Prion Disease

Prion Diseases, or transmissible spongiform encephalopathies (TSEs), are a group of progressive neurodegenerative disorders of the CNS. Rare but fatal, common TSEs in animals are Bovine Spongiform Encephalopathy and Chronic Wasting Disease; examples in humans include Creutzfeldt-Jakob disease and Kuru. The disease is thought to develop when abnormal protein molecules (prions) accumulate in the brain, causing convulsions, ataxia, dementia, and death. TSEs are difficult to diagnose, and lead to dead tissue and sponge-like holes in the brain. Scientists are trying to determine the normal role of prions in the brain, as well as the mechanisms by which they become misshapen and accumulate. TSEs are currently incurable, but the goal is to find ways to block the conversion of normal prion protein to the abnormal form. Sigma-Aldrich offers anti-prion antibodies for prion disease research. Forms include monoclonal purified immunoglobulin and polyclonal affinity isolated antibodies.

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P5999 Monoclonal Anti-Prion Protein antibody produced in mouse IPC1, monoclonal
purified immunoglobulin
mouse ... Prnp(19122)
rat ... Prnp(24686)
mouse, hamster, rat
ARR, WB
P6488 Monoclonal Anti-Prion Protein antibody produced in mouse F89/160.1.5, monoclonal
purified immunoglobulin
bovine ... PRNP(281427)
human ... PRNP(5621)
sheep ... PRNP(493887)
bovine, deer, human, sheep
ELISA (i), IHC, WB
SAB2500823 Anti-PRION Protein (143-153) antibody produced in goat polyclonal
affinity isolated antibody
human ... PRNP(5621)
mouse, canine, rat, human
ELISA (i), WB
P0110 Anti-Prion Protein antibody, Mouse monoclonal 8H4, monoclonal
purified immunoglobulin
bovine ... PRNP(281427)
human ... PRNP(5621)
mouse ... Prnp(19122)
rat ... Prnp(24686)
sheep ... PRNP(493887)
mouse, rat, sheep, human, monkey, bovine
ELISA (i), EM, FACS, ICC, IHC, IP, WB