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E3132 E-64 protease inhibitor E-64 is an irreversible, potent, and highly selective cysteine protease inhibitor. E-64 does not react with the functional thiol group of non-protease enzymes, such as L-lactate dehydrogenase or creatine kinase. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain. The trans-epoxysuccinyl group (active moiety) of E-64 irreversibly binds to an active thiol group in many cysteine proteases, such as papain, actinidase, and cathepsins B, H, and L to form a thioether linkage. E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition, it is permeable in cells and tissues and has low toxicity.
  
    • 45370 E-64 ≥99.0% (TLC) E-64 is an irreversible, potent, and highly selective cysteine protease inhibitor. E-64 does not react with the functional thiol group of non-protease enzymes, such as L-lactate dehydrogenase or creatine kinase. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain. The trans-epoxysuccinyl group (active moiety) of E-64 irreversibly binds to an active thiol group in many cysteine proteases, such as papain, actinidase, and cathepsins B, H, and L to form a thioether linkage. E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition, it is permeable in cells and tissues and has low toxicity.
    		  
    • E0514 E-64c Calpain Inhibitor Cysteine protease inhibitor; membrane-impermeable calpain inhibitor. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.1
    		 human ... CAPN1(823)
    • E8640 E-64d protease inhibitor   human ... CAPN1(823)
    • SML0197 4E1RCat ≥97% (HPLC) 4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc.
    		  
    • M5060 E-4031 ≥98% (HPLC), solid E-4031 selectively blocks hERG K+ channels.
    		  
    • SML0206 EAA-090 ≥98% (HPLC) EAA-090 is a potent NMDA receptor antagonist with neuroprotective properties. In isoflurane-anesthetized dogs, EAA-090 reduces the minimum alveolar concentration (MAC) of isoflurane and increases systolic, mean, and diastolic arterial blood pressure.
    		  
    • E8405 EB-47 ≥98% (HPLC), solid Potent inhibitor of poly (ADP-ribose) polymerase (PARP).
    		  
    • E9531 Ebastine ≥98% (HPLC), solid Ebastine is a non-sedating histamine H1 receptor antagonist, which inhibits allergen-induced bronchospasm in conscious guinea pigs. Unlike other compounds in this category, ebastine does not prolong the QT interval at up to five times the recommended therapeutic dose.
    		  
    • E0886 Ebelactone B microbial ≥95% (HPLC) Esterase (lipase) inhibitor. Also inhibits carboxypeptidase Y-like kininase that degrades bradykinin.1
    		  
    • SML0034 1-EBIO ≥98% (HPLC) 1-EBIO is an activator of epithelial Ca2+-activated K+ channel also known as the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) or KCa3.1.
    		  
    • PZ0140 EBPC ≥98% (HPLC) EBPC is an aldose reductase inhibitor; anti-cancer.
    		  
    • E3520 Ebselen cysteine modifier An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol.1 Inhibits oxidation of low density lipoproteins (LDL).
    		  
    • E0399 Edetate disodium meets USP testing specifications    
    • E3263 Efaroxan hydrochloride ≥98% (HPLC) (+)-Isomer is a selective α-adrenoceptor antagonist; (−)-isomer is an imidazoline ligand that induces insulin secretion, mediated by the blockade of ATP-sensitive potassium channels in pancreatic β cells; I1 imidazoline binding site antagonist.
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
    • E114 EHNA hydrochloride ≥98% (HPLC) Adenosine deaminase inhibitor.
    		 human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
    • E1657 EHT 1864 ≥99% (HPLC), white solid EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.
    		  
