Certain features of will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Heparinase Specificities

Heparinase selectively cleaves sulfated glycans containing a(1-4) glycosidic linkages between the glucosamine and uronic acid residues in the heparin polymer. The cleavage proceeds via an elimination reaction, resulting in the formation of oligosaccharides containing unsaturated uronic acid residues (double bond between C4 and C5). These cleavage products can be detected by UV spectroscopy (232 nm).