F

E | F | G

Product #

Image

Product Name

Biochem/physiol Actions

Gene Symbol (ID)

Add to Cart
F3680 10058-F4 ≥98% (HPLC), solid 10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. It is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 mM using c-Myc transfected Rat1a fibroblasts).
  
    • F1302   FADD human >85% (SDS-PAGE), recombinant, expressed in E. coli (maltose binding protein (MBP) fusion protein), buffered aqueous solution An apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. It contains a carboxy-terminal death domain, which interacts with the Fas receptor death domain while its NH2-terminal contains a death effector domain (DED) recruiting caspase-8 to the death inducing signaling complex (DISC) thus initiating apoptotic caspase cascade.
    Recently FADD was implicated in non-apoptotic cellular pathways, such as the regulation of cell cycle machinery in T lymphocytes, which was found to be connected to its phosphorylation state, and the FasL/TRAIL-induced transcriptional activation of c-fos protooncogene.
    FADD was also found to interact with hepatitis C virus core protein in HEK-293 cell line.
    		 human ... FADD(8772)
    • F7932 Famciclovir ≥98% (HPLC) Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.1
    		  
    • F6889 Famotidine H2 histamine receptor antagonist; anti-ulcer agent
    		 human ... HRH2(3274)
    • F6892 Farnesyl pyrophosphate ammonium salt methanol:ammonia solution, ≥95% (TLC) Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.
    		 rat ... Fnta(25318)
    • F8182 Faropenem sodium hydrate ≥98% (HPLC) Faropenem sodium is an ultra-broad spectrum, β-lactamase resistant, β-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.
    		  
    • F4429 FAUC 213 ≥98% (HPLC), solid Highly selective D4 dopamine receptor full antagonist
    		 human ... DRD2(1813), DRD3(1814), DRD4(1815)
    • T5699 m-3M3FBS >97% (HPLC) First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).
    		  
    • F0778 Felbamate Anticonvulsant agent that is an allosteric antagonist at the NR2B subunit of the NMDA glutamate receptor; also has γ-aminobutyric acid (GABAA) receptor agonist properties.
    		 human ... GRIN2B(2904)
    • F9677 Felodipine solid L-type calcium channel blocker
    		 human ... CACNA2D1(781)
    • F8755 Fenbufen analytical standard   human ... MMP2(4313), MMP3(4314), MMP9(4318)
    • F112 (+)-Fenfluramine hydrochloride (+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.
    		  
    • F113 R(−)-Fenfluramine hydrochloride Less active enantiomer
    Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic.
    		  
    • F0430 Fenobam ≥98% (HPLC), solid Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
    		  
    • F6020 Fenofibrate ≥99%, powder PPARα agonist; lipid regulating drug. Increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression.
    		 human ... PPARA(5465)
    • SML0198 Fenoldopam mesylate ≥98% (HPLC) Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.
    		  
    • F6800 Fenoldopam monohydrobromide ≥98% Fenoldopam is a selective dopamine agonist that is being considered for the parenteral treatment of systemic hypertension. In both an oral and parenteral form, fenoldopam causes peripheral vasodilation by stimulating dopamine-1 adrenergic receptors. Intravenous fenoldopam may provide advantages over sodium nitroprusside because it can induce both a diuresis and natriuresis, is not light sensitive, and is not associated with cyanide toxicity. There is no evidence for rebound hypertension after discontinuation of fenoldopam infusion.
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), DRD1(1812)
    • F1016 Fenoterol hydrobromide β2-adrenoceptor agonist; bronchodilator.
    		 human ... ADRB2(154)
    • 36772 Fenpropimorph PESTANAL®, analytical standard   human ... EBP(10682)
    • F6145 Fenspiride hydrochloride analytical standard, for drug analysis Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), HRH1(3269)
    • F3886 Fentanyl citrate salt Phenylpiperidine analgesic that is 80 times more potent than morphine as an analgesic and 6000 times more potent than morphine as a μ opioid receptor agonist.
    		  
    • 45494 Fenuron PESTANAL®, analytical standard   human ... EPHX2(2053)
    mouse ... Ephx2(13850)
    • F1428 Fenvalerate ≥97% Type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B).
    		  
    • F4503   Ferritin from equine spleen Type I, saline solution A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.
    		  
