Antibodies to Matrix Metalloproteinases and TIMPs

A number of different proteases play important roles in degrading and remodeling the extracellular matrix (ECM). The major type of proteases involved in these processes are tissue serine proteases (e.g., thrombin, plasmin, uPA and tPA), adamalysin-related proteases (ADAMs), and matrix metalloproteinases (MMPs). MMPs have been studied extensively and are thought to be involved in physiological processes, such as wound healing, ovulation, blastocyst implantation, bone growth and angiogenesis. They can have a pathological role in a variety of disease processes, such as tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and atherosclerosis. The MMPs are secreted, proteolytic enzymes that belong to a family of at least 18 members. They have a conserved structure composed of an Nterminal propeptide domain and a catalytic domain. In addition, other structural features, such as fibronectin-like repeats, transmembrane domains, furin cleavage sites, and Cterminal homopexin-like domains, allow them to be classified into subfamilies (collagenase, gelatinase, stromolysin and membrane-type MMP). Since active MMPs can catalyze the degradation of all protein components of the ECM, their activities are under tight control. This control is achieved by transcriptional regulation, proenzyme activation and by action of tissue inhibitors of MMPs (TIMPs). Four TIMPs are currently known that are specific for different MMPs.
The MMP/Cytokine Connection
The matrix metalloproteinases (MMPs) are members of a unique family of at least 20 proteolytic enzymes that contain a zinc ion at their active sites and can degrade collagen, elastins, and other components of the extracellular matrix (ECM). Cytokine activation of cells can lead to increased processing of MMPs from inactive zymogens to the active enzymes. Cytokines and their receptors can also be substrates for MMP action. Many of the membrane-bound cytokines, receptors, and adhesion molecules can be released from the cell surface by the action of a subset of metalloproteinases called convertases or adamalysins. This may be one mechanism for down-regulation of cell surface receptors.

Product #

Description

Clone

Form

Gene Symbol (ID)