    • E2011 cis-5,8,11,14,17-Eicosapentaenoic acid ≥99% 5-Lipoxygenase inhibitor; reduces thromboxane A2 production.
    		 human ... ALOX5(240)
    mouse ... ALOX5(11689), Pparg(19016)
    rat ... ALOX5(25290)
    • E7006 cis-5,8,11,14,17-Eicosapentaenoic acid ≥85%, liquid 5-Lipoxygenase inhibitor; reduces thromboxane A2 production.
    		 mouse ... Pparg(19016)
    • 44864 cis-5,8,11,14,17-Eicosapentaenoic acid analytical standard 5-Lipoxygenase inhibitor; reduces thromboxane A2 production.
    		 mouse ... Pparg(19016)
    • E6627   cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt ≥99% (capillary GC) 5-Lipoxygenase inhibitor; reduces thromboxane A2 production.
    		 human ... ALOX5(240)
    mouse ... ALOX5(11689)
    rat ... ALOX5(25290)
    • E1768 5,8,11,14-Eicosatetraynoic acid ≥97% Cyclooxygenase and lipoxygenase inhibitor.
    		 human ... ALOX15(246)
    • E3285 EIINFEKL trifluoroacetate salt ≥95% (HPLC) EIINFEKL is an antagonist variant of SIINFEKL [OVA (257-264)] [it induces positive selection T-cells].
    		  
    • E4637 Elaidic acid ≥99.0% (GC)   human ... SOAT1(6646), SOAT2(8435)
    • 45089 Elaidic acid analytical standard   human ... SOAT1(6646), SOAT2(8435)
    • E0881 Elastatinal microbial Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.1
    		  
    • PZ0011 Eletriptan hydrobromide ≥98% (HPLC) Eletriptan hydrobromide is a serotonin 5-HT1B/1D receptor agonist; second generation anti-migraine drug.
    		  
    • E2031 Eliprodil ≥98% (HPLC), solid NR2B selective NMDA glutamate receptor antagonist which appears to target the "polyamine site" on the NMDA receptor, setting it apart from other NR2B receptor antagonists. Possesses neuroprotective effects in models of ischemia, but prolongs the QT interval in patients; currently under investigation for acute and chronic pain.
    		 human ... GRIN2B(2904)
    rat ... Adra1a(29412)
    • E2250 Ellagic acid ≥95% (HPLC), powder, from tree bark A naturally occurring plant phenol that is a potent antioxidant presumably by acting as a scavenger of oxygen species produced by hydrogen peroxide treatment, and as a protector of the DNA double helix from alkylating agent injury. It therefore has anti-mutagenic and anti-carcinogenic properties. Also reported to inhibit topoisomerases I and II and gyrase.
    Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase.1 Used for the assay of factor XIIa in plasma.2 Contact activation in blood coagulation.3
    		 human ... CSK(1445), DYRK1A(1859), GSK3B(2932), SRC(6714)
    rat ... Lyn(81515), Syk(25155)
    • SML0183 EM20-25 ≥98% (HPLC) EM20-25 is an analog of HA14-1 that antagonizes the effects of the anti-apoptotic protein BCL-2, and causes opening of the mitochondrial permeability transition pore. Unlike HA14-1, EM20-25 does not effect mitochondrial respiration.
    		  
    • E1406 Embelin ≥98% (HPLC), powder Embelin is an inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein); in vivo antitumor and anti-inflammatory activity.
    		 human ... XIAP(331)
    • SML0139 EMD386088 ≥98% (HPLC) EMD-386088 is a potent serotonin 5-HT6-specific agonist. The IC50 for competition of LSD from 5-HT6 expressed in HEK cells is 7.4 nM, and the EC50 for stimulating cAMP production is 1 nM. EMD-386088 is inactive against other HT receptors except 5-HT3 (IC50 = 34 nM).
    		  
    • E2375 Emetine dihydrochloride hydrate    
    • 219282 (+)-Emetine dihydrochloride hydrate 97%    
    • E7881 Emodin from Frangula bark, ≥90% (HPLC) Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.
    		 human ... CSNK2A1(1457), CSNK2B(1460), ELA2(1991), NFKB1(4790), NKAP(79576), NKRF(55922)
    • E6888 Enalapril maleate salt powder, ≥98% (TLC) A long-acting angiotensin-converting enzyme inhibitor.
    		  
    • E111   (S)-ENBA Selective A1 adenosine receptor agonist.
    		 human ... ADORA1(134)
    • E9156 Encainide hydrochloride ≥98% (HPLC), powder Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.
    		  
