Sigma-Aldrich provides an extensive range of products and services for ADME and Toxicology studies. This includes innovative genetically engineered cell lines and validated assays designed to improve drug metabolism, transporter, and safety testing, as well as reagents, consumables, and labware.

Why choose Sigma-Aldrich?

  • Accuracy - Innovative model systems provide highly predictive and consistent results.
  • Selection - Wide variety of models systems and validated assays available.
  • Flexibility - Products and services for both in-house and outsourcing of studies.
  • Service - Ease of ordering, fast delivery worldwide, and world-class technical support.


Permeability & Transporter Assays
For the prediction of permeability and transporter interactions of therapeutics.


Intestinal cell line models
Liver cell line models
Kidney media and cell line models
SOLVO® Membrane Vesicle
  Transporter Assays

LOPAC small molecule collections
Substrates and inhibitors
Transwell plates

Services by BioReliance

Permeability assays
Drug transporter assay




Metabolism Assays
For the prediction of metabolic properties of therapeutics.

Liver metabolism cell line models
Liver preparations and fractions
Sciex iChemistry CYP450 kits
CYP450 microsomes and
  purified proteins

idMOC plates

Services by BioReliance

Cytochrome P450 induction assays
Nuclear receptor interaction assays
Microsomal stability assays



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