G-Protein Coupled Receptors (GPCR)

GPCRs are transmembrane receptor proteins that interact with ligands outside the cell, transmitting signals across the membrane and resulting in intracellular signaling and activity. G-Protein coupled receptors contain 7 transmembrane helices, and are activated by ligands that bind to the GPCR causing a conformational change. This alteration exchanges GDP (guanosine diphosphate) for GTP (Guanosine-5′-triphosphate) and activates the associated G-protein. GPCRs are only found in eukaryotes, and are the targets of over one-third of today’s drugs because of their cell signaling role in vision (photoreceptors), smell (olfactory receptors), mood and behavior regulation, the immune system, inflammation, the nervous system and many other biological processes. Sigma offers several GPCR membrane suspensions you can choose from for your research.

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A6728 β1-Adrenergic Receptor preparation human
A6853 α2A-Adrenergic Receptor preparation membrane suspension
B0184 Bacteriorhodopsin from Halobacterium salinarum native sequence, lyophilized powder
BM0033 BMS-665053 ≥98% (HPLC)
BM0031 BMS-763534 ≥98% (HPLC)
BM0034 BMS-764459 ≥98% (HPLC)
BM0026 BMS-986034 ≥98% (HPLC)
E7155 Endothelin A Receptor preparation human membrane suspension
E0160 Estrogen Receptor human membrane suspension
N4036 Neuropeptide Y Subtype 2 Receptor human membrane suspension
R9907 Progesterone Receptor human membrane suspension
S1943 Serotonin Transporter Receptor membrane suspension