Luciferase Substrates

We offer highly purified synthetic firefly (Photinus pyralis) D-luciferin in both carboxylic acid and salt forms. In recent years, bioluminescence imaging using the luciferase gene has become an important tool in cell biology and cancer research. However, for the luciferase enzyme to produce light, the substrate luciferin must penetrate the transfected cell. To reflect expression of the transgene, intracellar luciferin should be present in substrate saturation levels. The ATP-binding cassette (ABC) family of membrane proteins can affect the transport of luciferin. In at least one case, luciferin is a substrate for an ABC protein1 .

1. ABCG2/BCRP Expression Modulates D-Luciferin–Based Bioluminescence Imaging, Y. Zhang, J.P. Bressler, J. Neal, B.Lal, H.C. Bhang, J. Laterra, and M.G. Pomper. Cancer Res (2007) 67:9389

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L9504 D-Luciferin synthetic
L6152 D-Luciferin synthetic, BioXtra, ≥99% (HPLC)
50227 D-Luciferin potassium salt ≥98.0% (HPLC)
L6882 D-Luciferin sodium salt lyophilized powder, synthetic