Sigma-Aldrich
Decrease Font Size Increase Font Size Email this page to a friend Printer Friendly Page
Product Catalog >  Cancer Research >  Carcinogens

Carcinogens



Add to Cart
2950351,3-Butadiene ≥99% Environmental carcinogen. Induces cardiac hemangiosarcomas in mice.
pricing
A46261-Acetyl-2-phenylhydrazine ≥98% Vascular tumor initiator in experimental animal model.
pricing
1299411-Methyl-3-nitro-1-nitrosoguanidine 97% Environmental mutagen and carcinogen; used to induce gastric cancer in mice.
pricing
N229591-Nitropyrene 99% Potent mutagen, carcinogen, environmental pollutant.
pricing
N60071-Nitrosopiperidine Carcinogen that induces benign and malignant tumors of the respiratory tract, stomach and esophagus in rodents; potent nasal carcinogen in rats.
pricing
1582401-Nitrosopyrrolidine 99% Induces hepatocellular carcinomas and lung adenomas in mice. Forms DNA adducts that primarily result in A:T to G:C mutations.
pricing
N83812-Naphthylamine powder Environmental carcinogen; induces bladder cancer.
pricing
D98863,3′-Dichlorobenzidine dihydrochloride Industrial carcinogen that induces liver and bladder tumors in laboratory animals.
pricing
2139423-Methylcholanthrene 98% Carcinogen used to induce transformation of cultured cells; used to induce fibrosarcomas and skin carcinomas in laboratory animals.
pricing
4565276-Nitrochrysene 95% pricing
D32547,12-Dimethylbenz[a]anthracene ≥95% The oxidation of DMBA by P450 enzymes produces metabolites that form covalent adducts with DNA and the formation within DNA of depurinated abasic sites. It is most commonly used to induce skin or mammary tumors in animals, though it also can induce leukemias and tumors at other sites.
pricing
E1260L-Ethionine ≥99% (TLC) An analog of methionine that interferes with the normal methylation of DNA and other methylation pathways, and induces pancreatic toxicity and liver cancer. However, in animal studies, it has also been shown to act synergistically with methionine-depletion to block the growth and metastasis of methionine-dependent tumors.
pricing
A6636Aflatoxin B1 from Aspergillus flavus from Aspergillus flavus Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus. Aflatoxin is biotransformed to genotoxic intermediates by P450 Phase I enzymes, mainly CYP3A4 via aflatoxin B1 3-hydroxylation. Detoxification depends on Phase II enzymes, such as Glutathione S-Transferase and AFB(1)-aldehyde reductase (AFAR).
pricing
A9887Aflatoxin B2 Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus.
pricing
A0138Aflatoxin G1 from Aspergillus flavus Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus.
pricing
A0263Aflatoxin G2 Hepatocarcinogen. Food contaminant produced by Aspergillus flavus, a common soil fungus.
pricing
A6428Aflatoxin M1 from Aspergillus flavus Hepatocarcinogen.
pricing
A5512Aristolochic acid I, powder Potent phospholipase A2 inhibitor, including calcium ionophore-induced phospholipase A2 activity in neutrophils. Kidney tumor initiator in experimental animal model.1
pricing
A1010Arsenic(III) oxide ReagentPlus®, ≥99.0% Very potent agent against acute promyelocytic leukemia (APL). Causes skin, lung and bladder cancer.
pricing
A2853Azoxymethane Practical grade, 13.4 M, ≥90% (GC) Carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.
pricing
270709Benzene CHROMASOLV® Plus, for HPLC, ≥99.9% Environmental carcinogen; hematoxin that is linked to increased incidence of leukemia in humans.
pricing
B1760Benzo[a]pyrene ≥96% (HPLC) A polycyclic aromatic hydrocarbon (PAH), environmental pollutant and carcinogen. Used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it's oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.
pricing
C3141Cadmium chloride hemi(pentahydrate) ≥98% (titration) Carcinogen that acts by inhibiting DNA mismatch repair. Environmental pollutant.
pricing
D4628Diethylstilbestrol ≥99% (HPLC) Synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.
pricing
F1635Formaldehyde solution 37 wt. % in H2O Induces tumors in the nasal epithelium of rats, and is suspected to be a human carcinogen. Potent mutagen.
pricing
H9003Hydroquinone ReagentPlus®, ≥99% pricing
A7015N-(2-Fluorenyl)acetamide ≥90% (TLC) A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.
pricing
N8509N-Nitroso-N-ethylurea Bulk package DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.
pricing
N3385N-Nitroso-N-ethylurea ISOPAC® DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.
pricing
N4766N-Nitroso-N-methylurea Bulk package DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.
pricing
N1517N-Nitroso-N-methylurea ISOPAC® DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.
pricing
N0258N-Nitrosodiethylamine ISOPAC® Carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
pricing
N0756N-Nitrosodiethylamine liquid Carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
pricing
N3632N-Nitrosodimethylamine ISOPAC® Induces gastric, liver, kidney and lung cancer in mice and rats.
pricing
A6631Potassium arsenate monobasic pricing
P2870Pristane synthetic, ≥98% (GC) A hydrocarbon oil adjuvant widely used to induce tumorgenesis in mice and arthritis and lupus nephritis in rats.
pricing
S9652Safrole ≥97% Safrole is a naturally-occurring genotoxic compound found in Sassafras root and Areca (betel) quid. It is a hepatocarcinogen, and safrole-DNA adducts have also been seen in oral cancers of Areca users. Metabolites of safrole form adducts with DNA and induce chromasomal aberrations and sister chromatid exchanges.
pricing
T7500Tetrachloroethylene ReagentPlus®, 99% Animal carcinogen that produces increased incidence of renal adenomas, adenocarcinomas, mononuclear cell leukemia, and hepatocellular tumors.
pricing