Trypsin Inhibitors

We offer a variety of trypsin inhibitors, both macromolecules and small organic molecules. The proteins, often called serpins or serine protease inhibitors, are of mammalian, avian (egg white) or plant origin. Their association constants and specificities vary, none being completely specific for trypsin, but all mimic substrates. Most, like α-1-antitrypsin or Kunitz soybean trypsin inhbitor, bind to the active site of the protease, and act as competitive inhibitors. α-2-macroglobulin from human serum, which we offer in highly purified preparation, is unique in that it ‘traps’ proteolytic enzymes in an irreversible complex. The small organics also vary in specificity and tightness of binding. Leupeptin, for example, is a generalized inhibitor of trypsin, plasmin, papain, calpain, and cathepsins. As another example, 4-Amidinophenylmethanesulfonyl fluoride hydrochloride is an irreversible inhibitor of serine proteases, while benzamidine is reversible.

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A6664 4-Amidinophenylmethanesulfonyl fluoride hydrochloride serine protease inhibitor C8H9FN2O2S · HCl
A8456 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride ≥97% C8H10FNO2S · HCl
A6191 Antipain dihydrochloride from microbial source protease inhibitor C27H44N10O6 · 2 HCl
A9141   Antithrombin III from bovine plasma lyophilized powder, 200-400 units/mg protein (E1%/280 = 6.5)  
A2221   Antithrombin III from human plasma lyophilized powder, ≥95% (SDS-PAGE)  
A9024   α1-Antitrypsin from human plasma salt-free, lyophilized powder  
A6150   α1-Antitrypsin from human plasma salt-free, lyophilized powder  
ROAPRO   Aprotinin from bovine lung  
A1153 Aprotinin from bovine lung lyophilized powder, 3-8 TIU/mg solid C284H432N84O79S7
434760 Benzamidine hydrochloride 99% C7H8N2 · HCl
B6506 Benzamidine hydrochloride hydrate ≥99% C7H8N2 · ClH · xH2O
D7910 3,4-Dichloroisocoumarin serine protease inhibitor C9H4Cl2O2
D0879 Diisopropylfluorophosphate C6H14FO3P
G2417 Gabexate mesylate analytical standard, for drug analysis C16H23N3O4 · CH4O3S
L2023 Leupeptin trifluoroacetate salt ≥90% (HPLC), microbial C20H38N6O4 · xC2HF3O2
M6159 α2-Macroglobulin from human plasma BioUltra, ≥98% (SDS-PAGE)  
P7626 Phenylmethanesulfonyl fluoride ≥98.5% (GC) C7H7FO2S
T7254 Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride ≥96% (TLC), powder C14H21ClN2O3S · HCl
T9777 Trypsin-chymotrypsin inhibitor from Glycine max (soybean) lyophilized powder  
T0256 Trypsin inhibitor from bovine pancreas Type I-P, essentially salt-free, lyophilized powder  
T9253 Trypsin inhibitor from chicken egg white Type II-O, Partially purified ovomucoid, containing ovoinhibitor  
T2011 Trypsin inhibitor from chicken egg white Type III-O (free of ovoinhibitor)  
T9003 Trypsin inhibitor from Glycine max (soybean) Type I-S, lyophilized powder  
T9128 Trypsin inhibitor from Glycine max (soybean) lyophilized powder  
T9008 Trypsin inhibitor from Glycine max (soybean) 1% solution in water (contains no buffers)  
T2327 Trypsin Inhibitor from Glycine max (soybean) BioUltra, lyophilized powder, ≥95% (Kunitz inhibitor, SDS-PAGE)  
T9378   Trypsin inhibitor from Phaseolus limensis (lima bean) Type II-L, crude powder  
T4385 Trypsin inhibitor from turkey egg white Type II-T  
SRE0044 Trypsin Inhibitor from Glycine max (soybean) Suitable for manufacturing of diagnostic kits and reagents, suitable for cell culture