Dextrans

Dextrans are polysaccharides with molecular weights ≥1000 Dalton, which have a linear backbone of α-linked D-glucopyranosyl repeating units. Three classes of dextrans can be differentiated by their structural features:

  • Class 1 dextrans contain the α(1→6)-linked D-glucopyranosyl backbone modified with small side chains of D-glucose branches with α(1→2), α(1→3), and α(1→4)-linkage. The class 1 dextrans vary in their molecular weight, spatial arrangement, type and degree of branching, and length of branch chains, depending on the microbial producing strains and cultivation conditions. Isomaltose and isomaltotriose are oligosaccharides with the class 1 dextran backbone structure.
  • Class 2 dextrans (alternans) contain a backbone structure of alternating α(1→3) and α(1→6)-linked D-glucopyranosyl units with α(1→3)-linked branches.
  • Class 3 dextrans (mutans) have a backbone structure of consecutive α(1→3)-linked D-glucopyranosyl units with α(1→6)-linked branches. One and two-dimensional NMR spectroscopy techniques have been utilized for the structural analysis of dextrans.

The physical and chemical properties of purified dextrans vary depending on the microbial strains from which they are produced and by the production method. Dextrans have high water solubility and the solutions behave as Newtonian fluids. Solution viscosity depends on concentration, temperature, and molecular weight, which have a characteristic distribution. The hydroxyl groups present in dextran offer many sites for derivatization, and these functionalized glycoconjugates represent a largely unexplored class of biocompatible and environmentally safe compounds.

Sigma Life Sciences offers a large variety of dextrans with high polydispersity and dextran molecular weight standards with low polydispersity (Mw/Mn values close to 1.0). Dextran sulfate from Leuconostoc spp. and fluorophore-dextran conjugates are also available in a range of polymer sizes.

Dextrans for General Research Applications

Product #

Description

CAS Number

Molecular Weight

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31387 Dextran from Leuconostoc spp. Mr 15,000-25,000 9004-54-0 Mr 15,000-25,000
    • 31392 Dextran from Leuconostoc spp. Mr 450,000-650,000 9004-54-0 Mr 450,000-650,000
    • 09184 Dextran from Leuconostoc spp. Mr ~100,000 9004-54-0 Mr ~100,000
    • 95771 Dextran from Leuconostoc spp. Mr ~2,000,000 9004-54-0 Mr ~2,000,000
    • 31398 Dextran from Leuconostoc mesenteroides Mr ~200,000 9004-54-0 Mr ~200,000
    • 31389 Dextran from Leuconostoc spp. Mr ~40,000 9004-54-0 Mr ~40,000
    • 68084 Dextran from Leuconostoc spp. Mr ~40000 9004-54-0 Mr ~40000
    • 31388 Dextran from Leuconostoc spp. Mr ~6,000 9004-54-0 Mr ~6,000
    • 31397 Dextran from Leuconostoc mesenteroides Mr ~60,000 9004-54-0 Mr ~60,000
    • 31390 Dextran from Leuconostoc spp. Mr ~70,000 9004-54-0 Mr ~70,000
    • 44886 Dextran from Leuconostoc spp. Mr ~70000 9004-54-0 Mr ~70000
    • D5376 Dextran from Leuconostoc mesenteroides average mol wt 1,500,000-2,800,000 9004-54-0 average mol wt 1,500,000-2,800,000
    • D4876 Dextran from Leuconostoc mesenteroides average mol wt 150,000 9004-54-0 average mol wt 150,000
    • D1662 Dextran from Leuconostoc mesenteroides average mol wt 35,000-45,000 9004-54-0 average mol wt 35,000-45,000
    • D3759 Dextran from Leuconostoc mesenteroides average mol wt 48,000-90,000 9004-54-0 average mol wt 48,000-90,000
    • D9260 Dextran from Leuconostoc mesenteroides average mol wt 9,000-11,000 9004-54-0 average mol wt 9,000-11,000

    • Dextran Standards for Gel Permeation Chromatography (GPC)

