Apoptosis-related protein in TGF-b signaling pathway (ARTS) is a novel mitochondrial protein that mediates apoptosis induced by a variety of pro-apoptotic stimuli. Originally found to be essential for apoptosis induced by transforming growth factor-b (TGF-b) . 1, 2 ARTS was later shown to be a key apoptotic protein mediating apoptosis initiated by other inducers. The protein is derived form the human septin H5/PNUTL2/CSCrel-2b gene. It contains a phosphate-binding ({-loop) death domain, which is conserved in all septins and in many different classes of ATP/GRPases. Unlike other septins, ARTS is localized to mitochondria and translocates to the nucleus, coincident with apoptotic signals induced by TGF-b.2 In addition, mutation of GKS to ENP (amino acids 137-139) in the P-loop impairs the ability of ARTS to enter the nucleus and abolishes its ability to induce apoptosis.1, 2 While the N-terminus of arts is homologous with hCDrel2b, the C-terminus contains a unique amino acid sequence that is not contained in either hrel2b or H5. ARTS induces apoptosis in response to TGF-b, while hCDCrel2b and H5 do not, suggesting the C-terminus of ARTS is necessary for its pro-apoptotic function.
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| Product Table |
| Product Name |
Host |
Clone |
Product Code |
| Monoclonal Anti-ARTS |
Mouse |
ARTS51 |
A 4471 |
| Anti-ARTS |
Rabbit |
|
A 3720 |
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References
- Larisch-Block, S., et al., Cell Growth Differ., 11, 1-10 (2000)
- Larisch, S., et al., Nature Cell Biol., 2, 915-921 (2000)
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