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W4262 1400W dihydrochloride >98%, solid 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).
 human ... NOS1(4842), NOS2(4843), NOS3(4846)
    • W1020 W146 hydrate ≥98% (HPLC) Potent S1P(1) competitive antagonist; Ki = 10-77 nM.
    		  
    • W4392   W56 96% (HPLC), lyophilized powder W56 (concentrations >200 μM) selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1, and Tiam1, which activate subsequent G proteins. The peptide comprises residues 45-60 of the β3 region of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. W56 targets the Trp56 site of Rac1. It has implications in research of actin cytoskeleton reorganization, transcriptional activation of genes, stimulation of DNA synthesis, endocytic and exocytic membrane trafficking, regulation of translation, and pathologies such as cancer.
    		  
    • UC213 (R)-(+)-Warfarin ≥97% (HPLC) CYP1A2/3A4 substrate; anticoagulant.
    		 human ... CYP2C9(1559)
    • UC214 (S)-(−)-Warfarin ≥97% (HPLC) CYP2C9 substrate; anticoagulant.
    		 human ... CYP2C9(1559)
    • W1895 WAY-100135 ≥98% (HPLC) WAY-100135 is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). It is selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM).
    		 
    • W108 WAY-100635 maleate salt powder WAY-100635 maleate salt is a highly selective 5-HT1A serotonin receptor antagonist.
    		 human ... HTR1A(3350)
    • W1520 WAY-200070 ≥98% (HPLC) Potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.
    		  
    • W4016 Wedelolactone ≥98% (HPLC), solid Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.
    		  
    • W103 WIN 51708 hydrate solid WIN 51708 hydrate is a non-peptide NK1 tachykinin receptor antagonist.
    		 rat ... Tacr1(24807)
    • W102 (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) High affinity cannabinoid receptor agonist.
    		 human ... CNR1(1268), CNR2(1269)
    • W104 WIN 62,577 solid Non-peptide NK1 tachykinin receptor antagonist.
    		 human ... TACR1(6869)
    rat ... Tacr1(24807)
    • W2270 Wiskostatin Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization. Wiskostatin inhibits actin-dependent cellular functions, including migration, transmembrane transport and phagocytosis.
    		 
    • W3020 WKYMVdM trifluoroacetate salt ≥98% (HPLC), powder WKYMVm is a very potent agonist of formyl peptide receptor members FPR1/FPR2 (EC50 1 nM) and FPRL1/FPRL2 (75 pM and 3 nM, respectively). WKYMVm stimulation of leukocytes has been shown to elevate intracellular calcium, induce chemotaxis, superoxide generation, cell killing and phagocytosis.
    		 
    • W1628 Wortmannin from Penicillium funiculosum, ≥98% (HPLC and TLC) Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
    		 human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)
    • W3144   Wortmannin, Ready Made Solution from Penicillium funiculosum, ≥95% (HPLC) Wortmannin is a low molecular weight; hydrophobic fungal metabolite with a sterol-like structure produced by Penicilium fumiculosum.1, Inhibition of PI3K/Akt signal transduction cascade by wortmannin, enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines.2,3 PI3K inhibition by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.4 Research has demonstrated that wortmannin inhibits two enzymes from mitotical division, key regulators Polo-like kinase (Plk) family, Plk1 and Plk3.
    Wortmannin is a low-molecular-weight hydrophobic fungal metabolite with a sterol-like structure produced by Penicillium funiculosum.1 It is a selective inhibitor of phosphoinosidite 3-kinase. It interferes with Akt signal transduction cascade, enhancing the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines.2,3 Wortmannin is membrane-permeable, thus facilitating whole-cell studies of G-protein-coupled receptor and receptor tyrosine kinase signalling pathways. PI3K inhibition by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.4 Research has demonstrated that wortmannin inhibits two mitotic enzymes, key regulators in the Polo-like kinase (Plk) family, Plk1 and Plk3.
    		 human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)
    • W3763 WP631 methanesulfonate ≥97% (HPLC), solid Fluorescent bisintercalating anthracycline antibiotic. Inhibits basal transcription by RNA polymerase II.
    		  
    • W1770 WR99210 WR99210 is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (DHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mutant dihydrofolate reductases.
    		  
    • C7081   WY-14643 Selective PPARα agonist.
    		 human ... PPARA(5465), PPARD(5467), PPARG(5468)
    mouse ... Ppara(19013)
    rat ... Ppara(25747)
    • SML0088 WZ811 ≥98% (HPLC) WZ811 is a potent, specific antagonist of CXCR4 (IC50 = 0.3 nM). WZ811 blocks SDF-1 mediated changes in cellular cAMP levels in U87 glioma cells (IC50 = 1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (IC50 = 5.2 nM).