepts, introduction to a wide range of major applications, and simple protocols to provide empirical demonstrations.
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 | Z379646 | Plant Virology Protocols: From Virus Isolation to Transgenic Resistance | Comprehensive coverage of time-proven methods for constructing transgenic virus-resistant plants. By introducing expressible genes for virus coat proteins, plant scientists can with near certainty generate immunity to viral infection. This volume covers the methods, step by step, from virus isolation through cloning coat protein genes, transforming the plant genome, and testing for expression and resistance. contributors also discuss the history and ethical implications of transgenic technology.
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| | Z511633 | Plastics Additives Handbook, 5th ed. | This new, fully revised edition of Plastics Additives Handbook provides an excellent overview of the complex science and technology of plastics additives and their industry. It offers guidance for all professionals involved in the development of new thermoplastic resin grades and novel end-use applications.
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 | Z700479 | Platelet Protocols: Research and Clinical Laboratory Procedures | Scientists have made great strides in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has an effect on people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. . It is a comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. Topics range from the basics of anticoagulants to the latest developments in platelet testing.
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 | Z373583 | Platelets: A Practical Approach | This book describes state-of-the-art techniques for the experienced researcher, both in academe and industry. The seventeen chapters cover techniques from basic platelet preparation to the latest procedures such as monitoring calcium levels in single cells, tyrosine phosphorylation, and PER.
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 | Z700827 | Pocket Guide to Biotechnology and Genetic Engineering | Biotechnology and genetic engineering are the key technologies of the 21st century. They allow the findings in cell biology and genetics, biochemistry and microbiology, biochemical engineering and bioinformatics to be applied to health care, agriculture, food production, environmental protection and alternative production methods for chemicals. This pocket guide provides a broad overview of the relevant facts on products, methods and applications, while discussing the opportunities and risks of these new technologies.
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 | Z412473 | Polymer Handbook, 4th ed. | This one-stop reference, now almost 2,000 pages, brings together all the data needed in theoretical and experimental polymer research. It is designed so the scientist doesn't have to search through multitudes of literature for information on polymers. Features:* Continues to be the only source for fundamental, validated property data of polymeric material* Explores the developments in the field since 1989, such as new pvt relationships and new co-polymer reactivity parameters* Includes 30% new data - which is more reliable and accurate due to advances in instruments* Improved nomenclature to aid indexing and search & retrieval
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| | Z552151 | Polymer Optical Fibers | Summarizes research activities on polymer optical fibers to offer a complete perspective on this emerging topic. Covers all aspects of plastic optical fibers including different classes of polymers; fiber fabrication techniques; laser sources used for optical fibers, mechanical properties; photosensitivity; applications in telecommunication and high capacity transmission systems; etc.
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| | Z235938 | Polymer Syntheses, 2nd ed. Volume 1 | Provides detailed laboratory instructions for the synthesis of polymers.
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| | Z248495 | Polymer Syntheses, 2nd ed. Volume 2 | Provides detailed laboratory instructions for the synthesis of polymers.
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| | Z551309 | Polymer-Clay Nanocomposites | Polymer-clay nanocomposites are formed through the union of two very different materials with organic and mineral pedigrees. The hybrid compositions, however, exhibit large increases in tensile strength, modulus, and heat distortion temperature as compared with the pristine polymer. Covering both the theory and practical applications, this volume covers the key aspects of these important materials including: Polymer-clay intercalates; The preparation and general properties of special practical and commercial significance (including strength, stiffness, toughness, permeability, fire retardation and chemical stability); The elucidation of the structural and rheological factors influencing performance and processing properties.
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 | Z518492 | Polymers – A Property Database on CD-ROM | Provides scientific and commercial information on polymers in a single, first-stop reference invaluable to anyone involved in polymer science and echnology. It guides the user through the primary literature via reference citations and through the realm of supplier details by providing trade names and commercial product information.
Features:
• Trade names, commercial names, and synonyms
• Extensive physical property data
• Supplier information
• Polymer structures
• Search by monomer, application, properties, and manufacturing process
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 | P2231 | Positional Cloning by Exon Trapping, cDNA Selection | This book covers the practical and theoretical information on broadly applicable techniques to identify and characterize candidate genes that may be responsible for human diseases. In order to understand the function of these genes, it is essential to link the information on the phenotype, localized to specific regions of the genome by genetic analysis techniques.
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 | P7109 | Post-genome Informatics | New DNA and protein chip technologies rapidly produce functional data about genes. But there is a huge gap between information at the molecular level and at the level of integrated biological systems. This book addresses this gap. It is the analysis of biological functions in terms of the network of interacting molecules and genes with the aim of understanding how a biological system is organized from its individual building blocks. It contains computational technologies relevant to molecular sequence analysis.
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 | Z340839 | Post-translational Processing: A Practical Approach | This book and its companion volume Protein Expression: A Practical Approach form the final part of the PAS mini-series on protein synthesis and processing. This volume covers protein sequencing, protein folding and import, organelles, and the three major forms of covalent modification--phosphorylation, glycosylation, and lipid modification. It is an ideal resource for research on protein expression in cell free systems, viruses, and prokaryotic and eukaryotic cells
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 | Z704636 | Posttranslational Modification of Proteins: Expanding Nature’s Inventory | This book covers the wide range of posttranslational modifications found in Nature, many of which have been discovered relatively recently as a result of improved detection methods. It may be used as a reference or as a collection of the structural and functional variety of these modifications. The author covers the subject from the perspective of both the mechanism of formation of these protein conjugates and their biological function in processes like signal transduction and enzymatic catalysis. Several links are made between various modification processes and their roles in biological processes that tie together the heterogeneous collection of posttranslational modifications.
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 | P8742 | Posttranslational Modification of Proteins: Tools for Functional Proteomics | This volume describes reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins. Methods include those for analyzing the assignment of disulfide bond sites in proteins, protein N-glycosylation and protein O-glycosylation, and oligosaccharides present at specific single glycosylation sites in a protein. Additional techniques facilitate the analysis of glycosylphosphatidylinositols, lipid modifications, protein phosphorylation and sulfation, protein methylation and acetylation, a-amidation and lysine hydroxylation
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 | Z702781 | Practical Enzymology | Providing a broad experimental approach, this book contains a theoretical introduction together with practical protocols, considering all aspects of enzymology. The fundamental experiments in enzymology are presented in very clear and easily realizable protocols. Each experiment is accompanied by a section giving the theoretical background. This practical guide is an ideal supplement to "Enzyme Kinetics: Principles and Methods" (E2529). Essential reading for all scientists and practitioners working with enzymes.
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 | Z701769 | Practical Flow Cytometry, 4th ed. | The fourth edition of this benchmark text provides a comprehensive resource covering the technology, principles, and biomedical applications of analytical cytology using laser-activated detection and cell sorting. It is updated with several added features, including: a revised introduction, emphasizing connections between flow cytometry, static cytometry, and microscopy; expanded coverage of applications in biotechnology, cell biology, genetics, hematology, immunology, microbiology, and oncology; discussion of new commercial instrumentation; review of alternatives to flow sorting.
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| | Z408425 | Practical Guide to Combinatorial Chemistry | This book is a practical guide for those engaged in small-molecule combinatorial chemistry as well as those wishing to learn the field. Aimed at nonspecialists, the chapters are written in a tutorial style by internationally recognized experts. The text reviews the use of computational tools to analyze molecular diversity and presents a detailed survey of solid-phase peptide synthesis and the tools used for small-molecule synthesis. Up-to-date automated approaches and equipment for synthesizing solid- and solution-phase libraries are reviewed, including synthesis, analytical, and deconvolution tools.
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| | Z278963 | Practical Guide to Infrared Microspectroscopy | | pricing |
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 | Z364010 | Practical Guide to Membrane Protein Purification | Written for those who have some familiarity with separation of water-soluble proteins, but who may not be aware of the problems involved in the isolation of membrane proteins. This book is an essential manual for investigations of structure and function of native membrane proteins.
