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G154 Gabapentin solid Anticonvulsant with unknown mechanism of action; crosses the blood brain barrier; increases GABA concentrations in the brain and reduces excitatory amino acid neurotransmission, perhaps through its effects on voltage-gated calcium channels; exhibits antinociceptive, anxiolytic, neuroprotective and anti-epileptic effects.
 human ... ADORA1(134), CACNA2D1(781)
rat ... Cacna1a(25398)
    • G2417 Gabexate mesylate analytical standard, for drug analysis    
    • T101 Gaboxadol hydrochloride solid, ≥98% (HPLC) GABAA receptor agonist.
    		 human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)
    • C4905 Galactocerebrosides from bovine brain ≥97% (TLC) Galactose linked to ceramide by a β-glycosidic linkage; the major lipid in adult brain, representing approximately 16% of total lipid; they are mainly localized to myelin and are markedly reduced in demyelinating diseases.
    		  
    • 282200 Galangin autophagy inducing flavonoid Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity induced by molecules such as benzo[a]pyrene (B(a)P) and oxidation. Galangin may be used to study the expression of the cytochrome P450 isozyme CYP1A1 and to inhibit CYP1A1 activity. Autophagy inducer.
    		 human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
    rat ... Adora1(29290), Adora2a(25369)
    • G1660 Galanthamine hydrobromide from Lycoris sp. ≥94% (TLC) Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.
    		  
    • G8134 Gallamine triethiodide ≥98% (TLC), powder, muscarinic receptor antagonist Muscle relaxant; allosteric muscarinic receptor antagonist with an order of potency of M2 > M1 = M4 > M3 = M5. Ligand for the peripheral anionic binding site of acetylcholinesterase.
    		 human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
    • G6657 (−)-Gallocatechin ≥98% (HPLC) Possesses free radical scavenging ability. Inhibits the growth and adherence of P. gingivalis onto the buccal epithelial cells.
    		  
    • G6782 (−)-Gallocatechin gallate from green tea, ≥98% (HPLC) Antioxidant
    		  
    • G8171 Gambogic acid ≥95% (HPLC), powder Gambogic acid acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle.
    		  
    • G7795 Ganaxolone solid Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.
    		 human ... GABRA1(2554)
    mouse ... Gabrg2(14406)
    • G2536 Ganciclovir ≥99% (HPLC), powder Ganciclovir is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.
    Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell.1 The cell cycle is irreversibly arrested at the G2-M checkpoint.2 Gap junction involvement in the ganciclovir bystander effect has been studied.3 Ganciclovir has been used to study loss of telomeres4 and to evaluate sensitivity of viruses to antiviral treatments.5
    		  
    • D052 GBR 12909 dihydrochloride solid, ≥98% (HPLC) Highly selective dopamine reuptake inhibitor with behavioral effects similar to cocaine.
    		 human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
    • G9659 GBR 12935 dihydrochloride ≥98% (TLC), powder Inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. Does not inhibit the serotonin transporter (Ki = 6.5 μM). Binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.
    		  
    • G3381 Geldanamycin from Streptomyces hygroscopicus ≥98% (HPLC), powder Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
    It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
    		  
    • G6423 Gemcitabine hydrochloride ≥98% (HPLC) Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite.
    		  
    • G9518 Gemfibrozil Selectively increases Apolipoprotein A-I levels.
    		  
    • G4796 Genipin ≥98% (HPLC), powder Genipin stimulates insulin secretion in UCP2-dependent manner (Uncoupling protein 2). Genipin is a protein, collagen, gelatin, and chitosan cross-linker.
    		  
    • G6649 Genistein synthetic, ≥98% (HPLC), powder Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.
    		 human ... AKT1(207), CYP19A1(1588), EGFR(1956), ESR1(2099), ESR2(2100)
    mouse ... Esr1(13982), Hexa(15211)
    rat ... Adora1(29290), Adora2a(25369), Ar(24208)
    • G6776 Genistein from Glycine max (soybean), ~98% (HPLC) Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.
    		 human ... AKT1(207), CYP19A1(1588), EGFR(1956), ESR1(2099), ESR2(2100)
    mouse ... Esr1(13982), Hexa(15211)
    rat ... Adora1(29290), Adora2a(25369), Ar(24208)
    • G0897 Genistin from Glycine max (soybean), ≥95% (HPLC) Inactive analog of genistein; useful as a negative control for genistein and other tyrosine kinase inhibitors.
    Selective inhibitor of mammalian terminal deoxynucleotidyl transferase (TdT), with no measurable effect on mammalian or microbial DNA polymerases.
    		  