    • E3273 Endomorphin 1 Potent, selective endogenous μ opioid receptor agonist.
    		 human ... OPRM1(4988)
    mouse ... OPRM1(18390)
    rat ... OPRM1(25601)
    • E3148 Endomorphin 2 Potent, selective endogenous μ opioid receptor agonist.
    		 human ... OPRM1(4988)
    mouse ... OPRM1(18390)
    rat ... OPRM1(25601)
    • 32015 Endosulfan PESTANAL®, analytical standard   mouse ... Esr1(13982)
    rat ... Ar(24208)
    • E6877 [Ala1,3,11,15]-Endothelin 1 Selective agonist for ETB endothelin receptors.
    		 human ... EDNRB(1910)
    mouse ... EDNRB(13618)
    rat ... EDNRB(50672)
    • E7131 [D-Ala2, D-Leu5]-Enkephalin acetate salt ≥95% (HPLC) Prototypical δ-agonist; more potent and selective than Leu-enkephalin and Met-enkephalin; antinociceptive potency equivalent to that of β-endorphin
    		 human ... OPRD1(4985)
    mouse ... OPRD1(18386)
    rat ... OPRD1(24613)
    • E7384 [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt ≥97% (HPLC) Enkephalin analog that is a selective agonist at μ-opioid receptors.
    		 human ... OPRM1(4988)
    mouse ... OPRM1(18390)
    rat ... OPRM1(25601)
    • E1279 Enoximone solid Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.
    		 human ... PDE3A(5139), PDE3B(5140)
    • E3389 Epiamastatin hydrochloride ≥97% (HPLC) Epimer of amastatin at the 2-position. There are no reports of aminopeptidase inhibition by this epimer; on the contrary, there are suggestions that a 2S-hydroxyl group is important for the stability of an initial collision complex with the enzyme.
    		  
    • E1145 (±)-Epibatidine dihydrochloride hydrate ≥98% (HPLC), powder The activity of epibatidine at neuronal and neuromuscular nicotinic acetylcholine receptors was compared with the activity of nicotine and suxamethonium. Activation of ganglionic nicotinic receptors by epibatidine was shown in the guinea-pig ileum (contraction mediated by the cholinergic neurons of the ileum) and in pithed and atropinized rats (rise in blood pressure). Epibatidine also activated nicotinic receptors at the peripheral terminals of afferent C-fibres (rabbit ear) and in the brain (antidiuresis in rats). The agonistic effects of epibatidine were followed by long-lasting receptor desensitization. No antinociceptive effect of epibatidine was seen in rats at a dose free of motor impairment. On muscle end plate nicotinic receptors of the rat diaphragm (not responding to depolarizing agents by contraction), epibatidine was equipotent with suxamethonium in causing neuromuscular inhibition. On an extraocular muscle of the rabbit (responding to depolarizing agents by contraction) epibatidine in vitro and in situ caused a contraction at a 100-fold lower dose than suxamethonium. The Straub tail reaction in mice to epibatidine could be attributed to the sustained stimulation of motor end plate receptors of the "slow contracting" type of muscle fibres by epibatidine. Epibatidine was the most potent agonist on all neuronal and neuromuscular nicotinic receptors examined.
    		  
    • E152 Epiboxidine hydrochloride Potent nicotinic acetylcholine receptor agonist; analog of epibatidine
    		  
    • E1753 (−)-Epicatechin ≥90% (HPLC) Antioxidant
    		 human ... BACE1(23621), CYP1A2(1544)
    • 39263 (−)-Epicatechin purum, ≥95.0% (HPLC)   human ... BACE1(23621), CYP1A2(1544)
    • E4018 (−)-Epicatechin ≥98% (HPLC), from green tea Antioxidant found in chocolate.
    		 human ... BACE1(23621), CYP1A2(1544)
    • E3893 (−)-Epicatechin gallate ≥98% (HPLC), from green tea Antioxidant
    		 human ... CYP1A2(1544)
    • E3625 16-Epiestriol ~97% (HPLC) 16-Epiestriol is an estradiol metabolite that exhibits significant anti-inflammatory activity without glycogenic activity.
    		  
