AKT Antibodies

AKT, or PKB, is a serine/threonine-protein kinase that is involved in regulating metabolism, inhibiting apoptosis, and stimulating cell proliferation, growth and angiogenesis. Ligands including growth factors, cytokines, hormones and mitogens activate AKT signaling via PI3K (phosphatidylinositol 3-kinase). AKT1, AKT2 and AKT3 are three closely related isoforms of AKT. AKT1 plays a role in cell survival pathways by inhibiting apoptosis. Defects in AKT1 are associated with an increased incidence of breast cancer, colorectal cancer and ovarian cancer and are a cause of Proteus syndrome. AKT2 is involved with the insulin receptor signaling pathway. Defects in AKT2 are linked to an increased risk of breast cancer, metastasis of tumor cells, non-insulin-dependent diabetes mellitus (NIDDM), and hypoinsulinemic hypoglycemia with hemihypertrophy (HIHGHH). While the role of AKT3 is unclear, it is found primarily in brain and is a key modulator of tumors, such as melanoma, glioma and ovarian cancer. The aggressiveness of several types of solid tumors and hematologic malignancies is linked to the deregulation of AKT and its upstream signaling partners. Members of the AKT pathway are therefore potential targets for novel anti-cancer therapeutics.

Explore the PI3K/AKT Signaling Interactive Pathway
Explore the PI3K/AKT Signaling Interactive Pathway

AKT1 Antibodies

Product #

Description

Form

Gene Symbol (ID)

Species Reactivity

Application

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SAB4500797 Anti-AKT antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
mouse, rat, human
ELISA (i), WB
SAB4500799 Anti-AKT antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
rat, mouse, human
IHC, WB
SAB4500800 Anti-AKT antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
rat, human, mouse
IHC, WB
SAB4500802 Anti-AKT antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
rat, human, mouse
IHC, WB
SAB3500216 Anti-Akt1 antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
human, mouse, rat
ELISA (i), IF, IHC, IP, WB
HPA002891 Anti-AKT1 antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
human
IF, IHC
AV06008 Anti-AKT1 antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
human, mouse, goat, sheep, canine, bovine, rat, pig
WB
SAB4500007 Anti-AKT1 antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
mouse, human, rat
IHC, WB
WH0000207M3 Monoclonal Anti-AKT1 antibody produced in mouse purified immunoglobulin
human ... AKT1(207)
human, rat, mouse
ELISA (i), IF, IHC (p), WB
SAB1400005 Monoclonal Anti-AKT1 antibody produced in mouse purified immunoglobulin
human ... AKT1(207)
human
ELISA (i), IHC (p), WB
SAB1400006 Monoclonal Anti-AKT1 antibody produced in mouse purified immunoglobulin
human ... AKT1(207)
human
ELISA (i), IHC (p), WB
SAB1400007 Monoclonal Anti-AKT1 antibody produced in mouse purified immunoglobulin
human ... AKT1(207)
human
ELISA (i), IHC (p), WB
SAB1400008 Monoclonal Anti-AKT1 antibody produced in mouse purified immunoglobulin
human ... AKT1(207)
human
ELISA (i), IHC (p), WB
GW22757 Anti-AKT1 (ab1) antibody produced in chicken affinity isolated antibody
human ... AKT1(207)
mouse, human, rat
WB
GW22775 Anti-AKT1 (ab2) antibody produced in chicken affinity isolated antibody
human ... AKT1(207)
human, rat, mouse
ELISA (i), WB
SAB4300335 Anti-AKT1 (Ab-308) antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
human, mouse, rat
IHC (p), WB
SAB4300575 Anti-AKT1 (Ab-450) antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
rat, mouse, human
IF, IHC (p), WB
SAB4300334 Anti-AKT1 (Ab-473) antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
mouse, human
IHC (p), WB
SAB4300574 Anti-AKT1/AKT2/AKT3 (Ab-315/316/312) antibody produced in rabbit affinity isolated antibody
human ... AKT1(207), AKT2(208), AKT3(10000)
human, rat, mouse
IHC (p)
SAB1403538 Monoclonal Anti-AKT1, (C-terminal) antibody produced in mouse purified immunoglobulin
human ... AKT1(207)
human
ELISA (c), ELISA (i), WB
SAB4500796 Anti-AKT, C-Terminal antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
mouse, human, rat
IHC, WB
SAB4500798 Anti-AKT, C-Terminal antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
mouse, rat, human
ELISA (i), IHC
SAB4500004 Anti-AKT, C-Terminal antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
mouse, human, rat
IHC, WB
SAB4500801 Anti-AKT, N-Terminal antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
mouse, human, rat
IHC, WB
SAB4300259 Anti-phospho-AKT1/AKT2/AKT3 (pTyr315/pTyr316/pTyr312) antibody produced in rabbit affinity isolated antibody
human ... AKT1(207), AKT2(208), AKT3(10000)
mouse, rat, human
IF, IHC (p), WB
SAB4300042 Anti-phospho-AKT1 (pSer473) antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
rat, mouse, human
IHC (p), WB
SAB4300043 Anti-phospho-AKT1 (pThr308) antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
human, rat, mouse
IF, IHC (p), WB
SAB4300260 Anti-phospho-AKT1 (pThr450) antibody produced in rabbit affinity isolated antibody
human ... AKT1(207)
human, rat, mouse
IF, IHC (p), WB
P4112 Anti-phospho-PKB (pSer473) antibody produced in rabbit IgG fraction of antiserum
human ... AKT1(207)
mouse ... Akt1(11651)
rat ... Akt1(24185)
rat, mouse
ARR, WB
P3862 Anti-phospho-PKB (pThr308) antibody produced in rabbit IgG fraction of antiserum
human ... AKT1(207)
mouse ... Akt1(11651)
rat ... Akt1(24185)
mouse, rat
ARR, WB
P1601 Anti-Protein Kinase Bα antibody produced in rabbit IgG fraction of antiserum
human ... AKT1(207)
mouse ... Akt1(11651)
rat ... Akt1(24185)
mouse, rat, bovine, human
ARR, WB
P2482 Monoclonal Anti-Protein Kinase Bα antibody produced in mouse ascites fluid
human ... AKT1(207)
mouse ... Akt1(11651)
rat ... Akt1(24185)
bovine, rat, mouse, human, chicken
ARR, ELISA (i), WB

AKT2 Antibodies

Product #

Description

Form

Gene Symbol (ID)

Species Reactivity

Application

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SAB4500803 Anti-AKT antibody produced in rabbit affinity isolated antibody
human ... AKT2(207)
mouse, human, rat
IHC, WB
GW22776 Anti-AKT2 antibody produced in chicken affinity isolated antibody
human ... AKT2(208)
human
ELISA (i), WB
WH0000208M1 Monoclonal Anti-AKT2 antibody produced in mouse purified immunoglobulin
human ... AKT2(208)
human
ELISA (i), IF, WB
A4732 Anti-AKT2 (121-135) antibody produced in rabbit IgG fraction of antiserum
human ... AKT2(208)
human
IF, WB
A4857 Anti-AKT2 (454-469) antibody produced in rabbit IgG fraction of antiserum
human ... AKT2(208)
human
IF, WB
SAB4300423 Anti-AKT2 (Ab-474) antibody produced in rabbit affinity isolated antibody
human ... AKT2(208)
human, mouse, rat
IHC (p), WB
SAB4500808 Anti-AKT2, C-Terminal antibody produced in rabbit affinity isolated antibody
human ... AKT2(208)
human, rat, mouse
IHC, WB
SAB2103239 Anti-AKT2 antibody produced in rabbit affinity isolated antibody
human ... AKT2(208)
rat, canine, bovine, pig, mouse, horse, human, zebrafish
WB
SAB2104347 Anti-AKT2, (N-terminal) antibody produced in rabbit affinity isolated antibody
human ... AKT2(208)
rat, horse, mouse, bovine, canine, human
WB
SAB4300102 Anti-phospho-AKT2 (pSer474) antibody produced in rabbit affinity isolated antibody
human ... AKT2(208)
rat, human, mouse
IHC (p), WB

AKT3 Antibodies

Product #

Description

Form

Gene Symbol (ID)

Species Reactivity

Application

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GW22777 Anti-AKT3 antibody produced in chicken affinity isolated antibody
human ... AKT3(10000)
human, mouse, rat
ELISA (i), WB
SAB2500056 Anti-AKT3 antibody produced in goat affinity isolated antibody
human ... AKT3(10000)
mouse, rat, human
ELISA (i), WB
HPA026441 Anti-AKT3 antibody produced in rabbit affinity isolated antibody
human ... AKT3(10000)
human
IHC
WH0010000M2 Monoclonal Anti-AKT3 antibody produced in mouse purified immunoglobulin
human ... AKT3(10000)
mouse
ELISA (c), ELISA (i), IF, WB
SAB4100001 Monoclonal Anti-AKT3 antibody produced in mouse culture supernatant
human ... AKT3(10000)
human
WB
SAB1404769 Monoclonal Anti-AKT3 antibody produced in mouse purified immunoglobulin
human ... AKT3(10000)
human, mouse, rat
ELISA (c), ELISA (i), WB
A4982 Anti-AKT3 (119-135) antibody produced in rabbit IgG fraction of antiserum
human ... AKT3(10000)
human
WB
A5107 Anti-AKT3 (401-415) antibody produced in rabbit IgG fraction of antiserum
human ... AKT3(10000)
human
WB