Carcinogens

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295035 1,3-Butadiene ≥99% Environmental carcinogen. Induces cardiac hemangiosarcomas in mice.
    • A4626 1-Acetyl-2-phenylhydrazine ≥98% Vascular tumor initiator in experimental animal model.
    • N22959 1-Nitropyrene 99% Potent mutagen, carcinogen, environmental pollutant.
    • 158240 1-Nitrosopyrrolidine 99% Induces hepatocellular carcinomas and lung adenomas in mice. Forms DNA adducts that primarily result in A:T to G:C mutations.
    • N8381 2-Naphthylamine powder Environmental carcinogen; induces bladder cancer.
    • D9886 3,3′-Dichlorobenzidine dihydrochloride Industrial carcinogen that induces liver and bladder tumors in laboratory animals.
    • 213942 3-Methylcholanthrene 98% Carcinogen used to induce transformation of cultured cells; used to induce fibrosarcomas and skin carcinomas in laboratory animals.
    • D3254 7,12-Dimethylbenz[a]anthracene ≥95% The oxidation of DMBA by P450 enzymes produces metabolites that form covalent adducts with DNA and the formation within DNA of depurinated abasic sites. It is most commonly used to induce skin or mammary tumors in animals, though it also can induce leukemias and tumors at other sites.
    • E1260 L-Ethionine ≥99% (TLC) An analog of methionine that interferes with the normal methylation of DNA and other methylation pathways, and induces pancreatic toxicity and liver cancer. However, in animal studies, it has also been shown to act synergistically with methionine-depletion to block the growth and metastasis of methionine-dependent tumors.
    • A6636 Aflatoxin B1 from Aspergillus flavus from Aspergillus flavus Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR).
    • A9887 Aflatoxin B2 Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus.
    • A0138 Aflatoxin G1 from Aspergillus flavus Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus.
    • A0263 Aflatoxin G2 Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus.
    • A6428 Aflatoxin M1 from Aspergillus flavus Hepatocarcinogen.
    • A5512 Aristolochic acid I powder Potent phospholipase A2 inhibitor, including calcium ionophore-induced phospholipase A2 activity in neutrophils. Kidney tumor initiator in experimental animal model.1
    • A1010 Arsenic(III) oxide ReagentPlus®, ≥99.0% Very potent agent against acute promyelocytic leukemia (APL). Causes skin, lung and bladder cancer.
    • A5486 Azoxymethane 13.4 M, ≥98% Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.
    • 270709 Benzene CHROMASOLV® Plus, for HPLC, ≥99.9% Environmental carcinogen; hematoxin that is linked to increased incidence of leukemia in humans.
    • B1760 Benzo[a]pyrene ≥96% (HPLC)  
    • C3141 Cadmium chloride hemi(pentahydrate) ≥98% (titration) Carcinogen that acts by inhibiting DNA mismatch repair. Environmental pollutant.
    • D4628 Diethylstilbestrol ≥99% (HPLC) Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.
    • F1635 Formaldehyde solution contains 10-15% methanol as stabilizer, 37 wt. % in H2O Induces tumors in the nasal epithelium of rats, and is suspected to be a human carcinogen. Potent mutagen.
    • H9003 Hydroquinone ReagentPlus®, ≥99%  
    • A7015 N-(2-Fluorenyl)acetamide ≥90% (TLC) A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.
    • N8509 N-Nitroso-N-ethylurea Bulk package DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.
    • N3385 N-Nitroso-N-ethylurea ISOPAC® DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.
    • N4766 N-Nitroso-N-methylurea Bulk package DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.
    • N1517 N-Nitroso-N-methylurea ISOPAC® DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.
    • N0258 N-Nitrosodiethylamine ISOPAC® Carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
    • N0756 N-Nitrosodiethylamine liquid Carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
    • A6631 Potassium arsenate monobasic  
    • P2870 Pristane synthetic, ≥98% (GC) A hydrocarbon oil adjuvant widely used to induce tumorgenesis in mice and arthritis and lupus nephritis in rats.
    • S9652 Safrole ≥97% Safrole is a naturally-occurring genotoxic compound found in Sassafras root and Areca (betel) quid. It is a hepatocarcinogen, and safrole-DNA adducts have also been seen in oral cancers of Areca users. Metabolites of safrole form adducts with DNA and induce chromasomal aberrations and sister chromatid exchanges.