    • E3750 17-Epiestriol 17-epiestriol is an estradiol metabolite and a selective estrogen receptor (ER) beta agonist.
    		  
    • 08108 (−)-Epigallocatechin analytical standard Green tea polyphenol. Anticancer agent. Lower antioxidant activity than EGCG.
    		 human ... CYP1A2(1544)
    • E3768 (−)-Epigallocatechin ≥95% (HPLC), from green tea Antioxidant
    Green tea polyphenol. Anticancer agent. Lower antioxidant activity than EGCG.
    		 human ... CYP1A2(1544)
    • 50299 (−)-Epigallocatechin gallate purum, ≥97.0% (HPLC)   human ... CYP1A2(1544)
    • E4143 (−)-Epigallocatechin gallate ≥95%, from green tea Antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
    		 human ... CYP1A2(1544)
    • E4268 (−)-Epigallocatechin gallate ≥80% (HPLC), from green tea Catechins are a plant derived polyphenolic anti-oxidants with phytotoxic properties. Racemic catechin may be used in studies on seed germination and plant invasiveness. Catechin and Epigallocatechin gallate (EGCG) may be used with other polyphenol flavonoids to study their effects in oxidation and peroxidation-related processes.
    		 human ... CYP1A2(1544)
    • E5156 Epinastine hydrochloride ≥98% (HPLC), solid Epinastine hydrochloride is a non-sedating H1 histamine receptor antagonist.
    		  
    • SML0013 Epinecidine-1 trifluoroacetate salt ≥98% (HPLC) Epinecidin-1 is an antimicrobial peptide (AMP) with antitumor and antiviral activity, which was cloned from orange-spotted grouper (Epinephelus coioides). Apparently epinecidin-1 binds to microbial surface and next destroys microbial membrane. Epinecidin-1 was effective in protecting grouper larvae from nervous necrosis viral (NNV) disease.
    		 
    • E4250 (−)-Epinephrine Adrenoceptor agonist.
    		 rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176), Drd1a(24316), Drd2(24318)
    • 02252 (−)-Epinephrine USP Adrenoceptor agonist.
    		 rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176), Drd1a(24316), Drd2(24318)
    • E4375 (−)-Epinephrine (+)-bitartrate salt solid Adrenergic receptor agonist.
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
    • 02260 (−)-Epinephrine (+)-bitartrate salt ≥98.0% (sum of enantiomers, HPLC) Adrenergic receptor agonist.
    		  
    • E1635 (±)-Epinephrine ≥95% Adrenoceptor agonist.
    		 rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176)
    • E4642 (±)-Epinephrine hydrochloride Adrenergic receptor agonist.
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
    • E3656 (−)-Epothilone A from Sorangium cellulosum, >95% (HPLC), solid (-)-Epothilone A is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoA exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 20 nM for MDR CCRF-CEM/VBL100 cells). Epothilone A is a competitve inhibitor of 3H-paclitaxel binding with comparable IC50 to paclitaxel in displacement competition assays. EpoA causes cell cycle arrest at the G2/M transition leading to cytotoxicity.
    		  
    • E2656 (−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC), film (-)-Epothilone B is a microtubule (MT) stabilizing drug and natural macrolide antitumor from myxobacteria Sorangium cellulosum. EpoB has similar biological properties to EpoA. However, EpoB is 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells). (-)-Epothilone B is similar to paclitaxel in binding displacement, and a substitution for paclitaxel in dependent cell growth. EpoB causes cell cycle arrest (IC50 = 3.5 nM).
    		  
    • E5125 16α,17α-Epoxyprogesterone ~98%   human ... CYP17A1(1586)
    • E2535 Eprosartan mesylate ≥98% (HPLC) Angiotensin II type 1 (AT1) receptor antagonist; anti-hypertensive.
    		  
    • 45469 EPTC PESTANAL®, analytical standard   human ... EPHX2(2053)
    mouse ... Ephx2(13850)
    • 45405 (±)-Equol ≥99.0% (TLC) Metabolite of daidzein. Weak estrogenic agonist, and competitive inhibitor of 17β-estradiol at the estradiol receptor.1
    		 rat ... Ar(24208)
    • E0656 ER-27319 ≥98% (HPLC), solid ER-27319 inhibits Syk activation with an IC50 = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.1
    Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.
    		 
