Vitronectin

Vitronectin is a glycoprotein present in plasma and tissues. Together with fibronectin, vitronectin is one of the major cell adhesion proteins in plasma. Although these proteins have similar functions and have an Arg-Gly-Asp cell recognition sequence, they are structurally and immunologically distinct. In addition to promoting the adhesion of various cells in culture, vitronectin binds to glycosaminoglycans, is incorporated as an inhibitor to the membrane cytolytic attack complex of the complement system, interacts with thrombin and antithrombin III during coagulation, and may have a physiological role in the coagulation pathway. The N-terminal residues are identical to somatomedin B, which is also present in plasma. This sequence is followed by an RGD sequence, which interacts with a specific cell-surface receptor. Then a sequence of repeat units follows. The central domain of the molecule is enriched with hydrophobic residues. Near the C-terminus is a 12 kDa, arginine rich region responsible for heparin binding activity, expressed after a conformational change. The conformational change occurs in vivo upon binding to the thrombin-antithrombin III complex and in vitro with treatment with urea.

Product #

Description

Add to Cart

V9881 Vitronectin from bovine plasma lyophilized powder, BioReagent, suitable for cell culture
V8379 Vitronectin from human plasma lyophilized powder, BioReagent, suitable for cell culture
V0132 Vitronectin from rat plasma lyophilized powder, BioReagent, suitable for cell culture
SRP3186 Vitronectin human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested