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X3629 X80 ≥98% (HPLC) X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair.
 
X4879 Xaliproden hydrochloride ≥97% (HPLC), solid 5-HT1A serotonin receptor agonist; neuroprotectant
 
X2754 Xanomeline L-tartrate hydrate ≥98% (HPLC) Xanomeline L-tartate is a M1 muscarinic receptor agonist.
 
X103 Xanthine amine congener ≥96% (HPLC) Xanthine amine congener is a potent, nonselective adenosine receptor antagonist (A1 and A2B > A2A).
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)
SML1317 XAP044 ≥98% (HPLC) XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7’s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.
 
X3004 XAV939 ≥98% (HPLC) XAV939 is a Tankyrase inhibitor (thereby inhibiting Wnt / β-catenin signaling)
 
SML1223 XBD173 ≥98% (HPLC) XBD173 (emapunil, AC-5216) is a potent and selective translocator protein 18 kDa (TSPO) ligand with a Ki value of 0.297 nM. XBD173 acts at the TSPO translocator protein, formerly called the peripheral benzodiazepine receptor, which is involved in production of neuroactive steroids such as allopregnanolone in the brain. TSPO carries cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step of steroidogenesis. XBD173 enhances GABA-mediated neurotransmission via induction of neurosteroidogenesis and exhibits anti-anxiety and antidepressant-like effects.
 
X4753 XCT790 ≥98% (HPLC), solid XCT790 is a potent and specific inverse agonist of ERRα. XCT790 is selective; showing no significant antagonist activity on related nuclear receptors, such as ERRγ or ERα at concentrations below 10 μM. XCT790 inhibits the constitutive activity of ERRα in both biochemical and cell-based assays. The IC50 value is 300-500 nM in transient transfection assays using GAL4-ERR LBD or full-length ERR with the mSHP promoter.
 
X2254 XE-991 ≥98% (HPLC) XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).
 
SML1324   XEN445 ≥98% (HPLC) XEN445 is a potent and selective inhibitor of endothelial lipase with an IC50 of 237 nM and high selectivity over hepatic and lipoprotein lipases. In experiments with wild-type mice, XEN445 raised plasma HDL-cholesterol levels by 16% after 3 days and by 30% after 9 days dosing.
 
X2628 Xestospongin C film Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP3 receptor. Reversibly blocks bradykinin- and carbamylcholine- Ca2+ efflux from the endoplasmic reticulum stores.
 
SML1159 XIB4035 ≥98% (HPLC) XIB4035 is a reported agonist of the glial cell-line derived neurotrophic factor (GDNF) receptor GFRα1. XIB4035 induces GFRα1/RET phosphorylation in Neuro2A cells.
 
SML1768 Ximelagatran ≥98% (HPLC) Ximelagatran is orally active, selective and potent direct thrombin inhibitor. Ximelagatran is a prodrug of thrombin inhibitor melagatran.
 
SML0915   Xipamide ≥98% (HPLC) Xipamide is a sulfonamide diuretic that blocks sodium reabsorption in the distal tubules of the kidney, resulting in increased urine output. Xiopamide also blocks the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
 
X3628 XK469 ≥98% (HPLC), solid XK469 is a topoisomerase IIβ inhibitor; apoptosis inducer.
human ... TOP2B(7155)
SML1239   XL388 ≥98% (HPLC) XL388 is a potent, selective, orally bioavailable ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) with an IC50 of 9.9 nM for mTOR, 8 nM for mTORC1, 166 nM for mTORC2, and 1000-fold selectivity for mTOR over the closely related PI3K kinases and a panel of 141 protein kinases tested. XL388 blocked mTORC1 phosphorylation of p70S6K (T389) with an IC50 value of 94 nM and blocked mTORC2 phosphorylationof AKT (S473) with an IC50 value of 350 nM. XL388 showed complete tumor growth inhibition in mice bearing MCF-7 xenograft tumors.
 
SML1401 XL413 hydrochloride ≥98% (HPLC) XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that has been implicated in protecting tumor cells from apoptotic cell death during replication stress. XL413 has an IC50 of 3.4 nM for CDC7, compared to 215 nM, 42 nM and 18 nM for CK2, PIM1 and pMCM2, respectively. XL413 caused significant tumor growth regression in rodent models, causing cell cycle arrest in the late S to G2 phase.
 
SML1753   XMD17-109 ≥98% (HPLC) XMD17-109 is a cell-permeable, non-cytotoxic ATP site-targeting pyrimido-diazepinone derivative that acts as potent inhibitor against ERK5 (MAPK7, BMK1) kinase activity in cell-free assay (IC50 = 162 nM; [ATP] = 50 μM) and EGF-induced ERK5 autophosphorylation in HeLa cells (IC50  = 90 nM). XMD17-109 displayed excellent target selectivity on a 442-kinase panel. XMD17-109 effectively inhibits inflammatory stimuli-induced IL-6 and IL-8 production from human endothelial cells in vitro and protects mice from LPS-induced mortality and systemic inflammation & coagulopathy in vivo with good pharmacokinetics.
 
SML1382 XMD8-92 ≥98% (HPLC) XMD8-92 is a potent and selective inhibitor of BMK1/ERK5/MAPK7 and DCAMKL1 (DCLK1), kinases implicated in tumorigenesis. XMD8-92 has a Kd of 80 nM for ERK5 and a Kd of 97 nM for DCAMKL1. The next closest targets are DCAMKL2 (190 nM), TNK1 (890 nM), and PLK4 (600 nM). Through inhibition of BMK1 activity, XMD8-92 blocked tumor cell proliferation in vitro in a wide variety of cancer cell lines and significantly inhibited tumor growth in vivo by 95% in mouse studies. XMD8-92 inhibited AsPC-1 human pancreatic cancer cell proliferation and pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
 
X3129 XRP44X ≥98% (HPLC) XRP44X is a Ras-Net (Elk-3) pathway inhibitor; tubulin polymerization inhibitor Colchicine binding site.
 
SML1230   XW4.4 ≥98% (HPLC) XW4.4 can generate insulin-producing cells from rat mesenchymal stem cells. XW4.4 induced pancreatic differentiation of rat bone marrow derived mesenchymal stem cells into insulin-producing cells shown to release C-peptide and insulin in response to physiological or high glucose levels, which could lead to a possible treatment for Type 1 diabetes. Its mechanism of action is postulated to be through increasing expression of hepatocyte nuclear factor 3β (HNF3β), a member of the forkhead box transcription factor family that regulates expression of several genes in the pancreas during early embryogenesis.
 
X1126 Xylazine ≥99% α2-adrenoceptor agonist, sedative, muscle relaxant.
 
X1251 Xylazine hydrochloride ≥99% α2-Adrenergic receptor agonist, sedative, muscle relaxant.
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
X6000 Xylometazoline hydrochloride α-adrenoceptor agonist; imidazoline binding site ligand.
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)