    • E7781 Erastin ≥98% (HPLC), powder Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.
    		 human ... hRas(3265)
    mouse ... hRas(15461)
    rat ... hRas(293621)
    • PZ0183 ERB-041 ≥98% (HPLC) ERB-041 is a potent, selective estrogen ERβ receptor agonist (IC50 ERβ: 5.4 nM; > 200-fold selective over ERα). ERβ plays a minor role in mediating estrogen action in the uterus, the hypothalamus/pituitary, the skeleton, and other classic estrogen target tissues. However, a clear role for ERβ has been established in the ovary, cardiovascular system, and brain as well as in animal models of inflammation including arthritis, endometriosis, inflammatory bowel disease, and sepsis. There is increasing interest in finding ERβ agonists for potential use in a variety of clinical applications without triggering classic estrogenic side effects.
    		  
    • E7521 L-(+)-Ergothioneine Antioxidant which protects against γ and UV radiation.
    		  
    • 09258 Erythrodiol analytical standard   mouse ... Nos2(18126)
    • E6376 Erythromycin potency: ≥850 μg per mg Mode of Action: Inhibits elongation at transpeptidation step.
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    Mode of Action: Inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    		 human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
    mouse ... Abcb1a(18671), Abcb1b(18669)
    • E5389 Erythromycin BioReagent, suitable for cell culture Inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).
    Mode of Action: Inhibits elongation at transpeptidation step.
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    		 human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
    mouse ... Abcb1a(18671), Abcb1b(18669)
    • 45674 Erythromycin Ph Eur Mode of Action: Inhibits elongation at transpeptidation step.
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    Mode of Action: Inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    		 human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
    mouse ... Abcb1a(18671), Abcb1b(18669)
    • E0774 Erythromycin meets USP testing specifications Mode of Action: Inhibits elongation at transpeptidation step (aminoacyl translocation A-site to P-site).
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    Mode of Action: Inhibits elongation at transpeptidation step.
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    		 human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
    mouse ... Abcb1a(18671), Abcb1b(18669)
    • E7904 Erythromycin Biotechnology Performance Certified Mode of Action: Inhibits elongation at transpeptidation step (aminoacyl translocation A-site to P-site).
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    Mode of Action: Inhibits elongation at transpeptidation step.
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    		 human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
    mouse ... Abcb1a(18671), Abcb1b(18669)
    • E5627   Erythropoietin human recombinant, expressed in CHO cells, lyophilized powder, cell culture tested, ~100,000 units/mg protein Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.
    		 human ... EPO(2056), EPOR(2057)
    • E8375 Eserine Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.
    		 human ... ACHE(43), APP(351), BCHE(590)
    mouse ... Ache(11423), Bche(12038), Chrm1(12669)
    rat ... Ache(83817), Bche(65036), Chrm2(81645)
    • 45710 Eserine ≥98.0% (N) Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.
    		 human ... ACHE(43), APP(351), BCHE(590)
    mouse ... Ache(11423), Bche(12038), Chrm1(12669)
    rat ... Ache(83817), Bche(65036), Chrm2(81645)
    • E8625 Eserine hemisulfate salt Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.
    		  
    • E100 (−)-Eseroline fumarate salt analytical standard, for drug analysis Metabolite of physostigmine (eserine) that is cytotoxic in several neuronal cell lines; it displays both anti-acetylcholinesterase and opiate agonist activities; potent analgesic.
    		 human ... ACHE(43)
    • E7906 Esomeprazole magnesium hydrate ≥98% (HPLC), powder Esomeprazole magnesium dihydrate is a leading proton pump inhibitor.
    		  
    • E3638 Estazolam Hypnotic; ligand for the GABAA receptor benzodiazepine modulatory site.
    		  
