Histone deacetylase

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172050 Anacardic Acid - CAS 16611-84-0 - Calbiochem Anacardic Acid, CAS 16611-84-0, is a cell-permeable ginkgolic acid analog that targets SUMO-activating enzyme E1 and inhibits protein SUMO modification (IC50 = 2.2 µM) in an ATP-dependent manner., The Anacardic Acid, also referenced under CAS 16611-84-0, modulates the biological activity of Anacardic. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₂H₃₆O₃
178276 Apicidin, Fusarium sp. - Calbiochem A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. C₃₄H₄₉N₅O₆
324888 Epigenetic Multiple Ligand - CAS 1020399-52-3 - Calbiochem A cell-permeable bis-arylidene compound that acts as an epigenetic multiple ligand (epi-ML) and inhibits substrates processing by several chromatin-associated enzymes. C₁₉H₁₂Br₄O₄
382110 Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₀H₁₆Br₂O₃
382111 Histone Acetyltransferase Inhibitor IV, CPTH2 - CAS 357649-93-5 - Calbiochem C₁₄H₁₄ClN₃S
382113 Histone Acetyltransferase p300 Inhibitor, C646 - Calbiochem Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes with acetyl-CoA for the p300 Lys-CoA binding pocket. C₂₄H₁₉N₃O₆
382115 Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem The Histone Acetyl Transferase Inhibitor VII, CTK7A controls the biological activity of Histone Acetyl Transferase. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₈H₂₃N₂NaO₆
382148 Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem The Histone Deacetylase Inhibitor II, also referenced under CAS 174664-65-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. C₁₀H₁₀N₂O₄
382149 Histone Deacetylase Inhibitor III The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. C₁₆H₂₅N₃O₃
382170 Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem The Histone Deacetylase Inhibitor IV, also referenced under CAS 537034-15-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. C₁₉H₂₃N₃O₂
382172 Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase. C₁₇H₂₁NO₂S
382173 Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₀H₂₅N₃O₂
382175-M Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₂H₃₀N₄O₆
382177 HDAC Inhibitor XIX, Compound 2 - CAS 6953-61-3 - Calbiochem The HDAC Inhibitor XIX, Compound 2, also referenced under CAS 6953-61-3, controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. C₁₁H₉NO₂
382181 HDAC Inhibitor XXIV, OSU-HDAC-44 - Calbiochem C₁₉H₂₂N₂O₃
382185 HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem The HDAC Inhibitor XXII, NCH51, also referenced under CAS 848354-66-5, controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₀H₂₆N₂O₂S₂
382187 HDAC Inhibitor XXIII, Tubastatin A - Calbiochem The HDAC Inhibitor XXIII, Tubastatin A controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₀H₂₁N₃O₂
431050 InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem InSolution™ Leptomycin B, Streptomyces sp., CAS 87081-35-4, is a 20 µg/ml solution in ethanol. An antifungal agent that blocks nuclear export by impairing the function of nuclear export factor CRM1., An antifungal antibiotic that acts as an inhibitor of nuclear export because of its ability to interact with and impair the function of the nuclear export factor CRM1. C₃₃H₄₈O₆
5.00511 Histone Acetyltransferase Inhibitor VIII, NU9056 - Calbiochem C₆H₄N₂S₄
5.05298 p300/CBP Inhibitor VI, L002 - CAS 321695-57-2 - Calbiochem C₁₅H₁₅NO₅S
5.34034 Heterochromatin Inhibitor, HMS-I1 - Calbiochem A cell-permeable, reversible inhibitor of heterochromatin-mediated gene silencing in mammalian, plant, and fungal cells (5 - 10 µM). C₁₆H₁₄N₂O₂
5.34354 p300/CBP Inhibitor X, EML425 A cell-permeable, potent, reversible, non-competitive, and selective inhibitor of p300/CBP (IC₅₀ = 2.9 µM and 1.1 µM, respectively). C₂₇H₂₄N₂O₄
