Antibodies to Mouse Leukocytes

Signal transduction by the T-cell antigen receptor (TCR) is initiated by a rapid and transient phosphorylation of tyrosine residues within conserved motifs (ITAMs) in the cytoplasmic tails of the CD3 subunits. These immunoreceptor tyrosine-based activation motifs (ITAMs) possess two repeats of the conserved sequence Tyr-X-X-Leu/lle spaced by 6-8 residues (where X is any amino acid). The phosphorylated ITAMs are critical for TCR signaling because they serve as temporary binding sites for cytoplasmic signaling effector molecules operating downstream of the activated receptor. The TCR-CD3 multimeric complex is composed of TCRalpha beta, CD3gamma epsilon, CD3delta epsilon and zeta zeta dimers. The CD3gamma, CD3delta and CD3epsilon, each contain one ITAM, whereas the zeta chain contains three ITAMs. Amongst the TCR subunits, the CD3zeta chain plays a key role in regulating TCR assembly, transport, and cell surface expression. Down-regulation of TCRzeta chain expression associated with T cell dysfunction was described in various pathologies.

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Species Reactivity

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C3104 Anti-CD30 antibody produced in goat polyclonal
affinity isolated antibody
mouse ... Tnfrsf8(21941)
mouse
ELISA (i), WB
SAB4200330 Anti-phospho-CD3ζ (pTyr72) antibody produced in rabbit polyclonal
IgG fraction of antiserum
mouse ... Cd247(12503)
mouse
IP, WB
SAB4200331 Anti-phospho-CD3ζ (pTyr83) antibody produced in rabbit polyclonal
affinity isolated antibody
mouse ... Cd247(12503)
mouse
IP, WB
SAB4200332 Anti-phospho-CD3ζ (pTyr111) antibody produced in rabbit polyclonal
affinity isolated antibody
mouse ... CD247(12503)
mouse
IP, WB
SAB4200333 Anti-phospho-CD3ζ (pTyr123) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CD247(919)
mouse ... Cd247(12503)
mouse
IP, WB
SAB4200334 Anti-phospho-CD3ζ (pTyr142) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CD247(919)
mouse ... Cd247(12503)
mouse
IP, WB
SAB4200335 Anti-phospho-CD3ζ (pTyr153) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CD247(919)
mouse ... Cd247(12503)
mouse
IP, WB
Q4962 Monoclonal Anti-Qa-1b antibody produced in mouse 6A8.6F10.1A6, monoclonal
purified immunoglobulin
mouse ... H2-T23(15040)
mouse
ELISA (i), FACS, WB
M7898 Monoclonal Anti-Thy 1.1 antibody produced in mouse TN-26, monoclonal
purified immunoglobulin
mouse ... Thy1(21838)
mouse
complement-mediated cytotoxicity assay, IF