    • E1024 Estradiol meets USP testing specifications The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
    		 human ... ESR1(2099), ESR2(2100), ESRRB(2103), GPER(2852), SERPINA6(866)
    mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
    rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
    • E8750 α-Estradiol powder, ≥98% (TLC) Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
    		human ... ESR1(2099), ESR2(2100)
    rat ... Ar(24208)
    • E8875 β-Estradiol ≥98% The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
    		 human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
    mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
    rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
    • E2758 β-Estradiol BioReagent, powder, suitable for cell culture The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
    		 human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
    mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
    rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
    • E2257 β-Estradiol powder, γ-irradiated, BioXtra, suitable for cell culture The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
    		 human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
    mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
    rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
    • E1132 β-Estradiol analytical standard The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
    		 human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
    mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
    rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
    • E7879 β-Estradiol 17-acetate ≥99% β-Estradiol 17-acetate is a metabolite of estradiol.
    		  
    • E5630   β-Estradiol 6-(O-carboxy­methyl)oxime: BSA    
    • E6507   β-Estradiol 6-(O-carboxy­methyl)oxime: BSA fluorescein iso­thio­cyanate conjugate    
    • E8004 β-Estradiol 17-cypionate    
    • E1636 β-Estradiol 3,17-disulfate dipotassium salt ≥95% Among other effects, this conjugated estrogen selectively inhibits glutathione S-transferases.1
    		  
    • E2127 β-Estradiol 3-(β-D-glucuronide) sodium salt    
    • E1127 β-Estradiol 17-(β-D-glucuronide) sodium salt    
    • E2128 β-Estradiol 3-(β-D-glucuronide) 17-sulfate dipotassium salt    
    • E9252 β-Estradiol 17-hemisuccinate    
    • K1001 β-Estradiol-6-one    
    • K2126 β-Estradiol-6-one 6-(O-carboxymethyloxime)    
    • E9505 β-Estradiol 3-sulfate sodium salt ~95%    
    • E1631 β-Estradiol 17-valerate ≥98%    
    • E1253 Estriol ≥97% Estriol is a metabolite of 17β-estradiol with much lower biological activity. It is the primary estrogen found in the urine. Large quantities of estriol and estrone are produced by the placenta during pregnancy. These are also the primary estrogens produced by adipose tissue in men and in post-menopausal women.
    		 human ... SERPINA6(866)
    mouse ... Esr1(13982)
    rat ... Ar(24208)
    • E1149 Estriol meets USP testing specifications   human ... SERPINA6(866)
    mouse ... Esr1(13982)
    rat ... Ar(24208)
    • 46565 Estriol VETRANAL™, analytical standard   human ... SERPINA6(866)
    mouse ... Esr1(13982)
    rat ... Ar(24208)
    • E2002 Estriol 3-(β-D-glucuronide) sodium salt    
    • E1877 Estriol 16α-(β-D-glucuronide) ≥97%    
    • E5255 Estriol 16α-(β-D-glucuronide) sodium salt ≥95% (HPLC)    
    • E6375 Estriol 3-sulfate sodium salt    
    • E9750 Estrone ≥99% Estrone is a luteolytic estrogen produced by the corpus luteum.
    		 human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
    mouse ... Esr1(13982)
    rat ... Esr1(24890)
    • E1274 Estrone meets USP testing specifications   human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
    mouse ... Esr1(13982)
    rat ... Esr1(24890)
    • 46573 Estrone VETRANAL™, analytical standard   human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
    mouse ... Esr1(13982)
    rat ... Esr1(24890)
    • E1752 Estrone 3-(β-D-glucuronide) sodium salt    
    • E9875 Estrone 3-methyl ether ≥97% (HPLC)    
    • E9145 Estrone 3-sulfate potassium salt ≥98% The most abundant estrogen in adult human circulation. Conversion to estradiol requires steroid sulfatase activity. This activity was used to evaluate freshly resected bone fragments against cultured osteoblasts and osteosearcoma cells as models for studying human bone metabolism.1
    		  
    • E0251 Estrone 3-sulfate sodium salt contains ~35% Tris as stabilizer    
    • E1896 Etazolate hydrochloride solid Selective inhibitor of cAMP-specific phosphodiesterase.
    		 human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
    • E5277 Etbicyphat ≥95% (NMR), solid Blocker of neuronal voltage-dependent and GABA-gated chloride channels; non-competitive GABA antagonist; causes epileptiform seizures.
    		  