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| | P1436 | Practical Guide to Monoclonal Antibodies | This book is designed to provide all the information required to produce monoclonal antibodies and to prepare them for use in a given application. The procedures are dealt with in chronological order from basic tissue culture through antibody characterization, purification and labeling.
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| | Z350346 | Practical Guide to Protein and Peptide Purification for Microsequencing | This second edition provides a guideline for obtaining useful sequence information from proteins or peptides. Important new methods include ways of dealing with blocked N-termini, computer analysis of protein sequences, and the recent revolution in mass spectrometry.
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 | Z703338 | Practical Guide to Understanding the NMR of Polymers | A Practical Guide to Understanding the NMR of Polymers presents an introduction to the theory and practice of NMR, and includes sections on the fundamental principles of NMR and the applications to polymers. This book will help readers understand how these methods can be used to determine the chemical structure of polymers that influences the macroscopic properties. Solid state NMR methods are introduced to enable the readers to measure the structure of polymers on longer length scales. It is also shown how NMR is used to measure the molecular dynamics that can be related to the mechanical properties of polymers
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 | Z730289 | Practical Handbook of Preparative HPLC | This book is a distillation of twenty years of practical experience of the high pressure liquid chromatography (HPLC) process. Deliberately steering clear of complex theoretical aspects, this book concentrates on the everyday problems associated with the technique, making it perfect for frequent use in the laboratory and for those in the pharmaceutical, agrochemical and biotechnology industries for the analysis and purification of drugs, small molecules, proteins and DNA. This book provides practical, hands-on advice based on years of experience; Will help ensure optimal design, equipment and separation results for your particular task; Presents system layouts from laboratory to process scale; Will help you to devise or improve record-keeping and documentation systems.
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 | Z703133 | Practical High Performance Liquid Chromatography, 4th ed. | This book is a classic text and remains one of the few titles available on general HPLC. This fourth edition continues to provide users of HPLC in industry, government, academia, and service laboratories with a unified approach to HPLC and an equal treatment of the theory and practice of this important technique. The contents have been revised, expanded and updated. Where available, old literature references have been replaced by recent ones. New sections on the following topics have been included: Shelf-live of mobile phases; The mixing cross; Phase systems in ion chromatography; Measurement uncertainty.
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 | Z703397 | Practical NMR Relaxation for Chemists | This book demonstrates how NMR relaxation can be applied for structural diagnostics of chemical compounds, recognition of weak intermolecular interactions, determinations of internuclear distances and lengths of chemical bonds when compounds under investigation can exist only in solutions. Written as a textbook for chemists, it demands little background in physics and NMR. Its practical approach helps the reader to apply the techniques in the lab. It is first book to teach NMR Relaxation techniques to chemists.
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| | Z271713 | Practical Organic Mass Spectrometry: A Guide for Chemical and Biochemical Analysis, 2nd ed. | Text covers current techniques and recent advances in mass spectroscopy. Material divided to include theory, instrumentation requirements, and applications for mass spectrometry.
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 | Z705934 | Practical Organic Synthesis: A Student’s Guide | Success in an experimental science such as chemistry depends on good laboratory practice, a knowledge of basic techniques, and the intelligent and careful handling of chemicals. This is a concise, useful guide to good laboratory practice in the organic chemistry lab with hints and tips on successful organic synthesis. Topics covered include: safety in the laboratory; environmentally responsible handling of chemicals and solvents; crystallization; distillation; chromatographic methods; extraction and work-up; structure determination by spectroscopic methods; searching the chemical literature; laboratory notebooks; writing a report; hints on the synthesis of organic compounds; disposal and destruction of dangerous materials; drying and purifying solvents. Condensing over 30 years of the authors’ organic laboratory teaching experience into one easy-to-read volume, this is an essential guide for those new to the organic chemistry laboratory, and a handy benchtop guide for practising organic chemists
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 | Z701963 | Practical Pharmaceutical Laboratory Automation | Although many laboratory scientists understand the methods and principles involved in laboratory automation, most lack the necessary engineering and programming skills needed to successfully automate or interface equipment in the lab. This how-to reference guide explores the processes needed to automate the majority of tasks required in research. Author discusses topics ranging from automated mathematical analysis to robotic automation of chemical processes, to combinations of these and other processes. He presents a detailed discussion of high throughput screening and assay development and takes an in-depth look at Visual Basic as the primary programming language used in laboratories. The text has a dedicated web site (http://www.pharmalabauto.com ) which contains all the sample code and examples in the text as well as other information related to laboratory automation.
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 | Z506710 | Practical Problem Solving in HPLC | HPLC is one of the most frequently used techniques for separation and analysis of compounds, used extensively in food, pharmaceutical, biochemical, and environmental analysis. This highly practical guide shows how to solve real-world problems using HPLC, offering numerous tips and examples.
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 | Z536970 | Practical Process Research and Development | Teaches how to anticipate and avoid problems when processes are being scaled up from the research lab or pilot plant. The approach is pragmatic, with a minimum of theory and over 100 practical scale-up tips. Many tables and detailed reaction schemes allow the reader to identify critical processing steps quickly. This practical guide is essential reading for chemists and chemical engineers involved in industrial process research and/or process development.
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 | P4984 | Practical Protein Crystallography, 2nd ed. | Designed for easy use by both beginning and experienced protein crystallographers, the second edition of Practical Protein Crystallography is an essential handbook for any scientist interested in solving a protein structure. The book includes examples of actual experiments and data, electron density maps, and computer methods. This second edition has new material covering CCP4, SHELX, cryocrystallography, MAD and automated fitting.
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| | Z357502 | Practical Protein Electrophoresis For Genetic Research | This methodologically oriented book includes principles, gel interpretation, troubleshooting, isozyme nomenclature, data collection and analysis, and genetic and statistical procedures for studies in starch and polyacrylamide gels.
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 | P4859 | Practical in situ Hybridization | A detailed practical guide for laboratory use aimed at those who wish to use efficient and reliable protocols in their work and at researchers checking the validity and interpretation of published data. These molecular cytogenetic methods can be used to characterize and locate nucleic acid sequences within the cell. It is presented in a user-friendly, open format for easy access to information with an extensive troubleshooting guide.
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 | Z700819 | Practice of Medicinal Chemistry, 2nd ed | This is an essential handbook for the medicinal chemist - a complete guide to the drug discovery process. It reviews practical aspects of Medicinal Chemistry, emphasizing the daily problems when dealing with lead discovery/identification methodologies, with structure-activity relationship studies aimed to scale up potency and target selectivity, and when optimizing pharmacokinetic and pharmaceutical properties by means of ultimate chemical modifications. This edition is revised, with around 30% new material, and refocussed to reflect the developments in genomics, proteomics, high throughput screening of compounds and drug solubilization.
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| | P5691 | Practice of Thin Layer Chromatography, 3rd ed. | This book includes an expanded discussion of sample preparation with an enhanced look at applications. There is also a detailed description of scanners both for isotopes and densitometry.
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 | Z704628 | Precursor Chemistry of Advanced Materials | Material synthesis by the transformation of organometallic compounds (precursors) by vapor deposition techniques such as chemical vapor deposition (CVD) and atomic layer deposition (ALD) has been in the forefront of research and development of new materials. There exists a need for new routes for designing and synthesizing new precursors as well as the application of established molecular precursors to derive tuneable materials for technological demands. To emphasize research in these areas, this volume comprises a selection of case studies covering various key aspects of the interplay of precursor chemistry with the process conditions of materials formation, particularly looking at the similarities and differences of CVD, ALD and nanoparticle synthesis, e.g. colloid chemistry, involving tailored molecular precursors
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| | Z287768 | Preparative Carbohydrate Chemistry | Offers relevant chapters on reactions and derivative forms of carbohydrates, including commonly used methods as well as new experimental procedures. Also contains insightful chapter commentaries and succinct topic histories.
