Adrenergics - Antagonists

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L7045 L 748337 hydrate ≥98% (HPLC) L 748337 is a selective, competitive beta 3 adrenergic receptor antagonist, that binds to the receptor with an affinity of 04 nM. The affinities for beta-1 and beta-2 receptors are 154 and 204 nM, respectively. The compound potently inhibits agonist-stimulated lipolysis in adipocytes, as well as agonist induced relaxation of smooth muscle.
 
A6351 A-315456 >98% (HPLC), solid Selective α1D-adrenoceptor antagonist.
human ... ADRA1D(146)
A0232 Alfuzosin hydrochloride ≥98% (HPLC), solid Alfuzosin hydrochloride is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
 
A5736 ARC 239 dihydrochloride hydrate ≥98% (HPLC) ARC 239 is a selective α-2B adrenergic blocker. Although ARC-239, like prazosin, also has some alpha-1 antagonist activity, it is used most commomly to differentiate alpha-2A/D from alpha-2B and alpha-2C subtypes rather than for any alpha-1 inhibition..
 
A7655 Atenolol ≥98% (TLC), powder Selective β1-adrenoceptor antagonist; antihypertensive; antianginal; antiarrhythmic.
human ... ADRB1(153)
rat ... Adrb1(24925)
A143 (S)-(−)-Atenolol powder β1-Adrenergic receptor antagonist; active enantiomer of atenolol.
human ... ADRB1(153)
B016 Benoxathian hydrochloride solid Selective α1-adrenoceptor antagonist.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
B5683 Betaxolol hydrochloride >98% (HPLC) Selective β1 adrenoceptor antagonist.
human ... ADRB1(153)
B2185 Bisoprolol hemifumarate salt ≥98% (HPLC), solid Cardioselective β1-adrenoceptor antagonist.
 
B134 BMY 7378 dihydrochloride ≥98% (HPLC), solid BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist.
human ... ADRA1D(146), HTR1A(3350)
B4559 BRL 44408 maleate salt ≥98% (HPLC) BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.
 
C231 CGP-20712A methanesulfonate salt solid, ≥98% (HPLC) CGP-20712A methanesulfonate salt is a selective β1-adrenoceptor antagonist.
human ... ADRB1(153)
C247 Cyclazosin hydrochloride solid α1B-adrenoceptor antagonist.
 
D9815 Doxazosin mesylate ≥97% (HPLC), powder α1-adrenoceptor antagonist; relaxes smooth muscles of the prostate
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
F4303 Fiduxosin hydrochloride >98% (HPLC), solid α1-Adrenoceptor antagonist.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
I127 ICI 118,551 hydrochloride ≥98% (HPLC), powder ICI 118,551 hydrochloride is a highly selective β2-adrenoceptor antagonist.
human ... ADRB2(154)
I9531 Imiloxan hydrochloride >98% (HPLC), solid Selective α2B-adrenoceptor antagonist.
human ... ADRA2B(151)
I2909 Indoramin hydrochloride ≥98% (HPLC), solid α1-adrenoceptor antagonist.
 
L3040 L-765,314 hydrate ≥98% (HPLC), solid Potent and selective α1B-adrenoceptor antagonist.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
L1011 Labetalol hydrochloride >98% (TLC), powder Competitive β-adrenoceptor antagonist.
human ... ADRB1(153), ADRB2(154), ADRB3(155)
U101 5-Methylurapidil solid Selective α1A-adrenoceptor antagonist; antihypertensive.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
M5391 (±)-Metoprolol (+)-tartrate salt ≥98% (titration), powder β1-adrenoceptor antagonist.
human ... ADRB1(153)
M5154 Moxisylyte hydrochloride >99% (TLC), powder α1-adrenoceptor antagonist; peripheral vasodilator.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
N158 Naftopidil hydrochloride hydrate solid α1-Adrenoceptor antagonist; antihypertensive.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
N135 S(+)-Niguldipine hydrochloride solid α1A-adrenoceptor antagonist; antihypertensive agent; L-type Ca2+ channel blocker; potassium agonist that activates Ca2+-activated maxi K-channels.
 
B019 Phenoxybenzamine hydrochloride ≥97%, powder Calmodulin antagonist; α-adrenoceptor antagonist.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
P7547 Phentolamine hydrochloride ≥98% (TLC), powder α-adrenoceptor antagonist; peripheral vasodilator.
 
P7561 Phentolamine methanesulfonate salt ≥98% (TLC), powder α-Adrenergic receptor antagonist; peripheral vasodilator.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
P0778 Pindolol ≥98% (TLC), powder β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator.
human ... ADRB1(153), HTR1A(3350)
P152 S(–)-Pindolol solid β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Active enantiomer of pindolol.
human ... ADRB1(153), HTR1A(3350), HTR1B(3351)
P7791 Prazosin hydrochloride ≥99% (TLC) Peripheral α1-adrenoceptor antagonist; vasodilator.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
P0689 (R)-(+)-Propranolol hydrochloride ≥98% (TLC) Less active enantiomer of propranolol.
 
P8688 (S)-(−)-Propranolol hydrochloride ≥98% (TLC), powder Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites
human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)
P0884 (±)-Propranolol hydrochloride ≥99% (TLC), powder β-adrenoceptor antagonist; 5-HT1/5-HT2 serotonin receptor antagonist; cardiac depressant (anti-arrhythmic).
human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358)
R9525 RX 821002 hydrochloride solid, ≥98% (HPLC) Selective α2-adrenoceptor antagonist
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
S0278 (±)-Sotalol hydrochloride ≥98% (TLC), powder Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
human ... ADRB1(153), ADRB2(154), ADRB3(155)
S8688 SR 59230A ≥98% (HPLC), powder SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.1 It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.2
human ... ADRB3(155)
T4680 Terazosin hydrochloride ≥98% (TLC), powder α1-adrenoceptor antagonist.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
T6394 Timolol maleate salt ≥98% (TLC), powder Timolol maleate is a class II anti-arrhythmic agent that functions as a non-selective β-adrenoceptor antagonist, a vasodilator and an anti-glaucoma agent. Studies have reported that timolol maleate can be used for the treatment of infantile hemangioma (IH)7.
human ... ADRB1(153), ADRB2(154), ADRB3(155)
U100 Urapidil hydrochloride solid α1-adrenoceptor antagonist; 5-HT1A serotonin receptor partial agonist; anti-hypertensive.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), HTR1A(3350)
Y3125 Yohimbine hydrochloride ≥98% (TLC), powder α2-adrenoceptor antagonist.
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)