Antibodies to GABA and Glycine Receptors

Gamma-aminobutyric acid (GABA) is an amino acid which commonly acts as an inhibitory neurotransmitter in the central nervous system. Ionotropic GABA receptors increase intracellular chloride ions, which hyperpolarize the neuron and inhibit nerve transmission. Important drugs acting on GABA receptors include barbiturates, benzodiazepines, steroids, and alcohol. Glycine is a small amino acid and also a major inhibitory neurotransmitter in the brainstem, spinal cord, and retina. In other parts of the CNS Glycine has excitatory functions. Like GABA, glycine increases chloride ion conductance to inhibit postsynaptic cells. Inhibitory glycine receptors are blocked by the plant alkaloid strychnine, which causes muscular contractions and tetany due to overexcitation at the neuromuscular junction. Other psychoactive drugs also target glycine receptors to increase or decrease CNS excitability. Sigma-Aldrich has monoclonal and polyclonal antibodies that target GABA and glycine receptors, with reactivity in human, rat, and other species. Forms include affinity isolated antibodies.

Product #

Description

Clone

Form

Gene Symbol (ID)

Species Reactivity

Application

Add to Cart

G4416 Anti-GABAA Receptor (α1 subunit) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)
rat, mouse, human (predicted), bovine (predicted), chicken (predicted)
IHC, WB
G4291 Anti-GABAA Receptor (α3 subunit) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRA3(2556)
mouse ... Gabra3(14396)
rat ... Gabra3(24947)
rat
IHC, WB
G9169 Anti-GABAA Receptor (α4 subunit), C-Terminus antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabra4(140675)
rat
WB
G0170 Anti-GABAA Receptor (α4 subunit), N-Terminus antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabra4(140675)
rat
IP, WB
G9294 Anti-GABAA Receptor (α5 subunit), Cytosolic Loop antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabra5(29707)
rat
IP, WB
G5544 Anti-GABAA Receptor (α6 subunit) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRA6(2559)
mouse ... Gabra6(14399)
rat ... Gabra6(29708)
rat
WB
G0295 Anti-GABAA Receptor (α6 subunit), Cytosolic Loop antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabra6(29708)
rat
WB
G9419 Anti-GABAA Receptor (β1 subunit), Cytosolic Loop antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabrb1(25450)
rat
WB
G9544 Anti-GABAA Receptor (β2 subunit), Cytosolic Loop antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabrb2(25451)
rat
IP, WB
G9669 Anti-GABAA Receptor (β3 subunit), Cytosolic Loop antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabrb3(24922)
rat
WB
G0545 Anti-GABAA Receptor (γ2 subunit) (extracellular) antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRG2(2566)
mouse ... Gabrg2(14406)
rat ... Gabrg2(29709)
mouse, human, rat, bovine
WB
G9919 Anti-GABAA Receptor (γ2 subunit), Cytosolic Loop antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabrg2(29709)
rat
DB, WB
G9794 Anti-GABAA Receptor (δ subunit), N-Terminal antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Gabrd(29689)
rat
WB
G0157 Anti-GABA Transporter GAT-1 antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Slc6a12(50676)
rat
IHC
G7657 Anti-GABA Transporter GAT-2 antibody produced in rabbit polyclonal
affinity isolated antibody
rat ... Slc6a13(171163)
rat
IHC
AV34976 Anti-GABRA1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRA1(2554)
mouse, canine, bovine, human, rat, rabbit
WB
SAB2100876 Anti-GABRA1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRA1(2554)
, mouse, horse, human, rat, rabbit, guinea pig, bovine, canine, zebrafish
WB
HPA014261 Anti-GABRA2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRA2(2555)
human
IHC (p), WB
AV13026 Anti-GABRA2 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... GABRA2(2555)
canine, rat, horse, mouse, rabbit, bovine, human
WB
HPA000839 Anti-GABRA3 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRA3(2556)
human, mouse
IHC
AV34981 Anti-GABRA3 (AB1) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... GABRA3(2556)
horse, bovine, human, mouse, rabbit, rat, guinea pig, canine
WB
AV13027 Anti-GABRA3 (AB2) antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... GABRA3(2556)
horse, guinea pig, rabbit, rat, canine, bovine, mouse
WB
AV35574 Anti-GABRG2 antibody produced in rabbit polyclonal
IgG fraction of antiserum
human ... GABRG2(2566)
mouse, rabbit, zebrafish, bovine, canine, guinea pig, human, rat, horse
WB
SAB2100881 Anti-GABRG2 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GABRG2(2566)
rabbit, bovine, human, rat, mouse, canine, horse
WB
HPA016502 Anti-GLRA1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GLRA1(2741)
human
IHC
AV13003 Anti-GLRA1 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GLRA1(2741)
bovine, guinea pig, horse, human, mouse, canine, zebrafish, rat, rabbit
WB
WH0002741M1 Monoclonal Anti-GLRA1 antibody produced in mouse 2E6, monoclonal
purified immunoglobulin
human ... GLRA1(2741)
human
ELISA (i), WB
G0666 Anti-Glycine Receptor antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GLRA1(2741), GLRA2(2742)
rat ... Ptk2(25674)
human, rat
IP, WB
G0420 Anti-Glycine Receptor α3 antibody produced in rabbit polyclonal
affinity isolated antibody
human ... GLRA3(8001)
mouse ... Glra3(110304)
rat ... Glra2(24397)
rat, mouse, human
WB