    • F6754   Ferritin from human liver Type IV, 10 μg/mL A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.
    		 human ... FTH1(2495), FTL(2512), FTMT(94033)
    • F9427 Fexofenadine hydrochloride >98% (HPLC) Fexofenadine is a non-sedating H1 histamine receptor antagonist.
    		 human ... HRH1(3269)
    • F4303 Fiduxosin hydrochloride >98% (HPLC), solid α1-Adrenoceptor antagonist.
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
    • F1293 Finasteride ≥98% (HPLC), powder Selective 5α-reductase inhibitor; antiandrogen.
    		 human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716)
    rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)
    • 34202 Finasteride VETRANAL™, analytical standard Selective 5α-reductase inhibitor; antiandrogen.
    		 human ... HSD3B1(3283), SRD5A1(6715), SRD5A2(6716)
    rat ... Hsd3b1(360348), Srd5a1(24950), Srd5a2(64677)
    • F4043 Fisetin ≥98%   human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), GSK3A(2931)
    mouse ... Hexa(15211)
    rat ... Il4(287287), Tnf(24835)
    • F505 Fisetin   human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), GSK3A(2931)
    mouse ... Hexa(15211)
    rat ... Il4(287287), Tnf(24835)
    • F6051   Fisonate ≥99% (NMR), solid A broad spectrum inhibitor of serine protease.
    		  
    • F4679 FK-506 monohydrate ≥98% (HPLC) FK-506 is a potent immunosuppressant, neuroprotective and neuroregenerative, and in vitro T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
    		 human ... FKBP1A(2280)
    • 102032 Flavanone 98%   human ... ADORA3(140), CYP19A1(1588)
    mouse ... Hexa(15211)
    rat ... Adora1(29290), Ar(24208)
    • F2003 Flavone   human ... ADORA3(140), ANPEP(290), CYP1A2(1544)
    mouse ... Hexa(15211)
    rat ... Adora1(29290), Adora2a(25369), Ar(24208), Gabra2(29706)
    • F3055 Flavopiridol hydrochloride hydrate ≥98% (HPLC), powder Flavopiridol hydrochloride is a potent CDK (cyclin-dependent kinase), and a CDC25 phosphatase family inhibitor.
    		  
    • F8304 Flavoxate hydrochloride ≥98% (HPLC), solid L-type Ca2+ (Cav1.2) channel inhibitor
    		  
    • F6777 Flecainide acetate salt Class IC antiarrhythmic agent; sodium channel blocker
    		  
    • F8929 Fluconazole ≥98% (HPLC), powder Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.
    		 human ... CYP1A2(1544)
    • F6127 Fludrocortisone acetate ≥98% Fludrocortisone acetate is a synthetic corticosteroid with more mineralocorticoid than glucocorticoid activity.
    		  
    • F6300 Flumazenil >99% (HPLC), solid Highly specific benzodiazepine receptor antagonist.
    		 human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559), GABRG2(2566)
    rat ... Gabra2(29706), Gabrg1(140674)
    • F8257 Flunarizine dihydrochloride ≥98% (TLC) Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells
    		  
    • F9261 Flunitrazepam Hypnotic; anxiolytic; ligand for the GABAA receptor benzodiazepine modulatory site.
    		 human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559)
    rat ... Gabra2(29706)
    • F0429 Flunixin meglumine ≥98% (HPLC) COX1, COX2 and PLA2 inhibitor non-narcotic analgesic, anti-pyretic, anti-inflammatory.
    		  
    • 46394 Fluo 3-AM suitable for fluorescence    
    • SML0099 Fluocinonide ≥98% (HPLC) Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
    		  
