LOPAC®1280 – The Library of Pharmacologically Active Compounds

The power and performance of the bioactive small molecules in Sigma Life Science’s Library of Pharmacologically Active Compounds (LOPAC1280) is assured. This biologically annotated collection of inhibitors, receptor ligands, pharma-developed tools, and approved drugs impacts impacts most signaling pathways and covers all major drug target classes.

Please click below to request a complete list of compounds or an SD file.


 

Features Include:
  • 1,280 pharmacologically active compounds

  • Marketed drugs and pharmaceutically relevant structures annotated with biological activities

  • Pre-solubilized and normalized compounds to guide repurposing applications:
    Ready-to-use DMSO stocks require less time-consuming sample preparation

  • Guaranteed Sigma quality and easy re-supply:
    Highly pure compounds, each available as an individual catalog item

 

Pharmacologically Active Compounds

All major target classes are represented, including GPCRs and kinases, making LOPAC the most flexible target characterization and assay validation library available.

 

GPCRs:

 

Gene Regulation:

     

Kinases:

 

Neurotransmission:

 

Marketed Drugs & Pharmaceutically Relevant Structures

Predictable activities and proven scaffolds directed against a wide range of drug targets to guide repurposing applications.

 

Approved Drugs:

 

Pharma-developed Tools:

     

For more information on LOPAC products, please visit the product detail pages:

LOPAC®1280
Format: 250µL at 10mM in DMSO
Cat. No. LO1280 (LO3300 outside the U.S.)

 

LOPAC®1280 – Small Scale
Format: 25µL at 10mM in DMSO
Cat. No. LO4100 (LO4200 outside the U.S.)

 

LOPAC®Pfizer

In addition to the LOPAC1280 collection, a library of 90 high quality, Pfizer-developed and Sigma-validated compounds are available as LOPACPfizer. LOPACPfizer contains more than 25 marketed drugs, including sildenafil (PZ0003), celecoxib (PZ0008) and sunitinib (PZ0012), as well as more than 60 highly characterized literature compounds. LOPACPfizer can be used to complement LOPAC1280 or as a standalone library.

LOPAC®Pfizer
90 Pfizer commercial drugs and literature compounds
Format: 250µL at 10mM in DMSO
Cat. No. LO5100