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Chondroitinase C

Chondroitinase C
EC# 4.2.2.-
Chondroitinase C cleaves chondroitin sulfate C producing tetrasaccharide plus an unsaturated 6-sulfated disaccharide (delta Di-6S). It also cleaves hyaluronic acid producing unsaturated nonsulfated disaccharide (delta Di-OS). Chondroitin sulfate A is also degraded producing oligosaccharides and delta Di-6S but not delta Di-4S.1 Chondroitinase C cleaves the GalNAc bond of the pentasaccharides or hexasaccharides derived from the linkage region of chondroitin sulfate chains and tolerated sulfation of the C-4 or C-6 of the GalNAc residue and C-6 of the Gal residues, as well as 2-O-phosphorylation of the Xyl residue. In contrast, it does not act on a GalNAc–GlcA linkage when attached to a 4-O-sulfated Gal residue.2
1. Michelacci, Y.M., and Dietrich, C.,P., J. Biol. Chem., 251, 1154-8 (1976)
2. Tsuda, H., et al., Eur. J. Biochem. 262, 127-133 (1999)

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C0954 Chondroitinase C from Flavobacterium heparinum lyophilized powder, ≥200 units/mg solid