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W278106 gamma-Nonalactone ≥98%, FCC   human ... CYP1A2(1544)
    • M5939   (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide >95% (HPLC) Inhibits a wide variety of matrix metalloproteases with Kis in the nanomolar range. Active in a number of animal models of diseases where matrix metalloproteases are thought to be involved.
    		  
    • N3785 Nabilone solid, ≥98% (HPLC) CB1 and CB2 cannabinoid receptor agonist.
    		  
    • N6142 Nabumetone analytical standard Nonselective non-steroidal anti-inflammatory drug (NSAID)
    		 human ... PTGS1(5742), PTGS2(5743)
    • N1892 Nadolol analytical standard β-Adrenergic blocker
    		 human ... CYP1A2(1544)
    • N0912 NAEPA ≥98 (TLC), solid Selective lysophosphatidic acid-1 (LPA1) receptor agonist; LPA mimetic
    		  
    • N7662 Nafarelin acetate salt hydrate ≥95% (HPLC), solid Nafarelin acetate salt hydrate is a gonadotrophin releasing hormone analogue and luteinizing hormone releasing hormone (LH-RH) agonist.
    		  
    • PZ0118 Nafoxidine hydrochloride ≥98% (HPLC) Nafoxidine is a potent estrogen receptor antagonist that exhibits anti-proliferative properties. It is a non-steroidal antiestrogen, a derivative of Tamoxifen.
    		  
    • N158 Naftopidil hydrochloride hydrate solid α1-Adrenoceptor antagonist; antihypertensive.
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
    • N4396 Nalbuphine hydrochloride hydrate ≥98% (HPLC) Partial agonist for μ and κ opioid receptors.
    		 human ... OPRK1(4986), OPRM1(4988)
    • N8878 Nalidixic acid ≥98%    
    • N5035 Nalidixic acid meets USP testing specifications Used to modulate (inhibit) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependen)t DNA supercoiling, and chromosome fragmentation.
    		  
    • N4382 Nalidixic acid sodium salt powder Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.1
    		  
    • N3143 Nalidixic acid sodium salt powder Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.1
    		  
    • N5770 Nalmefene Nonselective opioid receptor antagonist.
    		 rat ... Oprd1(24613), Oprm1(25601)
    • N100 Nalorphine hydrochloride solid Mixed action opiate that is a partial agonist at μ and κ opioid receptors, and a low-affinity agonist at sigma receptors.
    		  
    • N176 Naloxonazine dihydrochloride hydrate powder, ≥95% (HPLC) Potent opioid antagonist that is selective for μ1 opioid receptors.
    		 human ... OPRM1(4988)
    • N7758 Naloxone hydrochloride dihydrate ≥98% (TLC and titration), powder Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites.
    		 human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
    • N165 Naloxone benzoylhydrazone solid Agonist for κ3 opioid receptors; antagonist for ORL1 and μ opioid receptors.
    		 human ... OPRK1(4986), OPRL1(4987), OPRM1(4988)
    • UC322 Naloxone-3-glucuronide Phase II metabolite of naloxone.
    		  
    • N129 Naloxone methiodide ≥98% (HPLC), solid Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.
    		  
    • N9412 6β-Naltrexol hydrate ≥96% (HPLC), powder Neutral antagonist of the μ-opioid receptor. A reduction of withdrawal effects associated with neutral μ-opioid receptor antagonists may offer advantages in treating opioid overdose and addiction.
    		 
    • N3136 Naltrexone hydrochloride Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.
    		 human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
    • 70128 Naltrexone hydrochloride ≥99.0% (TLC)    
    • N156 Naltriben methanesulfonate hydrate ≥98% (HPLC), solid Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkepha  
    • N115 Naltrindole hydrochloride solid Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier.
    		 human ... OPRD1(4985)
    • N157 Naltrindole isothiocyanate hydrochloride solid Selective irreversible δ2 opioid receptor antagonist.
    		  
