Antibodies to Lipids in Cell Signaling

PTEN is a tumor suppressor gene that is able to dephosphorylate phosphatidylinositol 3,4,5-triphosphate (PI-3,4,5-P3), the product of PIK. Many of the mutations that have arisen in cancerous cells have been mapped to the phosphatase catalytic domain of the protein. Data suggests that the phosphatase activity of PTEN is essential for its function as a tumor suppressor. The activation of Akt/PKB is regulated by the phosphorylation of Akt on Thr308 and Ser473 by phosphoinositide-dependent kinase (PDK) and integrin-linked kinase (ILK), respectively. Inactivation of PTEN allows constitutive and unregulated activation of the Akt/PKB signaling pathway. In addition to regulating the Akt/PKB signaling pathway, PTEN also inhibits growth factor (GF)-induced Shc phosphorylation and suppresses the MAP kinase signaling pathway. PTEN interacts directly with FAK and is able to dephosphorylate activated FAK. PTEN-induced down-regulation of p130CAS through FAK results in inhibition of cell migration and spreading.

References:
Simpson, L., and Parsons, R., PTEN: life as a tumor suppressor. Exp. Cell Res., 264, 29-41 (2001).
Besson, A., et al., PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. Eur. J. Biochem., 263, 605-611 (1999).
See also Cell Signaling & Neuroscience → Lipids in Cell Signaling and Lipids.

Product #

Description

Clone

Form

Gene Symbol (ID)

