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C8484 Z-Ala-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone solid    
C9359 Z-Ala-Ser-Thr-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid Cell-permeable inhibitor of endothelial monocyte-activating polypeptide II (EMAP-II).
 
C0605 Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone ≥90% (HPLC) A cell-permeable inhibitor of caspase 3, 6, 7, 8, 10, which exhibits competitive and irreversible inhibition.
 
C0480 Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethyl ketone powder A cell-permeable inhibitor of caspase 3 and 6, which exhibits competitive and irreversible inhibition.
 
F114 cis-(Z)-Flupenthixol dihydrochloride ≥98% (HPLC), solid Antipsychotic; neuroleptic agent; dopamine receptor antagonist.
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
C9984 Z-Gly-Leu-Phe-chloromethyl ketone ≥90% (TLC), solid Cathepsin G inhibitor.
 
C1105   Z-Gly-Pro-Arg 4-methoxy-2-naphthylamide trifluoroacetate salt ≥97% (HPLC), powder    
C1230 Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone ≥90% (TLC), powder    
C1355 Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate ≥90%    
C8859 Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-fluoromethyl ketone solid    
C0483 Z-Leu-Leu-Glu-7-amido-4-methylcoumarin ≥95%, solid Fluorogenic substrate for the measurement of the peptidylglutamyl-peptide hydrolyzing activity of the 20S proteasome.
 
C0788 Z-Leu-Leu-Glu β-naphthylamide ≥98%, powder    
C0608 Z-Leu-Leu-Leu-7-amido-4-methylcoumarin ≥95% (HPLC and TLC), solid Fluorogenic substrate for the measurement of the peptidase activity of the 20S proteasome.
 
C8984 Z-Leu-Leu-Leu-fluoromethyl ketone ≥90% (TLC) Z-Leu-Leu-Leu-fluoromethyl ketone is a proteosome inhibitor.
 
SML1442 (Z-LL)2 Ketone ≥98% (HPLC) (Z-LL)2 Ketone is a selective inhibitor of signal peptide peptidase (SPP) that inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
 
C1480 Z-Phe-Ala fluoromethyl ketone ≥90% (TLC), powder    
C9109 Z-Phe-Phe-fluoromethyl ketone ≥98% (TLC), solid    
SML0205   Z-Pro-prolinal ≥98% (HPLC) Z-Pro-prolinal is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = 1 nM.

POP has been connected to memory and mood through regulation of the brain levels of its peptide substrates, which include AVP, substance P, neurotensin and TRH and is a potential target in cognitive function, memory, and neurodegenerative disorders such as amnesia, Alzheimer’s disease, and depression. POP has recently been reported to be involved in the release of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Ac-SDKP) from its precursor, 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.
 
C1855   Z-Trp-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone crystalline A cell-permeable inhibitor of caspase-1 and -5, which exhibits competitive and irreversible inhibition.
 
V116   Z-VAD-FMK solid Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.
human ... CASP3(836)
mouse ... CASP3(12367)
rat ... CASP3(25402)
C2105 Z-Val-Ala-Asp fluoromethyl ketone powder, ≥90% (TLC) Non-methylated competitive and irreversible inhibitor of caspase-1, as well as other caspases, which can be used directly with purified enzymes. It does not require esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(OMe) fluoromethyl ketone (Product Code V-116).
 
C1730 Z-Val-Glu(O-Me)-Ile-Asp(O-Me) fluoromethyl ketone powder A cell-permeable inhibitor of caspase-6, which exhibits competitive and irreversible inhibition.
 
SML0176 Z36 ≥98% (HPLC) Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux.
Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1.
 
SML0081 Zacopride hydrochloride hydrate ≥98% (HPLC) Zacopride is a sub-nanomolar antagonist of the serotonin 5-HT3 receptor that also displays agonist-like activity against 5-HT4 receptors. It is a potent anxiolytic in animal models, and also has strong antiemetic effects, and also increases aldosterone levels via activation of 5-HT4 receptor in the adrenal glands.
 
Z4152 Zafirlukast ≥98% (HPLC) Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. Zafirlukast has over 1000-fold selectivity for CysLT1, one of two receptors for cysteinyl leukotrienes LTC4, LTD4, and LTE4, which are important mediators of human bronchial asthma.
 
Z0502 Zaleplon ≥98% (HPLC), solid Zaleplon is a non-benzodiazepine agonist at the benzodiazepine site of the GABAA receptor; sedative; hypnotic.
 