    • N3529 NAN-190 hydrobromide Potent 5-HT1A serotonin receptor antagonist active in the nM range.
    		 human ... HTR1A(3350)
    • N5504 Naphazoline hydrochloride α-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
    • 84679 Naphthalene analytical standard   human ... CYP1A2(1544)
    • 184500 Naphthalene suitable for scintillation, ≥99%   human ... CYP1A2(1544)
    • 147141 Naphthalene 99%   human ... CYP1A2(1544)
    • 48546 Naphthalene analytical standard   human ... CYP1A2(1544)
    • 40053 Naphthalene solution 5000 μg/mL in methanol, analytical standard   human ... CYP1A2(1544), CYP2A6(1548)
    mouse ... Cyp2a5(13087)
    • N0640 1-Naphthaleneacetic acid plant cell culture tested, BioReagent, ≥95%, crystalline   human ... CCKAR(886), CCKBR(887)
    • 35745 1-Naphthaleneacetic acid PESTANAL®, analytical standard   human ... CCKAR(886), CCKBR(887)
    • 317918 1-Naphthaleneacetic acid technical grade   human ... CCKAR(886), CCKBR(887)
    • N1145 1-Naphthaleneacetic acid potassium salt BioReagent, plant cell culture tested, ≥95%   human ... CCKAR(886), CCKBR(887)
    • 523763 2,6-Naphthalenedicarboxylic acid 99%   human ... PTPN1(5770)
    • 301353 2,6-Naphthalenedicarboxylic acid 95%   human ... PTPN1(5770)
    • 183458 1-Naphthaleneethanol 95%   human ... BAD(572)
    • 188107 2-Naphthaleneethanol 98%   human ... BAD(572)
    • 186341 1-Naphthalenesulfonic acid ~50%   human ... EGFR(1956), LCK(3932)
    • 249548 2-Naphthalenesulfonic acid technical grade, 70%   human ... EGFR(1956), LCK(3932)
    • N5757 α-Naphthoflavone   human ... ADORA3(140), CYP1A2(1544), PRKDC(5591)
    rat ... Adora1(29290), Adora2a(25369)
    • N3633 β-Naphthoflavone   rat ... Gabra2(29706)
    • SML0078 1-Naphthohydroxamic Acid ≥98% (HPLC) 1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
    		  
    • N1000 1-Naphthol ReagentPlus®, ≥99%   human ... CYP1A2(1544)
    • 31097 1-Naphthol PESTANAL®, analytical standard   human ... CYP1A2(1544)
    • N2780 1-Naphthol BioXtra, ≥99%   human ... CYP1A2(1544)
    • 33420 1-Naphthol puriss. p.a., Reag. Ph. Eur., ≥99% (GC)   human ... CYP1A2(1544)
    • 70442 1-Naphthol ≥98.0% (GC)   human ... CYP1A2(1544)
    • 70448 2-Naphthol BioXtra, ≥99.0% (GC)   human ... CYP1A2(1544)
    • 70450 2-Naphthol fluorescence indicator, ≥99.0%   human ... CYP1A2(1544)
    • 185507 2-Naphthol 99%   human ... CYP1A2(1544)
    • 130109 2-Naphthol 98%   human ... CYP1A2(1544)
    • 346616 1,2-Naphthoquinone 97%   human ... PTPRC(5788)
    • N1641 1-Naphthylacetic acid 1 mg/mL, BioReagent, plant cell culture tested   human ... CCKAR(886), CCKBR(887)
    • N193 1-Naphthylacetyl spermine trihydrochloride Blocks Ca2+ permeable AMPA receptor channels.
    		  
    • 346217 (R)-(+)-1-(2-Naphthyl)ethanol 98%   human ... UGT2B17(7367), UGT2B7(7364)
    • 127035 1-Naphthylmethylamine 97%   rat ... Adra2a(25083)
    • 559814 1-Naphthyl-N-methylcarbamate 97%   rat ... Faah(29347)
    • N5602 1-Naphthyl phosphate 99%   human ... EGFR(1956), LCK(3932)
    • N8280 Naproxen meets USP testing specifications Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor.
    		 human ... MAPK14(1432), PTGS1(5742), PTGS2(5743)
    rat ... Alox5(25290), Ptgs1(24693)
    • 46482 Naproxen VETRANAL™, analytical standard Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor.
    		 human ... MAPK14(1432), PTGS1(5742), PTGS2(5743)
    rat ... Alox5(25290), Ptgs1(24693)
    • N5160 Naproxen sodium meets USP testing specifications Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.
    		  
    • M1275 Naproxen sodium 98.0-102.0% Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.
    		 human ... PTGS1(5742), PTGS2(5743)
    • N1415 Naratriptan hydrochloride ≥98% (HPLC) Naratriptan hydrochloride is a serotonin 5-HT1B/1D receptor agonist.
    		  
    • N9789 Narciclasine ≥98% (HPLC) Narciclasine is a Rho/Rho kinase/LIM kinase/cofilin signaling pathway activator. Also narciclasine is an actin stress fiber formation inducer; a plant growth modulator.
    		  
    • T66001 Naringenin   human ... CYP1A2(1544)
    • N5893 (±)-Naringenin ≥95%   human ... CYP1A2(1544)
    • P0247   L-NASPA ≥98% (TLC), powder Competitive mammalian lysophosphatitic acid (LPA) receptor agonist; LPA mimetic; potent reversible antagonist of the LPA receptors expressed in Xenopus oocytes.
    		  
    • N3538 Nateglinide ≥98% (HPLC), solid Nateglinide is a Kir6.2/SUR1 channel inhibitor and antidiabetic. It is selective for the SUR1 subtype, which is found on pancreatic islet cells. Nateglinide evokes KATP channel-dependent insulin secretion (50-200 μM) in the absence and presence of insulin.
    		  
    • SML0060 NB001 ≥98% (HPLC) NB001 is a selective orally active inhibitor of adenylyl cyclase 1 (AC1). The compound has an analgesic effect in animal models of neuropathic pain, without any apparent side effects.
    		  