Species Reactivity

Application

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SAB2500025 Anti-Acylglycerol kinase antibody produced in goat polyclonal
affinity isolated antibody
human ... AGK(55750)
human, mouse
ELISA (i), WB
SAB4200452 Monoclonal Anti-ADFP / PLIN2 antibody produced in mouse ADFP-5, monoclonal
purified immunoglobulin
human ... PLIN2(123)
human
IF, WB
HPA020959 Anti-AGK antibody produced in rabbit polyclonal
affinity isolated antibody
human ... AGK(55750)
human
IHC
A3732 Anti-AGK (96-110) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... AGK(55750)
human
IF, WB
A3857 Anti-AGK (241-254) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... AGK(55750)
human
IF, WB
SAB4200458 Anti-ApoD (C-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... APOD(347)
human
IF, IHC, WB
SAB4200459 Anti-ApoD (N-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... APOD(347)
human
IF, WB
A3481 Anti-ApoER2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... LRP8(7804)
human
WB
SAB2500096 Anti-Arachidonate 5-lipoxygenase antibody produced in goat polyclonal
affinity isolated antibody
human ... ALOX5(240)
canine, rat, human, mouse
ELISA (i), WB
AV09019 Anti-CAV1 antibody produced in rabbit polyclonal
purified antibody
human ... CAV1(857)
mouse, horse, pig, rat, canine, human, bovine, rabbit, sheep
IHC, WB
SAB2900063 Anti-CAV1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CAV1(857)
human
IHC (p)
SAB2100344 Anti-CAV1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CAV1(857)
mouse, horse, human, sheep, rat, rabbit
WB
SAB2900061 Anti-CAV1 (AB1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CAV1(857)
mouse, dog, rat, monkey, sheep, bovine, pig, human, guinea pig, rabbit, horse
IHC (p)
SAB2900062 Anti-CAV1 (AB2) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CAV1(857)
human
IHC (p)
SAB2100345 Anti-CAV2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CAV2(858)
bovine, pig, rat, horse, guinea pig, sheep, rabbit, mouse, human
WB
SAB2500204 Anti-Caveolin 1 antibody produced in goat polyclonal
affinity isolated antibody
human ... CAV1(857)
human
ELISA (i), WB
C4490 Anti-Caveolin-1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)
mouse, human, rat
IF, WB
C3237 Anti-Caveolin-1 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)
mouse, human, rat
ARR, IF, WB
C9992 Anti-Caveolin-2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CAV2(858)
mouse ... Cav2(12390)
rat ... Cav2(363425)
canine, rat, human (predicted), pig (predicted), mouse
IF, WB
SAB4200216 Monoclonal Anti-Caveolin-1 antibody produced in mouse CAV1, monoclonal
tissue culture supernatant
human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)
human, mouse, rat
IF, IHC, WB
C1608 Monoclonal Anti-Cellular Retinoic Acid Binding Protein 1 antibody produced in mouse C-1, monoclonal
ascites fluid
human ... CRABP1(1381)
rat ... Crabp1(25061)
chicken, monkey, bovine, human, feline, rat, rabbit, turtle
ELISA (i), WB
C8104 Monoclonal Anti-Ceramide antibody produced in mouse MID 15B4, monoclonal
purified immunoglobulin
    ELISA (i), IHC (f)
C9354 Monoclonal Anti-COX II antibody produced in mouse AS66, monoclonal
purified immunoglobulin
human ... PTGS2(5743)
human
ARR, ELISA (i), FACS, WB
C9229 Monoclonal Anti-COX I antibody produced in mouse AS70, monoclonal
purified immunoglobulin
human ... PTGS1(5742)
human
ELISA (i), WB
HPA002834 Anti-COX1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PTGS1(5742)
human
IF, IHC
SAB2500266 Anti-COX1/PTGS1 antibody produced in goat polyclonal
affinity isolated antibody
human ... PTGS1(5742)
human, mouse
ELISA (i), IHC, WB
HPA001335 Anti-COX2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PTGS2(5743)
human
IF, IHC
SAB2500267 Anti-COX2/PTGS2 antibody produced in goat polyclonal
affinity isolated antibody
human ... PTGS2(5743)
pig, sheep, human, bovine, canine
ELISA (i), WB
HPA017203 Anti-CRABP1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CRABP1(1381)
human
IHC
HPA010546 Anti-CYSLTR1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CYSLTR1(10800)
human
IHC
C3491 Anti-Cysteinyl Leukotriene Receptor 1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... CYSLTR1(10800)
mouse ... Cysltr1(58861)
rat ... Cysltr1(114099)
human
IHC (p)
WH0001901M1 Monoclonal Anti-EDG1 antibody produced in mouse 2E12, monoclonal
purified immunoglobulin
human ... S1PR1(1901)
human
ELISA (i), WB
AV42662 Anti-EDG8 (AB1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... EDG8(53637)
pig, canine, human, rat, mouse
IHC, WB
AV42661 Anti-EDG8 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... EDG8(53637)
canine, pig, human, rat, zebrafish, mouse
IHC, WB
SAB2500356 Anti-EP4 Prostaglandin Receptor antibody produced in goat polyclonal
affinity isolated antibody
human ... PTGER4(5734)
canine, human
ELISA (i), WB
HPA006461 Anti-FASN antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FASN(2194)
human
IF, IHC