    Product #

    Description

    CAS Number

    Molecular Weight

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    31416 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 1,000 9004-54-0 Mn ~1,000
    Mp ~1,100
    Mw ~1,300
    • 00268 Dextran analytical standard, for GPC, 1,000 9004-54-0 Mn ~1,010
    Mp ~1,080
    Mw ~1,270
    • 31422 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 150,000 9004-54-0 Mn ~100,000
    Mp ~125,000
    Mw ~150,000
    • 00893 Dextran analytical standard, for GPC, 150,000 9004-54-0 Mn ~100,300
    Mp ~123,600
    Mw ~147,600
    • 00894 Dextran analytical standard, for GPC, 270,000 9004-54-0 Mn ~164200
    Mp ~196,300
    Mw ~273,000
    • 31423 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 270,000 9004-54-0 Mn ~165,000
    Mp ~195,000
    Mw ~270,000
    • 00271 Dextran analytical standard, for GPC, 25,000 9004-54-0 Mn ~18,300
    Mp ~21,400
    Mw ~23,800
    • 31419 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 25,000 9004-54-0 Mn ~20,000
    Mp ~20,000
    Mw ~25,000
    • 31424 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 410,000 9004-54-0 Mn ~235,000
    Mp ~275,000
    Mw ~410,000
    • 00895 Dextran analytical standard, for GPC, 410,000 9004-54-0 Mn ~236,300
    Mp ~276,500
    Mw ~409,800
    • 00269 Dextran analytical standard, for GPC, 5,000 9004-54-0 Mn ~3,260
    Mp ~4,440
    Mw ~5,220
    • 31417 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 5,000 9004-54-0 Mn ~3,300
    Mp ~4,400
    Mw ~5,200
    • 31425 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 670,000 9004-54-0 Mn ~330,000
    Mp ~400,000
    Mw ~670,000
    • 00896 Dextran analytical standard, for GPC, 670,000 9004-54-0 Mn ~332,800
    Mp ~401,300
    Mw ~667,800
    • 31420 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 50,000 9004-54-0 Mn ~35,000
    Mp ~45,000
    Mw ~50,000
    • 00891 Dextran analytical standard, for GPC, 50,000 9004-54-0 Mn ~35,600
    Mp ~43,500
    Mw ~48,600
    • 31421 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 80,000 9004-54-0 Mn ~55,000
    Mp ~65,000
    Mw ~80,000
    • 00892 Dextran analytical standard, for GPC, 80,000 9004-54-0 Mn ~55,500
    Mp ~66,700
    Mw ~80,900
    • 49297 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 1,400,000 9004-54-0 Mn ~65,100
    Mp ~1,223,000
    Mw ~1,394,000
    • 05391 Dextran analytical standard, for GPC, 1,100,000 9004-54-0 Mn ~705,000
    Mp ~1,050,000
    Mw ~1,185,000
    Mw/Mn ~1.68
    • 31418 Dextran from Leuconostoc mesenteroides analytical standard, for GPC, Mw 12,000 9004-54-0 Mn ~8,000
    Mp ~10,000
    Mw ~12,000
    • 00270 Dextran analytical standard, for GPC, 12,000 9004-54-0 Mn ~8,110
    Mp ~9,890
    Mw ~11,600
    • 31394 Dextran enzymatic synth. 9004-54-0 Mr ~1,500

