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BRCA1 Antibodies

The nuclear phosphoprotein encoded by BRCA1 functions as a tumor suppressor via a large multi-subunit protein complex, the BRCA1-associated genome surveillance complex (BASC), which contains other tumor suppressor proteins, DNA damage sensors and signal transducer proteins and participates in maintenance of genomic stability. Other functions ascribed to BRCA1 include double strand DNA break repair, chromatin remodeling and transcriptional regulation and links to cell cycle checkpoint regulation and induction of apoptosis. Loss of BRCA1 function leads to spontaneous chromosome breakage, and mutations in BRCA1 and BRCA2, another tumor suppressor and DNA repair mediating protein, are present in up to 80% of inherited breast and ovarian cancers. Functional characterization of these proteins in normal breast tissue development and of their interacting partners, which participate in other key signaling pathways such as p53 and cell checkpoint signaling, continues to be driven by the need for translational advances in personalized cancer therapeutics.

Explore the Role of BRCA1 in DNA Damage Response Interactive Pathway
Explore the Role of BRCA1 in DNA Damage Response Interactive Pathway

Product #

Description

Form

Gene Symbol (ID)

Species Reactivity

Application

Add to Cart

SAB2104043 Anti-BRCA1 antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human
WB
GW21183 Anti-BRCA1 antibody produced in chicken affinity isolated antibody
human ... BRCA1(672)
human
WB
AV02017 Anti-BRCA1 antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human, bovine, pig, canine
IHC, WB
HPA034966 Anti-BRCA1 antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human
IHC
SAB4502849 Anti-BRCA1, C-Terminal antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human
IHC, WB
SAB4300490 Anti-BRCA1 (Ab-1423) antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human
IHC (p), WB
SAB4300411 Anti-BRCA1 (Ab-1524) antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human
IF
SAB4502848 Anti-BRCA1, C-Terminal antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human, rat
ELISA (i), IHC
SAB4300192 Anti-phospho-BRCA1 (pSer1423) antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human
IHC (p), WB
SAB4300096 Anti-phospho-BRCA1 (pSer1524) antibody produced in rabbit affinity isolated antibody
human ... BRCA1(672)
human
IHC (p)