Species Reactivity

Application

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HPA014572 Anti-BMP1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... BMP1(649)
human
IHC
B4808 Anti-Bone Morphogenetic Protein 1, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... BMP1(649)
human
WB, WB CL
M4696 Anti-Matrix Metalloproteinase-1 antibody produced in goat polyclonal
affinity isolated antibody
human ... MMP1(4312)
human
ICC, IHC (p), WB
M4065 Anti-Matrix Metalloproteinase-2 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP2(4313)
rat, bovine, human, mouse
IHC (p), WB
M9570 Anti-Matrix Metalloproteinase-9 antibody produced in goat polyclonal
affinity isolated antibody
mouse ... Mmp9(17395)
mouse
IHC, IP, WB
M6559 Anti-Matrix Metalloproteinase-24, Cytoplasmic antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP24(10893)
mouse ... Mmp24(17391)
mouse, human
ELISA (i), FACS, IHC (f), IP, WB
M4442 Anti-Matrix Metalloproteinase-15, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP15(4324)
human
ELISA (i), FACS, IHC, IP, WB
M5059 Anti-Matrix Metalloproteinase-18 Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
Xenopus laevis ... mmp21-A(378572)
Xenopus
ELISA (i), IHC (f), IP, WB
M5434 Anti-Matrix Metalloproteinase-19, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP19(4327)
human
ELISA (i), IHC (f), IP, WB
M8692 Anti-Matrix Metalloproteinase-21, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP21(118856)
mouse ... Ighg(380794)
mouse, human, rat, Xenopus
WB
M4066 Anti-Matrix Metalloproteinase-22, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP23B(8510)
human
WB
M6309 Anti-Matrix Metalloproteinase-23, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP14(4323)
human
ELISA (i), IHC (f), IP, WB
M6684 Anti-Matrix Metalloproteinase-24, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP24(10893)
mouse ... Mmp24(17391)
human, mouse
ELISA (i), FACS, IHC, IP, WB
M4817 Anti-Matrix Metalloproteinase-25, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP25(64386)
mouse ... Mmp25(240047)
human, mouse
WB
M5442 Anti-Matrix Metalloproteinase-26, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP26(56547)
human
WB
M4941 Anti-Matrix Metalloproteinase-27, Hinge Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP27(64066)
human
WB
M6053 Anti-Matrix Metalloproteinase-3, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP3(4314)
human
WB
M8430 Anti-Matrix Metalloproteinase-8, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP8(4317)
human
WB, WB CL
M6057 Anti-Matrix Metalloproteinase-12, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP12(4321)
human
WB
M5684 Anti-Matrix Metalloproteinase-19, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP19(4327)
human
ELISA (i), IHC (f), IP, WB
M8817 Anti-Matrix Metalloproteinase-21, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP21(118856)
human
WB
M3941 Anti-Matrix Metalloproteinase-22, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP23B(8510)
human
WB
M6934 Anti-Matrix Metalloproteinase-24, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP24(10893)
mouse ... Mmp24(17391)
mouse, human
ELISA (i), FACS, IHC (f), IP, WB
M5067 Anti-Matrix Metalloproteinase-25, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP25(64386)
mouse ... Mmp25(240047)
mouse, human
WB
M5192 Anti-Matrix Metalloproteinase-26, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP26(56547)
human
WB
M3816 Anti-Matrix Metalloproteinase-27, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP27(64066)
human
WB
M5191 Anti-Matrix Metalloproteinase-28, Propeptide Region antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP28(79148)
human
WB
M5177 Anti-Matrix Metalloproteinase-9, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP9(4318)
human
WB
M0806 Anti-Matrix Metalloproteinase-11, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP11(4320)
human
ELISA (i), IHC, IP, WB
M0807 Anti-Matrix Metalloproteinase-12, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP12(4321)
human
ELISA (i), IHC (f), IP, WB
M5808 Anti-Matrix Metalloproteinase-14, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP14(4323)
human
ELISA (i), IHC (p), WB
M4934 Anti-Matrix Metalloproteinase-18, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
Xenopus laevis ... mmp21-A(378572)
Xenopus
ELISA (i), IHC (f), IP, WB
M5184 Anti-Matrix Metalloproteinase-18, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
Xenopus laevis ... mmp21-A(378572)
Xenopus
ELISA (i), IHC (f), IP, WB
M5559 Anti-Matrix Metalloproteinase-19, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP19(4327)
human
ELISA (i), IHC (f), IP, WB
M8442 Anti-Matrix Metalloproteinase-21, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP21(118856)
mouse ... Mmp21(214766)
rat ... Mmp13(171052)
mouse, human, rat, Xenopus
WB
M8567 Anti-Matrix Metalloproteinase-21, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP21(118856)
human
WB
M4191 Anti-Matrix Metalloproteinase-22, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP23B(8510)
human
WB
M4316 Anti-Matrix Metalloproteinase-22, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP23B(8510)
human
WB
M6184 Anti-Matrix Metalloproteinase-23, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP23B(8510)
human
ELISA (i), IHC (f), IP, WB
M6809 Anti-Matrix Metalloproteinase-24, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP24(10893)
mouse ... Mmp24(17391)
mouse, human
ELISA (i), FACS, IHC (f), IP, WB
M4692 Anti-Matrix Metalloproteinase-25, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP25(64386)
mouse ... Mmp25(240047)
mouse, human
WB
M4816 Anti-Matrix Metalloproteinase-27, C-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP27(64066)
human
WB