WH0002194M1 Monoclonal Anti-FASN antibody produced in mouse 3F2-1F3, monoclonal
purified immunoglobulin
human ... FASN(2194)
human
ELISA (i), IF, IHC (p), WB
F9554 Anti-Fatty Acid Synthase antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FASN(2194)
mouse ... Fasn(14104)
rat ... Fasn(50671)
human (predicted), mouse, rat
WB
F9679 Anti-Fatty Acid Synthase (C-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FASN(2194)
mouse ... Fasn(14104)
rat ... Fasn(50671)
rat, mouse, human
WB
HPA001393 Anti-FLOT1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FLOT1(10211)
mouse, rat, human
IHC
HPA001396 Anti-FLOT2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FLOT2(2319)
human, mouse, rat
IHC
SAB2500404 Anti-Flotillin 1 antibody produced in goat polyclonal
affinity isolated antibody
human ... FLOT1(10211)
human, bovine, pig, canine
ELISA (i), IHC, WB
F1180 Anti-Flotillin 1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FLOT1(10211)
mouse ... Flot1(14251)
rat ... Flot1(64665)
human, rat, mouse
IF, WB
F1805 Anti-Flotillin 2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FLOT2(2319)
mouse ... Flot2(14252)
rat ... Flot2(83764)
rat, human, mouse
IF, WB
F8931 Anti-Flotillin 1-CY3 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FLOT1(10211)
mouse ... Flot1(14251)
rat ... Flot1(64665)
rat, mouse, human
IF (d)
SAB2500405 Anti-Flotillin 2/FLOT2, C-Terminal antibody produced in goat polyclonal
affinity isolated antibody
human ... FLOT2(2319)
bovine, human, canine
ELISA (i), WB
F1680 Anti-Flotillin 2 (C-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... FLOT2(2319)
mouse ... Flot2(14252)
rat ... Flot2(83764)
human
IF, WB
G9152 Anti-Galactocerebroside antibody produced in rabbit polyclonal
whole antiserum
human ... GALC(2581)
human
DB
SAB2100885 Anti-GALC antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GALC(2581)
horse, rabbit, mouse, human, rat, canine, bovine, guinea pig
WB
SAB4200528 Anti-HMGCR antibody produced in rabbit polyclonal
affinity isolated antibody
human ... HMGCR(3156)
human
IF, WB
SAB4200529 Anti-HMGCR (internal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... HMGCR(3156)
human, rat, mouse
WB
SAB2101186 Anti-ITPK1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... ITPK1(3705)
mouse, guinea pig, rabbit, human, bovine, pig, rat, horse, zebrafish,
WB
WH0003705M1 Monoclonal Anti-ITPK1 antibody produced in mouse 2C8, monoclonal
purified immunoglobulin
human ... ITPK1(3705)
human
ELISA (i), WB
P1791 Anti-6-Ketoprostaglandin F antibody produced in rabbit polyclonal
whole antiserum
    RIA
L8270 Monoclonal Anti-Leukotriene (C4, D4, E4) antibody produced in rat 6E7, monoclonal
tissue culture supernatant
    RIA
L6917 Anti-Leukotriene B4 Receptor BLT1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... LTB4R(1241)
mouse ... Ltb4r1(16995)
rat ... Ltb4r(59264)
human, rat (predicted), mouse (predicted)
IHC (p)
L7042 Anti-Leukotriene B4 Receptor BLT2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... LTB4R2(56413)
mouse ... Ltb4r2(57260)
rat ... Ltb4r2(114098)
rat (predicted), human, mouse (predicted)
IHC (p)
GERPN224 Leukotriene C4/D4/E4, Biotrak EIA System          
L2790 Anti-Lipid Phosphate Phosphatase 2 (LPP2) antibody produced in rabbit polyclonal
fractionated antiserum
human ... PPAP2C(8612)
human
WB
L1168 Anti-phospho-5-Lipoxygenase (pSer523) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... ALOX5(240)
rat ... Alox5(25290)
human, rat
IF, IHC (p), IP, WB
SAB1401121 Monoclonal Anti-LPAR1 antibody produced in mouse 2E2, monoclonal
purified immunoglobulin
human ... LPAR1(1902)
human
ELISA (c)
HPA019616 Anti-LPAR2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... LPAR2(9170)
human
IHC
E5017 Anti-LPA1, C-Terminal antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... LPAR1(1902)
rat ... Lpar1(116744)
human, rat
WB
WH0007804M1 Monoclonal Anti-LRP8 antibody produced in mouse 3H2, monoclonal
purified immunoglobulin
human ... LRP8(7804)
human
ELISA (i), WB
HPA029680 Anti-LTB4R2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... LTB4R2(56413)
human
IHC
P5868 Anti-PC-Specific PLD1, Internal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PLD1(5337)
human
IP, WB
P5743 Anti-PC-Specific PLD1, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PLD1(5337)
human
IP, WB
SAB4200211 Anti-Phospholipase A2 (cPLA2) (N-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PLA2G4A(5321)
human
IP, WB
SAB4200129 Anti-Phospholipase A2 (iPLA2) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PLA2G6(8398)
mouse ... pla2g6(53357)
rat ... pla2g6(360426)
human, mouse, rat
WB
P5242 Monoclonal Anti-Phospholipase A2, Secretory Group V antibody produced in mouse MCL-3G1, monoclonal
purified immunoglobulin
human ... PLA2G5(5322)
human
ARR, WB
K3141 Anti-PIK3C3 (841-853) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... PIK3C3(5289)
human
WB