    • E7023 Ethanol 200 proof (absolute), for molecular biology Positive allosteric modulator of GABAA receptors, and negative allosteric modulator of NMDA glutamate receptors.
    		 human ... GABRA1(2554), GLRA1(2741), GLRA2(2742)
    • E3258 Ethinamate analytical standard, for drug analysis Urethane derivative with rapid onset and short duration of action.
    		 human ... CA1(759)
    • E1001 Ethisterone ≥99% (HPLC)    
    • E5406 Ethopropazine hydrochloride ≥98% (HPLC), powder Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.
    		  
    • E7138 Ethosuximide Used for the treatment of absence-type seizures
    		 human ... CACNA1G(8913)
    • 333328 6-Ethoxy-2-benzothiazolesulfonamide 97%   human ... CA1(759), CA2(760), CA5A(763), CA5B(11238), CA9(768)
    mouse ... Car5a(12352)
    • 46123 1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide suitable for fluorescence, ≥97.0% (TLC)    
    • SML0149 3-Ethoxy-5,6-dibromosalicylaldehyde ≥95% (HPLC) 3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1). It inhibits XBP-1 splicing induced pharmacologically in human cells. 3-Ethoxy-5,6-dibromosalicylaldehyde potently inhibits the endoribonuclease of IRE1 but does not inhibit RNases A, T1, or L.
    		  
    • 535524 5-(2-Ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-7-pyrimidinone 97%   human ... PDE5A(8654)
    • 159182 Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 97%   human ... ADORA1(134)
    • 244309 Ethyl β-carboline-3-carboxylate 97%   human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRG2(2566)
    rat ... Gabra2(29706)
    • E2387 5′-(N-Ethylcarboxamido)adenosine powder Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.
    		 human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
    rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)
    • E1904 Ethyl-3,4-dephostatin >99% (HPLC), solid Stable analog of dephostatin. Selective inhibitor of protein tyrosine phosphatase 1B and SHPTP-1. Does not inhibit CD45-associated phosphatases.
    		  
    • E1521 Ethylenediamine BioXtra   human ... FNTA(2339)
    • 03550 Ethylenediamine puriss. p.a., absolute, ≥99.5% (GC)   human ... FNTA(2339)
    • 41008 Ethylenediamine analytical standard    
    • 391085 Ethylenediamine purified by redistillation, ≥99.5%   human ... FNTA(2339)
    • E26266 Ethylenediamine ReagentPlus®, ≥99%   human ... FNTA(2339)
    • E1649 Ethylenediamine meets USP testing specifications   human ... FNTA(2339)
    • 15068 Ethylenediamine solution technical, 75-80%   human ... FNTA(2339)
    • 03690 Ethylenediaminetetraacetic acid solution BioUltra, for molecular biology, pH 8.0, ~0.5 M in H2O    
    • E6511 Ethylenediaminetetraacetic acid tetrasodium salt dihydrate BioReagent, suitable for cell culture, 99.0-102.0%    
    • E0396 Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid BioUltra, ≥97%    
    • E8145   Ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid tetrasodium salt ≥97%    
    • E3145 3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene ≥90%    
    • E2895 (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide ≥98% Activates intracellular guanylyl cyclase.
    		  
    • A3085 5-(N-Ethyl-N-isopropyl)amiloride Selective blocker of Na+/H+ antiport
    		 human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553)
    mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
    rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)
    • E3876 N-Ethylmaleimide crystalline, ≥98% (HPLC) Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
    Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
    		 human ... KCNQ2(3785), KCNQ4(9132), KCNQ5(56479), SLC6A3(6531), SLC6A4(6532)
    • E1271 N-Ethylmaleimide BioXtra, ≥98% (HPLC) Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
    Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
    		 human ... SLC6A3(6531), SLC6A4(6532)
    • 04259 N-Ethylmaleimide BioUltra, ≥99.0% (HPLC) Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
    Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
    		 human ... SLC6A3(6531), SLC6A4(6532)
    • 04260 N-Ethylmaleimide purum p.a., ≥99.0% (HPLC) Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
    Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.
    		 human ... SLC6A3(6531), SLC6A4(6532)
    • E8512 Ethylmorphine Narcotic analgesic; antitussive
    		  
