Excitatory Amino Acids - Opiod Agonists

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A114 (+)-N-Allylnormetazocine hydrochloride ≥98% (HPLC) Selective σ1 receptor agonist.
human ... OPRS1(10280)
B9275 Buprenorphine hydrochloride Full agonist at ORL1 receptors, antagonist or partial agonist at μ, κ, and δ opioid receptors.
 
B1935 Butorphan S(+)-mandelate ≥98% (HPLC), solid κ/μ opioid receptor agonist.
 
B9156 Butorphanol (+)-tartrate salt ≥99% κ/μ opioid receptor agonist.
human ... OPRK1(4986), OPRM1(4988)
B8930 BW373U86 dihydrobromide powder Potent, non-peptide δ-opioid receptor agonist.
 
C4662   Carbetapentane citrate salt High affinity σ1 agonist; ORL1 antagonist; antitussive.
human ... OPRL1(4987), OPRS1(10280)
E8512 Ethylmorphine Narcotic analgesic; antitussive
 
F3886 Fentanyl citrate salt Phenylpiperidine analgesic that is 80 times more potent than morphine as an analgesic and 6000 times more potent than morphine as a μ opioid receptor agonist.
 
G133 GR 89696 fumarate salt solid Selective κ2 opioid receptor agonist.
human ... OPRK1(4986)
H4516 Hydrocodone (+)-bitartrate salt μ opioid receptor agonist; narcotic analgesic and antitussive.
 
H5136 Hydromorphone hydrochloride Narcotic opiate analgesic; μ opioid receptor agonist.
 
I122 ICI 204,448 hydrochloride solid κ opioid receptor agonist that does not cross the blood-brain barrier.
human ... OPRK1(4986)
L8539 L-687,384 hydrochloride ≥98% (HPLC), powder σ1 receptor agonist.
human ... OPRS1(10280)
L7418 LAAM hydrochloride ≥98% (HPLC), solid LAAM hydrochloride is μ opioid receptor agonist. LAAM hydrochloride is a DEA-controlled substance, which has a slow onset, but a long duration of action. LAAM is a useful tool for studying opiate tolerance and cross-reactivity with other μ opioid receptor agonists.
 
L5143 Levorphanol (+)-tartrate salt dihydrate white powder, ≥98% (HPLC) Synthetic morphine analog that is a narcotic analgesic and μ opioid receptor agonist.
 
L3669 LPK-26 ≥98% (HPLC), powder LPK-26 is an analog of ICI-199441 and (-)U50,488H (classic kappa agonists). It has extremely high kappa affinity (0.64 nM) and low mu and delta receptor affnities (1170 and 10,000nM). LPK-26 produces an antinocicpetive effect with much higher potency in vivo than morphine or U50488. LPK-26 does not produce physical dependence in mice, but it does suppress naloxone-induced behavioral effects in mice treated with morphine.
 
PZ0159 MCOPPB trihydrochloride hydrate >98% (HPLC) MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
 
M3142 Meperidine hydrochloride Phenylpiperidine analgesic; sedative; μ opioid receptor agonist with greater κ opioid receptor agonist activity than morphine.
 
M0267 (±)-Methadone hydrochloride powder, ≥98% (TLC) μ opioid receptor agonist that desensitizes both the μ opioid receptor and the δ opioid receptor on chronic exposure; narcotic analgesic, characterized by a gradual onset of action and prolonged, milder withdrawal; may also block L-type calcium channels independently of its effects on opioid receptors.
 
M8777 Morphine sulfate salt pentahydrate Narcotic analgesic; prototypic μ opioid receptor agonist; also agonist at κ opioid receptors.
 
M3528 Morphine 6-β-D-glucuronide hydrate ≥90% (HPLC) Major metabolite of morphine that is a potent μ−opioid receptor agonist.
 
N165 Naloxone benzoylhydrazone solid Agonist for κ3 opioid receptors; antagonist for ORL1 and μ opioid receptors.
human ... OPRK1(4986), OPRL1(4987), OPRM1(4988)
O5889 Opipramol dihydrochloride ≥98% (HPLC), solid σ12 opioid receptor agonist; an antagonist at D2, 5HT2 and H1 receptors; atypical antidepressant, antipsychotic and anxiolytic
 
P9246 PB28 dihydrochloride ≥98% (HPLC), solid Selective σ2 opioid receptor ligand; putative σ2 agonist
 
P134 (−)-Pentazocine ≥98% (HPLC)    
P127 (+)-Pentazocine solid σ receptor agonist; active enantiomer of pentazocine.
human ... EBP(10682)
rat ... Chrm1(25229), Chrm2(81645), Drd2(24318), Oprm1(25601)
P3029 Phencyclidine hydrochloride σ opioid receptor agonist and psychostimulant; inhibits NMDA glutamate receptor activation by binding to an allosteric site within the ion channel.
 
P2607 PRE-084 solid Potent and highly selective σ1 opioid receptor agonist.
human ... OPRS1(10280)
rat ... Oprs1(29336), Slc6a3(24898)
R1908 Remifentanil hydrochloride ≥97% (HPLC), powder Remifentanil hydrochloride is a mu opioid receptor agonist, anesthetic, and analgesic compound. Remifentanil was developed as an ultra-short-acting mu opioid receptor agonist with improved pharmacodynamic properties.
 
S8071 Salvinorin A ≥98% (HPLC), powder Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Oprk1(29335)
S2812 SNC80 ≥98% (HPLC), solid SNC80 is a δ opioid receptor agonist.
SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4
human ... OPRD1(4985)
mouse ... Oprd1(18386)
rat ... Oprd1(24613), Oprm1(25601)
U111 (−)-trans-(1S,2S)-U-50488 hydrochloride hydrate solid, ≥98% (HPLC) Potent κ opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.
human ... OPRK1(4986)
D8040 (±)-trans-U-50488 methanesulfonate salt Selective κ-opioid receptor agonist.
human ... OPRK1(4986)
U105 U-62066 solid Highly selective κ opioid receptor agonist; antitussive.
human ... OPRK1(4986)
U103 U-69593 solid U-69593 is a selective κ opioid receptor agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
mouse ... Oprk1(18387)
rat ... Oprd1(24613), Oprk1(29335), Oprm1(25601)