HPA017168 Anti-PIP5K1C antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PIP5K1C(23396)
human
IHC
WH0023396M10 Monoclonal Anti-PIP5K1C antibody produced in mouse 7D11, monoclonal
purified immunoglobulin
human ... PIP5K1C(23396)
human
ELISA (i), WB
K1894 Anti-PIP5K1C (C-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PIP5K1C(23396)
mouse ... Pip5k1(18717)
rat ... Pip5k1c(314641)
rat, mouse, human
IP, WB
K2019 Anti-PIP5K1C (N-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PIP5K1C(23396)
mouse ... Pip5k1c(18717)
rat ... Pip5k1c(314641)
human, mouse, rat
IP, WB
WH0200576M1 Monoclonal Anti-PIP5K3 antibody produced in mouse 6C7, monoclonal
purified immunoglobulin
human ... PIP5K3(200576)
human
ELISA (i), IF, IHC (p), WB
P0054 Anti-PIP5K3 (N-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PIP5K3(200576)
mouse ... Pip5k3(18711)
rat ... Pip5k3(316457)
human
WB
WH0005335M1 Monoclonal Anti-PLCG1 antibody produced in mouse 2A2, monoclonal
purified immunoglobulin
human ... PLCG1(5335)
human
ELISA (i), IF, WB
WH0005337M1 Monoclonal Anti-PLD1 antibody produced in mouse 2F3, monoclonal
purified immunoglobulin
human ... PLD1(5337)
human
ELISA (i), WB
HPA028892 Anti-PPAP2B antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PPAP2B(8613)
human
IHC
P5164 Anti-Prostaglandin E2 antibody produced in rabbit polyclonal
whole antiserum
    RIA
P8497 Anti-EP4 Prostanoid Receptor antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PTGER4(5734)
rat ... Ptger4(84023)
human
IHC (p)
P8622 Anti-FP Prostanoid Receptor antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PTGFR(5737)
mouse ... Ptgfr(19220)
rat ... Ptgfr(25652)
human
IHC (p)
P7482 Anti-PTEN antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... PTEN(5728)
mouse ... Pten(19211)
rat ... Pten(50557)
human, rat
ARR, WB
WH0005728M1 Monoclonal Anti-PTEN antibody produced in mouse 2G9, monoclonal
purified immunoglobulin
human ... PTEN(5728)
human
ELISA (i), WB
P3487 Monoclonal Anti-PTEN antibody produced in mouse PTN-18, monoclonal
purified immunoglobulin
human ... PTEN(5728)
mouse ... Pten(19211)
rat ... Pten(50557)
rat, human, mouse
ARR, ELISA (i), ICC, WB
HPA011226 Anti-PTGER4 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PTGER4(5734)
human
IHC
HPA012756 Anti-PTGER4 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PTGER4(5734)
human, mouse
IHC
AV41836 Anti-PTGS1 (AB1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PTGS1(5742)
mouse, horse, sheep, guinea pig, rat, canine, pig, human, rabbit, bovine, zebrafish, rabbit
WB
AV41835 Anti-PTGS1 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... PTGS1(5742)
canine, guinea pig, bovine, human, pig, mouse, horse, rat
IHC, WB
PRS4809 Anti-S1P1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... S1PR1(1901)
rat, mouse, human
ELISA (i), IHC, WB
HPA029683 Anti-S1PR5 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... S1PR5(53637)
human
IHC
E7403 Anti-S1P1, C-Terminal antibody produced in rabbit polyclonal
fractionated antiserum
human ... S1PR1(1901)
human
WB
E7278 Anti-S1P2, C-Terminal antibody produced in rabbit polyclonal
fractionated antiserum
human ... S1PR2(9294)
human
WB
E7653 Anti-S1P4, C-Terminal antibody produced in rabbit polyclonal
fractionated antiserum
human ... S1PR4(8698)
human
WB
E7528 Anti-S1P5, C-Terminal antibody produced in rabbit polyclonal
fractionated antiserum
human ... S1PR5(53637)
human
WB
E4767 Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse AS65, monoclonal
purified immunoglobulin
human ... S1PR2(9294)
rat ... S1pr2(29415)
human, rat
WB
E4141 Monoclonal Anti-S1P3, C-Terminal antibody produced in mouse AS61, monoclonal
purified immunoglobulin
human ... S1PR3(1903)
rat ... Edg3l(29736)
rat, human
WB
E9529 Monoclonal Anti-S1P4, C-Terminal antibody produced in mouse 1, monoclonal
purified immunoglobulin
human ... S1PR4(8698)
human
FACS, WB
S1186 Anti-SHIP (SH2-containing inositol phosphatase) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... INPP5D(3635)
mouse ... Inpp5d(16331)
mouse, human
IP, WB
P7291 Anti-Thromboxane B2 antibody produced in rabbit polyclonal
whole antiserum
human ... PTGS1(5742)
human
RIA
SAB1400627 Anti-VAC14 antibody produced in mouse polyclonal
IgG fraction of antiserum
human ... VAC14(55697)
human
ELISA (c), IF, WB
HPA027766 Anti-VAC14 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... VAC14(55697)
human
IHC
SAB4200074 Anti-VAC14 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... VAC14(55697)
human
IF, IP, WB
SAB1401760 Monoclonal Anti-VAC14 antibody produced in mouse 3B2, monoclonal
purified immunoglobulin
human ... VAC14(55697)
human
ELISA (c), WB
SAB4200075 Anti-VAC14 (C-terminal) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... VAC14(55697)
rat ... Vac14(307842)
mouse, rat, human
IF, IP, WB
V9764 Anti-VPS34 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... PIK3C3(5289)
mouse ... Pik3c3(225326)
rat ... Pik3c3(65052)
human, rat, mouse
IF, WB