Mistaminergics - Agonists

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H7125 Histamine ≥97.0% Endogenous H1 and H2 histamine receptor agonist; H1 activation mobilizes Ca2+; H2 activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.
human ... CA1(759), CA2(760), HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)
rat ... Hrh1(24448), Hrh3(85268)
H7250 Histamine dihydrochloride ≥99% (TLC), powder   human ... HRH1(3269), HRH2(3274)
H7375 Histamine bisphosphate monohydrate    
I135 Imetit dihydrobromide ≥98% (HPLC) Potent and selective H3 histamine receptor agonist.
human ... HRH3(11255)
I4034 Immepip dihydrobromide ≥97% (HPLC), powder Immepip is a H3 and H4 histamine receptor agonist. Immepip is a selective H3 agonist equipotent to (R)-α-methylhistamine and also effective in vitro and in vivo. It is devoid of side activities elicited at H1 and α2 receptors and 5-HT3 receptors.
 
H128 (R)(−)-α-Methylhistamine dihydrochloride solid, ≥98% (HPLC) Potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier; inhibits histamine synthesis and release.
human ... HRH3(11255)
H5914 Nα-Methylhistamine dihydrochloride solid Production of N-alpha-methyl-histamine (NAMH), a histamine H(3) receptor (H3R) agonist, is promoted in Helicobacter pylori infected human gastric mucosa. NAMH acts directly on histamine H(2) receptors (H2Rs) in animals to stimulate acid secretion and to be a H2R agonist. NAMH dose dependently stimulated cAMP productions in CHO-H2R cells. This production was inhibited by famotidine but not by thioperamide. Control CHO cells were unresponsive to either histamine or NAMH. In addition, the effect of NAMH, in terms of cAMP production in CHO-H2R cells, was more potent than that of histamine-that is, with a lower EC50 concentration and higher maximal cAMP production. Both NAMH and histamine, but not R-alpha-methyl-histamine, effectively inhibited [(3)H] tiotidine binding to CHO-H2R cells. These results confirm that NAMH, which is produced in the gastric mucosa by H pylori, is a potent H2R agonist as well as a H3R agonist.
 
T4951 2-((3-Trifluoromethyl)phenyl)histamine dimaleate ≥98% (HPLC), powder 2-((3-Trifluoromethyl)phe