Cyclooxygenase (COX) Enzymes

Cyclooxygenase (COX) produces the key cyclic endoperoxide intermediate in the arachidonic acid cascade. The two COX isoforms are the constitutive form (COX1) and the inducible form (COX2). Many of the COX inhibitors are classic analgesics and non-steroidal anti-inflammatory drugs (NSAIDs). COX inhibitors have recently been implicated in cancer prevention and the slowing of atherosclerosis.