Membrane Protein Biology Tools

Membrane proteins have long been considered recalcitrant research targets due to their dependence on a surrounding lipid bilayer to impart an active conformation. This limitation introduces several obsticales to the elucidation of membrane protein structure and function. Despite this, membrane proteins are among the most important, yet least investigated members of the proteome. It is estimated that as much as 29% of all proteins possess regions that share homology with known transmembrane domains. In addition, as much as half of all protein drug targets, such as GPCRs, are membrane-bound.