    • N9158 N-(NBD-Aminolauroyl)ceramide ≥98%    
    • N3409   N-(NBD-Aminolauroyl)sphingosine β-D-lactosyl >98%    
    • N3911 NBI 27914 ≥98% (HPLC) NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.
    		 human ... CRHR1(1394)
    • N183 NBQX disodium salt hydrate ≥98% (HPLC), lyophilized solid NBQX disodium salt hydrate is a neuroprotective AMPA/kainate glutamate receptor antagonist.
    		 human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
    • N171 NBQX hydrate powder, ≥98% (HPLC) Neuroprotective AMPA/kainate glutamate receptor antagonist.
    		  
    • N4159 NCS-382 hydrate solid, ≥98% (HPLC) γ-Hydroxybutyrate (GHB) receptor antagonist; anti­convulsant.
    		  
    • N5537 NDNI hydriodide solid, (The product is pure based on CHN, NMR, MS) Highly selective α4β2 nicotinic receptor antagonist
    		  
    • N1915 Nebivolol hydrochloride ≥98% (HPLC) Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).
    		 
    • N9037 Necrostatin-1 ≥98% (HPLC) Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway).
    		  
    • N0164 Necrostatin-5 ≥98% (HPLC), solid Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensation, organelle swelling, loss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5, since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1, but does not inhibit recombinant RIP1.
    		  
    • N5536 Nefazodone hydrochloride ≥98% (HPLC), solid Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.
    		  
    • N2288 Nefiracetam solid Nefiracetam (NEF) is a pyrrolidonetype nootropic agent with various pharmacologic as well as cognition enhancing effects. In amygdala-kindled seizures, nefiracetam inhibits both electroencephalographic and behavioral seizures. NEF has a distinct anticonvulsant spectrum.
    		  
    • PZ0013 Nelfinavir mesylate hydrate ≥98% (HPLC) Nelfinavir is a HIV protease inhibitor; antiretroviral; and anti-tumor agent.
    		 
    • N9162 Neocarzinostatin from Streptomyces carzinostaticus ≥90% (SDS-PAGE), ~0.5 mg/mL Neocarzinostatin is a protein-small molecule complex composed of an enediyne chromophore tightly bound to a 113 amino acid single chain protein. The complex possesses antiproliferative and antitumor activity. The chromophore is the active compound, which is responsible for DNA cleavage; while the apoprotein stabilizes and regulates the availability of the labile chromophore. NCS chromophore is bound non-covalently in a cleft of the binding protein and is dissociable. Upon addition of a thiol, the chromophore forms a highly reactive biradical species that can induce sequence-specific single and double strand breaks in DNA. Neocarzinostatin inhibits DNA synthesis and possesses antitumor activity in various human and animal tumors. NCS inhibits cellular proliferation by inducing G2 cell cycle arrest and apoptosis in both human papillomavirus (HPV) positive and negative cell lines.
    		  
    • N1142   Neomycin solution with 10 mg/mL neomycin in 0.9% NaCl, sterile-filtered, BioReagent, suitable for cell culture Mode of action: binds to the 30S and in some cases the 50S subunit causing miscoding; inhibits initiation and elongation during protein synthesis.
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    		 human ... TERT(7015)
    • N1876 Neomycin trisulfate salt hydrate powder Mode of action: binds to the 30S and in some cases the 50S subunit causing miscoding; inhibits initiation and elongation during protein synthesis. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. Neomycin blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.
    Mode of action: binds to the 30S and in some cases the 50S subunit causing miscoding; inhibits initiation and elongation during protein synthesis.
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    		  
    • N5285 Neomycin trisulfate salt hydrate meets USP testing specifications, powder Mode of action: binds to the 30S and in some cases the 50S subunit causing miscoding; inhibits initiation and elongation during protein synthesis.
    Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
    		  
    • N2001 Neostigmine bromide ≥98% (HPLC and titration), powder Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.
    		 human ... ACHE(43)
    • N2126 Neostigmine methyl sulfate Reversible inhibitor of acetylcholinesterase that is similar to eserine, but does not cross the blood-brain barrier.
    		  
    • N6037 Neridronate ≥97% (NMR), solid Neridronate is a bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta, an "orphan disease" characterized by a fragility of the bone enough to be named the "illness of bones of crystal".
    		  
    • W525308 Nerolin Yara Yara ≥99%   human ... CYP1A2(1544)
    • N9653 Netropsin dihydrochloride from Streptomyces netropsis, ≥98% (HPLC and TLC), powder Netropsin is an unusual n-methylpyrrole-containing oligopeptide that binds to AT-rich sequences of dsDNA, especially in the minor groove. Thus, it protects such regions from DNase I and other endonucleases, and also inhibits topoisomerases. Netropsin disrupts the cell cycle, prolonging G and arresting in G.
    		  
    • N2412   Neuropeptide S from rat ≥98% (HPLC), powder Neuropeptide S is a novel modulator of wakefulness and anxiety.
    		  
    • SML0097 Nevirapine Nevirapine is an allosteric, non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The Ki for inhibition of wild-type RT by Nevirapine is 200 nM.
    		  
    • N8652 NF 023 hydrate ≥98% (HPLC), solid NF 023 is a potent, selective P2X1 purinoceptor antagonist.
    		 human ... P2RX1(5023), P2RY1(5028), P2RY11(5032), P2RY2(5029)
    • N7032   NFAT Inhibitor >96% (HPLC), solid High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
    		 human ... NFATC1(4772), NFATC2(4773)
    mouse ... Nfatc1(18018), Nfatc2(18019)
    • SML0066 NGB 2904 hydrochloride ≥98% (HPLC) NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.
    		  
    • N2162 NH125 ≥98% (HPLC), solid NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).
    		  
    • N5535 Niacinamide meets USP testing specifications Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
    		 human ... PARP1(142), SIRT2(22933)
    • N7510 Nicardipine hydrochloride powder, ≥98% Blocks L-type voltage-dependent calcium channels; antihypertensive.
    		  
    • N7889 Nicergoline analytical standard, for drug analysis Cerebral and peripheral vasodilator
    		 human ... ADRA1A(148)
    • 72340 Nicotinamide ≥99.5% (HPLC) Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.
    Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
    		 human ... PARP1(142), SIRT2(22933)
    • N3376 Nicotinamide ≥98% (TLC), powder Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
    		 human ... PARP1(142), SIRT2(22933)
    • N0636 Nicotinamide BioReagent, suitable for cell culture, suitable for insect cell culture Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
    		 human ... PARP1(142), SIRT2(22933)
    • 72347 Nicotinamide Ph Eur Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
    		 human ... PARP1(142), SIRT2(22933)
    • N4505 β-Nicotinamide adenine dinucleotide, reduced dipotassium salt Electron donor
    		 human ... IMPDH2(3615)
    • 47865-U Nicotinamide (Niacinamide) analytical standard Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
    		 human ... PARP1(142), SIRT2(22933)
    • N3876 (−)-Nicotine ≥99% (GC), liquid Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
    		 human ... CHRNA2(1135), CHRNA3(1136), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756)
    mouse ... Chrna7(11441), Chrnb1(11443)
    rat ... Chrna1(79557), Chrna2(170945), Chrna4(25590), Chrna7(25302), Chrnb2(54239), Chrnb4(25103)
    • 36733 (−)-Nicotine PESTANAL®, analytical standard Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
    		 human ... CHRNA2(1135), CHRNA3(1136), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756)
    mouse ... Chrna7(11441), Chrnb1(11443)
    rat ... Chrna1(79557), Chrna2(170945), Chrna4(25590), Chrna7(25302), Chrnb2(54239), Chrnb4(25103)
    • 72290 (−)-Nicotine ≥99.0% (sum of enantiomers, GC) Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
    		 human ... CHRNA2(1135)
    • N1019   (−)-Nicotine hemisulfate salt ≥95% (TLC), ~40 % (w/v) in H2O (based on free base) Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
    		  
    • N5260   (−)-Nicotine hydrogen tartrate salt ≥98% (TLC), powder Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
    		 human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)
    • 46343 (−)-Nicotine solution 100 ng/μL in acetonitrile, PESTANAL®, analytical standard   human ... CHRNA3(1136), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756)
    mouse ... Chrna7(11441), Chrnb1(11443)
    rat ... Chrna1(79557), Chrna2(170945), Chrna4(25590), Chrna7(25302), Chrnb2(54239), Chrnb4(25103)
    • N5511 (−)-Nicotine solution 1.0 mg/mL, analytical standard, for drug analysis   human ... CHRNA3(1136), CHRNB2(1141), CHRNB4(1143), CYP2A6(1548), KCNH1(3756)
    mouse ... Chrna7(11441), Chrnb1(11443)
    rat ... Chrna1(79557), Chrna2(170945), Chrna4(25590), Chrna7(25302), Chrnb2(54239), Chrnb4(25103)
    • N0267 (±)-Nicotine ≥99% (TLC), liquid Prototype nicotinic acetylcholine receptor agonist.
    		 human ... CHRNA2(1135), CHRNA3(1136), CHRNA4(1137)
    rat ... Chrna3(25101), Chrna4(25590), Chrna7(25302)
    • N4126 Nicotinic acid ≥98% Decreases hepatic production of very-low density lipoproteins and apolipoprotein B.
    		 human ... CYP1A2(1544)
    rat ... Chrnb2(54239)
    • 72309 Nicotinic acid ≥99.5% (HPLC)   human ... CYP1A2(1544)
    rat ... Chrnb2(54239)
    • N0765 Nicotinic acid plant cell culture tested   human ... CYP1A2(1544)
    rat ... Chrnb2(54239)
    • 72311 Nicotinic acid matrix substance for MALDI-MS, ≥99.5% (HPLC)   human ... CYP1A2(1544)
    rat ... Chrnb2(54239)
    • N0761 Nicotinic acid BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%   human ... CYP1A2(1544)
    rat ... Chrnb2(54239)
    • 72312 Nicotinic acid Ph Eur   human ... CYP1A2(1544)
    rat ... Chrnb2(54239)
    • 47864 Nicotinic acid analytical standard   human ... CYP1A2(1544)
    rat ... Chrnb2(54239)
    • N5410 Nicotinic acid meets USP testing specifications   human ... CYP1A2(1544)
    rat ... Chrnb2(54239)
    • N5655 Nicotinic acid adenine dinucleotide phosphate sodium salt ≥92.5% Potent activator of intracellular Ca2+ release via an IP3 and cyclic ADP ribose-independent mechanism.
    		  
    • N8162 NIDA-41020 ≥97% (HPLC), solid NIDA-41020 is a CB1 cannabinoid receptor antagonist. NIDA-41020 is structurally similar to Rimonabant, which is currently in clinical development. NIDA-41020 is less lipophilic; developed at NIDA as a potential radioligand for CB1 receptors, Ki = 4.1 nM [in comparison AM 251, AM 281, SR 141716 (Rimonabant) have Ki of 0.6, 4.5 and 1.8 nM respectively].
    		  
    • N7634 Nifedipine ≥98% (HPLC), powder L-type Ca2+ channel blocker; induces apoptosis in human glioblastoma cells.
    		 human ... ADORA2A(135), ADORA3(140), CACNA2D1(781), CYP1A2(1544), KCNH1(3756), TTR(7276)
    mouse ... Cacna1c(12288)
    rat ... Adora1(29290), Adora2a(25369), Cacna1c(24239), Cacna1d(29716), Kcnj1(24521), Kcnn4(65206), Tbxas1(24886)
    • N0630 Niflumic acid Selective cyclooxygenase-2 (COX-2) inhibitor.
    		 human ... PTGS1(5742)
    • N7143 Nigericin sodium salt ≥98% (TLC) Ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria.
    Polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K+> Rb+≥ Cs+>> Na+.
    		  
    • N135 S(+)-Niguldipine hydrochloride solid α1A-adrenoceptor antagonist; antihypertensive agent; L-type Ca2+ channel blocker; potassium agonist that activates Ca2+-activated maxi K-channels.
    		  
    • N8534   Nilutamide solid Nilutamide is an antiandrogen used in the treatment of prostate cancer.
    		 human ... AR(367)
    • N1016 Nimesulide Highly selective cyclooxygenase-2 inhibitor.
    		 human ... ALB(213), PTGS1(5742), PTGS2(5743)
    • N149 Nimodipine solid Potent L-type Ca2+ channel antagonist.
    		 human ... ADORA3(140), CACNG1(786)
    rat ... Adora1(29290), Adora2a(25369)
    • N8659 Nimustine hydrochloride solid    
    • 211672 Nipecotic acid 98%   human ... SLC23A2(9962)
    • UC179 (R)-(−)-Nirvanol CYP2B6 metabolite of (S)-(+)-mephenytoin; anticonvulsant; hypnotic.
    		  
    • UC180 (S)-(+)-Nirvanol CYP2B6 metabolite of (R)-(-)-mephenytoin; anticonvulsant; hypnotic.
    		  
    • UC178 (±)-Nirvanol CYP2B6 N-demethyl metabolite of (±)-mephenytoin; anticonvulsive; hypnotic
    		  
    • N0165 Nisoldipine ≥98% (HPLC) L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.
    		  
    • N151 Nisoxetine hydrochloride solid, ≥98% (HPLC) Potent and selective inhibitor of the norepinephrine transporter (Ki = 5.1 nM).
    		  
    • N0290 Nitazoxanide ≥98% (HPLC) Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.
    		 
    • N3889 Nitrazepam Hypnotic; ligand for the GABAA receptor benzodiazepine modulatory site.
    		  
    • N144 Nitrendipine >95%, powder Ca2+ channel blocker; anti-hypertensive.
    		 human ... ADORA3(140), CACNG1(786), KCNH1(3756), TTR(7276)
    rat ... Adora1(29290), Adora2a(25369)
    • N5501 Nω-Nitro-L-arginine ≥98% (TLC) Irreversible inhibitor of constitutive nitric oxide synthase (nNOS) and a reversible inhibitor of inducible nitric oxide synthase (iNOS).
    		 human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
    mouse ... Nos2(18126)
    rat ... Grin2a(24409), Nos1(24598)
    • N4770 Nω-Nitro-D-arginine methyl ester hydrochloride    
    • N5751 Nω-Nitro-L-arginine methyl ester hydrochloride ≥98% (TLC), powder An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodilation when used to pretreat aortic ring preparations of mice. Induces leukocyte adhesion and increases microvascular fluid and protein fluxes and permeability. It has also been used in many studies of learning and memory.
    		  
    • 72760 Nω-Nitro-L-arginine methyl ester hydrochloride ≥99.0% (AT)    
    • N2255 S-(4-Nitrobenzyl)-6-thioinosine ≥98%, solid Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system1 and vascular smooth muscle.2
    Potent adenosine uptake inhibitor
    		 human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), SLC29A1(2030)
    • N7126 4-Nitrocatechol Sigma Grade   rat ... Nos1(24598)
    • N15553 4-Nitrocatechol 97%   rat ... Nos1(24598)
    • 657239 6-Nitro-2,3-dihydroxyquinoxaline 96%   rat ... Gria1(50592), Grik1(29559), Grin2a(24409)
    • N7778 7-Nitroindazole ≥98% Selective inhibitor of nitric oxide synthase from mouse brain.
    		 human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
    rat ... Nos1(24598)
    • 1048 4-Nitrophenol spectrophotometric grade   human ... UGT1A4(54657)
    • 35836 4-Nitrophenol PESTANAL®, analytical standard   human ... UGT1A4(54657)
    • 73560 4-Nitrophenol puriss. p.a., indicator (pH 5.6-7.6), ≥99.5%   human ... UGT1A4(54657)
    • 241326 4-Nitrophenol ReagentPlus®, ≥99%   human ... UGT1A4(54657)
    • 48549 4-Nitrophenol analytical standard   human ... UGT1A4(54657)
    • N7660 4-Nitrophenol solution 10 mM   human ... UGT1A4(54657)
    • 48695 4-Nitrophenol solution 500 μg/mL in methanol, analytical standard   human ... UGT1A4(54657)
    • 40056 4-Nitrophenol solution 5000 μg/mL in methanol, analytical standard   human ... UGT1A4(54657)
    • N8130 4-Nitrophenyl acetate esterase substrate   human ... PON1(5444)
    • 46021 4-Nitrophenyl acetate ≥99.0% (GC)   human ... PON1(5444)
    • N4779   5-Nitro-2-(3-phenylpropylamino)benzoic acid ≥98% Potent chloride channel blocker.
    		  
    • N5636 3-Nitropropionic acid ≥97% Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.
    		  
    • 73808 3-Nitropropionic acid purum, ≥96.0% (T) Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.
    		  
    • Q109 6-Nitroquipazine maleate salt solid Potent and selective serotonin transport blocker.
    		 human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
    • N3398 S-Nitroso-N-acetyl-DL-penicillamine ≥97%, powder NO donor; vasodilator, smooth muscle relaxant, lymphocyte activator. Activates soluble guanylyl cyclase.
    SNAP, a nitrosothiol derivative, releases nitric oxide (NO.) under physiological conditions thus making it a useful tool for studying pharmacological and physiological actions of NO. Because of its NO releasing properties SNAP is a potent vasodilator in vitro and in vivo and is less prone to produce pharmacological tolerance.
    		  
    • N4148 S-Nitrosoglutathione ≥97% NO donor in vivo, smooth muscle relaxant, vasodilator, inhibits platelet activation.
    		  
    • N27802 4-Nitro-3-(trifluoromethyl)phenol 99%   human ... CA2(760)
    • N7389 3-Nitro-L-tyrosine crystalline Oxidant and cytotoxic agent.
    		  
    • N3290 NKH 477 ≥98% (HPLC), powder NKH 477 is a potent, orally active adenylyl cyclase activator. It is a water soluble derivative of forskolin, and dose dependentyl increases cAMP and blocks potassium-induced contraction concetrations in smooth muscle strips (IC50 = 80 nM). NKH 477 causes relaxation of histamine treated guinea pig smooth muscle (IC50 = 32 nM).
    		  
    • N4912   NMA-Gly-Cys-Gly-Val-Leu-Leu-Lys(dnp)-Arg-Arg-NH2 trifluoroacetate salt ≥95% (HPLC), solid Notch 1 Peptide, fluorogenic
    		  
    • N0287 NNC 55-0396 hydrate ≥98% (HPLC) Selective T-type calcium channel inhibitor
    		  
    • N1540 NO-1886 Lipoprotein lipase activator. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Long-term administration of NO-1886 protects against the development of experimental atherosclerosis in animals.
    		  
    • N142 NO-711 hydrochloride solid, ≥98% (HPLC) Potent and selective GABA uptake inhibitor that crosses the blood-brain barrier.
    		 human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)
    • M1404 Nocodazole ≥99% (TLC), powder Antimitotic agent that disrupts microtubules by binding to β‑tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex. Arrests the cell cycle at G2/M phase. Prevents phosphorylation of the T cell antigen receptor and inhibits its activity. Stimulates the intrinsic GTPase activity of tubulin. Activates the JNK/SAPK signaling pathway and induces apoptosis in several normal and tumor cell lines.
    		 human ... TUBB(203068)
    • SML0133 Nomegestrol acetate ≥98% (HPLC) Nomegestrol acetate (NOMAc) is a potent, highly selective progestogen, a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors. It shows potent antigonadotropic activity mediated at the hypothalamic and pituitary level with strong antiestrogenic effects and a partial antiandrogenic effect. NOMAc is used in various formulations as a contraceptive.
    		  
    • N1530 Nomifensine maleate salt Selective dopamine uptake inhibitor interacting with the dopamine transporter at a site different from that of cocaine; antidepressant.
    		 human ... DBH(1621)
    • 292370 γ-Nonanoic lactone 97%   human ... CYP1A2(1544)
    • C2137   Non-hydroxy fatty acid ceramide from bovine brain ≥99% Involved in the action of phospholipase C on sphingomyelin.
    		  
    • 290858 Nonylphenol technical grade, mixture of ring and chain isomers   mouse ... Esr1(13982)
    rat ... Ar(24208)
    • 46018 Nonylphenol PESTANAL®, analytical standard, technical mixture   mouse ... Esr1(13982)
    rat ... Ar(24208)
    • 46405 4-Nonylphenol PESTANAL®, analytical standard   mouse ... Esr1(13982)
    rat ... Ar(24208)
    • 442873 4-Nonylphenol analytical standard   mouse ... Esr1(13982)
    rat ... Ar(24208)
    • N8784 Norcantharidin solid Potential antitumor agent
    		 human ... PPP2R5A(5525)
    • 74540 Nordihydroguaiaretic acid ≥97.0% (HPLC) Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure.
    		 mouse ... Alox12(11684)
    • N5023 Nordihydroguaiaretic acid ≥90% (HPLC), from Larrea divaricata (creosote bush) Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure.
    		 human ... ALOX15(246), PTGS1(5742), PTGS2(5743)
    mouse ... Alox12(11684)
    • 282553 (1R,2S)-(−)-Norephedrine 99%   rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
    • 74530 L-(−)-Norephedrine purum, ≥98.0% (NT)   rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
    • P7876 DL-Norephedrine hydrochloride ≥99% Mixed-acting sympathomimetic amine.
    		  
    • A7257 (−)-Norepinephrine ≥98%, crystalline Adrenergic neurotransmitter
    		 human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
    rat ... Adra1a(29412), Adra1d(29413), Adra2a(25083), Adrb1(24925), Adrb2(24176), Drd1a(24316), Drd2(24318)
    • A0937 (±)-Norepinephrine (+)-bitartrate salt Adrenergic neurotransmitter
    		 human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
    • N5785 L-(−)-Norepinephrine (+)-bitartrate salt monohydrate meets USP testing specifications    
    • A9512 L-(−)-Norepinephrine (+)-bitartrate salt monohydrate ≥99%, solid Adrenergic neurotransmitter, vasoconstrictor.
    		  
    • N4128 19-Norethindrone ≥98%, powder 19-norethindrone is an oral contraceptive involved in the inhibition of cytosolic sulfotransferases (SULT).
    		human ... AR(367), PGR(5241)
    rat ... Ar(24208)
    • N3288 (+)-Norfenfluramine hydrochloride ≥98% (HPLC), powder (+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is primarily responsible for the anorexic effect, as well as side effects; (+)-norfenfluramine causes vasoconstriction and a blood pressure increase in rats with normal blood; acts primarily on the cytoplasmic pool of serotonin; more potent than fenfluramine at inducing dopamine release.
    		  
    • N9890 Norfloxacin ≥98% (TLC) Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
    Mode of action: inhibits bacterial DNA replication
    Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria
    		 human ... CYP1A2(1544)
    rat ... Gabra1(29705)
    • 33899 Norfloxacin VETRANAL™, analytical standard Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
    Mode of action: inhibits bacterial DNA replication
    Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria
    		 human ... CYP1A2(1544)
    rat ... Gabra1(29705)
    • N2144 Norfludiazepam analytical standard, for drug analysis The major human metabolite of flurazepam
    		  
    • F133 Norfluoxetine hydrochloride ≥97%, solid Fluoxetine metabolite; more potent inhibitor of serotonin uptake than fluoxetine with a half-life in vivo of 5-7 days.
    		  
    • N2260 D(−)-Norgestrel analytical standard, for drug analysis   rat ... Ar(24208)
    • N6252 Norharmane crystalline Inhibitor of indoleamine 2,3-dioxygenase (IDO).
    		 human ... IKBKB(3551)
    rat ... Gabra2(29706)
    • N7127 DL-Normetanephrine hydrochloride ≥98% Norepinephrine metabolite.
    		  
    • N3018 (±)-Nornicotine ≥98% (TLC), liquid Nicotinic acetylcholine receptor agonist; active metabolite of nicotine; tobacco alkaloid.
    		 mouse ... Chrna1(11435), Chrna7(11441)
    rat ... Chrna4(25590)
    • 74600 (±)-Nornicotine ≥98.0% (GC)    
    • N2390 19-Norprogesterone powder   human ... SERPINA6(866)
    • N7261 Nortriptyline hydrochloride ≥98% (TLC), powder Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.
    		 human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)
    • V108 (±)-Norverapamil hydrochloride ≥98% (HPLC), solid (±)-Norverapamil is a Ca2+ channel (L-type) antagonist; N-demethylated metabolite of verapamil.
    		  
    • N9286   Notch-1/Fc Chimera from rat recombinant, expressed in NSO cells, ≥90% (SDS-PAGE), lyophilized powder, from rat   human ... JAG1(182)
    mouse ... JAG1(16449)
    rat ... JAG1(29146)
    • N0415 Novokinin trifluoroacetate salt ≥95% (HPLC) Novokinin trifluoroacetate is a angiotensin II receptor 2 (AT2) agonist.
    		  
    • N161 NPC-15437 dihydrochloride hydrate ≥98% (HPLC), solid Selective protein kinase C inhibitor.
    		  
    • SML0185 NQDI-1 ≥98% (HPLC) NQDI-1 is an inhibitor of apoptosis signal-regulating kinase (ASK1), Ki = 500 nM. NQDI-1 shows little or no inhibitory activity against Aurora A or ROCK kinases, or several receptor tyrosine kinases.
    		  
    • N179 NS 102 solid Competitive glutamate receptor antagonist with high selectivity for the low-affinity [3H] kainate binding site.
    		 human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
    mouse ... GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
    rat ... GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)
    • N170 NS 1619 powder Selective large conductance Ca2+-activated K+-channel activator.
    		 mouse ... Kcnma1(16531)
    rat ... Kcnma1(83731)
    • N0663 NS1643 ≥98% (HPLC), solid The new diphenylurea compound 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) was tested in hERG channel. In Xenopus laevis oocytes, NS1643 increased both steady-state and tail current at all voltages tested. The EC50 value for hERG channel activation was 10.5 μM. The effect could be reverted by application of the specific hERG channel inhibitor 4′-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide (E-4031) at 100 nM. Application of NS1643 also resulted in a prolonged postrepolarization refractory time. hERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents a new antiarrhythmic approach.
    		  
    • N211 NS 2028 solid Specific, soluble guanylyl cyclase inhibitor.
    		 human ... GUCY1A2(2977), GUCY1A3(2982), GUCY1B2(2974), GUCY1B3(2983)
    • N8161 NS309 ≥98% (HPLC), solid NS309 is a Ca2+-activated IK/SK potassium channel activator.
    		  
    • N7787 NS3694 ≥98%, powder NS3694 is an Inhibitor of apoptosome formation.
    		 human ... GRIK1(2897)
    • N1162 NS3763 ≥98% (HPLC), solid First non-competitive antagonist of GluK5 receptor.
    		  
    • N194 NS-398 ≥98% (HPLC), solid Selective cyclooxygenase-2 (COX-2) inhibitor.
    		 human ... ALOX5(240), CYP19A1(1588), PTGS1(5742), PTGS2(5743)
    mouse ... Ptgs2(19225)
    • N2538 NS8593 hydrochloride ≥98% (HPLC), powder The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.
    		 
    • SML0069 NSC 33994 ≥98% (HPLC) NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.
    Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation
    		  
    • N3414 NSC348884 hydrate NSC 348884 is a putative inhibitor of nucleophosmin (NPM). NSC 348884 inhibits NMP oligomer formation, up-regulates p53 and induces apoptosis.
    		  
    • N0915 NSC43067 ≥98% (HPLC) NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.
    		  
    • N8287 NSC 625987 ≥97% (HPLC) NSC 625987 is a selective, potent Cdk4/cyclin D1 inhibitor.
    		  
    • N7537 NSC 663284 ≥98% (HPLC), solid Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor
    		 human ... CDC25B(994), DUSP3(1845), PTPN1(5770)
    • SML0046 NSC 668036 hydrate ≥98% (HPLC) NSC 668036 binds to the PDZ domain of the Wnt-pathway signaling molecule Disheveled (Dvl), blocking the binding and activation of Dvl by Frizzled. In Xenopus embryos, NSC 668036 inhibited Wnt3A-induced expression of the target gene Siamois and formation of secondary axes.
    		  
    • N8164 NSC727447 ≥98% (HPLC) NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H.
    		  
    • N1786 NSC 95397 ≥97% (HPLC) Irreversible Cdc25 dual specificity phosphatase inhibitor.
    		 human ... CDC25A(993), CDC25B(994), CDC25C(995)
    • N1413 NSCI ≥97% (HPLC), solid NSCI is a nonpeptide caspase 3 selective inhibitor.
    		 human ... CASP1(834), CASP3(836), CASP6(839), CASP7(840), SUMO1(7341)
    • N7287 NU-1025 ≥97% (HPLC), solid NU-1025 is a PARP inhibitor.
    		 mouse ... Parp2(11546)
    • N4286 NU2058 >98% (HPLC) Selective cyclin-dependent kinase-2 (CDK2) inhibitor.
    		 human ... CDK2(1017)
    • N4411 NU6027 ≥98% (HPLC) NU6027 is a potent inhibitor of ATR signalling
    Selective cyclin-dependent kinase-2 (CDK2) inhibitor.
    		 human ... CDK2(1017), MGMT(4255)
    • N1537 NU7026 ≥98% (HPLC), solid Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).
    		  
    • N6287 Nutlin-3 ≥98% (HPLC), powder Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist, p53 pathway activator, and apoptosis inducer.