Adenosines/P2 Nucleotide Receptor - Agonists

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A236 AB-MECA solid High affinity A3 adenosine receptor agonist.
human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
A9251 Adenosine ≥99% Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).
human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066)
rat ... Adcy2(81636), Adora1(29290), Adora2a(25369), Adora3(25370)
A111 Adenosine amine congener hydrate solid, ≥98% (HPLC) Potent aqueous-soluble A1 adenosine receptor agonist.
rat ... Adora1(29290)
A5285 Adenosine 5′-diphosphate monopotassium salt dihydrate bacterial, ≥95%, powder P2Y receptor agonist.
human ... HSP90AA1(3320), P2RY1(5028)
A202 N6-2-(4-Aminophenyl)ethyladenosine >95% Potent, non-selective A3 adenosine receptor agonist.
human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
C141 CGS-21680 hydrochloride hydrate solid Adenosine receptor agonist, which possesses selectivity for A2 verses A1 receptors.
human ... ADORA2A(135), ADORA2B(136)
C5134 2-Chloroadenosine Selective A1 adenosine receptor agonist.
human ... ADORA1(134), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
C9901 N6-Cyclohexyladenosine Selective A1 adenosine receptor agonist.
human ... ADORA1(134)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
C8031 N6-Cyclopentyladenosine solid Selective A1 adenosine receptor agonist.
human ... ADORA1(134), ADORA2A(135), ADORA3(140)
mouse ... Adora1(11539)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
C1506 Cytidine 5′-triphosphate disodium salt ≥95% P2X4 purinergic receptor agonist.
 
C9274 Cytidine 5′-triphosphate disodium salt ~95% P2X4 purinergic receptor agonist.
 
E2387 5′-(N-Ethylcarboxamido)adenosine powder Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)
G5794 GR 79236X ≥99% (HPLC), solid A1 adenosine receptor agonist
 
K3769 KW-3902 ≥98% (HPLC) KW-3902 is an A1 adenosine receptor antagonist and is over 800 fold more selective for an A1 receptor versus the A2A receptor.
 
M6517 α,β-Methyleneadenosine 5′-triphosphate lithium salt ≥93% (HPLC), solid P2 purinoceptor agonist that is more potent than ATP at the P2X subtype.
human ... P2RX1(5023)
M7510 β,γ-Methyleneadenosine 5′-triphosphate disodium salt ≥95%, solid Selective P2X purinoceptor agonist that is more potent than ATP, but less potent than α, β-methylene-L-adenosine 5′-triphosphate.
 
M152 2-(Methylthio)adenosine 5′-diphosphate trisodium salt hydrate ≥89% (HPLC), solid 2-Methylthio-ADP (2-ME-SADP) is a P2 purinoceptor agonist, which induces platelet aggregation and shape change and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1. Compared with ADP, 2-methylthio-ADP was 3-5 times as active as an aggregating agent and 150-200 times as active as an inhibitor of cyclic AMP accumulation. Purinergic signaling may be an important factor in TSP-1-mediated cell-matrix and cell-cell interactions such as those occurring during development and repair.
 
P1123 PD 81,723 ≥98% (HPLC), solid Allosteric enhancer of A1 adenosine receptors
 
P101 2-Phenylaminoadenosine >97%, solid Selective A2 adenosine receptor agonist; potent coronary vasodilator; weak inhibitor of adenosine uptake by rat cerebral cortical synaptosomes.
human ... ADORA2A(135), ADORA2B(136)
rat ... Adora1(29290), Adora2a(25369)
P4532 (−)-N6-(2-Phenylisopropyl)adenosine solid A1 adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.
human ... ADORA1(134)
U4125 Uridine 5′-(trihydrogen diphosphate) sodium salt from Saccharomyces cerevisiae 95-100% P2Y receptor agonist.
human ... LPAR4(2846), LTB4R(1241), P2RY1(5028), P2RY10(27334), P2RY11(5032), P2RY12(64805), P2RY13(53829), P2RY14(9934), P2RY2(5029), P2RY4(5030), P2RY5(10161), P2RY6(5031), P2RY8(286530)
U6875 Uridine 5′-triphosphate tris salt Type VI, ≥90% P2Y receptor agonist.
 
U6625 Uridine 5′-triphosphate trisodium salt hydrate from yeast, Type III, ≥96% P2Y receptor agonist.
 
U6750 Uridine 5′-triphosphate trisodium salt hydrate Type IV, 90-95% P2Y receptor agonist.