    • Dextran Sulfates for General Research Applications

    Product #

    Description

    CAS Number

    Molecular Weight

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    31404 Dextran sulfate sodium salt from Leuconostoc spp. Mr 5,000 9011-18-1 Mr 5,000
    • 51227 Dextran sulfate sodium salt Mr ~15,000   Mr ~15,000
    • 68841 Dextran sulfate sodium salt from Leuconostoc spp. Mr ~20,000 9011-18-1 Mr ~20,000
    • 67578 Dextran sulfate sodium salt Mr ~200,000   Mr ~200,000
    • 75027 Dextran sulfate sodium salt low sulfate content, Mr ~4,000   Mr ~4,000
    • 42867 Dextran sulfate sodium salt Mr ~40,000   Mr ~40,000
    • 52423 Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content, Mr ~40,000 9011-18-1 Mr ~40,000
    • 38739 Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content 9011-18-1 Mw ~10,000
    • 40357 Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content 9011-18-1 Mw ~20,000
    • D8906 Dextran sulfate sodium salt from Leuconostoc spp. for molecular biology, average Mw >500,000 (dextran starting material), contains 0.5-2% phosphate buffer 9011-18-1 average Mw >500,000 (dextran starting material)
    • D6001 Dextran sulfate sodium salt from Leuconostoc spp. average mol wt >500,000 (dextran starting material), contains 0.5-2.0% phosphate buffer, pH 6-8 9011-18-1 average mol wt >500,000 (dextran starting material)
    • D6924 Dextran sulfate sodium salt from Leuconostoc spp. average mol wt 9,000-20,000 9011-18-1 average mol wt 9,000-20,000
    • 68076 Dextran sulfate sodium salt from Leuconostoc spp. low sulfate content 9011-18-1 average mol wt ~500
    • D4911 Dextran sulfate sodium salt from Leuconostoc spp. mol wt 6,500-10,000 9011-18-1 mol wt 6,500-10,000

    • CM-Dextran and Fluorescein Isothiocyanate (FITC) Conjugates

    Product #

    Description

    CAS Number

    Molecular Weight

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    74817 FITC-CM-Dextran average mol wt 150,000   average mol wt 150,000
    • 68059 FITC-CM-Dextran average mol wt 4,000   average mol wt 4,000
    • 53379 FITC-CM-Dextran average mol wt 40,000   average mol wt 40,000
    • 53471 FITC-CM-Dextran average mol wt 70,000   average mol wt 70,000
    • 86524 CM-Dextran sodium salt BioXtra 39422-83-8  

    • Fluorescent Dye-Dextran Conjugates

    Product #

    Description

    CAS Number

    Molecular Weight

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    90718 Fluorescein isothiocyanate–dextran average Mw 70,000   average Mw 70,000
    • FD10S Fluorescein isothiocyanate–dextran average mol wt 10,000   average mol wt 10,000
    • 69658 Fluorescein isothiocyanate–dextran average mol wt 150,000   average mol wt 150,000
    • FD2000S Fluorescein isothiocyanate–dextran average mol wt 2,000,000   average mol wt 2,000,000
    • 52471 Fluorescein isothiocyanate–dextran average mol wt 2,000,000   average mol wt 2,000,000
    • FD20S Fluorescein isothiocyanate–dextran average mol wt 20,000   average mol wt 20,000
    • 73766 Tetramethylrhodamine isothiocyanate–Dextran average mol wt 20,000   average mol wt 20,000
    • FD4 Fluorescein isothiocyanate–dextran average mol wt 3,000-5,000   average mol wt 3,000-5,000
    • FD40S Fluorescein isothiocyanate–dextran average mol wt 40,000   average mol wt 40,000
    • FD40 Fluorescein isothiocyanate–dextran average mol wt 40,000   average mol wt 40,000
    • 42874 Tetramethylrhodamine isothiocyanate–Dextran average mol wt 40,000   average mol wt 40,000
    • 52194 Tetramethylrhodamine isothiocyanate–Dextran average mol wt 500,000   average mol wt 500,000
    • 46945 Fluorescein isothiocyanate–dextran average mol wt 70,000, (FITC:Glucose = 1:250)   average mol wt 70,000
    • 46947 Fluorescein isothiocyanate – Dextran 500000-Conjugate (FITC:Glucose = 1:100)    

    • Fluoroscein Isothiocyanate (FITC)-DEAE-Dextran Conjugates

    Product #

    Description

    CAS Number

    Molecular Weight

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    75005 FITC–DEAE–Dextran average mol wt 150,000   average mol wt 150,000
    • 95648 FITC–DEAE–Dextran average mol wt 20,000   average mol wt 20,000
    • 01649 FITC–DEAE–Dextran average mol wt 40,000   average mol wt 40,000
    • 54702 FITC–DEAE–Dextran average mol wt 70,000   average mol wt 70,000