M4441 Anti-Matrix Metalloproteinase-27, N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP27(64066)
human
WB
M4942 Anti-Matrix Metalloproteinase-25, N-Terminal Active antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP25(64386)
mouse ... Mmp25(240047)
mouse, human
WB
M5317 Anti-Matrix Metalloproteinase-26, N-Terminal Active antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP26(56547)
human
WB
M8683 Anti-Matrix Metalloproteinase-7, N-Terminal of Catalytic Zinc Site antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP7(4316)
human
ELISA (i), IHC, IP, WB
HPA001939 Anti-MMP2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP2(4313)
human
IHC
HPA007875 Anti-MMP3 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP3(4314)
human
IHC
HPA001238 Anti-MMP9 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP9(4318)
human
IF, IHC
GW21122 Anti-MMP11 antibody produced in chicken polyclonal
affinity isolated antibody
human ... MMP11(4320)
human, rat, mouse
WB
SAB1300333 Anti-MMP11 (C-term) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP11(4320)
mouse, human
ELISA (i), WB
GW22689B Anti-MMP12 antibody produced in chicken polyclonal
affinity isolated antibody
human ... MMP12(4321)
human
WB
GW21124 Anti-MMP13 antibody produced in chicken polyclonal
affinity isolated antibody
human ... MMP13(4322)
human
WB
WH0004322M7 Monoclonal Anti-MMP13 antibody produced in mouse 3B11, monoclonal
purified immunoglobulin
human ... MMP13(4322)
human
ELISA (i), WB
GW21125 Anti-MMP14 antibody produced in chicken polyclonal
affinity isolated antibody
human ... MMP14(4323)
rat, human
WB
GW21128 Anti-MMP16 antibody produced in chicken polyclonal
affinity isolated antibody
human ... MMP16(4325)
human
WB
HPA023693 Anti-MMP16 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP16(4325)
human
IHC
HPA012845 Anti-MMP19 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP19(4327)
mouse, human, rat
IHC (p), WB
AV32314 Anti-MMP19 (AB1) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP19(4327)
rat, horse, rabbit, canine, bovine, mouse, human
IHC, WB
AV32315 Anti-MMP19 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP19(4327)
human, canine, bovine, mouse, rabbit, rat, guinea pig, horse
IHC, WB
AV42039 Anti-MMP1 (AB1) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP1(4312)
horse, human
IHC, WB
AV42040 Anti-MMP1 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP1(4312)
human, bovine, pig, rabbit, rabbit, horse
WB
AV20016 Anti-MMP2 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP2(4313)
human, canine, mouse, horse, rabbit, bovine, rat, guinea pig, sheep
WB
SAB2101490 Anti-MMP20 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP20(9313)
rabbit, human, pig, rat, bovine, mouse, canine, horse
WB
AV46808 Anti-MMP23B antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP23B(8510)
canine, mouse, rat, pig, bovine, human, guinea pig, horse
WB
WH0008510M1 Monoclonal Anti-MMP23B antibody produced in mouse 200, monoclonal
purified immunoglobulin
human ... MMP23B(8510)
human
ELISA (i)
SAB2101491 Anti-MMP24 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP24(10893)
guinea pig, horse, zebrafish, rat, mouse, rabbit, human, rabbit
WB
SAB1300747 Anti-MMP25 (C-term) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP25(64386)
human, mouse
ELISA (i), WB
GW21139 Anti-MMP26 antibody produced in chicken polyclonal
affinity isolated antibody
human ... MMP26(56547)
human
WB
WH0056547M1 Monoclonal Anti-MMP26 antibody produced in mouse 6C6, monoclonal
purified immunoglobulin
human ... MMP26(56547)
human
ELISA (i), WB
SAB1300748 Anti-MMP26 (N-term) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP26(56547)
human
ELISA (i), WB
WH0079148M1 Monoclonal Anti-MMP28 antibody produced in mouse 3C11, monoclonal
purified immunoglobulin
human ... MMP28(79148)
human
ELISA (i), WB
SAB2500637 Anti-MMP7 antibody produced in goat polyclonal
affinity isolated antibody
human ... MMP7(4316)
human
ELISA (i), IHC, WB
AV46075 Anti-MMP7 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP7(4316)
guinea pig, bovine, human, rabbit, horse, sheep
WB
HPA021221 Anti-MMP8 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP8(4317)
human
IHC
HPA022935 Anti-MMP8 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... MMP8(4317)
human
IHC
AV33090 Anti-MMP9 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... MMP9(4318)
canine, rabbit, bovine, human, mouse, zebrafish, rat, guinea pig, sheep, pig, horse
IHC
WH0007076M1 Monoclonal Anti-TIMP1 antibody produced in mouse 4D12, monoclonal
purified immunoglobulin
human ... TIMP1(7076)
human
ELISA (i)
WH0007077M1 Monoclonal Anti-TIMP2 antibody produced in mouse 5D7, monoclonal
purified immunoglobulin
human ... TIMP2(7077)
human
ELISA (i), IF, IHC (p), WB
T8322 Anti-Tissue Inhibitor of Metalloproteinase-1, First Loop antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TIMP1(7076)
human
ELISA (i), IHC (f), IP, WB, WB CL
T8062 Anti-Tissue Inhibitor of Metalloproteinase-2, First Loop antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TIMP2(7077)
human
WB
T8072 Anti-Tissue Inhibitor of Metalloproteinase-2, Second Loop antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TIMP2(7077)
human
WB, WB CL
T7687 Anti-Tissue Inhibitor of Metalloproteinase-3, First Loop antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TIMP3(7078)
human
WB
T8537 Anti-Tissue Inhibitor of Metalloproteinase-4, First Loop antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TIMP4(7079)
human
WB
T0913 Anti-Tissue Inhibitor of Metalloproteinase-4, Second Loop antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TIMP4(7079)
human
WB
T9289 Anti-Tissue Inhibitor of Metalloproteinase-4, Third Loop antibody produced in rabbit polyclonal
affinity isolated antibody
human ... TIMP4(7079)
human
WB