    • 328898 9-Fluoreneacetic acid 99%   rat ... Akr1b1(24192)
    • F1409 Fluorene-9-carboxylic acid 96%   rat ... Akr1b1(24192)
    • 32615 Fluorescein Reag. Ph. Eur., free acid   human ... PTPN1(5770), PTPRF(5792)
    • 46955 Fluorescein for fluorescence, free acid   human ... PTPN1(5770), PTPRF(5792)
    • F2773 2-Fluoroadenine-9-β-D-arabinofuranoside DNA synthesis and methylation inhibitor Fludarabine (the 5′-phosphate) is a prodrug that is converted to F-ara-A, which enters cells and accumulates primarily as the 5′-triphosphate. F-ara-A interferes with DNA synthesis and repair and induces apoptosis of cancer cells. F-ara-A also strongly inhibits DNA methylation, particularly methylation of cytosine in CpG dinucleotide sequences.1
    		 human ... ADORA3(140)
    rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
    • 656402 2-Fluoroadenosine 97%   human ... ADORA3(140)
    rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
    • 162493 4-Fluorobenzylamine 97%   human ... AOC3(8639)
    mouse ... Aoc3(11754)
    • F2927 1-(4-Fluorobenzyl)-5-methoxy-2-methylindole-3-acetic acid ≥98% (HPLC), solid Putative inhibitor of multidrug resistance-associated protein 1 (MRP1).
    		 human ... ABCC1(4363)
    • 543624 6-Fluorochromone-3-carboxaldehyde 97%   human ... PTPN1(5770)
    • 656399 2-Fluoro-2′-deoxyadenosine 96%   rat ... Adcy2(81636)
    • F5307 5−Fluoro−2′−deoxycytidine ≥98% (HPLC), powder 5-Fluoro-2′-deoxycytidine is a mechanism based DNMT (DNA cytosine-5 methyltransferase) inhibitor, that forms a covalent link with the cysteine residue in the active site of DNMT.
    		  
    • F0503 5-Fluoro-2′-deoxyuridine thymidylate synthase inhibitor Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase1 Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.2
    		 mouse ... Tyms(22171)
    • F8791 5-Fluoro-5′-deoxyuridine Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.
    		  
    • H127 p-Fluorohexahydro-sila-difenidol hydrochloride powder, ≥98% (HPLC) High affinity M3 muscarinic acetylcholine receptor antagonist.
    		 human ... CHRM3(1131)
    • F9381 Fluorometholone ≥98% Clinically significant in allergic conjunctivitis and as anti-inflammatory following cataract surgery.1
    		  
    • 545740 (R)-(−)-2-Fluoro-α-methyl-4-biphenylacetic acid 97% gamma secretase inhibitor; amyloid Abeta 42 lowering agent
    		 human ... IL8RA(3577)
    • F2929 6-Fluoromevalonate ≥90% (GC), viscous liquid Mevalonate-pyrophosphate decarboxylase inhibitor
    		  
    • 361828 4-Fluorophenethylamine 99%   human ... AOC3(8639)
    mouse ... Aoc3(11754)
    • F4646 p-Fluoro-L-phenylalanine   human ... TH(7054)
    mouse ... TH(21823)
    rat ... TH(25085)
    • 651710 4-(4-Fluorophenyl)benzoic acid 97%   human ... BAD(572)
    • 191337 1-(4-Fluorophenyl)piperazine 98%   rat ... Chrnb2(54239)
    • F6627 5-Fluorouracil ≥99% (HPLC), powder A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.
    		 human ... TYMS(7298)
    • F132 Fluoxetine hydrochloride solid Selective serotonin reuptake inhibitor; antidepressant.
    		 human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
    • F1678 R-(−)-Fluoxetine hydrochloride >98% (HPLC), solid Selective serotonin reuptake inhibitor.
    		 human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
    • F1553 S-(+)-Fluoxetine hydrochloride ≥98% (HPLC), solid Selective serotonin reuptake inhibitor.
    		 human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
    • F4765 Fluphenazine dihydrochloride D1/D2 dopamine receptor antagonist; phenothiazine antipsychotic; H1 histamine receptor antagonist.
    		 human ... DRD1(1812), DRD2(1813), HRH1(3269)
    • F8927 Flupirtine maleate salt ≥98% (HPLC) Non-opioid analgesic; cytoprotective versus PrP fragment 106-126
    		  
    • F8549 Fluprostenol 10 mg/mL in ethanol, 98%    
    • F2427 Fluprostenol isopropyl ester ≥98%, ethanol solution Potent FP prostanoid receptor agonist used in animal models for glaucoma.
    		  
    • F103 Flurazepam dihydrochloride solid Benzodiazepine anxiolytic; anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site.
    		  
