Carbonic Anhydrase

The carbonic anhydrases are a family of metalloenzymes that catalyze the rapid conversion of carbon dioxide to bicarbonate and protons, a reaction that occurs slowly in the absence of a catalyst. Carbonic anhydrases are widely distributed in plant and animal tissues where they are involved in diverse physiological processes, such as photosynthesis, pH homeostasis, calcification, and bone resorption. There are at least five distinct CA families (α, β, γ, δ, and ε). These families have no significant amino acid sequence similarity and, in most cases, are thought to be an example of convergent evolution.

In mammals, carbonic anhydrases play a role in multiple physiological processes. In addition to their roles in carbon dioxide transport and the maintenance of the acid-base balance in blood and tissues, these enzymes are involved in gluconeogenesis, lipogenesis, ureagenesis, and tumorogenicity. Carbonic anhydrase activity and dysfunction is also associated with mental retardation, Alzheimer′s disease, and aging. The expression of certain carbonic anhydrase isoforms have been linked with the agressiveness and prognosis of various human cancers, including renal, colon, and lung.

Bovine Carbonic Anhydrase

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C3934 Carbonic Anhydrase from bovine erythrocytes lyophilized powder, ≥2,000 W-A units/mg protein
C7025 Carbonic Anhydrase from bovine erythrocytes BioReagent, suitable for GFC marker
C2273 Carbonic Anhydrase from bovine erythrocytes For use as a marker in SDS-PAGE
C5024 Carbonic Anhydrase from bovine erythrocytes non-denaturing PAGE marker
C2624 Carbonic Anhydrase from bovine erythrocytes ≥95% (SDS-PAGE), specific activity ≥3,500 W-A units/mg protein, lyophilized powder
C7749 Carbonic Anhydrase II bovine ≥90% (SDS-PAGE), recombinant, expressed in E. coli, ≥5,000 units/mg protein, buffered aqueous solution
C3640 Carbonic Anhydrase Isozyme II from bovine erythrocytes lyophilized powder, ≥2,000 W-A units/mg protein
C3666 Carbonic Anhydrase Isozyme II from bovine erythrocytes Isoelectric focusing marker, pI 5.4
C2522 Carbonic Anhydrase Isozyme II from bovine erythrocytes lyophilized powder, ≥3,000 W-A units/mg protein

Human Carbonic Anhydrase

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C6624 Carbonic Anhydrase II human recombinant, expressed in E. coli, buffered aqueous solution
C4396 Carbonic Anhydrase I from human erythrocytes
C6653 Carbonic Anhydrase I from human erythrocytes Isoelectric focusing marker, pI 6.6
C6165 Carbonic Anhydrase Isozyme II human ≥80%, powder, ≥3,000 W-A units/mg protein
A4112 Carbonic Anhydrase IV human ≥90% (SDS-PAGE), recombinant, expressed in E. coli, >5,000 units/mg protein, buffered aqueous solution