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 | Z705586 | Preparative Chromatography of Fine Chemicals and Pharmaceutical Agents | High performance adsorbents prepared the ground for increasing applications of preparative chromatography in the field of fine chemicals and pharmaceutical agents. But a real breakthrough was stimulated by additional research and development in the field of continuous separation processes like Simulated Moving Bed technology (SMB). The contents of this book start with an introductory section and go on to explain fundamentals and to define the general terminology. Other sections are on solid materials and packed columns followed by procedures to select chromatographic systems for given tasks and a characterisation of process concepts for batch as well as continuous operation. Subsequent chapters focus on modelling and process simulation including determination of model parameters as well as the design and optimization of preparative chromatographic processes and close with design and operation of chromatographic reactors.
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 | Z705144 | Preparative Enantioselective Chromatography | The development of chiral liquid chromatography, facilitating the straightforward separation of enantiomers, was a significant advance in chromatography, leading to widespread application in analytical chemistry. Application in preparative chromatography has been less rapid, but with the development of single enantiomer pharmaceuticals its use is increasingly common in chemical synthesis at laboratory, pilot plant and even full production scale. This book brings non-experts up to speed quickly and comprehensively, facilitating the rapid development of effective separations of enantiomeric mixtures on a range of process scales. It presents case studies drawn from within the pharmaceutical industry to clearly illustrate the utility and value of preparative scale enantioselective chromatography.
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 | P7359 | Primer Premier™ | A comprehensive primer design tool
• PCR primer design- design primer pairs for PCR and multiplex experiments.
• Cross species- Amplify sequences from multiple species.
• Pathogenic detection- Locate oligos in highly conserved regions.
• Allele specific- Exclusively amplify a single member of a set of related sequences.
• Degenerate- Start with an amino acid sequence, reverse translate and design oligos in regions of low degeneracy automatically.
• Nested/multiplex- Checking homology among multiple candidate oligos.
• Restriction enzyme and motif analysis- Select from the database of over 800 enzymes and 200 common motifs.
• Long PCR- Handles sequences up to 50 KB.
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 | P5736 | Principles Of Molecular Recognition | Conn and Means provide an integrated review of the key areas—membrane receptor-initiated cell signaling and nuclear-receptor initiated gene regulation. These authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases.
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| | Z511811 | Principles and Applications of Asymmetric Synthesis | Covers more than 450 reactions, including important stoichiometric and catalytic asymmetric reactions. The first chapter reviews the basic principles, common nomenclature, and analytical methods, while the remainder of the book is organized according to reaction type. The text examines such topics as: C-C and C-O bond formations, asymmetric synthesis using the Diels-Alder reaction and other cyclizations, applications to the total synthesis of natural products, and the use of enzymes.
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 | P3238 | Principles and Practice of Biological Mass Spectrometry | Beginning with a review of fundamentals and recent developments in biological mass spectrometry instrumentation, this book contains well-illustrated instances of important techniques that includes tandem mass spectrometry, collision-induced dissociation, molecular mass determination, coupling of mass spectrometry with separation techniques, and quantitation. Contemporary approaches to characterization of various classes of compounds is provided along with numerous examples of applications.
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 | Z703109 | Principles and Reactions of Protein Extraction, Purification and Characterization | This book provides the mechanisms and experimental procedures for classic to cutting-edge techniques used in protein extraction, purification, and characterization. The author presents the principles and reactions behind each procedure and uses tables to compare the different methods. The book also discusses the development of antibodies and immunochemical techniques as tools for characterizing proteins and modified proteins such as glycoproteins. Along with methodical working procedures for most techniques, the book also offers useful advice on which technique to use and when to apply a particular method.
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 | Z552208 | Principles of Chemical Vapor Deposition: What’s Going on Inside the Reactor | Provides a simple introduction to heat and mass transfer, surface and gas phase chemistry, and plasma discharge characteristics. In addition, the book includes discussions of practical films and reactors to help in the development of better processes and equipment. This book will assist workers new to chemical vapor deposition (CVD) to understand CVD reactors and processes and to comprehend and exploit the literature in the field.
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 | P7242 | Principles of Development, 2nd ed. | The authors’ approach is the idea that understanding how genes control cell behavior is the key to understanding development. Resisting the temptation to cover every aspect of developmental biology, the authors have instead focused on those systems that best illuminate common principles. The theme is that universal principles govern the process of development. The text also focuses on vertebrates and Drosophila, but without excluding other systems, such as the nematode and the sea urchin. Another feature is the inclusion of the development of plants--usually neglected in other textbooks.
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 | Z705969 | Principles of Fluorescence Spectroscopy 3rd ed. | The third edition of the established classic text reference, will enhance upon the earlier editions' successes. It will maintain the emphasis on basics, while updating the examples to include recent results from the literature. This edition also includes new chapters on single molecule detection, fluorescence correlation spectroscopy, novel probes and radiative decay engineering. The full color text features the following: - Problem sets following every chapter - Glossaries of commonly used acronyms and mathematical symbols - Appendices containing a list of recommended books which expand on various specialized topics - Sections describing advanced topics will indicate as such, to allow these sections to be skipped in an introductory course, allowing the text to be used for classes of different levels.
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 | P6736 | Principles of Fluorescence Spectroscopy, 2nd ed. | This edition maintains emphasis on basics, while updating the examples to include more recent results. There is a new chapter providing an overview of extrinisic fluorophores. The discussion of time resolved measurements has been expanded to two chapters. Quenching has also been expanded in two chapters. Energy transfer and anisotropy have each been expanded to three chapters. There is also a new chapter on fluorescence sensing. Glossaries are provided for commonly used acronyms and mathematical symbols.
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 | Z700630 | Principles of Genome Analysis and Genomics, 3rd ed. | With the first draft of the human genome project in the public domain and full analyses of model genomes now available, the subject matter of 'Principles of Genome Analysis and Genomics' is even hotter now than when the first two editions were published. In this edition of this very practical guide to the different techniques and theory behind genomes and genome analysis, the authors provide a fresh look at this topic. In the light of recent advancements in the field, the authors have completely revised and rewritten many parts of the new edition with the addition of five new chapters.
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 | Z705071 | Principles of Inorganic Materials Design | This book discusses a number of topics that are pertinent to the design of new inorganic materials but are typically not covered in standard solid-state chemistry books. Authors start with an introduction to structure at the mesoscopic level and progress to smaller-length scales. Next, detailed consideration is given to both phenomenological and atomistic-level descriptions of transport properties, the metal-nonmetal transition, magnetic and dielectric properties, optical properties, and mechanical properties. Finally, the authors present introductions to phase equilibria, synthesis, and nanomaterials. Features include worked examples demonstrating concepts unfamiliar to the chemist and extensive references to related literature.
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 | Z705926 | Principles of Molecular Medicine 2nd ed. | This fully updated edition provides an integrated survey of the basic principles of internal medicine, in light of recent dramatic discoveries in molecular medicine and new technologies for the diagnosis and treatment of human disease. In addition to fully revised sections on neurology, cardiology, hematology, nephrology, endocrinology, dermatology, immunology, gastroenterology, pulmonary disease, musculoskeletal medicine, and psychiatry, this volume contains new sections on genetics, oncology, metabolic diseases, and infectious diseases. These sections include the latest findings about direct links between genetic mutations and diseases, genomic approaches to a variety of diseases, and stem cell populations that regenerate muscle, heart, and neural cell populations. Other advances elucidated include the roles of bone morphogenetic proteins in pulmonary hypertension and mutations involved in an array of cardiomyopathies.
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| | Z250821 | Principles of Organic Synthesis, 3rd Edition | | pricing |
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| | Z527637 | Principles of Polymer Chemistry, 2nd ed. | Principles of Polymer Chemistry, Second Edition was written for advanced undergraduate and graduate students in polymer chemistry, along with practicing chemists who need a reference guide. Many important events have taken place since the First Edition was published in 1995, and they are updated here. For example, sections have been included on controlled/living free radical polymerization, and sections on metathesis type polymerization and metallocene catalysts were expanded. The book was also expanded to include discussions of thermodynamics of elasticity, thermodynamics of polymeric solutions, and rheology and viscoelasticity. A chapter on degradation of polymers was also added.
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| | Z555630 | Principles of Polymerization, 4th edition | Different methods of polymerization, reaction parameters for synthesis, molecular weight, branching and crosslinking, and the chemical and physical structure of polymers all receive ample coverage. A thorough discussion at the elementary level prefaces each topic, with a more advanced treatment following. Yet the language throughout remains straightforward and geared towards the student.
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| | Z423017 | Principles of Process Research and Chemical Development in the Pharmaceutical Industry | The purpose of process research and development is to transform a research synthetic procedure into a large-scale plant process. In essence, it involves taking a few milligrams of a drug, pesticide or chemical and redesigning the steps to accommodate large scale production of the substance. This book covers the key aspects of synthesis that must be considered when scaling up a process. It discusses such topics as minimizing by-product impurities, synthesizing enantipure compounds, criteria for an ideal cost effective synthesis and licensing.
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 | Z703494 | Principles of Proteomics | This book provides a comprehensive introduction to this relatively new field, for the first time bringing together all the disparate themes of proteomics. The book covers the development of large-scale technologies for protein separation, isolation, detection and quantitation. It describes in detail the role of mass spectrometry in high-throughput protein annotation. It also covers the emerging fields of structural proteomics, interaction proteomics and the recent development of chip-based analysis techniques. The final chapter provides some examples of how proteomics is being applied in the fields of medicine, biotechnology and agriculture. Each chapter ends with a short bibliography containing some classic papers and useful reviews for further reference.
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 | P5738 | Principles of Tissue Engineering, 2nd ed. | This edition combines prerequisites for a understanding of tissue growth and development, tools and theoretical information needed to design tissues and organs, and applications of tissue engineering to diseases affecting specific organ systems. Few experts would have predicted the explosion in knowledge of gene expression, cell growth and differentiation, variety of stem cells, new polymers and materials available, or introduction of the first tissue-engineered products into the marketplace. This provides detailed analysis of research on all of the major systems of the human body and has new chapters on fetal tissue engineering and the universal cell.
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| | Z538078 | Principles of Toxicology: Environmental and Industrial Applications, 2nd ed. | Provides health protection for professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the science of toxicology in both the occupational and environmental setting. Features occupational medicine and epidemiological issues, the manifestation of toxic agents, evaluation and control of toxic hazards, and specific case histories.
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 | Z701912 | Prion Biology and Diseases,2nd ed. | This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize–winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches This book is by far the most authoritative summary of the complex data that form the basis of our understanding of the molecular basis of this esoteric group of diseases.
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 | Z361976 | Prism® For Windows | Prism is a powerful combination of biostatistics, curve fitting (nonlinear regression) and scientific graphing in one comprehensive program. Easily organize, analyze and graph repeated experiments; pick appropriate statistical tests and interpret the results. Seamless data analysis and full-featured graphing in one integrated program. You control the structure of your data table: store replicate determinations, related data sets, and repeated experiments all together; analyze all the data at once. Enter data directly or import ASCII files or data from other Windows programs. Menu-driven data analysis: select one of the built-in nonlinear regression models or define your own. Versatile graphing allows you to define all aspects of your graph design and save your choices with the data set. Context-sensitive help offers suggestions and background theory on data analyses, explains calculations, and lets you customize elements of a graph by clicking on them.
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 | Z703427 | Production of Recombinant Proteins: Novel Microbial and Eukaryotic Expression Systems | The choices of microbial and eukaryotic expression systems for production of recombinant proteins are many, but most researchers do not have ready access to pertinent information that is scattered throughout the scientific literature. This book provides information on the general biology of the host organism, a description of the expression platform, a methodological section as well as examples of proteins produced with the respective platform. The systems described are well balanced by the inclusion of three prokaryotes (two Gram-negatives and one Gram-positive), four yeasts, two filamentous fungi and two higher eukaryotic cell systems. The book provides valuable information on the criteria and schemes for selecting the appropriate expression platform, the possibility and practicality of a universal expression vector, and on comparative industrial-scale fermentation.
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 | Z702285 | Programmed Cell Death in Plants | This single volume draws together new information from researchers on this emerging topic. The book refers to relevant PCD paradigms in other organisms, describes the cell death events in reproductive tissues, and discusses PCD events in vegetative tissues and the evidence that links PCD regulation to cell cycle regulation. It also investigates the important role of PCD in plant responses to biotic stress. The author distills the difficult literature and summarizes the various signaling pathways involved, clarifying a subject critical to plant breeding. This volume concludes by stating how new model systems, careful assessment of cell death events, and markers specific to plant PCD are each required for additional insight into plant PCD processes
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 | Z730114 | Promoter and CpG Island Microarrays | Promoter binding analysis has largely been a laborious and inefficient process. With the advent of Chromatin Immunoprecipitation on Microarrays or Chips, the research community has been given a new, powerful and high throughput option. This book aims to not only introduce the power of this technology but specifically to provide detailed protocols as to how to perform a ChIP on chip experiment. This book provides a number of benefits such as Detailed explanations of the Chromatin Immunoprecipitation technique; Protocols for performing ChIP on chip experiment; Informatics approaches to identifying promoter regions in genomic DNA; Guidelines for analyzing the data that is obtained from a ChIP on chip experiment; Techniques for methylation analysis of CpG islands using CpG microarrays; Indications of future directions for improvements to the technology including the development of promoter specific arrays, and regulatory region arrays (enhancers and suppressors).
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 | Z380121 | Prop-It® portable bookrest | Rugged plastic stand for hands-free reading. Especially useful to workers in the lab who must have ready access to reference books; an invaluable computer accessory; also useful as a portable lectern. Supports heavy manuals, large periodicals, and individual papers at the optimal angle for reading. Adjustable supports hold papers up to 14" H × 18" W. Adjustable page holder keeps even stiffly bound volumes open for easy reading. Reduces neck and eye strain. Collapses flat (8 × 11"), stores in a briefcase or drawer.
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 | Z500119 | Properties of Organic Compounds on CD-ROM Version 6.0 | Contains more than 29,000 of the most commonly sought organic compounds, featuring physical data, spectral data, and structures. With a high-quality display, powerful search capabilities, high-resolution output, and superior help utility, this relational database acts as an easy-to-use tool for identifying unknown compounds or for locating additional data and references for a known compound.
Features:
• Spectral data and physical constants for over 29,000 compounds
• Complete text/keyword search
• Searches for compounds on spectral peaks, physical properties, synonyms, molecular formula, or CAS® registry number
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 | Z518921 | Properties of Organic Solvents | Covers 564 of the most common solvents used in industry, academic research, and general commerce. This database outlines health hazards and safety guidelines, including the limiting values for airborne exposure, carcinogenicity status, flammability, and various official hazard ratings. With this flexible, powerful electronic reference, users can easily and quickly select a solvent that meets their criteria for a particular application.
Contains data fields such as:
• Physical properties such as melting and boiling points,vapor pressure, refractive index, and density
• Chemical structure
• Solubility
• Dielectric constant and dipole moment
• Heat capacity
• Health and safety information
• IR, UV, NMR, Raman, and mass spectral data
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 | Z701777 | Proteases and Their Inhibitors in Cancer Metastasis | In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also addressed.
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| | Z551554 | Protecting Groups, 3rd edition | Provides a concise and understandable presentation of modern protecting group methods. This edition is a valuable addition to the synthetic chemist's bookshelf. The introductory chapter provides a sophisticated overview of the application of protecting groups in contemporary syntheses. At the heart of the book are seven chapters which deal authoritatively and thoroughly with the protection of the various core functional groups, from carbonyl to amino. The final chapter presents an insight into the realities of synthetic practice and twenty-five problems for people who love to understand chemistry.
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 | Z412422 | Protective Groups in Organic Synthesis, 3rd ed. | Now in its third edition, this comprehensive laboratory reference covers protective groups--functional groups used by chemists during synthesis to protect parts of molecules that should not undergo a reaction. The third edition retains the format and coverage of the second edition, with the addition of all literature updates for new groups since 1991.
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 | Z373907 | Protein Analysis and Purification: Benchtop Techniques | This manual guides the reader through 185 proven and productive methods for both soluble and membrane proteins. Topics covered include protein labeling, protein modification analysis, recombinant protein expression, chromatography, electrophoresis and more. A must for all workers in the laboratory.
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 | Z702323 | Protein Arrays, Biochips, and Proteomics: The Next Phase of Genomic Discovery | From disease marker identification to accelerated drug development, this reference offers a detailed overview of current and emerging trends in the field of proteomics—focusing on innovations in protein microarrays and biochips, mass spectrometry, high-throughput protein expression, protein–protein interactions, structural proteomics, and the proteomic marketplace for comprehensive understanding of proteomic research in the past, present, and future
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 | Z702749 | Protein Arrays: Methods and Protocols | A diverse collection of unique methodologies to synthesize and construct protein arrays for basic and clinical research in a high-throughput manner. These readily reproducible techniques can be applied to such applications as quantifying specific proteins of interest and discovering novel proteins, as well as to a variety of affinity substances, including antibodies, peptides, proteins, aptamers, and chemicals. The techniques can be used for biomarkers discovery, assay development, clinical sample testing, and building the next generation of molecular tools
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 | Z702013 | Protein Crystallography in Drug Discovery | Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. In this book, researchers from academia and from leading pharmaceutical companies present valuable first-hand information on how to obtain the desired protein structures and how to exploit crystallographic data for the drug discovery process. Topics include: Crystallography of important target classes such as kinases and proteases; Structure-based design of protease inhibitors; Structure-based design of kinase inhibitors; Ribosome and the proteasome as drug targets; Recent methodological advances in high-throughput crystallography and microcrystallization.
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 | Z705160 | Protein Degradation: Ubiquitin and the Chemistry of Life, volume 1 | The first volume in a new series dedicated to protein degradation, this book explains the fundamentals of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad overview of protein degradation and its functions in cellular regulation, it then goes on to discuss the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated; this includes latest structural data on these enzymes.
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| | Z371955 | Protein Engineering: Principles and Practice | Designing proteins with novel structures and properties requires a clear understanding of natural structure-function relationships. This book introduces the main concepts of protein folding, conformation prediction, metal binding sites, and generation of therapeutic antibodies. Also covered: aspects of protein structure and function as relates to drug design.
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 | Z340820 | Protein Expression: A Practical Approach | Details of the expression of cloned DNA or RNA templates in all the major in vivo and in vitro systems are included such as cultured mammalian cells, the yeasts Saccharomyces cerevisiae and Pichia pastoris, baculovirus, Xenopus oocytes and prokaryotic cells. Cell-free systems of both eukaryotes and prokaryotes are described in addition to the prokaryotic systems that offer coupled transcription-translation.
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| | P1568 | Protein Folding | This book presents key experiments and investigative techniques as well as the implications of recent findings for modern biotechnology and biomedicine. The protein folding problem refers to the difficulty in determining how and why a protein adopts a particular conformation, given that the number of possible conformations for an average-sized protein approaches 10 to the 270th power. This subject is summarized in chapters on the physical basis of stability of folded conformations, mutational analysis of folding and stability, folding pathways, and other avenues of exploration.
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 | P2244 | Protein Folding in the Cell: Advances in Protein Chemistry Volume 59 | This volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new. Ten years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics covered include a review of the structure and mechanism of the major chaperone components, prion formation in yeast, and the use of microarrays in studying stress response.
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| | P7548 | Protein Function: A Practical approach | The analysis of protein function is a vital step in the characterization of any newly discovered protein. This new edition brings up to date the techniques used, and presents experimental procedures that can be performed in the average laboratory without recourse to highly specialised equipment. The protocols will be of use to both experienced and novice researchers and are accompanied by background information, hints and tips, and troubleshooting guides to ensure successful elucidation of protein function.
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 | Z701009 | Protein Kinase C Protocols | The first compilation of classic and emerging laboratory techniques for the study of the biochemistry and cell biology of protein kinase C (PKC). These detailed methods can be used to explore the structure, function, regulation, subcellular localization, and macromolecular interactions of protein kinase C.. Each protocol is introduced in the context of PKC function and regulation and contains many notes on how best to deal with the problems that may occur. It is a compilation of biophysical, biochemical, cell biological, and molecular biological approaches that brings protein kinase C research into any laboratory.
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 | P3113 | Protein Kinase Functions | This provides a new focus on context and function of protein kinases, thus reflecting recent advances in kinase biology. Chapters on genetic approaches to protein kinase functions, MAP kinase pathway, and cyclin-dependent kinases are updated. Topics covered in depth are phosphatidylinositol 3-kinase signaling, JAK-STAT signaling, suppression of tyrosine kinases by the SOCS family proteins, TGFss superfamily, and involvement of protein kinases in response to DNA damage. Throughout, emphasis is placed not on individual kinases, but on functional aspects of the whole system and relationship between processes and molecules.
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 | P5611 | Protein Kinase Protocols | Basic and more sophisticated methods are described for the analysis of kinase-mediated signaling cascades, with emphasis on the identification of proteins according to their interactive relationships and the analysis of their functional properties. Emphasis is given to critical technical steps that are often omitted from other published methods. This offers tools for understanding the functional roles of specific protein kinases within signaling cascades and for identification and evaluation of novel therapeutic targets.
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 | P9359 | Protein Lipidation Protocols | This is a collection of reproducible techniques for studying protein lipidation. These methods, deal with glycosyl phosphatidylinositol (GPI)-containing compounds, protein fatty acylation, and protein prenylation. Included are techniques for determining the chemical structure of GPI-anchors, for radiolabeling the prenyl groups of protein in eukaryotic cells, a tool for developing inhibitors of the protein farnesyltransferase, and for a lysosomal enzyme that cleaves fatty acyl groups from proteins.
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 | Z340847 | Protein Localization by Fluorescence Microscopy: A Practical Approach | The ability to determine the location of gene products within a cell by the use of antibodies or by production of chimeras with green fluorescent protein is a vital step towards understanding what they do. This guide provides detailed, practical advice from choosing the right equipment to interpreting results. It balances the advantages of a range of techniques, including live cell work, against potential pitfalls, offering invaluable "tricks of the trade" along the way.
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 | P6308 | Protein Methods, 2nd ed. | Revised and expanded, this edition remains the key source for tested and proven techniques. Four new chapters are devoted to protein purification by ion exchange, gel filtration, and affinity chromatography, and to protein crystallization.
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 | Z701734 | Protein Microarray Technology | This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins. The authors provide a roadmap for solving the complex challenges that are currently faced while monitoring protein-protein interactions over a wide range of microarray platforms. In doing so, they also offer a comprehensive overview of microarray surface chemistry, detection technologies, fabrication options for array development, and data analysis of numerous types of protein interactions. Topics covered include: Types of biomolecular interactions; Surface chemistry; Detection technologies; Spotting technologies; Bioinformatics/data analysis.
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 | Z701882 | Protein Misfolding and Disease: Principles and Protocols | A comprehensive review of the latest thinking about the molecular processes underlying conformational diseases, combined with a remarkable set of biochemical, genomic cellular, and chemical laboratory techniques for studying their genesis and pathologies. The authors apply their carefully refined methods to a variety of metabolic and neurodegenerative disorders, as well as to the aging process. The techniques presented are broadly applicable in many diverse disease contexts and may be used in both diagnosis and research on new treatment strategies.
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 | Z702846 | Protein NMR Techniques, 2nd ed. | This collection of reproducible methods using the latest advances in NMR technology includes methods for high-level recombinant protein expression using sophisticated isotopic labeling strategies, TROSY methods for the study of structure and dynamics, and methods for the acquisition and interpretation of residual dipolar coupling data. There are also applications of dynamics measurements on multiple timescales, new developments in NMR data analysis, structure calculation protocols, and solid-state methods. It offers detailed laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
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 | Z703680 | Protein Nanotechnology: Protocols, Instrumentation and Applications | Experts in nanobiotechnology review the recent advances in instrumentation and methodology, and their applications in genomics and proteomics. Authors provide a wide variety of techniques and methods for dealing with protein functions and structures at the nanoscale level, including nanostructured systems, nanomaterials, carbon nanotubes and nanowires, optical nanosensors, and nanoelectrodes. Among the highlights are techniques for the in vivo tracking of biochemical processes using fluorescent molecular probes and nanosensors, and the development of nanocarrier methodology for the targeted delivery of drugs whose shells are conjugated with antibodies for targeting specific antigens.