    • E40005 2-Ethylnaphthalene ≥99%   human ... CYP1A2(1544)
    • 557560 Ethyl phenyl sulfone 97%   human ... LOC129293(129293)
    • E3020 (±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide ≥97%    
    • E4876 17α-Ethynylestradiol ≥98% 17α-Ethynylestradiol is an orally bio-active synthetic estrogen used as an oral contraceptive.
    		 rat ... Afp(24177), Esr1(24890), Shbg(24775)
    • 02463 17α-Ethynylestradiol ≥98.0% (HPLC)    
    • 46263 17α-Ethynylestradiol VETRANAL™, analytical standard   rat ... Afp(24177), Esr1(24890), Shbg(24775)
    • E101 S-(−)-Eticlopride hydrochloride ≥98% (HPLC), powder Potent and selective D2 dopamine receptor antagonist.
    		 human ... DRD2(1813)
    • P5248 Etidronate disodium hydrate ≥97% (NMR), solid Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
    		  
    • E5126 Etiocholan-3α-ol-17-one   human ... SERPINA6(866)
    rat ... Gabra1(29705), Gabra2(29706), Gabrg2(29709)
    • E0516 Etodolac Non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX-1 and COX-2.
    		 human ... PTGS1(5742), PTGS2(5743)
    • E6530 Etomidate >98% (HPLC), powder Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage
    		 human ... GABRA1(2554)
    • E1905 (+)-Etomoxir sodium salt hydrate ≥98% (HPLC), powder Irreversible O-carnitine palmitoyltransferase-1 (CPT-1) inhibitor; PPARα activator
    		  
    • E1383 Etoposide synthetic, ≥98%, powder Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.
    		 human ... ABCB1(5243), CYP3A4(1576), TOP2A(7153)
    mouse ... Abcb1a(18671), Abcb1b(18669)
    rat ... Top2a(360243)
    • 35995 Eugenol PESTANAL®, analytical standard   human ... UGT1A4(54657)
    • 46129 Eugenol Ph Eur   human ... UGT1A4(54657)
    • E51791 Eugenol ReagentPlus®, 99%   human ... UGT1A4(54657)
    • W246700 Eugenol ≥98%, FCC, FG   human ... UGT1A4(54657)
    • W246719 Eugenol natural, ≥98%, FG   human ... UGT1A4(54657)
    • E4660 Eupatorin ≥97% (HPLC) Eupatorin acts as an antiproliferative in cells expressing the CYP1A- family. It induces G2/M block follow by apoptosis in cells expressing the CYP1A- family. It also functions as an anti-inflammatory.
    		  
    • E2129 Evans Blue Dye content ≥75 %   human ... PTPN1(5770), PTPRF(5792)
    • E7019   Exendin-3 ≥97% 39 amino acid peptide that activates VIP receptors and stimulates amylase release from pancreatic acinar cells. Its interaction with GLP-1 (glucagon-like peptide-1) receptors increases intracellular cAMP.
    		 human ... GLP1R(2740)
    • E7144   Exendin-4 ≥97% Exendin-4, a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors.
    		 human ... GLP1R(2740)
    • E7269   Exendin Fragment 9-39 ≥95% (HPLC) GLP-1 (glucagon-like peptide-1) receptor antagonist. Competitive inhibitor of exendin-3 and exendin-4.
    		 human ... GCG(2641), GLP1R(2740)
    • E8280 Exo 1 ≥98% (HPLC), solid Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.
    		  
    • SML0051   E-Resveratrol Trimethyl Ether ≥98% (HPLC) E-Resveratrol Trimethyl Ether, also known as trimethoxy-trans-stilbene, has been shown to inhibit migration and invasion of tumor cell lines such as HepG2 and A549 by a mechanism that involves the reduction of matrix metalloproteinase (MMP) expression.