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Phosphoserine, Phosphothreonine, and Phosphotyrosine Antibodies

Phospho Antibodies

Protein phosphorylation constitutes a key post-translational modification involved in regulation of cell signaling pathways governing a diversity of cellular processes. Events surrounding phosphorylation or proteins serve as critical steps directing normal cell processes such as cell cycle progression, development and differentiation, migration, apoptosis and so on. Aberrant phosphorylation shows association with multiple diseases including neurodegenerative disease, chronic inflammatory diseases such as atherosclerosis and arthritis, and various cancers. Intensive research has focused on signaling pathways relating to cancer, where phosphorylation in the context of tumor suppression, oncogene expression, metastases, and other hallmarks of cancer plays a key role in development and progression of the disease.

Common protein targets for phosphorylation include enzymes, structural proteins, cell receptors, and other signaling proteins including activators of transcription factors to regulate gene expression. Dynamic modulation of phosphorylation state occurs via kinases, which phosphorylate serine, threonine or tyrosine residues, and phosphatases, including dual specificity phosphatases such as PTEN. The use of phospho antibodies has been critical in elucidating the role of phosphorylation events in producing complex biological effects. Sigma Life Science offers a diverse and extensive selection of phospho antibodies to meet your research needs.