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 | P1478 | Protein Phosphatase Protocols: Methods in Molecular Biology, Vol. 93 | Cutting-edge techniques presented with step-by-step instructions make this indispensable for investigating the structure and function of protein serine/threonine phosphatases. Contains methods designed to isolate, identify, and assay phosphatase activities from both prokaryotic and eukaryotic sources. Some of the points covered are step-by-step instructions on how to isolate novel phosphatases and regulatory subunits; detailed methods for generating immunological reagents to characterize protein phosphatases; cloning of novel phosphatases and regulatory subunits; notes about potential pitfalls and tips on how to avoid failure.
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 | Z340855 | Protein Phosphorylation: A Practical Approach, 2nd Edition | This new edition provides a description of current methods used to study protein phosphorylation and the kinases and phosphatases which catalyse it. It includes protocols for studying phosphorylation in intact cells, analysis of signal transduction pathways, kinase specificity and kinase interactions, assay and purification of kinases and phosphatases, and identification of substrates.
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 | P4742 | Protein Protocols Handbook, 2nd ed. | This edition provides a cross-section of analytical techniques commonly used for proteins and peptides. The text is significantly updated and expands on a number of chapters from the first edition. The Notes section complements the Methods by indicating how best to deal with any problem or difficulty that may arise when using a given technique. Further chapters examine the developments in the use of mass spectrometry in protein characterization. Recognition of the central role of 2-D PAGE in proteomics has resulted in an expansion of chapters on this subject, as well as a number of new techniques for staining and analyzing protein blots.
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 | P7618 | Protein Protocols on CD-ROM, Version 2.0 | Here is instant access to over 5000 tested, state-of-the-art protein methods and supporting protocols that are reproducible and accessible on a CD-ROM. Unprecedented in scope and depth of coverage, this collection contains the major procedures needed for isolating, characterizing, and analyzing proteins, including powerful techniques in mass spectroscopy, NMR, proteomics, and immunochemistry. This CD-ROM includes cutting-edge NMR techniques, physical methods of analysis, and protocols for peptide synthesis, membrane proteins, ELISA, proteolytic enzymes, and epitope mapping.
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 | P5238 | Protein Purification Applications: A Practical Approach, 2nd ed. | With protein purification workload reduced by improved techniques, there is still a need to consider how unit operations link together to form a purification strategy. This book describes purification strategies from common sources: mammalian cell culture, microbial cell culture, milk, animal tissue, and plant tissue. It also includes chapters on purification of inclusion bodies, fusion proteins, and purification for crystallography. A purification strategy that can produce a highly pure single protein from a crude mixture of proteins, carbohydrates, lipids, and cell debris is a work of art.
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 | Z701483 | Protein Purification Protocols, 2nd ed. | Experts update this classic protocols manual for protein purification techniques. New chapters include those on protein fractionation and chromatographic techniques. New developments in proteomics are included such as the use of 2-D gel electrophoresis as a preparative technique for protein characterization. They also include newer techniques using analytical chromatography for the multidimensional separations of proteins and peptides as well as mass spectrometric techniques for isolating proteins. The authors provide descriptions of how to scale-up purification methods and the purification of proteins for therapeutic use.
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 | P5363 | Protein Purification Techniques: A Practical Approach, 2nd ed. | Protein purification techniques have evolved with improvements in equipment control, automation, and separation materials, and the introduction of new techniques such as affinity membranes and expanded beds. This book focuses on unit operations and analytical techniques. It starts with an overview of purification strategy and then covers initial extraction and clarification techniques. The rest of the book concentrates on different purification methods with the emphasis being on chromatography. The final chapter considers general scale-up considerations.
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 | Z379883 | Protein Purification: Principles, High Resolution Methods, and Applications, 2nd ed. | State-of-the-art coverage of chromatographic and electrophoretic protein separation and characterization methods. Balances theory and applications, offers professionals and students access to all the important techniques for analytical and small- and large-scale purification of proteins.
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 | Z700282 | Protein Sequencing Protocols, 2nd ed. | This book is an update to the much-acclaimed first edition with new and updated techniques for determining the sequence of proteins and peptides. This edition includes not only novel approaches to the validation of quality assurance methods, reflecting the current importance of biopharmaceuticals, but also offers a guide to analysis of protein sequence information via the powerful new tools of bioinformatics. This comprehensive book provides investigators a ready source of easy-to-follow protocols that simplify choosing the most appropriate method for protein sequence determination.
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 | P3363 | Protein Sequencing and Identification Using Tandem Mass Spectrometry | Readers will find in this book complete experimental detail to apply mass spectrometry techniques in their laboratoriess and learn about the proper selection and operation of instruments. Coverage includes peptide fragmentation and interpretation of product ion spectra, preparation of protein digests for sequencing experiments, mass spectrometric analysis using capillary liquid chromatography, characterization of modified peptides using tandem mass spectrometry and techniques for protein identification by database searches.
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 | P2494 | Protein Staining and Identification Techniques | Staining techniques are fundamental tools for the study of proteins, but information on protein-specific staining procedures has remained scattered. This book presents a spectrum of protein staining procedures, including wool-dye, metallic, enzyme, fluorescence, and immunostaining, the latter both in situ and following transfer to membranes. Many of these stains have their origins as histochemical techniques. Finally, techniques for obtaining photographic or electronic images of gel separations are presented in a section on the preparation, archiving, and presentation of gel reproductions.
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| | Z375470 | Protein Structure Prediction: A Practical Approach | Describes in detail the various computer-based strategies for translating the sequence of proteins into structure, highlighting the degree of confidence that can be attributed to different algorithms. Covers the principles of protein folding, “secondary structure,” and tertiary fold recognition. Invaluable reference for those requiring up-to-date information on the latest techniques in the field.
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 | Z701254 | Protein Structure Prediction: Bioinformatic Approach | An example of new generations of software is in the field of protein structure prediction. Here new approaches to fold recognition, structural alignment and threading continue to appear at a rate that leaves the investigator at a loss of which way to turn to solve any particular problem. This book serves as an excellent guide to the very newest approaches. A wide variety of programs and strategies are discussed, including new applications of hidden Markov models and novel Bayesian approaches for building up model from block fragments. The theme throughout is determining three-dimensional structures for the plethora of newly determined amino acid sequences.
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 | Z705829 | Protein Structure Prediction: Concepts and Applications | Protein structure prediction is evolving as a component of the standard tools of the molecular biologist. While most books on bioinformatics focus on genetic algorithms and treat protein structure prediction only superficially, this book assumes a novel and unique focus. Adopting a didactic approach, the author explains all the current methods in terms of their reliability, limitations and user-friendliness. Knowing how far to trust predictions, one must understand how the methods work. Topics covered include homology modeling, secondary structure prediction, fold recognition and prediction of three dimensional structure of proteins with novel folds. The author also provides practical examples to help first-time users become familiar with the possibilities and pitfalls of computer-based structure prediction.
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 | P6988 | Protein Structure, Stability and Folding | Volume 164 of the Methods in Molecular Biology series describes the newest experimental and theoretical methods. Among the techniques discussed are the methods for calculating aspects of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments.
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 | Z705195 | Protein Synthesis and Ribosome Structure | Based on more than 30 years of ribosome research and recent structural evidence, this book presents a uniform picture of the largest enzyme complex found in living cells, shedding light on many decades-old questions in molecular biology. Topics include Structure of the Ribosome; Ribosome Assembly; tRNA and Synthetases; mRNA Degradation; Initiation and Elongation; Termination and Ribosome Recycling; Regulation of Ribosome Biosynthesis; Inhibition of the Translational; and Apparatus by Antibiotics.
