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Chondroitinase ABC

Chondroitinase ABC
EC# 4.2.2.4
(Formerly EC# 4.2.99.6)
Synonyms: Chondroitin ABC Lyase
Chondroitinase ABC catalyzes the eliminative degradation of polysaccharides containing 1,4-β-D-hexosaminyl and 1,3-β-D-glucuronosyl or 1,3-α-L-iduronosyl linkages to disaccharides containing 4-deoxy-b-D-gluc-4-enuronosyl groups. It acts on chondroitin 4-sulfate, chondroitin 6-sulfate, dermatan sulfate, and acts slowly on hyaluronate. Initial rates of degradation of chondroitin sulfate B, chondroitin, and hyaluronic acid were 40%, 20%, and 2%, respectively, that of chondroitin sulfate A and chondroitin sulfate C.
References
Enzyme Nomenclature, p. 425, 1992 Academic Press, San Diego, California
Yamagata, T., et al., J. Biol. Chem., 243, 1523-1535 (1968).
Martinez, J.B., et al., J. Biol. Chem., 234, 2236 (1959).
Saito, H., et al., J. Biol. Chem., 243, 1536-1542 (1968).
Suzuki, S., et al., J. Biol. Chem., 243, 1543 (1968).
Oike, Y., et al., J. Biol. Chem., 257, 9751 (1982).

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C3667 Chondroitinase ABC from Proteus vulgaris BSA free, lyophilized powder, 50-250 units/mg protein (using chondroitin sulfate C as substrate)