    • F8514 Flurbiprofen cyclooxygenase inhibitor Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
    		 human ... ALB(213), APP(351), CYP1A2(1544), CYP2C9(1559)
    rat ... Ptgs1(24693)
    • F100 Fluspirilene Dopamine receptor antagonist; antipsychotic; calcium channel blocker.
    		 human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
    • F9397 Flutamide Flutamide is a non-steroidal anti-androgen.
    		 human ... AR(367)
    mouse ... Ar(11835)
    rat ... Ar(24208)
    • F9428 Fluticasone propionate ≥98% (HPLC), powder Fluticasone propionate is a second generation glucocorticoid. Used as an anti-inflammatory agent for asthma. Shown to enhance eosinophil apoptosis in a concentration-dependent manner via the glucocorticoid receptor.
    		  
    • SML0038 Fluvastatin sodium hydrate ≥98% (HPLC) Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
    		  
    • F2802 Fluvoxamine maleate solid Selective serotonin reuptake inhibitor; antidepressant.
    		 human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
    • 47633 Fmoc-Leu-OH ≥97.0% PPARγ ligand that induces insulin sensitization, but not adipogenesis.
    		  
    • F4021   Follicle Stimulating Hormone from human pituitary ~7,000 IU/mg (vs. IRP reference preparation 68/140) The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
    		 human ... FSHB(2488), FSHR(2492)
    • F2293   Follicle Stimulating Hormone from porcine pituitary The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
    		 human ... FSHR(2492)
    pig ... FSHB(396895)
    • F8174   Follicle Stimulating Hormone from sheep pituitary The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
    		 human ... FSHR(2492)
    sheep ... FSHB(443387)
    • 32057 Folpet PESTANAL®, analytical standard    
    • 222569 Fomepizole 99% Alcohol dehydrogenase inhibitor
    		 human ... ADH1A(124), ADH1B(125), ADH1C(126)
    • F2552 Formestane solid Aromatase inhibitor used as an anti-cancer agent against estrogen-dependent tumors.
    		 human ... CYP19A1(1588)
    • F9552 Formoterol fumarate dihydrate >98% (HPLC) β2-Adrenoreceptor agonist.
    		 human ... ADRB2(154)
    • 383449 3-Formylchromone 97%   human ... PTPN1(5770)
    • 402141 3-Formyl-6-isopropylchromone 99%   human ... PTPN1(5770)
    • F3506 N-Formyl-Met-Leu-Phe ≥97% (HPLC) Potent chemotactic peptide.1 Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.2
    Potent inducer of leucocyte chemotaxis and macrophage activator. Receptors that bind formylpeptides are found on phagocytic neutrophils and have recently been identified on cells of the intestinal mucosa.
    		 human ... FPR1(2357)
    • 47729 N-Formyl-Met-Leu-Phe BioXtra, ≥99.0% (TLC) N-Formyl-Met-Leu-Phe is a potent chemotactic peptide and formyl peptide receptor (FPR) agonist that induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
    Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
    		human ... FPR1(2357)
    • 402192 3-Formyl-6-nitrochromone 99%   human ... PTPN1(5770)
    • F6886 Forskolin from Coleus forskohlii, ≥98% (HPLC), powder Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.
    		 human ... OPRK1(4986), SLC2A10(81031), TNF(7124)
    • F3917 Forskolin from Coleus forskohlii, BioReagent, for molecular biology, ≥98% Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.1 Forskolin effects calcium currents and inhibits MAP kinase.
    		 human ... OPRK1(4986), SLC2A10(81031), TNF(7124)
    • SML0117 Fosphenytoin disodium salt hydrate ≥98% (HPLC) Fosphenytoin is a water soluble phenytoin prodrug.
    		 
    • F4425 Fostriecin sodium salt from Streptomyces pulveraceus ≥98% (HPLC) Fostriecin was discovered as an anti-tumor antibiotic isolated from the fermentation beer of Streptomyces pulveraceus (subspecies fostreus). Fostriecin has antitumor activity against a wide spectrum of tumor cells in vitro and excellent activity against P388 and L1210 leukemias in vivo. The antitumor activity of fostriecin originates from its ability to interfere with the reversible phosphorylation of proteins that are critical for progression through the cell cycle.
    		  
    • F7307 Fotemustine ≥98% (HPLC) Fotemustine is a third generation nitrosourea, chloroethylating agent used in the treatment of glioma and malignant melanoma.
    		 
    • F1179 FPL-55712 ≥97% (HPLC), solid CysLT1 leukotriene receptor antagonist.
    		  