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| | P2356 | Protein Synthesis: Methods and Protocols | This book presents a collection of molecular biological methods specific to protein synthesis. Chapters open with a discussion of basic background information and strategy which is then complemented by comprehensive methodological details. The book is divided into seven significant areas that cover all of the research techniques required by both experienced researchers and newcomers to the field of protein synthesis, and will prove to be an invaluable reference source on the benchtop of many protein laboratories.
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 | Z374008 | Protein Targeting | | pricing |
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 | Z704725 | Protein Tyrosine Kinases: From Inhibition to Useful Drugs | Leading researchers survey the state of the art in the drug discovery processes aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating “selective” low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists, and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining “on-target” vs “off-target” effects of kinase inhibitors.
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 | P8739 | Protein-Ligand Interactions: A Practical Approach 2 volume set | The two Practical Approach volumes on protein-ligand interaction do not comprise a comprehensive compilation of all the methods that can be used to investigate protein-ligand interactions. Instead, they are a selection of the most useful and easily applied methods and will be an invaluable guide to the principal techniques used to study the interactions of proteins and ligands.
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| P8864 | Protein-Ligand Interactions: A Practical Approach Hydrodynamics and Calorimetry, Volume 1 | This volume covers the principle hydrodynamic and calorimetric techniques for studying protein-ligand interactions. It includes equilibrium dialysis, rate dialysis, quantitative characterization by chromatography, sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation for probing ligand binding, surface plasmon resonance, capillary electrophoresis, molecular electro-optics, high flux x-ray and neutron scattering, isothermal titration calorimetry and differential scanning microcalorimetry.
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| P8989 | Protein-Ligand Interactions: A Practical Approach Structure and Spectrocopy, Volume 2 | This second volume is a compilation of key spectroscopic and other high resolution techniques for studying protein-ligand interactions. It includes x-ray crystallography, molecular modelling, fluorescence real time kinetics, spatial imaging, stopped flow techniques, Fourier Transform infrared spectroscopy, Raman and resonance-Raman spectroscopy, electrospray ionization mass spectrometry, spin label paramagnetic probes, nuclear magnetic resonance and atomic force microscopy.
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 | Z701181 | Protein-Ligand Interactions: From Molecular Recognition to Drug Design | The lock-and-key principle has still not lost any of its significance. The basic aspects of ligand-protein interaction may be summarized under the term ‘molecular recognition’ and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a contribution to the constant search for improved enzyme inhibitors, and new concepts such as that of pharmacophores.
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 | Z704792 | Protein-Lipid Interactions: From Membrane Domains to Cellular Networks | This first handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant thermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source.
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 | Z719153 | Protein-Protein Interactions: A Molecular Cloning Manual, 2nd Edition soft cover | This is an updated edition of a manual that provides a thorough collection of the technical and theoretical issues involved in the study of protein associations, including standard methods, biophysical approaches, and, in a final section, a collection of computational methods for integrating and analyzing interactions.
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 | Z702471 | Protein-Protein Interactions: Methods and Protocols | This collection of successful techniques demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein-protein interactions as they occur in living cells, and determine interaction interfaces. The techniques described utilize a variety of cutting-edge technologies, including surface plasmon resonance (SRP), fluorescence resonance energy transfer (FRET), fluorescence polarization (FP), isothermal titration calorimetry (ITC), circular dichroism (CD), protein fragment complementation assays (PCA), various two-hybrid systems, and proteomics and bioinformatics-based approaches.
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 | P1619 | Protein-Protein Recognition | This book brings together concepts and systems pertaining to protein-protein interactions in an examination of how and why proteins form complexes with each other. The emphasis is on heteromeric complexes and uses model systems to explain the processes of forming complexes. There is a section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions. MHC proteins and their interactions with T-cell receptors is used to explain complexes with intermediate affinities. The themes used are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.
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 | Z702307 | Proteinase and Peptidase Inhibition | Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest recently. Proteinase and Peptidase Inhibition presents new reports on a wide range of cellular proteinases whose inhibitors may hold the key to the development of new drugs. It deals with enzyme classes, inhibitor types and regulatory mechanisms governing proteinase activity. Target enzymes are fully described and classified by structural similarity, rather than by pharmacological effects. This is a valuable reference for researchers in medicinal chemistry, drug design and development, pharmacology, biochemistry, and molecular and cell biology.
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| | Z373648 | Proteins Labfax | | pricing |
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 | Z700428 | Proteins and Proteomics: A Laboratory Manual | Completion of sequencing of the human genome has opened the door for exploration of the proteome. Critical to tackling the complexity of the proteome is a workable strategy using reliable and tested protocols for identifying, isolating, and quantifying proteins in cells and cell pathways and for performing functional assays. This book provides the first authoritative and protocol-based approach to proteomics. It provides information about protein structure and numerous methods for the preparation and analysis of protein samples ranging from electrophoresis and mass spectrometry to protein chips and informatics. Extensive background information and references are provided regarding the theoretic aspects of the techniques and their applications.
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 | P0868 | Proteins, Peptides and Amino Acids SourceBook | Building on the success of their Source Book of Enzymes, the authors have assembled a catalog of over 26,000 commercially available proteins, peptides, and amino acids. All are arranged alphabetically and by sequence for fast access, and are replete with technical details and vendor information. Compounds can be easily located by either directly searching the appropriate section by chemical name or by consulting the general index by name, synonym, or derivative formula. The data covers sequence, sequence modification, chemical derivatives, preparation form, purity, composition, activity, functionality, as well as applications and literature references.
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 | P7492 | Proteins: Biochemistry and Biotechnology | This book provides an overview of the various medical, diagnostic and industrial uses of proteins. It has evolved from an earlier text “Protein Biotechnology” and includes the latest developments in the field and offers a varied selection of relevant case study material. Initial chapters focus upon issues such as protein structure, folding, stability, purification and characterization. Later chapters detail the industrial production of proteins, and their applications in medicine, analysis and industry. It presents a comprehensive review of proteins and enzymes used in the diagnostic, therapeutic and industrial areas.
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 | P2863 | Proteolytic Enzymes: A Practical Approach, 2nd ed. | This second edition has been thoroughly updated to take into account advances in the last 10 years in both the increased understanding of the role of peptidases in many critical cellular processes, e.g. apoptosis, as well as their use as enzymatic tools in such diverse areas as proteomics, protein sequencing, peptide synthesis and protein structure studies. Some topics covered are: inhibition and prevention of unwanted proteolytic activity; characterizing natural inhibitors; proteolytic enzymes in peptide mapping and primary structure elucidation by mass spectrometry and Edman sequencing; limited proteolysis as a structural probe.
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 | Z378321 | Proteome Research: New Frontiers in Functional Genomics | “Proteome” research is the other side of the genome project. Using high-resolution two-dimensional gel electrophoresis to analyze proteins, one can determine which genes are expressed, how the products are modified after translation, and how proteins interact. This book summarizes the state of the art in 2-D electrophoresis, proteome databases, 3-D protein modelling, and biomedical applications of proteomics. A brief, well organized introduction to this fundamentally important area of research.
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 | P4617 | Proteome Revisited: Theory and Practice of all Relevant Electrophoretic Steps | This covers electrophoretic steps leading to proteome analysis, i.e. isoelectric focusing (including immobilized pH gradients), SDS-PAGE electrophoresis and finally two-dimensional maps. It is a collection of modern methodologies leading to successful fractionation, analysis and characterization of every polypeptide spot in 2-D map analysis. It includes chapters on sophisticated mass spectrometry developments and navigating important databases. It contains several as yet unpublished protocols, correcting some of the existing ones and showing the pitfalls and limitations of others.
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 | Z731188 | Proteomic Biology Using LC-MS: Large Scale Analysis of Cellular Dynamics and Function | This is one of the first books to focus on the dynamic aspect of proteomes. The book introduces proteomics to the newcomer, reviews the theoretical aspects of proteomics and its state-of-the art technologies, along with a number of biological applications using "classical" proteomic technology. The book also presents a new concept, the Dynamome, or the expression of a comprehensive molecular set that participates in the whole dynamic process of a series of cellular events.
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 | Z701041 | Proteomic and Genomic Analysis of Cardiovascular Disease | This is the very first book to focus on this new approach that will eventually aid in the development of new diagnostic markers and therapies for controlling and treating heart disease. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. They highlight the various strategies and technical aspects so as to assist the number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing researchers about the latest developments.
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 | Z703893 | Proteomics Protocols Handbook | Hands-on researchers describe in step-by-step detail 73 proven laboratory methods and bioinformatics tools essential for analysis of the proteome. These cutting-edge techniques address such important tasks as sample preparation, 2D-PAGE, gel staining, mass spectrometry, and post-translational modification. There are also readily reproducible methods for protein expression profiling, identifying protein-protein interactions, and protein chip technology, as well as a range of newly developed methodologies for determining the structure and function of a protein. The bioinformatics tools include those for analyzing 2D-GEL patterns, protein modeling, and protein identification.
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 | Z704024 | Proteomics Today: Protein Assessment and Biomarkers Using Mass spectrometry, 2-D Electrophoresis and Microarray Technology | The last years have seen a drive toward the application of proteomics to resolving biomedical and biochemical tasks. Separation techniques combined with mass spectrometry are playing a central role. This book discusses the role of mass spectrometry in proteomic research, and emphasizes advances in the existing technology and describes the advantages and pitfalls. It provides a scientifically valid method for analyzing the approximatey 500,000 proteins that are encoded in the human genome, and explains the hows and whys of using mass spectrometry in proteomic analysis. It also includes sections on troubleshooting.
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 | P5618 | Proteomics in Practice: A Laboratory Manual of Proteome Analysis | A reference for the analysis of proteins using the classical approach of 2-D gel electrophoresis, mass spectrometry and related sequence database inquiries. The first section introduces the entire technology, while the second section represents a laboratory manual spanning the range of methods from sample preparation to protein identification. The third section is a troubleshooting guide to answer questions regarding proteome analysis. The final section contains a reference list to guide readers towards further detail. Updates of recipes and animations are available at http://www.wiley-vch.de/books/info/3-527-30354-5
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 | P5986 | Proteomics: From Protein Sequence to Function | Following the announcement of the draft sequence of the human genome, attention is now increasingly turning to the analysis of the proteins encoded by genomes - proteomics. This is a rapidly emerging research area and this book reviews recent developments in proteomics and compares them with current genomics technologies. The book is written by experts who review their area in a concise yet easy to understand style, providing a comprehensive review volume that integrates genomics with proteomics.
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| | Z249491 | Protocols For Oligonucleotide Conjugates: Synthesis and Analytical Techniques | Leading researchers provide the latest protocols for synthesizing oligonucleotide conjugates and explain the latest techniques for analyzing them. These techniques are widely used by pharmaceutical companies as part of the permit process for new drugs. They are also useful to molecular biologists and antisense researchers. Each protocol includes an introduction, a list of materials (including suppliers), step-by-step instructions, and notes for avoiding pitfalls and achieving the best results
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| | Z357391 | Protocols for Gene Analysis: Methods in Molecular Biology, Vol. 31 | A set of techniques is presented for the basic manipulation and mutagenesis of the cloned sequences. Also addressed are genome structure, sequence variation, gene expression, protein function, and methods used to take the step from the first gene to those with which it interacts.
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| | Z271799 | Prudent Practices in the Laboratory: Handling and Disposal of Chemicals | This volume updates and combines two National Academy Press bestsellers--Prudent Practices for Handling Hazardous
Chemicals in Laboratories and Prudent Practices for Disposal of Chemicals from Laboratories--which have served for more than a decade as leading sources of chemical safety guidelines for the laboratory. Developed by experts from academia and industry, with specialties in such areas as chemical sciences, pollution prevention, and laboratory safety, Prudent Practices for Safety in Laboratories provides step-by-step planning procedures for handling, storage, and disposal of chemicals. The volume explores the current culture of laboratory safety and provides an updated guide to federal regulations. Organized around a recommended workflow protocol for experiments, the book offers prudent practices designed to promote safety and it includes practical information on assessing hazards, managing chemicals, disposing of wastes, and more. Prudent Practices for Safety in Laboratories is essential reading for people working with laboratory chemicals: research chemists, technicians, safety officers, chemistry educators, and students.
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| | Z557749 | Pseudo-Peptides in Drug Discovery | Peptides are among the most versatile bioactive molecules, yet they do not make good drugs, because they are quickly degraded or modified in the body. Thus, drug discovery has turned to the field of peptidomimetics, i.e. to design non-peptide compounds mimicking the pharmacophore and thus the activity of the original peptide. These compounds open up new perspectives in drug design by providing a range of highly specific pharmaceuticals that have a high bioavailability. The following classes of pseudo-peptides are examined with regard to their chemical properties, pharmacological activity, as well as practical aspects of synthesis: Oligo-glycines; Beta-peptides; Gamma-peptides; Pyrrole-imidazole polyamides; DNA-like peptide nucleic acids; Alpha-helical peptide nucleic acids; DNA-cleaving pseudo-peptides.
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 | P1364 | Purification and Analysis of Recombinant Proteins | Covering vital and traditional topics in the purification and analysis of recombinant proteins, this volume demonstrates how to overcome problems in protein research and presents practical methods used in protein work, explaining their theoretical basis. The collection also explores innovative concepts, such as receptor affinity chromatography and the introduction of sites that facilitate purification. This aid uses specific examples of proteins obtained from bacterial and nonbacterial sources and supplies helpful approaches and techniques.
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 | Z541834 | Purification of Laboratory Chemicals, 5th Edition | The purpose of this book is to help chemists, biochemists and other scientists purify the chemical reagents that they use in their work. Despite the fact that commercially available chemicals are often of a very high quality, and quite satisfactory for some applications within science and technology, it is becoming almost as important to know what impurities are present and make allowance for them as to remove them completely. This book will show you how.
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 | Z567930 | Purification of Laboratory Chemicals, 6th edition  | This new edition keeps engineers, scientists, chemists, biochemists and students up-to-date with the processes for purification of the chemical reagents with which they work, and guides readers on critical safety and hazards for the safe handling of chemicals and processes. The 6th Edtion is updated and provides expanded coverage of the latest chemical products and processing techniques, safety and hazards. The book has been reorganized and is now fully indexed by CAS Registry Numbers. Compounds are now grouped to make navigation easier, and literature references for all substances and techniques have been added, and ambiguous alternate names and cross references have been removed.
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 | Z701793 | Purifying Proteins for Proteomics: A Laboratory Manual | This manual complements Simpson's Proteins and Proteomics manual (Sigma # Z70,042-8), with a comprehensive collection of methods for protein purification from a variety of source preparations. The protocols are accompanied by extensive discussion of potential pitfalls and troubleshooting advice.
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 | Z730424 | Pyrosequencing Protocols | This comprehensive volume enables quick reference by collecting the primary applications for Pyrosequencing®, and supplementing each protocol with troubleshooting tips specific to that method. Chapters 1 and 2 present an introductory overview of the origins of the Pyrosequencing® methodology and its key applications. Chapters 3 and 4 describe primer selection and the basic Pyrosequencing® technique, and Chapters 5–7 provide methods for improving throughput and decreasing cost. Detailed applications for Pyrosequencing® comprise Chapters 8–13, and the important aspects of data storage is discussed in Chapter 14. This text both highlights the versatility of and provides detailed protocols for the application of Pyrosequencing®.
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 | Z701262 | p53 Protocols | This collection of novel techniques has proven useful for studying the physiological properties of p53 both in vitro and in vivo. The techniques provide solutions to problems in studying the purification, target identification, gene expression, quantitation, interaction, signaling, transactivation, and transrepression of p53. The methods are also useful for delineating the functions of other proteins that may act as tumor or growth suppressors. Each technique includes step-by-step instructions, troubleshooting notes, a theoretical review, and discussion of associated problems.
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