SML0492 Zanamivir ≥98% (HPLC) Zanamivir is an influenza viral neuraminidase inhibitor.
 
Z4652 Zapotin from Casimiroa edulis (white sapote tree), ≥98% (HPLC) Zapotin is a 5,6,2′,6′-tetramethoxyflavone which is found in leaves and seeds of the Zapote blanco tree. Zapotin is a non toxic inducer of cellular differentiation, apoptosis, and cell cycle arrest. Hydroxylated flavonoids posses potent anti invasive and antimetastatic activities. Treatment with Zapotin markedly suppressed cell line proliferation and increased apoptosis in many colon cancer cell lines studied. Zapotin was found to induce both cell differentiation and apoptosis in cultured human promyelocytic leukemia cells (HL-60 cells). In addition, Zapotin inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA-c)-induced ornithine decarboxylase (ODC) activity in human bladder carcinoma cells (T24 cells). ODC is a rate-limiting enzyme for the biosynthesis of polyamines in mammalian cells. It is highly induced by growth factors and tumor promoters, and overexpressed in a variety of cancer cell lines. Zapotin inhibits also TPA-induced NF-κB activity in human hepatocellular liver carcinoma cells (HepG2 cells). Thus, Zapotin has the potential to inhibit carcinogenesis and serve as a chemopreventive agent in various biological systems.
 
Z2626 Zaragozic acid A trisodium salt ≥95% (HPLC), microbial Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
 
Z0127 Zatebradine hydrochloride ≥98% (HPLC), powder HCN channel blocker: blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels.
 
Z4902 ZD 7114 hydrochloride ≥98% (HPLC) ZD 7114 is a selective β3 adrenergic receptor agonist. β3 adrenoceptors are expressed in adipose tissue and smooth muscle.
 
Z3777 ZD7288 hydrate ≥98% (HPLC) Selective blocker of cation channel Ih; If blocker and sino-atrial node function modulator, blocks hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels.
 
Z0292 α-Zearalanol ~98% (HPLC)    
Z0417 β-Zearalanol ~98% (HPLC)   rat ... Ar(24208)
Z0167 Zearalanone   rat ... Ar(24208)
Z0166 α-Zearalenol   rat ... Ar(24208)
Z4775 Zebularine ≥98% (HPLC), solid Zebularine is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent.
 
Z3902 Zerumbone ≥98% (HPLC) Zerumbone is a TRAIL-induced apoptosis potentiator. It potentiates TRAIL-induced apoptosis through the up-regulation of DR4 and DR5 expression and the down-regulation of cFLIP. Zerumbone has very little or no cytotoxic effect on the normal human endothelial cells and dermal fibroblasts. Zerumbone is a sesquiterpene isolated from in Zingiber zerumbet Smith (wild ginger).
 
SML1550 Zibotentan ≥98% (HPLC) Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.
Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50 of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.
 
Z4277 Zileuton ≥98% (HPLC) Zileuton is an anti-asthmatic, an inhibitor of 5-lipoxygenase; the initial enzyme in the biosynthesis of leukotrienes from arachidonic acid.
 
Z101 Zimelidine dihydrochloride solid Serotonin transport blocker; antidepressant.
human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
SML1568   ZINC05626394 ≥98% (HPLC) ZINC05626394 is a derivative of propylthiouracil. It is a cell penetrant and a potent inhibitor of CYB5R3 (NADH cytochrome b5 reductase 3).
 
SML1699 (R)-ZINC-3573 ≥98% (HPLC) (R)-ZINC-3573 is a selective agonist probe of the orphan receptor Mas-related G-protein coupled receptor member X2 (MRGPRX2), a G-protein coupled receptor (GPCR) selectively expressed in mast cells and dorsal root and trigeminal ganglia primary sensory neurons of primates. Lack of selective and potent probes has made it difficult to determine MRGPRX2 funtion. (R)-ZINC-3573 was shown to be a potent and selective agonist with an EC50 value of 760 nM for MRGPRX2 and little activity for MRGPRX1 or over 350 other GPCRs and 97 kinases tested. (R)-ZINC-3573 activates endogenous MRGPRX2 expressed in a human mast cell line and induced degranulation and calcium release. (S)-ZINC-3573 is inactive and can be used as a control.
 
SML1700 (S)-ZINC-3573 ≥98% (HPLC) (S)-ZINC-3573 is an inactive control probe for (R)-ZINC-3573, which is a selective agonist probe of the GPCR orphan receptor MRGPRX2.
 
