HIF1A Antibodies

HIF1α is the alpha subunit of the hypoxia-inducible factor-1 (HIF-1) transcription factor, which responds to hypoxia by activating the transcription of genes involved in energy metabolism, angiogenesis, apoptosis and increased oxygen delivery. Hypoxia is a contributing factor in the pathophysiology of diseases such as various types of ischemia, cancer, hypertension and pulmonary diseases. The expression of HIF-1α and the transcriptional activity of HIF-1 are tightly controlled by the concentration of O2 in the cell. During hypoxia, p53 facilitates the MDM2-mediated ubiquitination and proteasomal degradation of HIF1α and, thus, limits the hypoxia-induced expression of HIF1α. HIF-1 is over expressed in many common cancers, and this over expression often results in a decrease in tumor latency and an increase in the vascular density, volume and permeability of tumors. Deregulation of both HIF-1 and NF-κB has been implicated in rheumatoid arthritis and cancer. The role of HIF-1 in embryonic vascularization, tumor angiogenesis and the pathophysiology of ischemic disease make the study of HIF-1 relevant to both development and disease.

Explore the HIF1α Signaling Interactive Pathway
Explore the HIF1α Signaling Interactive Pathway

Product #

Description

Form

Gene Symbol (ID)

Species Reactivity

Application

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SAB2104366 Anti-HIF1A antibody produced in rabbit affinity isolated antibody
human ... HIF1A(3091)
rabbit, mouse, horse, canine, rat, rabbit, pig, human, bovine, guinea pig
WB
H6536 Monoclonal Anti-HIF-1α antibody produced in mouse purified immunoglobulin
human ... HIF1A(3091)
mouse ... Hif1a(15251)
rat ... Hif1a(29560)
human, sheep, mouse, ferret, rat
IHC (p), IP, WB
H6411 Monoclonal Anti-HIF-1α antibody produced in mouse purified immunoglobulin
human ... HIF1A(3091)
human
IF, IP
SAB1405933 Anti-HIF1A antibody produced in mouse purified immunoglobulin
human ... HIF1A(3091)
human
IF, WB
HPA001275 Anti-HIF1A antibody produced in rabbit affinity isolated antibody
human ... HIF1A(3091)
human
IHC
SAB2101039 Anti-HIF1A antibody produced in rabbit affinity isolated antibody
human ... HIF1A(3091)
horse, human, pig, rat, bovine, rabbit, mouse, rabbit, guinea pig
WB
SAB1403916 Monoclonal Anti-HIF1A, (C-terminal) antibody produced in mouse purified immunoglobulin
human ... HIF1A(3091)
human
ELISA (c), ELISA (i), WB