    • G1914 Gentamicin sulfate meets USP testing specifications, powder Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.1,2 The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.3
    Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria
    		  
    • G4918 Gentamicin sulfate meets EP, USP testing specifications Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.1,2 The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.3
    Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria
    		  
    • UC18 (±)-Geosmin ≥97% (GC)    
    • G2543 Geranylgeranyl monophosphate ammonium salt solution ≥95% (TLC), methanol:ammonia solution    
    • G6025 Geranylgeranyl pyrophosphate ammonium salt solution, ≥95% (TLC), ~1 mg/mL in methanol: NH4OH (7:3) Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular weight G proteins, including Ras. Intermediate in terpene biosynthesis.
    		  
    • G2418 Geranyl triphosphate ammonium salt solution methanol:ammonia solution    
    • B6292 GF 109203X hydrochloride ≥95% Inhibitor of protein kinase C; potent inhibitor of GSK-3.
    		  
    • G5294 GGTI-2133 ≥98% (HPLC), solid GGTI-2133 is a cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I; IC50 = 38 nM) with a 140-fold selectivity over farnesyltransferase (FTase; IC50 = 5.4 μM).
    		 human ... FNTA(2339), PGGT1B(5229)
    • G5169 GGTI 298 trifluoroacetate salt hydrate ≥90% (HPLC), film GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.
    		 human ... PGGT1B(5229)
    • SML0184 Ginsenoside Rg3 ≥98% (HPLC) Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation.
    		 
    • G2167 Gliclazide powder, ≥98% Oxidative modification of low-density lipoprotein (LDL) plays an important role in vascular dysfunction associated with diabetes mellitus. Gliclazide is a second-generation sulfonylurea with free-radical-scavenging activity. Incubation of human aortic smooth muscle cell (HASMC) with native human LDL (100 μg/mL) in the presence of increasing concentrations of gliclazide (1 to 10 μg/mL) resulted in a dose-dependent decrease in HASMC-mediated LDL oxidation. Exposure of HASMCs to gliclazide (1 to 10 μg/mL) and native LDL (100 μg/mL) also led to a dose-dependent decrease in oxidized LDL-induced human monocyte adhesion to HASMCs. In addition, incubation of HASMCs with gliclazide dramatically reduced the ability of oxidized LDL to stimulate the proliferation of these cells. Finally, treatment of HASMCs with gliclazide resulted in a marked decrease in oxidatively modified LDL-induced monocyte chemoattractant protein (MCP)-1 and human heat shock protein 70 (HSP 70) expression, both at the gene and protein levels. These results show that gliclazide, at concentrations in the therapeutic range (5 to 10 μg/mL), is effective in vitro in reducing vascular smooth muscle cell (VSMC) dysfunction induced by oxidatively modified LDL. Administration of gliclazide to type 2 diabetic patients could form part of the strategy for the prevention and management of diabetic cardiovascular diseases
    		 human ... KCNJ1(3758)
    • G2295 Glimepiride ≥98% (HPLC), solid Glimepiride is a potent blocker of cardiac KATP channels activated by pinacidil with an IC50 of 6.8 nM.
    		 human ... KCNJ1(3758)
    • G9893 Gliotoxin from Gliocladium fimbriatum An antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups.
    		  