Z4402 Zinterol hydrochloride ≥98% (HPLC) Zinterol Hydrochloride is a β2 adrenergic receptor selective agonist.
 
Z2777 Ziprasidone hydrochloride monohydrate ≥98% (HPLC), solid Ziprasidone is an atypical antipsychotic; FDA approved for the treatment of schizophrenia.
 
Z4777 ZK 200775 hydrate ≥98% (HPLC), powder    
SML0146 ZL006 ≥98% (HPLC) ZL006 inhibits the ischemia-induced interaction of nNOS with postsynaptic density protein-95 (PSD-95), preventing glutamate-induced excitotoxicity and cerebral ischemic damage. It does not inhibit nNOS itself. ZL006 is brain penetrant, and has been tested in both rat and mouse models of stroke.
 
SML0802   ZLN005 ≥95% (HPLC) ZLN005 is a transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). ZLN005 increased PGC-1 and downstream gene transcription in skeletal muscle, while reducing hepatic PGC-1α and gluconeogenesis genes. ZLN005 increased fat oxidation and improved the glucose tolerance, pyruvate tolerance, insulin sensitivity, hyperglycemia and dyslipidemia of diabetic db/db mice.
 
SML0900   ZLN024 ≥98% (HPLC) ZLN024 is an allosteric activator of AMPK hetero-trimers. The compound ZLN024 protects against dephosphorylation of Thr172, which is critical for activity, and antagonizes AMPK autoinhibition. ZLM024 improves glucose tolerance and lowers total cholesterol levels in db/db mice.
 
Z0153 ZM 241385 ≥98% (HPLC) ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.
 
SML1691   ZM323881 hydrochloride ≥98% (HPLC) ZM323881 is a selective inhibitor of VEGFR-2 with an IC50 value of 2 nM. ZM323881 is selective for VEGFR-2 over VEGFR-1 and other receptor tyrosine kinases including PDGFRβ, FGFR1, EGFR and erbB2. ZM323881 inhibited VEGF-A-induced endothelial cell proliferation with an IC50 value of 8 nM.
 
SML0236 ZM 336372 ≥98% (HPLC) ZM-336372 is a potent inhibitor of the MAP kinase c-raf in in vitro assay systems (IC50 = 70 nM). In cell-based experiments, ZM-336372 induces c-raf activation through a novel feedback loop in which inhibition is counterbalanced by reactivation.
 
Z1252 Zofenopril calcium >98% (HPLC), powder Zofenopril is a long-lasting, lipophilic ACE inhibitor. Zofenopril is also an inhibitor of PEPT2, the predominant peptide transporter in kidney and choroid plexus.
 
SML0223 Zoledronic acid monohydrate ≥98% (HPLC) Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.
 
SML0248 Zolmitriptan ≥98% (HPLC) Zolmitriptan is a selective serotonin receptor agonist of the 5HT1B and 5HT1D subtypes, both centrally and peripherally. It has been used clinically for the acute treatment of migraine attacks with or without aura and cluster headaches.
 
Z103 Zolpidem ≥98% (HPLC), solid Potent and selective agonist for the benzodiazepine receptor associated with the GABAA receptor; hypnotic.
human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559)
rat ... Gabra1(29705), Gabra2(29706), Gabra5(29707), Tspo(24230)
Z2625 Zomepirac sodium salt    
SML0076 Zoniporide hydrochloride hydrate ≥98% (HPLC) Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.
 
Z2001 Zonisamide sodium salt ≥98% (HPLC), powder Zonisamide sodium salt is an anti-epileptic. It is effective in various animal epilepsy models and humans with both partial and generalized epileptic seizures. Zonisamide sodium salt also scavenges nitric oxide (NO).
 
Z4900 Zopiclone Benzodiazepine receptor agonist
human ... BZRAP1(9256)
Z4527 Zopolrestat ≥98% (HPLC) Zopolrestat is an inhibitor of Aldose Reductase. AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.
 
SML1044 Zosuquidar hydrochloride ≥98% (HPLC) Zosuqidar is a potent inhibitor of P-glycoprotein (P-gp, MDR1) a transporter protein that is a key modulator of cellular drug efflux. Zosuquidar sensitizes AML, and other cancer cell lines to cytotoxic drugs.
 
Z0877 Zotepine Zotepine is an atypical antipsychotic.
 
SML1646 ZQ-16 ≥98% (HPLC) ZQ-16 is a potent and selective agonist for medium-chain free fatty acid receptor GPR84 (G protein-coupled receptor 84). ZQ-16 activates GPR84-mediated calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction.