DNA polymerase - alpha

Enzyme Inhibitors

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114666 Actinomycin D, Streptomyces sp. - CAS 50-76-0 - Calbiochem Actinomycin D, Streptomyces sp., CAS 50-76-0, is an anti-neoplastic antibiotic that inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues., Anti-neoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. C₆₂H₈₆N₁₂O₁₆
129741 α-Amanitin, Amanita sp. - CAS 23109-05-9 - Calbiochem α-Amanitin, Amanita sp., CAS 23109-05-9, is a toxic bicyclic octapeptide isolated from mushrooms. A potent & specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes. C₃₉H₅₄N₁₀O₁₄S
129935 Actinomycin D, 7-Amino- - CAS 7240-37-1 - Calbiochem Actinomycin D, 7-Amino, CAS 7240-37-1, is a DNA intercalator that complexes with DNA. Absorbs at 555 nm & emits at 655 nm. Exhibits growth-inhibitory activity against certain leukemias and sarcomas., 7-Aminoactinomycin D, like its parent molecule, actinomycin D, is a DNA intercalator and has antibacterial properties. Exhibits growth-inhibitory activity against certain leukemias and sarcomas. C₆₂H₈₇N₁₃O₁₆
178273 Aphidicolin - CAS 38966-21-1 - Calbiochem Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. C₂₀H₃₄O₄
491207 Novobiocin, Sodium Salt - CAS 1476-53-5 - Calbiochem Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases., Novobiocin, Sodium Salt, CAS 1476-53-5, is a DNA gyrase inhibitor that is used for the production of positively supercoiled plasma DNA. Inhibits retrovirus RNA-dependent DNA polymerases. C₃₁H₃₅N₂O₁₁ · Na
5.09911 RNA Polymerase I Inhibitor II, BMH-21 - Calbiochem A cell-permeable compound that blocks the growth and viability of a variety of cancer cell lines (GI₅₀ = 160 nM in NCI-60 cells), but does not affect normal cells. C₂₁H₂₀N₄O₂
557303 Rifampicin - CAS 13292-46-1 - Calbiochem Rifampicin, CAS 13292-46-1, is an antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex. Does not affect mammalian RNA polymerase., Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex. C₄₃H₅₈N₄O₁₂
557403 RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). C₁₉H₁₅Cl₂N₃O₂S₂
557404-M InSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem The InSolution™ RNA Polymerase III Inhibitor, also referenced under CAS 577784-91-9, controls the biological activity of RNA Polymerase III. This small molecule/inhibitor is primarily used for Cell Structure applications. C₁₉H₁₅Cl₂N₃O₂S₂
C4991 Cephalomannine ≥97% (HPLC), solid C45H53NO14