Fibronectin

Cellular fibronectin is an adhesion glycoprotein of theextracellular matrix, which exists as a dimer with a molecular mass of ~550 kDa. It contains two heterodimers, the A chain and the B chain containing the type III connecting segment (IIIcs) region. Cellular fibronectin differs from plasma fibronectin, a 200–250 kDa monomer, by the presence of additional polypeptide segments and in altering morphology of transformed cells and hemagglutination. Different forms of fibronectin appear to be generated from tissue specific splicing of fibronectin mRNA, transcribed from a single gene. Multiple domains of fibronectin show binding affinities for collagen, fibrin, heparin, and specific cell membrane receptors. The most notable domain, Arg-Gly-Asp (RGD), is recognized by integrins and mediates cell adhesion. Fibronectin is involved in widespread interactions and functions, such as the attachment and migration of many cell types, cytoskeletal assembly, tyrosine phosphorylation, and metastasis.
Fibronectin

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F1141 Fibronectin from bovine plasma solution, sterile-filtered, BioReagent, suitable for cell culture
F4759 Fibronectin from bovine plasma powder, BioReagent, suitable for cell culture
F2518 Fibronectin from human foreskin fibroblasts lyophilized powder, BioReagent, suitable for cell culture
F2006 Fibronectin from human plasma lyophilized powder, BioReagent, suitable for cell culture
F0895 Fibronectin from human plasma liquid, 0.1% (Solution), BioReagent, suitable for cell culture
F0635 Fibronectin from rat plasma powder, BioReagent, suitable for cell culture
S5171 Superfibronectin from human plasma solution, sterile-filtered, BioReagent, suitable for cell culture
F3667 Fibronectin Adhesion-promoting Peptide ≥95% (HPLC)
F3542 Fibronectin Fragment III1-C human recombinant, expressed in E. coli, lyophilized powder, ≥90% (SDS-PAGE)
F8141 Fibronectin-like Engineered Protein Polymer-plus genetically engineered powder, sterile; autoclaved, BioReagent, suitable for cell culture
F5022 Fibronectin-like Protein Polymer genetically engineered lyophilized powder, autoclaved, BioReagent, suitable for cell culture
F0162 Fibronectin Proteolytic Fragment from human plasma lyophilized powder, 45 kDa
F0287 Fibronectin Proteolytic Fragment from human plasma lyophilized powder, 70 kDa
F9911 Fibronectin Proteolytic Fragment from human plasma lyophilized powder, 30 kDa
F5007 Fibronectin Type III Connecting Segment Fragment 1-25 ≥90% (HPLC)