    • F131 FPL 64176 ≥98% (HPLC), powder Potent Ca2+ channel (L-type) activator.
    		 rat ... Cacnb3(25297)
    • F7553 FR 122047 hydrochloride ≥98% (HPLC), powder Selective cyclooxgenase-1 (COX-1) inhibitor.
    		  
    • SML0028 FR-171113 ≥98% (HPLC) FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. FR171113 inhibits either thrombin or TRAP-6-induced platelet aggregation (IC50 = 290 and 150 nM, respectively). The compound does not affect the protease activity of thrombin or clotting time.
    		  
    • F9553 FTI-276 trifluoroacetate salt ≥95% (HPLC) FTI-276 is a highly potent RasCAAX peptidomimetic. FTI-276 antagonizes both H and K-Ras oncogenic signaling. It is an inhibitor of farnesyltransferase (Ftase) in vitro with an IC50 of 500 pM and is an anti-cancer agent.
    		  
    • F9803 FTI-277 trifluoroacetate salt ≥95% (HPLC), amorphous semi-solid Highly potent (pM/nM) Ras CAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. Inhibitor of farnesyltransferase (Ftase) IC50 = 50 nM.
    		  
    • I4409 Fulvestrant >98% (HPLC) Fulvestrant (ICI 182,780) is a selective estrogen receptor down-regulator (SERD). Fulvestrant is a high affinity estrogen receptor antagonist. IC50 = 0.29 nM. Fulvestrant is the first "pure" antiestrogen with no agonistic activity both in vitro and in vivo.
    		  
    • F6771 Fumagillin from Aspergillus fumigatus ≥90%, powder Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.
    		  
    • F9054 Fumitremorgin C from Neosartorya fischeri, >98% (HPLC and TLC), film Fumitremorgin C (FTC) is a fungal toxin of the diketopiperazines family of compounds. In mammalian cells, FTC is tremorgenic and causes cell cycle arrest. Fumitremorgin C has been shown to reverse resistance to doxorubicin, mitoxantrane, and topotecan in non-Pgp (P-glyco­protein), non-MRP (multidrug resistance protein) multidrug-resistance (MDR) cells. This reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C is a specific, selective, and potent inhibitor at micromolar concentrations of the breast cancer resistant protein (BCRP/ABCG2), an ABC transporter associated with chemotherapy resistance. FTC, in combination with mitoxantrone, can be used for the detection of ABCG2 functional activity in several cell lines.
    		  
    • F1147 Fumonisin B1 from Fusarium moniliforme ≥98% (HPLC) Fungal metabolite believed to cause leukoencephalomalacia in horses.
    		  
    • O003 β-Funaltrexamine hydrochloride solid Selective irreversible μ opioid receptor antagonist that is also a κ opioid receptor agonist.
    		  
    • F0763 Fura 2 pentapotassium salt ≥80%    
    • 17195 Fura 2 pentapotassium salt for fluorescence, ≥95% (TLC)    
    • F0888 Fura 2-AM ≥95% (HPLC)    
    • 47989 Fura 2-AM BioReagent, suitable for fluorescence, ≥95.0% (HPLC)    
    • F5645 Fura 2 magnesium-selective analog tetrapotassium salt ~90% (TLC)    
    • F124 Furafylline ≥98% (HPLC) Furafylline is a methyl xanthine derivative with longer duration of action than theophylline and an inhibitor of cytochrome P4501A2.
    		 human ... CYP1A2(1544)
    • F0918 Fura-2 LeakRes (AM) ≥85%    
    • 17081 Fura-2 LeakRes (AM) for fluorescence, ≥95% (TLC)    
    • 138029 Furil 98%   human ... ACHE(43), BCHE(590), CES1(1066)
    • 192651 Furoin 98%   human ... ACHE(43), BCHE(590), CES1(1066)
    • F4381 Furosemide "High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.
    Inhibits ion co-transport in the kidney.
    		 human ... ALB(213), CYP1A2(1544), SLC12A1(6557)
    • F7131 N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly   human ... ACE(1636), ACE2(59272)
    mouse ... ACE3(217246)
    rat ... ACE(11421), ACE2(70008), ACE3(498012)
    • F6513 Fusaric acid from Gibberella fujikuroi Dopamine β-hydroxylase inhibitor.
    		 human ... DBH(1621)
    • F0756 Fusidic acid Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.
    		  
    • F0881 Fusidic acid sodium salt ≥98% (TLC) Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.