553590 InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem A cell-permeable polyketide that displays potent antitumor properties in eukaryotes. C₂₈H₄₀O₅
559418 SBHA - CAS 38937-66-5 - Calbiochem A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. C₈H₁₆N₂O₄
565730 Scriptaid - CAS 287383-59-9 - Calbiochem A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. C₁₈H₁₈N₂O₄
566320 Sirtinol - CAS 410536-97-9 - Calbiochem A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1. C₂₆H₂₂N₂O₂
566321 InSolution™ Sirtinol - Calbiochem C₂₆H₂₂N₂O₂
566322-M SIRT1 Inhibitor III The SIRT1 Inhibitor III, also referenced under CAS 49843-98-3, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications. C₁₃H₁₃ClN₂O
566323 SIRT1/2 Inhibitor IV, Cambinol The SIRT1/2 Inhibitor IV, Cambinol, also referenced under CAS 14513-15-6, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₁H₁₆N₂O₂S
566324 SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₃H₁₃Cl₂N₃O₂
566325 SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem SIRT1 Inhibitor IV, (S)-35, CAS 848193-72-6, is a cell-permeable, entiomerically pure compound that displays similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322)., The SIRT1 Inhibitor IV, (S)-35, also referenced under CAS 848193-72-6, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications. C₁₄H₁₅ClN₂O
566326 SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem The SIRT2 Inhibitor, Inactive Control, AGK7, also referenced under CAS 304896-21-7, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₃H₁₃Cl₂N₃O₂
566327 SIRT1/2 Inhibitor VII - CAS 143034-06-4 - Calbiochem The SIRT1/2 Inhibitor VII, also referenced under CAS 143034-06-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications. C₁₅H₁₀N₂O₂S
566330-M SIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem The SIRT1/2 Inhibitor VIII, Salermide, also referenced under CAS 1105698-15-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₆H₂₂N₂O₂
566331 SIRT2 Inhibitor II, AK-1 - CAS 330461-64-8 - Calbiochem The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications. C₁₉H₂₁N₃O₅S
566332 Sirt1 Inhibitor VII, Inauhzin - Calbiochem The Sirt1 Inhibitor VII, Inauhzin controls the biological activity of Sirt1. This small molecule/inhibitor is primarily used for Cell Structure applications. C₂₅H₁₉N₅OS₂
567750 Splitomicin - CAS 5690-03-9 - Calbiochem A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC₅₀ = 60 µM). C₁₃H₁₀O₂
567860 SRT1720 - CAS 925434-55-5 - Calbiochem SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 µM; Km = 2.44 µM), but NAD+-uncompetitive (Ki = 0.34 µM; Km = 280 µM). C₂₅H₂₃N₇OS
580566 Tenovin-1 - CAS 380315-80-0 - Calbiochem A cell-permeable benzoylthiourea compound that acts as a reversible inhibitor of class III HDAC sirtuins against SirT2 (IC₅₀ = ~ 10 µM). C₂₀H₂₃N₃O₂S
647925 Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem Trichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively)., A potent and reversible, cell-permeable inhibitor of histone deacetylase. C₁₇H₂₂N₂O₃
647926-M InSolution™ Trichostatin A, Streptomyces sp. - Calbiochem C₁₇H₂₂N₂O₃
676380 Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem Valproic Acid, Sodium Salt, CAS 1069-66-5, is a cell-permeable inhibitor of histone deacetylase (IC50 = 400 µM for HDAC1). Inhibits proliferation of human malignant glioma cell lines., A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1). C₈H₁₅O₂Na
A2478 APHA Compound 8 ≥98% (HPLC), solid C16H16N2O3
A8851 Apicidin ≥98% (HPLC), from microbial C34H49N5O6
S7817 Scriptaid ≥95%, solid C18H18N2O4
S7942 Sirtinol ≥95% (NMR) C26H22N2O2
B5887 Sodium butyrate ≥98.5% (GC) C4H7NaO2
T8552 Trichostatin A ≥98% (HPLC), from Streptomyces sp. C17H22N2O3