    • G117 Glipizide solid ATP-dependent K+ channel blocker.
    		 human ... KCNJ1(3758)
    • G5297 Glp-Asn-Pro-d-Tyr-d-Trp-NH2 ≥98% (HPLC), solid The synthetic peptide Glp-Asn-Pro-d-Tyr-d-Trp-NH2 mimics and amplifies central actions of TRH in rat without releasing TSH. Glp-Asn-Pro-d-Tyr-d-Trp-NH2 has dual pharmacological activities: it inhibits TRH-DE and binds to central TRH receptors with nM affinity in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRH receptor 1 (TRHR1) or TRH receptor 2 (TRHR2). The peptide can be a potent tool for probing the role of TRH actions in the CNS and a platform for development of novel TRH-based therapeutics for neuro diseases.
    		 rat ... TRH(7200), TRHDE(29953), TRHR(7201)
    • 49163 Glucose solution BioUltra, for molecular biology, ~20% in H2O   human ... PYGM(5837)
    • 158968 α-D-Glucose anhydrous, 96%   human ... PYGM(5837)
    • G7528 D-(+)-Glucose BioXtra, ≥99.5% (GC)   human ... PYGM(5837)
    • G8270 D-(+)-Glucose ≥99.5% (GC)   human ... PYGM(5837)
    • G5767 D-(+)-Glucose ACS reagent   human ... PYGM(5837)
    • G7021 D-(+)-Glucose powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99.5%   human ... PYGM(5837)
    • G5400 D-(+)-Glucose ≥99% (GC)   human ... PYGM(5837)
    • G6152 D-(+)-Glucose suitable for mouse embryo, ≥99.5% (GC)   human ... PYGM(5837)
    • G5146 D-(+)-Glucose Hybri-Max™, powder, BioReagent, suitable for hybridoma   human ... PYGM(5837)
    • G7520 D-(+)-Glucose plant cell culture tested, BioReagent   human ... PYGM(5837)
    • 49139 D-(+)-Glucose BioUltra, anhydrous, ≥99.5% (sum of enantiomers, HPLC)   human ... PYGM(5837)
    • 16325 D-(+)-Glucose meets analytical specification of Ph. Eur., BP, anhydrous   human ... PYGM(5837)
    • G8769 D-(+)-Glucose solution 45% in H2O, sterile-filtered, BioXtra, suitable for cell culture   human ... PYGM(5837)
    • G8644 D-(+)-Glucose solution 100 g/L in H2O, sterile-filtered, BioXtra, suitable for cell culture   human ... PYGM(5837)
    • G3285 D-(+)-Glucose solution 1 mg/mL in 0.1% benzoic acid, standard for enzymatic assay kits GAGO20, GAHK20, STA20, analytical standard   human ... PYGM(5837)
    • G3291 Glutamate, Caged hydrate powder Glutamate derivative that is resistant to hydrolysis and biologically inert prior to photolysis.
    		  
    • G1001 D-Glutamic acid ≥99% (TLC) Unnatural isomer of glutamic acid.
    		 human ... CCR2(1231)
    • W328502 L-Glutamic acid ≥98.5%, FCC An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
    		 human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
    rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)
    • G8415 L-Glutamic acid from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5% An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
    Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter. Glutamic acid also plays a key role in many metabolic pathways. It is converted to α-ketoglutarate, a key component of the TCA cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase.
    		 human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
    rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)
    • 49449 L-Glutamic acid BioUltra, ≥99.5% (NT) An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
    		 human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
    rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)
    • G1251 L-Glutamic acid ReagentPlus®, ≥99% (TLC) An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
    		 human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
    rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)
    • 09581 L-Glutamic acid Ph Eur An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
    		 human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
    rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)
    • G5667 L-Glutamic acid PharmaGrade, Ajinomoto, EP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
    		 human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506)
    rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)
    • G2128 L-Glutamic acid hydrochloride ≥99% (TLC) Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
    		 human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
    • G1626 L-Glutamic acid monosodium salt hydrate ≥99% (TLC), powder Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
    		 human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
    mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
    rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)
    • G5889 L-Glutamic acid monosodium salt hydrate BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99% Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
    		  
    • G1501 L-Glutamic acid potassium salt monohydrate ≥99% (TLC), powder Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
    		 human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
    mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
    rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)
    • G1149 L-Glutamic acid potassium salt monohydrate BioReagent, suitable for insect cell culture, ≥99% (TLC) Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
    		  
    • 309346 L-Glutamic acid diethyl ester hydrochloride 97%    
    • 49550 L-Glutamic acid diethyl ester hydrochloride puriss., ≥99.0% (AT)    
    • G9003 D-Glutamine ≥98% (TLC)    
    • G3126 L-Glutamine ReagentPlus®, ≥99% (TLC) L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
    		 rat ... Ggt1(116568)
    • G8540 L-Glutamine meets USP testing specifications, cell culture tested, 99.0-101.0%, from non-animal source L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
    		 rat ... Ggt1(116568)
    • G6392 L-Glutamine γ-irradiated, BioXtra, suitable for cell culture L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
    L-glutamine is an essential amino acid that is a crucial component of culture media, and serves as a major energy source for cells in culture. Optimal cell performance usually requires supplementation of the medium with L-glutamine prior to use.
    		 rat ... Ggt1(116568)
    • G5792 L-Glutamine Ajinomoto Amino Acid, ≥99%, from non-animal source, USP, suitable for manufacturing use, suitable for cell culture L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
    		 rat ... Ggt1(116568)
    • 49419 L-Glutamine BioUltra, ≥99.5% (NT) L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
    		 rat ... Ggt1(116568)
    • G7513 L-Glutamine solution 200 mM, solution, sterile-filtered, BioXtra, suitable for cell culture L-glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
    		 rat ... Ggt1(116568)
    • G2150 L-Glutamine solution 200 mM, Hybri-Max™, sterile-filtered, suitable for hybridoma L-glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
    		 rat ... Ggt1(116568)
    • G111 γ-D-Glutamylaminomethylsulfonic acid solid Gamma-D-Glutamylaminomethylsulfonic acid (GAMS) is used as a selective antagonist of AMPA/kainate glutamatergic receptors and as an anticonvulsant.
    		 human ... GRIK1(2897)
    • G9027 L-Glutathione oxidized ~98%, lyophilized powder    
    • G8291 Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe >93% (HPLC), solid Inhibitor of brain β-secretase
    		  
    • G4391 Gly-Arg-Gly-Asp-Ser ≥97% (HPLC) Antagonist of integrin function
    		 human ... ITGB3(3690)
    • G1269 Gly-Arg-Gly-Asp-Ser-Pro-Lys ≥97% (HPLC) Fibronectin analog that binds to integrins.
    		 human ... ITGA2B(3674), ITGAV(3685)
    • G5646 Gly-Arg-Gly-Asp-Thr-Pro ≥97% (HPLC) Inhibits cell attachment of fibronectin, vitronectin, and Type I collagen.
    		 human ... COL1A1(1277), COL1A2(1278), FN1(2335), VTN(7448)
    mouse ... COL1A1(12842), COL1A2(12843), FN1(14268), VTN(22370)
    rat ... COL1A1(29393), COL1A2(84352), FN1(25661), VTN(29169)
    • G2754 Gly-DL-Asp   human ... SLC15A1(6564)
    • G0639 Glybenclamide ≥99% (HPLC) Selectively blocks ATP-sensitive K+ channels; high affinity binding sites found in brain, pancreatic β cells, and cardiovascular system.
    		 human ... KCNH2(3757), KCNJ1(3758), KCNJ11(3767)
    rat ... Kcnj1(24521)
    • G2539 Glyburide meets USP testing specifications   human ... KCNH2(3757), KCNJ11(3767)
    rat ... Kcnj1(24521)
    • 410225 Glycine ACS reagent, ≥98.5% Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • G7126 Glycine ReagentPlus®, ≥99% (TLC) Glycine is a non-chiral amino acid that can be synthesized in the body from the amino acid serine by Serine Hydroxymethyltransferase.
    Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • 50046 Glycine BioUltra, for molecular biology, ≥99.0% (NT) Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • G8898 Glycine for electrophoresis, ≥99% Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • G7403 Glycine BioXtra, ≥99% (titration) Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • G8790 Glycine from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, ≥98.5% Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • G5417 Glycine PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • 33226 Glycine puriss. p.a., Reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance) Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • 50058 Glycine Ph Eur Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		  
    • 15527 Glycine meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance) Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • W328707 Glycine ≥98.5%, FCC Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		 rat ... Grin2a(24409)
    • G2879 Glycine hydrochloride ≥99% (TLC) Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
    		  
    • G6761 Glycine sodium salt hydrate ≥99% (TLC)    
    • SML0029 Glycopyrrolate ≥98% (HPLC) Glycopyrrolate is long-acting muscarinic antagonist (LAMA). It is kinetically selective muscarinic M3 receptor antagonist.
    		  
    • G10105 18β-Glycyrrhetinic acid 97%   human ... HSD11B1(3290), HSD11B2(3291)
    rat ... Hsd11b1(25116), Hsd11b2(25117)
    • G1002 Gly-Gly ≥99% (titration)   human ... SLC15A1(6564)
    • G3915 Gly-Gly BioReagent, cell culture tested, ≥99% (titration)   human ... SLC15A1(6564)
    • 50199 Gly-Gly BioUltra, ≥99.5% (NT)   human ... SLC15A1(6564)
    • G2002 Gly-Leu   human ... SLC15A1(6564)
    • G3127 Gly-Sar   human ... SLC15A1(6564)
    • 50430 Gly-Sar puriss., ≥99.0% (T)   human ... SLC15A1(6564)
    • SML0109 GLYX-13 trifluoroacetate ≥98% (HPLC) GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.
    		  
    • G9420 GNF-2 ≥98% (HPLC), solid GNF-2 belongs to a new class of Bcr-abl inhibitors. GNF-2 appears to bind to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. It inhibits Bcr-abl phosphorylation with an IC50 of 267 nM, but does not inhibit a panel of 63 other kinases, including native c-Abl, and shows complete lack of toxicity towards cells not expressing Bcr-Abl. GNF-2 shows great potential for a new class of inhibitor to study Bcr-abl activity and to treat resistant Chronic myelogenous leukemia (CML), which is caused the Bcr-Abl oncoprotein.
    		  
    • G1171 Gö 6976 ≥98% (HPLC), powder Gö 6976 is an inhibitor of protein kinase C (PKC) specific for α (IC50=2.3 nM) and β1 (IC50=6.2 nM) isozymes.
    		  
    • G1918 Gö 6983 ≥97% Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).
    		  
    • G4919 Goserelin acetate ≥99% (HPLC), white powder Goserelin is a synthetic analog of LHRH (leutinizing hormone releasing hormone). Goserelin is a LHRH agonist It is used in prostate cancer and breast cancer therapies and also in the treatment of endometriosis.
    		 human ... GNRH1(2796), GNRHR(2798)
    mouse ... GNRH1(14714), GNRHR(14715)
    rat ... GNRH1(25194), GNRHR(81668)
    • G8761 (±)-Gossypol from cotton seeds ≥95% (HPLC) Gossypol is a male antifertility agent and PAF antagonist/inhibitor. Gossypol is a poisonous pigment found in cottonseed and its name is derived from the botanical name of the cotton plant, Gossypium.. Gossypium is extracted from selected hybrid species between two Gossypium species, Gossypium hirsutum and Gossypium barbadens. As a PAF antagonist/inhibitor, Gossypium markedly inhibited the contractile responses of guinea pig lung parenchyma strips stimulated with leukotriene B4, seukotriene D4, and PAF-acether.
    		 human ... AKR1B1(231), BAD(572), BCL2(596), LDHA(3939), LDHB(3945), MCL1(4170)
    • H6153 gp120 Fragment 421-438 ≥90% (HPLC)    
    • SML0174 GPR35 Agonist, Compound 10 ≥98% (HPLC) GPR35 agonist Compound 10 is a GPR35 agonist the binds with higher affinity than other known agonists, such as kynurenic acid and zaprinast. Compound 10 was more potent than zaniprast (pEC50 = 5.3 vs 4.18) for recombinantly expressed human GPR35, and unlike zaprinast, is equipotent for human and rat GPR35
    		  
    • G9541   G Protein Antagonist ≥90% (HPLC) Inhibits the activation of Gαi or Gαo by M2 muscarinic cholinergic receptor.
    		 human ... CHRM2(1129)
    • SML0135 GPV574 ≥98% (HPLC) GPV574 is a derivative of the Class 1C antiarrhythmic drug propafenone. GPV574 inhibits the delayed rectifier K+ channel HERG with similar affinity and time constant as propafenone (IC50 = 5 mM), but unlike the parent compound, does not remain permanently trapped in the channel pore. After wash-out of GPV574, channel activity is recovered within 60 seconds.
    		  
    • G0544 GR 103691 >98% (HPLC), solid D3 dopamine receptor antagonist.
    		 rat ... Htr1a(24473)
    • G5918 GR 113808 ≥98% (HPLC), solid GR 113808 is a 5-HT4 serotonin receptor antagonist.
    		 human ... HTR4(3360)
    rat ... Htr3a(79246), Htr4(25324)
    • G5793 GR 127935 hydrochloride hydrate >98% (HPLC), solid Potent, selective and orally active 5-HT1B/1D serotonin receptor antagonist.
    		 human ... HTR1B(3351), HTR1D(3352)
    • N8648   GR 231118 ≥95% (HPLC), lyophilized powder High affinity and selective NPY Y1 receptor antagonist.
    		 human ... NPY1R(4886)
    mouse ... NPY1R(29358)
    rat ... NPY1R(18166)
    • G5044 GR 32191B ≥98% (HPLC), solid Selective TP prostanoid receptor antagonist. Inhibits U-46619-induced contraction of guinea pig trachea with IC50=1.8 nM.
    		  
    • G113 GR 64349 >96% Potent and selective agonist at the NK-2 tachykinin receptor.
    		 human ... TACR2(6865)
    mouse ... TACR2(21337)
    rat ... TACR2(25007)
    • G114 GR 73632 >97% Potent and specific agonist at the NK-1 tachykinin receptor.
    		 human ... TAC1(6863), TACR1(6869)
    mouse ... TAC1(21333), TACR1(21336)
    rat ... TAC1(24806), TACR1(24807)
    • G115 GR 82334 ≥95% Potent and specific reversible antagonist at the NK-1 tachykinin receptor.
    		 human ... TACR1(6869)
    mouse ... TACR1(21336)
    rat ... TACR1(24807)
    • G133 GR 89696 fumarate salt solid Selective κ2 opioid receptor agonist.
    		 human ... OPRK1(4986)
    • G130 GR 94800 >96%, powder Selective NK-2 tachykinin receptor antagonist.
    		 human ... TACR2(6865)
    mouse ... TACR2(21337)
    rat ... TACR2(25007)
    • G5002   Gramicidin from Bacillus aneurinolyticus (Bacillus brevis) Linear polypeptide antibiotic complex. A mixture of gramicidins A, B, C, and D. Linear polypeptide antibiotic, a mixture of gramicidin A, B, C, and D. Gramicidin D, a channel-forming ionophore that flip-flops slowly across the membrane is a known Pgp substrate and surprisingly was found to inhibit Pgp ATPase activity. This inhibition was reversed by other Pgp substrates suggesting a common drug binding site among MDR substrate-type drugs and chemosensitizers.
    		  
    • G3796 Granisetron hydrochloride ≥98% (HPLC), solid Granisetron hydrochloride is a serotonin 5-HT3 receptor antagonist and antiemetic.
    		  
    • G4410   Griess reagent (modified)    
    • G6771 Growth Hormone Releasing Factor Fragment 1-29 amide human ≥97% (HPLC) Amidated GRF fragment that is equipotent to GRF in releasing somatotropin from anterior pituitary.
    		 human ... GHRH(2691), GHRHR(2692)
    • PZ0187 GSI-953 ≥98% (HPLC) Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch.
    		  
    • G5797 GSK0660 ≥98% (HPLC) GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (160 nM). GSK0660 is nearly inactive on PPARα and PPARγ with IC50s greater than 10 μM.
    		  
    • SML0083 GSK 1059615 sodium salt hydrate ≥98% (HPLC) GSK 1059615 is a potent inhibitor of PI3 Kinase. (IC50 = 2 nM)
    		  
    • SML0217 GSK2334470 ≥98% (HPLC) GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). GSK2334470 can be used in cells to ablate T-loop phosphorylation and activate SGK, S6K1 and RSK as well as suppress the activation of Akt.
    		  
    • G7423 GSK3787 ≥98% (HPLC), white to off-white, powder GSK3787 is an orally available selective irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) antagonist (pIC50=6.6) with no measurable affinity for hPPARR or hPPARγ (pIC50<5). It acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells.
    		  
    • SML0231   GSK-429286 ≥98% (HPLC) GSK-429286 is a potent, selective, orally available Rho kinase (ROCK1) inhibitor and reduced arterial pressure in spontaneously hypertensive rats
    		  
    • G6173 GSK 4716 ≥98% (HPLC) GSK 4716 is an Estrogen-related receptors ERRβ and ERRγ agonist with minimal activity for ERRα, ERα and ERβ
    		  
    • G7012 Guaiacol glyceryl ether carbamate   human ... CYP1A2(1544)
    • G110 Guanabenz acetate salt powder Centrally acting α2 adrenoceptor agonist; I2 imidazoline binding site ligand; antihypertensive.
    		 human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
    • G1043 Guanfacine hydrochloride ≥98% (TLC) α-2 noradrenergic receptor agonist.
    		 human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
    • G3416 5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate solid, ≥98% (HPLC) Selective κ opioid receptor antagonist; GNTI is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations.
    		 human ... OPRK1(4986)
    • G0635 Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate ≥85% (HPLC), powder Binds and irreversibly activates G proteins.1 Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.2,3
    		  
    • G7504 Guanosine 3′,5′-cyclic monophosphate ≥98% (HPLC), powder An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).
    		  
    • G6129 Guanosine 3′,5′-cyclic monophosphate sodium salt ≥99% (HPLC), powder An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).
    		  
    • G136 Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt solid Sp-cGMPS is a metabolically resistant activator of cGMP-dependent protein kinases.
    		  
    • G135 Guanosine 3′,5′-cyclic monophosphorothioate, Rp Isomer triethylammonium salt solid cGMPS-dependent protein kinase Iα inhibitor.
    		  
    • G7637 Guanosine 5′-[β-thio]diphosphate trilithium salt ≥85% (HPLC), powder    
    • G8634 Guanosine 5′-[γ-thio]triphosphate tetralithium salt ≥75% (HPLC), powder GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.
    		  
    • G5884 Guanosine 5′-triphosphate lithium salt ~95% (HPLC), powder GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
    		  
    • G8877 Guanosine 5′-triphosphate sodium salt hydrate ≥95% (HPLC), powder GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
    		 human ... HRAS(3265)
    • G3776 Guanosine 5′-triphosphate sodium salt solution HPLC purified, aqueous solution for RNA polymerase transcription   human ... HRAS(3265)
    • G5168 (Z)-Guggulsterone ≥89% (HPLC), powder (Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.
    		  
    • G4923 (E)-Guggulsterone ≥95% (HPLC), powder Naturally occuring bioactive plant sterol isolated from the gum resin of guggul (Commiphora wightii). Antihyperlipidemic. Induces the expression of human CYP3A.1. Guggulsterone potently reverses multi-drug resistance in a number of human cancer cell lines, extending the efficacy of chemotherapy.2
    		  
    • G007 Guvacine hydrochloride ≥97% (NMR), solid GABA uptake inhibitor.
    		 human ... FGF9(2254), GABBR1(2550), GABBR2(9568), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)
    • G3295 GW0742 ≥98% (HPLC), solid GW0742 is a highly selective PPARδ agonist. EC50 = 1 nM vs 1 and 2 mM for PPARα and PPARγ, respectively.
    		 human ... PPARA(5465), PPARD(5467), PPARG(5468)
    • G5668 GW1929 hydrate >98% (HPLC), solid GW1929 is a high affinity agonist of PPAR-γ.
    		 human ... PPARG(5468)
    • G0668 GW2974 ≥98% (HPLC), solid Potent and selective dual inhibitor of EGFR (IC50 = 0.016 mM) and ErbB-2 receptor tyrosine kinase.
    		human ... EGFR(1956), ERBB2(2064)
    • G8419 GW311616A ≥97% (HPLC), solid Potent, intracellular human neutrophil elastase (HNE, α-1-proteinase) inhibitor.
    		  
    • G6295 GW3965 hydrochloride ≥98% (HPLC), powder GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
    		  
    • G1421 GW405833 hydrochloride ≥98% (HPLC), solid GW405833 is a selective cannabanoid CB2 receptor agonist; analgesic. GW405833 binds with high affinity at both human and rat CB2 receptors (Ki′s 3.9 and 3.6 nM); acts as a partial agonist (50% inhibition of forskolin-stimulated cAMP formation compared to full agonist CP55,940). GW405833 has potent analgesic activity in rat models of inflammatory, neuropathic and incisional pain; devoid of CNS effects common with CB1 agonists.
    		  
    • G3420 GW441756 hydrochloride ≥97% (HPLC), powder, red Highly selective and potent TrkA kinase inhibitor. Orally active. IC50 = 2 nM
    		  
    • D1692 GW4869 ≥90% (NMR) A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)
    		  
    • G6416 GW5074 powder cRaf1 kinase inhibitor, immediately downstream of Ras in the MAPK signaling pathway.
    		 human ... RAF1(5894)
    • G3545 GW583340 dihydrochloride ≥97% (HPLC), solid Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC50= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active.
    		  
    • G5045 GW6471 solid, ≥98% (HPLC), off-white to light yellow GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.
    		  
    • G6793 GW7647 ≥98% (HPLC) Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.
    		 human ... PPARA(5465)
    • SML0116 GW788388 Hydrate ≥98% (HPLC) GW788388 is a potent selective inhibitor of TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)]. GW788388 is orally available with a half-life of approximately 4 hours.
    		  
    • SML0230   GW-803430 ≥98% (HPLC) GW-803430 is a centraly active and selective melanin-concentrating hormone receptor (MCHR) 1 antagonist
    		  
    • G2171 GW843682X ≥98% (HPLC), solid GW843682X is a polo-like kinase-1 (PLK1) and polo-like kinase-3 (PLK3) inhibitor with nanomolar activity. It shows potent inhibition of proliferation of a wide variety of tumor cell lines.
    		  
    • G7791 GW8510 solid GW8510 is an inhibitor of cyclin kinase 2 (CDK2). It prevents and/or reduces the side effects of chemotherapy (alopecia, plantar-palmar syndrome and mucositis).
    		 human ... CDC2(983), CDK2(1017)
    • M6191 GW9662 >98% (HPLC) GW9662 is an irreversible PPARγ antagonist. GW9662 inhibits connective tissue growth factor and activation of CD36 by IL-4.
    		 human ... PPARG(5468)
    • G119 GYKI 52466 hydrochloride solid Selective allosteric AMPA receptor antagonist; anti­convulsant; skeletal muscle relaxant.
    		 human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
    • G120 GYKI 52895 solid Selective dopamine uptake inhibitor; antiparkinsonian; antidepressant.
    		 human ... DBH(1621)
    rat ... Gabra2(29706), Gria1(50592), Grik1(29559), Grin2a(24409)
    • G9423 GYPGQV trifluoroacetate salt ≥98% (HPLC), powder Protease-activated receptor-4 (PAR4) agonist
    		  
    • SML0100 GYY4137 Dichloromethane complex ≥98% (HPLC) GYY4137 is a small molecule releaser of H2S with vasodilator and antihypertensive activity. H2S has been found to be an important biological mediator with multiple effects on neuromodulation, hypertension, inflammation, and vascular tone. GYY4137 should prove useful in the study of the many and varied biological effects of H2S.
    		  
    • T2955 γ6 TM1a trifluoroacetate salt ≥95% (HPLC) The calcium channel γ family is a subgroup of the tetraspanin proteins. There are the eight γ subunits that have been identified to date. Among these γ1 subunit acts as an endogenous antagonist of the skeletal HVA calcium current, and γ6 inhibits the low voltage-activated (LVA) Cav3.1 calcium current. A GxxxA motif in the first transmembrane domain (TM1) of γ6 was identified as critical for inhibiting the Cav3.1 current. γ6 TM1a is an octapeptide contains residues 41 through 48 of the native γ6 protein. The peptide inhibits the Cav3.1 calcium current in a dose-dependent manner. The reduction of channel current is mostly due to the inhibition of both resting and inactivated channels relatively independent of membrane potential. Thus γ6 TM1might function as a pore blocker. Also γ6 TM1a peptide inhibits Cav1.2 current with reduced efficacy. The γ6 TM1a peptide has the potential of being further developed as a novel therapeutic agent targeting Cav3.1 and possibly Cav1.2 calcium current.